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Autoimmune disorder of the nervous system

MedGen UID:
155946
•Concept ID:
C0751871
•
Disease or Syndrome
Synonym: Autoimmune disease of the nervous system
 
Monarch Initiative: MONDO:0002977

Definition

A disorder characterized by the degeneration of the nervous system due to autoimmunity. Representative examples include multiple sclerosis, Guillain-Barre syndrome, and myasthenia gravis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAutoimmune disorder of the nervous system

Professional guidelines

PubMed

European Academy of Neurology/Peripheral Nerve Society Guideline on diagnosis and treatment of Guillain-Barré syndrome.
van Doorn PA, Van den Bergh PYK, Hadden RDM, Avau B, Vankrunkelsven P, Attarian S, Blomkwist-Markens PH, Cornblath DR, Goedee HS, Harbo T, Jacobs BC, Kusunoki S, Lehmann HC, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Umapathi T, Topaloglu HA, Willison HJ
Eur J Neurol 2023 Dec;30(12):3646-3674. Epub 2023 Oct 10 doi: 10.1111/ene.16073. PMID: 37814552
Diagnosis and Treatment of Multiple Sclerosis: A Review.
McGinley MP, Goldschmidt CH, Rae-Grant AD
JAMA 2021 Feb 23;325(8):765-779. doi: 10.1001/jama.2020.26858. PMID: 33620411
Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria.
Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA
Lancet Neurol 2018 Feb;17(2):162-173. Epub 2017 Dec 21 doi: 10.1016/S1474-4422(17)30470-2. PMID: 29275977

Recent clinical studies

Etiology

Autonomic neuropathies.
Kaur D, Tiwana H, Stino A, Sandroni P
Muscle Nerve 2021 Jan;63(1):10-21. Epub 2020 Sep 14 doi: 10.1002/mus.27048. PMID: 32926436
Autoimmune seizures and epilepsy.
Geis C, Planagumà J, Carreño M, Graus F, Dalmau J
J Clin Invest 2019 Mar 1;129(3):926-940. Epub 2019 Feb 4 doi: 10.1172/JCI125178. PMID: 30714986Free PMC Article
Multiple sclerosis.
Cotsapas C, Mitrovic M, Hafler D
Handb Clin Neurol 2018;148:723-730. doi: 10.1016/B978-0-444-64076-5.00046-6. PMID: 29478610
Vascular brain pathologies.
Garg A
Neuroimaging Clin N Am 2011 Nov;21(4):897-926, ix. Epub 2011 Sep 23 doi: 10.1016/j.nic.2011.07.007. PMID: 22032506
Multiple sclerosis.
Compston A, Coles A
Lancet 2002 Apr 6;359(9313):1221-31. doi: 10.1016/S0140-6736(02)08220-X. PMID: 11955556

Diagnosis

Diagnostic criteria for autoimmune encephalitis: utility and pitfalls for antibody-negative disease.
Dalmau J, Graus F
Lancet Neurol 2023 Jun;22(6):529-540. doi: 10.1016/S1474-4422(23)00083-2. PMID: 37210100
Sensory Ganglionopathy.
Amato AA, Ropper AH
N Engl J Med 2020 Oct 22;383(17):1657-1662. doi: 10.1056/NEJMra2023935. PMID: 33085862
"Time to recharge".
Dalmau J
Neurol Neuroimmunol Neuroinflamm 2020 Jul;7(4) Epub 2020 Jun 11 doi: 10.1212/NXI.0000000000000779. PMID: 32527761Free PMC Article
Encephalitis and meningoencephalitis: chasing the culprit.
Schibler M, Zanella MC, Kaiser L, Lalive PH
Clin Microbiol Infect 2019 Apr;25(4):406-407. Epub 2019 Jan 29 doi: 10.1016/j.cmi.2019.01.013. PMID: 30703529
Foreword.
Aminoff MJ, Boller F, Swaab DF
Handb Clin Neurol 2016;133:vii. doi: 10.1016/B978-0-444-63432-0.09992-8. PMID: 27112696

Therapy

Immunotherapy for Refractory Autoimmune Encephalitis.
Yang J, Liu X
Front Immunol 2021;12:790962. Epub 2021 Dec 16 doi: 10.3389/fimmu.2021.790962. PMID: 34975890Free PMC Article
Anti-MAG neuropathy: From biology to clinical management.
Steck AJ
J Neuroimmunol 2021 Dec 15;361:577725. Epub 2021 Sep 28 doi: 10.1016/j.jneuroim.2021.577725. PMID: 34610502
Autonomic neuropathies.
Kaur D, Tiwana H, Stino A, Sandroni P
Muscle Nerve 2021 Jan;63(1):10-21. Epub 2020 Sep 14 doi: 10.1002/mus.27048. PMID: 32926436
Critical review: Typical and atypical optic neuritis.
Abel A, McClelland C, Lee MS
Surv Ophthalmol 2019 Nov-Dec;64(6):770-779. Epub 2019 Jun 20 doi: 10.1016/j.survophthal.2019.06.001. PMID: 31229520
Multiple sclerosis.
Compston A, Coles A
Lancet 2002 Apr 6;359(9313):1221-31. doi: 10.1016/S0140-6736(02)08220-X. PMID: 11955556

Prognosis

Systemic complications of rheumatoid arthritis: Focus on pathogenesis and treatment.
Wu D, Luo Y, Li T, Zhao X, Lv T, Fang G, Ou P, Li H, Luo X, Huang A, Pang Y
Front Immunol 2022;13:1051082. Epub 2022 Dec 22 doi: 10.3389/fimmu.2022.1051082. PMID: 36618407Free PMC Article
Neurological Syndromes Associated with Anti-GAD Antibodies.
Dade M, Berzero G, Izquierdo C, Giry M, Benazra M, Delattre JY, Psimaras D, Alentorn A
Int J Mol Sci 2020 May 24;21(10) doi: 10.3390/ijms21103701. PMID: 32456344Free PMC Article
Autoimmune Epilepsy.
Husari KS, Dubey D
Neurotherapeutics 2019 Jul;16(3):685-702. doi: 10.1007/s13311-019-00750-3. PMID: 31240596Free PMC Article
Critical review: Typical and atypical optic neuritis.
Abel A, McClelland C, Lee MS
Surv Ophthalmol 2019 Nov-Dec;64(6):770-779. Epub 2019 Jun 20 doi: 10.1016/j.survophthal.2019.06.001. PMID: 31229520
GAD65 neurological autoimmunity.
McKeon A, Tracy JA
Muscle Nerve 2017 Jul;56(1):15-27. Epub 2017 Apr 11 doi: 10.1002/mus.25565. PMID: 28063151

Clinical prediction guides

Neurological Syndromes Associated with Anti-GAD Antibodies.
Dade M, Berzero G, Izquierdo C, Giry M, Benazra M, Delattre JY, Psimaras D, Alentorn A
Int J Mol Sci 2020 May 24;21(10) doi: 10.3390/ijms21103701. PMID: 32456344Free PMC Article
Autoimmune Epilepsy.
Husari KS, Dubey D
Neurotherapeutics 2019 Jul;16(3):685-702. doi: 10.1007/s13311-019-00750-3. PMID: 31240596Free PMC Article
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature.
Shan F, Long Y, Qiu W
Front Immunol 2018;9:2802. Epub 2018 Dec 5 doi: 10.3389/fimmu.2018.02802. PMID: 30568655Free PMC Article
GAD65 neurological autoimmunity.
McKeon A, Tracy JA
Muscle Nerve 2017 Jul;56(1):15-27. Epub 2017 Apr 11 doi: 10.1002/mus.25565. PMID: 28063151
Vaccination and Induction of Autoimmune Diseases.
Toussirot É, Bereau M
Inflamm Allergy Drug Targets 2015;14(2):94-8. doi: 10.2174/1871528114666160105113046. PMID: 26728772

Recent systematic reviews

Primary Sjögren syndrome-related peripheral neuropathy: A systematic review and meta-analysis.
Liampas A, Parperis K, Erotocritou MF, Nteveros A, Papadopoulou M, Moschovos C, Akil M, Coaccioli S, Hadjigeorgiou GM, Hadjivassiliou M, Zis P
Eur J Neurol 2023 Jan;30(1):255-265. Epub 2022 Sep 23 doi: 10.1111/ene.15555. PMID: 36086910Free PMC Article
Triggers of Guillain-Barré Syndrome: Campylobacter jejuni Predominates.
Finsterer J
Int J Mol Sci 2022 Nov 17;23(22) doi: 10.3390/ijms232214222. PMID: 36430700Free PMC Article
Low-Dose Naltrexone for Chronic Pain: Update and Systemic Review.
Kim PS, Fishman MA
Curr Pain Headache Rep 2020 Aug 26;24(10):64. doi: 10.1007/s11916-020-00898-0. PMID: 32845365
Efficacy of aquatic therapy for multiple sclerosis: a systematic review.
Corvillo I, Varela E, Armijo F, Alvarez-Badillo A, Armijo O, Maraver F
Eur J Phys Rehabil Med 2017 Dec;53(6):944-952. Epub 2017 Feb 17 doi: 10.23736/S1973-9087.17.04570-1. PMID: 28215060
Recommendation for a definition of acute symptomatic seizure.
Beghi E, Carpio A, Forsgren L, Hesdorffer DC, Malmgren K, Sander JW, Tomson T, Hauser WA
Epilepsia 2010 Apr;51(4):671-5. Epub 2009 Sep 3 doi: 10.1111/j.1528-1167.2009.02285.x. PMID: 19732133

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