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Contact hypersensitivity

MedGen UID:
102380
•Concept ID:
C0162351
•
Pathologic Function
Synonyms: Contact Hypersensitivities; Contact Hypersensitivity; Hypersensitivities, Contact; Hypersensitivity, Contact
SNOMED CT: Contact hypersensitivity (29268000)

Definition

A hypersensitivity condition of skin or mucous membranes at the site of direct surface contact with irritants or allergens. A general class that includes both immunologic and non-immunologic conditions. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVContact hypersensitivity

Professional guidelines

PubMed

The Unique Molecular Signatures of Contact Dermatitis and Implications for Treatment.
Leonard A, Guttman-Yassky E
Clin Rev Allergy Immunol 2019 Feb;56(1):1-8. doi: 10.1007/s12016-018-8685-0. PMID: 29754191
Immediate and Delayed Hypersensitivity Reactions to Corticosteroids: Evaluation and Management.
Otani IM, Banerji A
Curr Allergy Asthma Rep 2016 Mar;16(3):18. doi: 10.1007/s11882-016-0596-7. PMID: 26857016
Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation.
Ismail SB, Kumar SK, Zain RB
J Oral Sci 2007 Jun;49(2):89-106. doi: 10.2334/josnusd.49.89. PMID: 17634721

Recent clinical studies

Etiology

Role of Innate Immunity in Allergic Contact Dermatitis: An Update.
Yamaguchi HL, Yamaguchi Y, Peeva E
Int J Mol Sci 2023 Aug 19;24(16) doi: 10.3390/ijms241612975. PMID: 37629154Free PMC Article
ILCs and Allergy.
Kabata H, Motomura Y, Kiniwa T, Kobayashi T, Moro K
Adv Exp Med Biol 2022;1365:75-95. doi: 10.1007/978-981-16-8387-9_6. PMID: 35567742
Contact hypersensitivity in adolescents.
Pap EB, Temesvári E, Németh I, Sárdy M, Pónyai G
Pediatr Dermatol 2018 Nov;35(6):769-773. Epub 2018 Aug 28 doi: 10.1111/pde.13609. PMID: 30152547
Immunology of metal allergies.
Schmidt M, Goebeler M
J Dtsch Dermatol Ges 2015 Jul;13(7):653-60. Epub 2015 Jun 4 doi: 10.1111/ddg.12673. PMID: 26053629
Contact hypersensitivity: quantitative aspects, susceptibility and risk factors.
Friedmann PS, Pickard C
Exp Suppl 2014;104:51-71. doi: 10.1007/978-3-0348-0726-5_5. PMID: 24214618

Diagnosis

Oral Hypersensitivity Reactions.
Reinhart JP, Stoopler ET, Crawford GH
Dermatol Clin 2020 Oct;38(4):467-476. Epub 2020 Aug 11 doi: 10.1016/j.det.2020.05.007. PMID: 32892855
Allergy topics for dental practitioners.
Ramsey A, Brodine AH
Gen Dent 2019 Jul-Aug;67(4):38-45. PMID: 31355763
GOLD: human exposure and update on toxic risks.
Lansdown ABG
Crit Rev Toxicol 2018 Aug;48(7):596-614. doi: 10.1080/10408444.2018.1513991. PMID: 31851875
Food allergy in children.
Radlović N, Leković Z, Radlović V, Simić D, Ristić D, Vuletić B
Srp Arh Celok Lek 2016 Jan-Feb;144(1-2):99-103. doi: 10.2298/sarh1602099r. PMID: 27276868
Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation.
Ismail SB, Kumar SK, Zain RB
J Oral Sci 2007 Jun;49(2):89-106. doi: 10.2334/josnusd.49.89. PMID: 17634721

Therapy

Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate.
Hobson AD, McPherson MJ, Hayes ME, Goess C, Li X, Zhou J, Wang Z, Yu Y, Yang J, Sun L, Zhang Q, Qu P, Yang S, Hernandez A Jr, Bryant SH, Mathieu SL, Bischoff AK, Fitzgibbons J, Santora LC, Wang L, Wang L, Fettis MM, Li X, Marvin CC, Wang Z, Patel MV, Schmidt DL, Li T, Randolph JT, Henry RF, Graff C, Tian Y, Aguirre AL, Shrestha A
J Med Chem 2022 Dec 8;65(23):15893-15934. Epub 2022 Nov 17 doi: 10.1021/acs.jmedchem.2c01579. PMID: 36394224
Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin.
Salminen A, Kaarniranta K, Kauppinen A
Inflamm Res 2022 Aug;71(7-8):817-831. Epub 2022 Jun 24 doi: 10.1007/s00011-022-01598-8. PMID: 35748903Free PMC Article
Oral Hypersensitivity Reactions.
Reinhart JP, Stoopler ET, Crawford GH
Dermatol Clin 2020 Oct;38(4):467-476. Epub 2020 Aug 11 doi: 10.1016/j.det.2020.05.007. PMID: 32892855
Copper hypersensitivity.
Fage SW, Faurschou A, Thyssen JP
Contact Dermatitis 2014 Oct;71(4):191-201. Epub 2014 Aug 7 doi: 10.1111/cod.12273. PMID: 25098945
Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation.
Ismail SB, Kumar SK, Zain RB
J Oral Sci 2007 Jun;49(2):89-106. doi: 10.2334/josnusd.49.89. PMID: 17634721

Prognosis

An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases.
McPherson MJ, Hobson AD, Hernandez A Jr, Marvin CC, Waegell W, Goess C, Oh JZ, Shi D, Hayes ME, Wang L, Wang L, Schmidt D, Wang Z, Pitney V, McCarthy K, Jia Y, Wang C, Kang BN, Bryant S, Mathieu S, Ruzek M, Parmentier J, D'Cunha RR, Pang Y, Phillips L, Brown NJ, Xu J, Graff C, Tian Y, Longenecker KL, Qiu W, Zhu H, Liu W, Zheng P, Bi Y, Stoffel R
Sci Transl Med 2024 Mar 20;16(739):eadd8936. doi: 10.1126/scitranslmed.add8936. PMID: 38507467
Contact hypersensitivity in patients with psoriasis.
Žužul K, Kostović K, Čeović R, Ljubojević Hadžavdić S
Contact Dermatitis 2018 Apr;78(4):287-289. doi: 10.1111/cod.12921. PMID: 29527724
Immunomodulation of malignant melanoma by contact sensitizing agents.
Trowbridge RM, Mitkov MV, Pittelkow MR, Agrawal DK
Expert Rev Clin Immunol 2014 Jan;10(1):63-76. Epub 2013 Nov 22 doi: 10.1586/1744666X.2014.850415. PMID: 24308833
Contact hypersensitivity: quantitative aspects, susceptibility and risk factors.
Friedmann PS, Pickard C
Exp Suppl 2014;104:51-71. doi: 10.1007/978-3-0348-0726-5_5. PMID: 24214618
DNA repair, immunosuppression, and skin cancer.
Yarosh DB
Cutis 2004 Nov;74(5 Suppl):10-3. PMID: 15603216

Clinical prediction guides

An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases.
McPherson MJ, Hobson AD, Hernandez A Jr, Marvin CC, Waegell W, Goess C, Oh JZ, Shi D, Hayes ME, Wang L, Wang L, Schmidt D, Wang Z, Pitney V, McCarthy K, Jia Y, Wang C, Kang BN, Bryant S, Mathieu S, Ruzek M, Parmentier J, D'Cunha RR, Pang Y, Phillips L, Brown NJ, Xu J, Graff C, Tian Y, Longenecker KL, Qiu W, Zhu H, Liu W, Zheng P, Bi Y, Stoffel R
Sci Transl Med 2024 Mar 20;16(739):eadd8936. doi: 10.1126/scitranslmed.add8936. PMID: 38507467
Clinical predictors of metal allergic sensitization in orthodontic patients.
Zigante M, Špalj S
Cent Eur J Public Health 2022 Sep;30(3):173-178. doi: 10.21101/cejph.a7122. PMID: 36239365
Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin.
Salminen A, Kaarniranta K, Kauppinen A
Inflamm Res 2022 Aug;71(7-8):817-831. Epub 2022 Jun 24 doi: 10.1007/s00011-022-01598-8. PMID: 35748903Free PMC Article
Contact hypersensitivity: quantitative aspects, susceptibility and risk factors.
Friedmann PS, Pickard C
Exp Suppl 2014;104:51-71. doi: 10.1007/978-3-0348-0726-5_5. PMID: 24214618
Galectin-3 and the skin.
Larsen L, Chen HY, Saegusa J, Liu FT
J Dermatol Sci 2011 Nov;64(2):85-91. Epub 2011 Aug 11 doi: 10.1016/j.jdermsci.2011.07.008. PMID: 21889881Free PMC Article

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