U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Blue nevus

MedGen UID:
104930
Concept ID:
C0206736
Neoplastic Process
Synonym: Jadassohn's blue nevus
SNOMED CT: Blue nevus (63166000); Jadassohn's blue nevus (63166000); Dermal melanocytoma (63166000); Blue nevus of skin (254806009)
 
HPO: HP:0100814
Monarch Initiative: MONDO:0006680

Definition

A solitary, bluish, smooth surfaced macule, papule or plaque that is generally round or oval in shape. The histopathology of blue nevi varies by subtype, but general characteristics include a vertical wedge or bulbous shaped proliferation of spindle cells, dendritic melanocytes, and melanophages into a sclerotic dermis or subcutis. [from HPO]

Conditions with this feature

Intellectual disability, autosomal dominant 53
MedGen UID:
1623344
Concept ID:
C4540481
Mental or Behavioral Dysfunction
Suleiman-El-Hattab syndrome
MedGen UID:
1738652
Concept ID:
C5436458
Disease or Syndrome
Suleiman-El-Hattab syndrome (SULEHS) is an autosomal recessive multisystem developmental disorder characterized by hypotonia and feeding difficulties soon after birth, global developmental delay with impaired intellectual development and poor expressive speech, and a general happy demeanor. There is a distinctive facial appearance with microcephaly, thick arched eyebrows with synophrys, hypertelorism, epicanthal folds, low-set ears, broad nasal bridge, and thin upper lip. Additional more variable features include recurrent respiratory infections, cardiovascular malformations, cryptorchidism, seizures, and distal anomalies of the hands and feet (summary by Suleiman et al., 2019).
Liver disease, severe congenital
MedGen UID:
1823968
Concept ID:
C5774195
Disease or Syndrome
Severe congenital liver disease (SCOLIV) is an autosomal recessive disorder characterized by the onset of progressive hepatic dysfunction usually in the first years of life. Affected individuals show feeding difficulties with failure to thrive and features such as jaundice, hepatomegaly, and abdominal distension. Laboratory workup is consistent with hepatic insufficiency and may also show coagulation defects, anemia, or metabolic disturbances. Cirrhosis and hypernodularity are commonly observed on liver biopsy. Many patients die of liver failure in early childhood (Moreno Traspas et al., 2022).

Professional guidelines

PubMed

Custer PL, Council ML
Orbit 2024 Feb;43(1):8-15. Epub 2023 Jan 23 doi: 10.1080/01676830.2023.2169717. PMID: 36688501
Yaman B, Kandiloğlu G, Kumbaraci BS, Akalin T
Turk Patoloji Derg 2015;31(2):89-94. doi: 10.5146/tjpath.2014.01296. PMID: 25690862
González-Cámpora R, Galera-Davidson H, Vázquez-Ramírez FJ, Díaz-Cano S
Pathol Res Pract 1994 Jun;190(6):627-35. doi: 10.1016/S0344-0338(11)80402-4. PMID: 7984522

Recent clinical studies

Etiology

Boutko A, Asadbeigi S, Roth A, Lampley N, Olivares S, Dittmann D, Dittmann D, Jennings L, Gerami P
Am J Dermatopathol 2023 May 1;45(5):289-299. Epub 2023 Feb 17 doi: 10.1097/DAD.0000000000002366. PMID: 36898007
de la Fouchardiere A
Pathology 2023 Mar;55(2):187-195. Epub 2022 Dec 28 doi: 10.1016/j.pathol.2022.12.342. PMID: 36641378
Zhou J, Zhao Z, Sun T, Liu W, Yu Z, Liu J, Yu Y, Ning S, Zhang H
Am J Gastroenterol 2021 May 1;116(5):1044-1052. doi: 10.14309/ajg.0000000000001117. PMID: 33416235
Cooke-Barber J, Dasgupta R
Semin Pediatr Surg 2020 Oct;29(5):150977. Epub 2020 Sep 16 doi: 10.1016/j.sempedsurg.2020.150977. PMID: 33069283
Sugianto JZ, Ralston JS, Metcalf JS, McFaddin CL, Smith MT
Semin Diagn Pathol 2016 Jul;33(4):219-24. Epub 2016 Apr 19 doi: 10.1053/j.semdp.2016.04.006. PMID: 27199078

Diagnosis

de la Fouchardiere A
Pathology 2023 Mar;55(2):187-195. Epub 2022 Dec 28 doi: 10.1016/j.pathol.2022.12.342. PMID: 36641378
Zembowicz A
Clin Lab Med 2017 Sep;37(3):401-415. Epub 2017 Jul 4 doi: 10.1016/j.cll.2017.05.001. PMID: 28802492
Borgenvik TL, Karlsvik TM, Ray S, Fawzy M, James N
ANZ J Surg 2017 May;87(5):345-349. Epub 2017 Mar 20 doi: 10.1111/ans.13946. PMID: 28318130
Longo C, Scope A, Lallas A, Zalaudek I, Moscarella E, Gardini S, Argenziano G, Pellacani G
Dermatol Clin 2013 Oct;31(4):637-47, ix. Epub 2013 Aug 23 doi: 10.1016/j.det.2013.07.001. PMID: 24075551
Campos-do-Carmo G, Ramos-e-Silva M
Int J Dermatol 2008 Jul;47(7):712-9. doi: 10.1111/j.1365-4632.2008.03556.x. PMID: 18613881

Therapy

Wataya-Kaneda M, Maeda S, Nakamura A, Hayashi M, Fujimoto M
J Dermatol 2023 Dec;50(12):1619-1624. Epub 2023 Aug 31 doi: 10.1111/1346-8138.16930. PMID: 37649426
Zhou J, Zhao Z, Sun T, Liu W, Yu Z, Liu J, Yu Y, Ning S, Zhang H
Am J Gastroenterol 2021 May 1;116(5):1044-1052. doi: 10.14309/ajg.0000000000001117. PMID: 33416235
Isoldi S, Belsha D, Yeop I, Uc A, Zevit N, Mamula P, Loizides AM, Tabbers M, Cameron D, Day AS, Abu-El-Haija M, Chongsrisawat V, Briars G, Lindley KJ, Koeglmeier J, Shah N, Harper J, Syed SB, Thomson M
Dig Liver Dis 2019 Nov;51(11):1537-1546. Epub 2019 Jul 26 doi: 10.1016/j.dld.2019.04.020. PMID: 31358484
Jin XL, Wang ZH, Xiao XB, Huang LS, Zhao XY
World J Gastroenterol 2014 Dec 7;20(45):17254-9. doi: 10.3748/wjg.v20.i45.17254. PMID: 25493043Free PMC Article
Pathak MA
Skin Pharmacol 1991;4 Suppl 1:85-94. doi: 10.1159/000210987. PMID: 1764252

Prognosis

Colebatch AJ, Adhikari C, Diefenbach RJ, Rawson RV, Ferguson PM, Rizos H, Long GV, McCarthy SW, Thompson JF, Wilmott JS, Scolyer RA
Am J Surg Pathol 2022 Aug 1;46(8):1048-1059. Epub 2022 Apr 20 doi: 10.1097/PAS.0000000000001902. PMID: 35439782
Griewank KG, Müller H, Jackett LA, Emberger M, Möller I, van de Nes JA, Zimmer L, Livingstone E, Wiesner T, Scholz SL, Cosgarea I, Sucker A, Schimming T, Hillen U, Schilling B, Paschen A, Reis H, Mentzel T, Kutzner H, Rütten A, Murali R, Scolyer RA, Schadendorf D
Mod Pathol 2017 Jul;30(7):928-939. Epub 2017 Apr 14 doi: 10.1038/modpathol.2017.23. PMID: 28409567Free PMC Article
Borgenvik TL, Karlsvik TM, Ray S, Fawzy M, James N
ANZ J Surg 2017 May;87(5):345-349. Epub 2017 Mar 20 doi: 10.1111/ans.13946. PMID: 28318130
Phadke PA, Zembowicz A
Clin Lab Med 2011 Jun;31(2):345-58. doi: 10.1016/j.cll.2011.03.011. PMID: 21549247
Anderco D, Lazăr E, Tăban S, Miclea F, Dema A
Rom J Morphol Embryol 2010;51(3):555-7. PMID: 20809037

Clinical prediction guides

de la Fouchardiere A
Pathology 2023 Mar;55(2):187-195. Epub 2022 Dec 28 doi: 10.1016/j.pathol.2022.12.342. PMID: 36641378
Zhou J, Zhao Z, Sun T, Liu W, Yu Z, Liu J, Yu Y, Ning S, Zhang H
Am J Gastroenterol 2021 May 1;116(5):1044-1052. doi: 10.14309/ajg.0000000000001117. PMID: 33416235
Borgenvik TL, Karlsvik TM, Ray S, Fawzy M, James N
ANZ J Surg 2017 May;87(5):345-349. Epub 2017 Mar 20 doi: 10.1111/ans.13946. PMID: 28318130
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
Mehregan DA, Mehregan AH
Arch Dermatol 1993 Mar;129(3):328-31. PMID: 8447669

Recent systematic reviews

Rimondi A, Sorge A, Murino A, Nandi N, Scaramella L, Vecchi M, Tontini GE, Elli L
Dig Endosc 2024 Feb;36(2):162-171. Epub 2023 May 9 doi: 10.1111/den.14564. PMID: 37029779
Wong XL, Phan K, Rodríguez Bandera AI, Sebaratnam DF
J Paediatr Child Health 2019 Feb;55(2):152-155. Epub 2018 Dec 18 doi: 10.1111/jpc.14345. PMID: 30565378

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...