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Cervical Blue Nevus

MedGen UID:
273906
•Concept ID:
C1516410
•
Neoplastic Process
Synonym: Blue Nevus of the Cervix

Definition

A nevus that arises from the cervix. It is characterized by the presence of benign, heavily pigmented dendritic melanocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Blue Nevus

Professional guidelines

PubMed

Vascular Anomaly Syndromes in the ISSVA Classification System: Imaging Findings and Role of Interventional Radiology in Management.
Wang MX, Kamel S, Elsayes KM, Guillerman RP, Habiba A, Heng L, Revzin M, Mellnick V, Iacobas I, Chau A
Radiographics 2022 Oct;42(6):1598-1620. doi: 10.1148/rg.210234. PMID: 36190850
Management of visceral vascular anomalies.
Dasgupta R, Fishman SJ
Semin Pediatr Surg 2014 Aug;23(4):216-20. Epub 2014 Jul 15 doi: 10.1053/j.sempedsurg.2014.07.003. PMID: 25241101
Differential diagnosis of pediatric tumors of the nasal cavity and paranasal sinuses: a 45-year multi-institutional review.
Holsinger FC, Hafemeister AC, Hicks MJ, Sulek M, Huh WW, Friedman EM
Ear Nose Throat J 2010 Nov;89(11):534-40. PMID: 21086277

Recent clinical studies

Etiology

Melanomas Associated With Blue Nevi or Mimicking Cellular Blue Nevi: Clinical, Pathologic, and Molecular Study of 11 Cases Displaying a High Frequency of GNA11 Mutations, BAP1 Expression Loss, and a Predilection for the Scalp.
Costa S, Byrne M, Pissaloux D, Haddad V, Paindavoine S, Thomas L, Aubin F, Lesimple T, Grange F, Bonniaud B, Mortier L, Mateus C, Dreno B, Balme B, Vergier B, de la Fouchardiere A
Am J Surg Pathol 2016 Mar;40(3):368-77. doi: 10.1097/PAS.0000000000000568. PMID: 26645730
BRAF, KIT, NRAS, GNAQ and GNA11 mutation analysis in cutaneous melanomas in Turkish population.
Yilmaz I, Gamsizkan M, Kucukodaci Z, Berber U, Demirel D, Haholu A, Narli G
Indian J Pathol Microbiol 2015 Jul-Sep;58(3):279-84. doi: 10.4103/0377-4929.162831. PMID: 26275246
Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature.
Loghavi S, Curry JL, Torres-Cabala CA, Ivan D, Patel KP, Mehrotra M, Bassett R, Prieto VG, Tetzlaff MT
Mod Pathol 2014 Nov;27(11):1468-78. Epub 2014 Apr 18 doi: 10.1038/modpathol.2014.62. PMID: 24743221
Proposal for a clinical-dermoscopic classification of scalp naevi.
Zalaudek I, Schmid K, Niederkorn A, Fink-Puches R, Richtig E, Wolf I, Hofmann-Wellenhof R
Br J Dermatol 2014 May;170(5):1065-72. doi: 10.1111/bjd.12722. PMID: 24641327
Cutaneous signs of systemic disease.
Patel LM, Lambert PJ, Gagna CE, Maghari A, Lambert WC
Clin Dermatol 2011 Sep-Oct;29(5):511-22. doi: 10.1016/j.clindermatol.2011.01.019. PMID: 21855727

Diagnosis

Invasive cellular blue nevus in the cervical spine: A case report.
Rao X, Kang Z, Chen J, Wang T, Ma M, Yang S, Wu Z, Wang B, Zhang Q
Medicine (Baltimore) 2024 Feb 9;103(6):e37097. doi: 10.1097/MD.0000000000037097. PMID: 38335405Free PMC Article
Sinonasal blue nevus: a case report and review.
Lu R, Xiao W, Chen X, Li Z
Ear Nose Throat J 2024 Jul;103(7):416-419. Epub 2021 Dec 10 doi: 10.1177/01455613211064014. PMID: 34892997
Blue rubber bleb nevus syndrome: a case report and literature review.
Jin XL, Wang ZH, Xiao XB, Huang LS, Zhao XY
World J Gastroenterol 2014 Dec 7;20(45):17254-9. doi: 10.3748/wjg.v20.i45.17254. PMID: 25493043Free PMC Article
Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature.
Loghavi S, Curry JL, Torres-Cabala CA, Ivan D, Patel KP, Mehrotra M, Bassett R, Prieto VG, Tetzlaff MT
Mod Pathol 2014 Nov;27(11):1468-78. Epub 2014 Apr 18 doi: 10.1038/modpathol.2014.62. PMID: 24743221
Cervical melanosis.
Deppisch LM
Obstet Gynecol 1983 Oct;62(4):525-6. PMID: 6888833

Therapy

Sirolimus alternative to blood transfusion as a life saver in blue rubber bleb nevus syndrome: A case report.
Wang KL, Ma SF, Pang LY, Zhang MN, Hu LY, Liu MJ, Zou LP
Medicine (Baltimore) 2018 Feb;97(8):e9453. doi: 10.1097/MD.0000000000009453. PMID: 29465551Free PMC Article
An institution-wide algorithm for direct-stick embolization of peripheral venous malformations.
Nassiri N, Huntress LA, Simon M, Murphy S
J Vasc Surg Venous Lymphat Disord 2018 May;6(3):351-357. Epub 2018 Feb 1 doi: 10.1016/j.jvsv.2017.12.011. PMID: 29396158
Blue rubber bleb nevus syndrome: a case report and literature review.
Jin XL, Wang ZH, Xiao XB, Huang LS, Zhao XY
World J Gastroenterol 2014 Dec 7;20(45):17254-9. doi: 10.3748/wjg.v20.i45.17254. PMID: 25493043Free PMC Article

Prognosis

Blue rubber bleb nevus syndrome with the complication of intussusception: A case report and literature review.
Hu Z, Lin X, Zhong J, He Q, Peng Q, Xiao J, Chen B, Zhang J
Medicine (Baltimore) 2020 Jul 10;99(28):e21199. doi: 10.1097/MD.0000000000021199. PMID: 32664167Free PMC Article
Blue nevus-like melanoma of the uterine cervix. Case report and review of the literature.
Eniu DT, Staicu A, Şomcutian O, Buiga R, Albu C, Goidescu IG, Chiorean AR, Nistor-Ciurba CC
Rom J Morphol Embryol 2019;60(4):1317-1321. PMID: 32239111
Genomic Assessment of Blitz Nevi Suggests Classification as a Subset of Blue Nevus Rather Than Spitz Nevus: Clinical, Histopathologic, and Molecular Analysis of 18 Cases.
Isales MC, Haugh AM, Bubley J, Verzì AE, Zhang B, Kudalkar E, Lee CY, Yazdan P, Guitart J, Gerami P
Am J Dermatopathol 2018 Feb;40(2):118-124. doi: 10.1097/DAD.0000000000000918. PMID: 28475519
Blue rubber bleb nevus syndrome: a case report and literature review.
Jin XL, Wang ZH, Xiao XB, Huang LS, Zhao XY
World J Gastroenterol 2014 Dec 7;20(45):17254-9. doi: 10.3748/wjg.v20.i45.17254. PMID: 25493043Free PMC Article
Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature.
Loghavi S, Curry JL, Torres-Cabala CA, Ivan D, Patel KP, Mehrotra M, Bassett R, Prieto VG, Tetzlaff MT
Mod Pathol 2014 Nov;27(11):1468-78. Epub 2014 Apr 18 doi: 10.1038/modpathol.2014.62. PMID: 24743221

Clinical prediction guides

Melanomas Associated With Blue Nevi or Mimicking Cellular Blue Nevi: Clinical, Pathologic, and Molecular Study of 11 Cases Displaying a High Frequency of GNA11 Mutations, BAP1 Expression Loss, and a Predilection for the Scalp.
Costa S, Byrne M, Pissaloux D, Haddad V, Paindavoine S, Thomas L, Aubin F, Lesimple T, Grange F, Bonniaud B, Mortier L, Mateus C, Dreno B, Balme B, Vergier B, de la Fouchardiere A
Am J Surg Pathol 2016 Mar;40(3):368-77. doi: 10.1097/PAS.0000000000000568. PMID: 26645730
BRAF, KIT, NRAS, GNAQ and GNA11 mutation analysis in cutaneous melanomas in Turkish population.
Yilmaz I, Gamsizkan M, Kucukodaci Z, Berber U, Demirel D, Haholu A, Narli G
Indian J Pathol Microbiol 2015 Jul-Sep;58(3):279-84. doi: 10.4103/0377-4929.162831. PMID: 26275246
Blue rubber bleb nevus syndrome: a case report and literature review.
Jin XL, Wang ZH, Xiao XB, Huang LS, Zhao XY
World J Gastroenterol 2014 Dec 7;20(45):17254-9. doi: 10.3748/wjg.v20.i45.17254. PMID: 25493043Free PMC Article
Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature.
Loghavi S, Curry JL, Torres-Cabala CA, Ivan D, Patel KP, Mehrotra M, Bassett R, Prieto VG, Tetzlaff MT
Mod Pathol 2014 Nov;27(11):1468-78. Epub 2014 Apr 18 doi: 10.1038/modpathol.2014.62. PMID: 24743221
Cutaneous signs of systemic disease.
Patel LM, Lambert PJ, Gagna CE, Maghari A, Lambert WC
Clin Dermatol 2011 Sep-Oct;29(5):511-22. doi: 10.1016/j.clindermatol.2011.01.019. PMID: 21855727

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