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Calcifying Cystic Odontogenic Tumor

MedGen UID:
104931
•Concept ID:
C0206740
•
Neoplastic Process
Synonyms: Calcifying Odontogenic Cyst; Calcifying Odontogenic Cysts; Cyst, Calcifying Odontogenic; Cysts, Calcifying Odontogenic; Odontogenic Cyst, Calcifying; Odontogenic Cysts, Calcifying
SNOMED CT: Calcifying odontogenic cyst (75248003)

Definition

A benign, intraosseous or extraosseous cystic neoplasm arising from tooth-forming tissues. It is characterized by the presence of a cyst lined by an ameloblastoma-like epithelium and ghost cells formation. The ghost cells may undergo calcification. It is treated with enucleation. Few recurrences have been reported for intraosseous neoplasms whereas no recurrences have been reported for extraosseous neoplasms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCalcifying Cystic Odontogenic Tumor

Professional guidelines

PubMed

Differential diagnosis between calcifying odontogenic cyst and adenomatoid odontogenic tumor by computed tomography images.
Okura S, Igarashi C, Wakae-Morita S, Eda T, Ito H, Nakashima K, Sugisaki M, Ito Y, Kobayashi K
Oral Radiol 2022 Jan;38(1):99-104. Epub 2021 Apr 27 doi: 10.1007/s11282-021-00531-9. PMID: 33907948
Genetic screening for nevoid basal cell carcinoma syndrome in patients with a solitary keratocystic odontogenic tumour is not useful.
Karagozoglu KH, Van Hagen JM, Baart JA, Van Der Waal I
Minerva Stomatol 2011 Jan-Feb;60(1-2):1-4. PMID: 21252844
Peripheral odontogenic tumours--differential diagnosis in gingival lesions.
Manor Y, Mardinger O, Katz J, Taicher S, Hirshberg A
Int J Oral Maxillofac Surg 2004 Apr;33(3):268-73. doi: 10.1006/ijom.2003.0508. PMID: 15287310

Recent clinical studies

Etiology

Calcifying cystic odontogenic tumor associated with ameloblastoma - A rare histological variant.
Muddana K, Maloth AK, Dorankula SPR, Kulkarni PG
Indian J Dent Res 2019 Jan-Feb;30(1):144-148. doi: 10.4103/ijdr.IJDR_105_17. PMID: 30900676
Calcifying epithelial odontogenic cyst.
Manohar B, Baidya D, Shetty N, Mathur A, Makhijani B
J Exp Ther Oncol 2017 Nov;12(2):151-156. PMID: 29161784
Histologic Variants of Calcifying Odontogenic Cyst: A Study of 52 Cases.
Irani S, Foroughi F
J Contemp Dent Pract 2017 Aug 1;18(8):688-694. doi: 10.5005/jp-journals-10024-2108. PMID: 28816191
Immunohistochemical expression of WNT5A and MMPs in odontogenic epithelial tumors and cysts.
Guimarães DM, Antunes DM, Saturno JL, Massuda F, Paiva KB, Nunes FD
Acta Histochem 2015 Oct;117(8):667-74. Epub 2015 Nov 7 doi: 10.1016/j.acthis.2015.10.006. PMID: 26558991
Thirty years clinicopathological study of 60 calcifying cystic odontogenic tumors in Iranian population.
Habibi A, Saghravanian N, Salehinejad J, Jafarzadeh H
J Contemp Dent Pract 2011 May 1;12(3):171-3. doi: 10.5005/jp-journals-10024-1029. PMID: 22186811

Diagnosis

Calcifying Odontogenic Cyst Demonstrates Recurrent WNT Pathway Mutations and So-Called Adenoid Ameloblastoma-Like Histology: Evidence Supporting Its Classification as a Neoplasm.
Oh KY, Kim JH, Yoon HJ
Mod Pathol 2024 Jun;37(6):100484. Epub 2024 Apr 2 doi: 10.1016/j.modpat.2024.100484. PMID: 38574817
Calcifying epithelial odontogenic cyst.
Manohar B, Baidya D, Shetty N, Mathur A, Makhijani B
J Exp Ther Oncol 2017 Nov;12(2):151-156. PMID: 29161784
Odontogenic Cysts and Neoplasms.
Bilodeau EA, Collins BM
Surg Pathol Clin 2017 Mar;10(1):177-222. Epub 2016 Dec 29 doi: 10.1016/j.path.2016.10.006. PMID: 28153133
Ghost Cell Tumors.
Sheikh J, Cohen MD, Ramer N, Payami A
J Oral Maxillofac Surg 2017 Apr;75(4):750-758. Epub 2016 Oct 26 doi: 10.1016/j.joms.2016.10.013. PMID: 27865804
Odontogenic tumors of the maxillary sinus.
Press SG
Curr Opin Otolaryngol Head Neck Surg 2008 Feb;16(1):47-54. doi: 10.1097/MOO.0b013e3282f419da. PMID: 18197022

Prognosis

Odontogenic Cysts and Neoplasms.
Bilodeau EA, Collins BM
Surg Pathol Clin 2017 Mar;10(1):177-222. Epub 2016 Dec 29 doi: 10.1016/j.path.2016.10.006. PMID: 28153133
Complete resolution of a calcifying cystic odontogenic tumor with physiological eruption of a dislocated permanent tooth after marsupialization in a child with a mixed dentition: a case report.
Masuda K, Kawano S, Yamaza H, Sakamoto T, Kiyoshima T, Nakamura S, Nonaka K
World J Surg Oncol 2015 Sep 17;13:277. doi: 10.1186/s12957-015-0697-0. PMID: 26376974Free PMC Article
A prospective epidemiological study for odontogenic and non-odontogenic lesions of the maxilla and mandible in Queensland.
Johnson NR, Savage NW, Kazoullis S, Batstone MD
Oral Surg Oral Med Oral Pathol Oral Radiol 2013 Apr;115(4):515-22. doi: 10.1016/j.oooo.2013.01.016. PMID: 23522645
Expression of metallothionein in ameloblastoma. A regulatory molecule?
Ribeiro AL, Nobre RM, Rocha GC, de Souza Lobato IH, de Melo Alves Junior S, Jaeger RG, de Jesus Viana Pinheiro J
J Oral Pathol Med 2011 Jul;40(6):516-9. Epub 2011 Mar 4 doi: 10.1111/j.1600-0714.2011.01025.x. PMID: 21371124
Hamartomatous proliferations of odontogenic epithelium within the jaws: a potential histogenetic source of intraosseous epithelial odontogenic tumors.
Ide F, Obara K, Yamada H, Mishima K, Saito I, Horie N, Shimoyama T, Kusama K
J Oral Pathol Med 2007 Apr;36(4):229-35. doi: 10.1111/j.1600-0714.2007.00488.x. PMID: 17391301

Clinical prediction guides

Calcifying Odontogenic Cyst Demonstrates Recurrent WNT Pathway Mutations and So-Called Adenoid Ameloblastoma-Like Histology: Evidence Supporting Its Classification as a Neoplasm.
Oh KY, Kim JH, Yoon HJ
Mod Pathol 2024 Jun;37(6):100484. Epub 2024 Apr 2 doi: 10.1016/j.modpat.2024.100484. PMID: 38574817
Clinical and Histopathological Analysis of Odontogenic Tumors in Institution-A 10 Years Retrospective Study.
Mehngi R, Rajendra K, Bhagwat P, Hegde SS, Sah D, Rathod VS
J Contemp Dent Pract 2018 Oct 1;19(10):1288-1292. PMID: 30498188
Role of HIF-1α and CASPASE-3 in cystogenesis of odontogenic cysts and tumors.
da Costa NMM, de Siqueira AS, Ribeiro ALR, da Silva Kataoka MS, Jaeger RG, de Alves-Júnior SM, Smith AM, de Jesus Viana Pinheiro J
Clin Oral Investig 2018 Jan;22(1):141-149. Epub 2017 Feb 25 doi: 10.1007/s00784-017-2090-6. PMID: 28238093
Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study.
Mendes RB, Dias RB, Figueiredo AL, Gurgel CA, Santana Filho M, Melo LA, Trierveiler M, Cury PR, Leonardi R, Dos Santos JN
J Oral Pathol Med 2017 Apr;46(4):297-300. Epub 2016 Oct 13 doi: 10.1111/jop.12501. PMID: 27647326
Keratocystic odontogenic tumor overexpresses invadopodia-related proteins, suggesting invadopodia formation.
Ribeiro Ribeiro AL, da Costa NM, de Siqueira AS, Brasil da Silva W, da Silva Kataoka MS, Jaeger RG, de Melo Alves-Junior S, Smith AM, de Jesus Viana Pinheiro J
Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Oct;122(4):500-8. Epub 2016 Jun 22 doi: 10.1016/j.oooo.2016.06.004. PMID: 27554376

Recent systematic reviews

Synchronous cemento-ossifying fibromas: a systematic review.
Neumann BL, Mendes EM, Só BB, Silveira FM, Wagner VP, Vargas PA, Santos JN, Fonseca FP, Bologna-Molina RE, Mosqueda-Taylor A, Martins MA, Martins MD
Med Oral Patol Oral Cir Bucal 2024 Sep 1;29(5):e591-e597. doi: 10.4317/medoral.26501. PMID: 39088716Free PMC Article

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