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Benign Head and Neck Neoplasm

MedGen UID:
1747379
•Concept ID:
C5420464
•
Neoplastic Process

Definition

A neoplasm that arises from the head and neck and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Head and Neck Neoplasm

Professional guidelines

PubMed

2023 European Thyroid Association Clinical Practice Guidelines for thyroid nodule management.
Durante C, Hegedüs L, Czarniecka A, Paschke R, Russ G, Schmitt F, Soares P, Solymosi T, Papini E
Eur Thyroid J 2023 Oct 1;12(5) Epub 2023 Aug 14 doi: 10.1530/ETJ-23-0067. PMID: 37358008Free PMC Article
Management of thyroid nodules.
Alexander EK, Doherty GM, Barletta JA
Lancet Diabetes Endocrinol 2022 Jul;10(7):540-548. doi: 10.1016/S2213-8587(22)00139-5. PMID: 35752201
Contemporary Thyroid Nodule Evaluation and Management.
Grani G, Sponziello M, Pecce V, Ramundo V, Durante C
J Clin Endocrinol Metab 2020 Sep 1;105(9):2869-83. doi: 10.1210/clinem/dgaa322. PMID: 32491169Free PMC Article

Recent clinical studies

Etiology

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Paraganglioma of the Head and Neck: A Review.
Sandow L, Thawani R, Kim MS, Heinrich MC
Endocr Pract 2023 Feb;29(2):141-147. Epub 2022 Oct 15 doi: 10.1016/j.eprac.2022.10.002. PMID: 36252779Free PMC Article
Update of Radiofrequency Ablation for Treating Benign and Malignant Thyroid Nodules. The Future Is Now.
Tufano RP, Pace-Asciak P, Russell JO, Suárez C, Randolph GW, López F, Shaha AR, Mäkitie A, Rodrigo JP, Kowalski LP, Zafereo M, Angelos P, Ferlito A
Front Endocrinol (Lausanne) 2021;12:698689. Epub 2021 Jun 24 doi: 10.3389/fendo.2021.698689. PMID: 34248853Free PMC Article
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Head and neck paragangliomas.
Mendenhall WM, Amdur RJ, Vaysberg M, Mendenhall CM, Werning JW
Head Neck 2011 Oct;33(10):1530-4. Epub 2010 Nov 4 doi: 10.1002/hed.21524. PMID: 21928426

Diagnosis

Desmoid tumors of the head and neck in the pediatric population: Has anything changed?
Zhao CX, Dombrowski ND, Perez-Atayde AR, Robson CD, Afshar S, Janeway KA, Rahbar R
Int J Pediatr Otorhinolaryngol 2021 Jan;140:110511. Epub 2020 Nov 18 doi: 10.1016/j.ijporl.2020.110511. PMID: 33271436
The management of head-and-neck paragangliomas.
Capatina C, Ntali G, Karavitaki N, Grossman AB
Endocr Relat Cancer 2013 Oct;20(5):R291-305. Epub 2013 Aug 23 doi: 10.1530/ERC-13-0223. PMID: 23921204
Cervical lymph nodes.
Mack MG, Rieger J, Baghi M, Bisdas S, Vogl TJ
Eur J Radiol 2008 Jun;66(3):493-500. Epub 2008 Mar 11 doi: 10.1016/j.ejrad.2008.01.019. PMID: 18337039
Evaluating neck masses.
Prisco MK
Nurse Pract 2000 Apr;25(4):30-2, 35-6, 38 passim; quiz 50-1. doi: 10.1097/00006205-200025040-00002. PMID: 10790797
Desmoplastic melanoma.
Batsakis JG, Raymond AK
Ann Otol Rhinol Laryngol 1994 Jan;103(1):77-9. doi: 10.1177/000348949410300115. PMID: 8291864

Therapy

Discovery and validation of methylation signatures in circulating cell-free DNA for early detection of esophageal cancer: a case-control study.
Qiao G, Zhuang W, Dong B, Li C, Xu J, Wang G, Xie L, Zhou Z, Tian D, Chen G, Tang J, Zhou H, Zhang D, Shi R, Chen R, Nian W, Zhang Y, Zhao J, Wen X, Xu Y, Li B, Zhang Z, Cai S, Ben X, Qi Y
BMC Med 2021 Oct 13;19(1):243. doi: 10.1186/s12916-021-02109-y. PMID: 34641873Free PMC Article
Radiofrequency ablation and thyroid nodules: updated systematic review.
Muhammad H, Santhanam P, Russell JO
Endocrine 2021 Jun;72(3):619-632. Epub 2021 Jan 15 doi: 10.1007/s12020-020-02598-6. PMID: 33449296
Effectiveness of Molecular Testing Techniques for Diagnosis of Indeterminate Thyroid Nodules: A Randomized Clinical Trial.
Livhits MJ, Zhu CY, Kuo EJ, Nguyen DT, Kim J, Tseng CH, Leung AM, Rao J, Levin M, Douek ML, Beckett KR, Cheung DS, Gofnung YA, Smooke-Praw S, Yeh MW
JAMA Oncol 2021 Jan 1;7(1):70-77. doi: 10.1001/jamaoncol.2020.5935. PMID: 33300952Free PMC Article
IgG4-related disease in the head and neck.
Johnston J, Allen JE
Curr Opin Otolaryngol Head Neck Surg 2018 Dec;26(6):403-408. doi: 10.1097/MOO.0000000000000487. PMID: 30234659
Hoarseness-causes and treatments.
Reiter R, Hoffmann TK, Pickhard A, Brosch S
Dtsch Arztebl Int 2015 May 8;112(19):329-37. doi: 10.3238/arztebl.2015.0329. PMID: 26043420Free PMC Article

Prognosis

Head and neck cancer with synchronous nodules of the lung as a diagnostic and therapeutic challenge - A systematic review.
Müller M, Li J, Giger R, Elicin O
Oral Oncol 2023 Oct;145:106529. Epub 2023 Jul 26 doi: 10.1016/j.oraloncology.2023.106529. PMID: 37506514
Fetal brain, head, and neck tumors: Prenatal imaging and management.
Feygin T, Khalek N, Moldenhauer JS
Prenat Diagn 2020 Sep;40(10):1203-1219. Epub 2020 May 26 doi: 10.1002/pd.5722. PMID: 32350893
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
Cervical lymph nodes.
Mack MG, Rieger J, Baghi M, Bisdas S, Vogl TJ
Eur J Radiol 2008 Jun;66(3):493-500. Epub 2008 Mar 11 doi: 10.1016/j.ejrad.2008.01.019. PMID: 18337039
Desmoplastic melanoma.
Batsakis JG, Raymond AK
Ann Otol Rhinol Laryngol 1994 Jan;103(1):77-9. doi: 10.1177/000348949410300115. PMID: 8291864

Clinical prediction guides

Head and neck cancer with synchronous nodules of the lung as a diagnostic and therapeutic challenge - A systematic review.
Müller M, Li J, Giger R, Elicin O
Oral Oncol 2023 Oct;145:106529. Epub 2023 Jul 26 doi: 10.1016/j.oraloncology.2023.106529. PMID: 37506514
Paraganglioma of the Head and Neck: A Review.
Sandow L, Thawani R, Kim MS, Heinrich MC
Endocr Pract 2023 Feb;29(2):141-147. Epub 2022 Oct 15 doi: 10.1016/j.eprac.2022.10.002. PMID: 36252779Free PMC Article
Desmoid tumors of the head and neck in the pediatric population: Has anything changed?
Zhao CX, Dombrowski ND, Perez-Atayde AR, Robson CD, Afshar S, Janeway KA, Rahbar R
Int J Pediatr Otorhinolaryngol 2021 Jan;140:110511. Epub 2020 Nov 18 doi: 10.1016/j.ijporl.2020.110511. PMID: 33271436
Performance of a Multigene Genomic Classifier in Thyroid Nodules With Indeterminate Cytology: A Prospective Blinded Multicenter Study.
Steward DL, Carty SE, Sippel RS, Yang SP, Sosa JA, Sipos JA, Figge JJ, Mandel S, Haugen BR, Burman KD, Baloch ZW, Lloyd RV, Seethala RR, Gooding WE, Chiosea SI, Gomes-Lima C, Ferris RL, Folek JM, Khawaja RA, Kundra P, Loh KS, Marshall CB, Mayson S, McCoy KL, Nga ME, Ngiam KY, Nikiforova MN, Poehls JL, Ringel MD, Yang H, Yip L, Nikiforov YE
JAMA Oncol 2019 Feb 1;5(2):204-212. doi: 10.1001/jamaoncol.2018.4616. PMID: 30419129Free PMC Article
Evaluating neck masses.
Prisco MK
Nurse Pract 2000 Apr;25(4):30-2, 35-6, 38 passim; quiz 50-1. doi: 10.1097/00006205-200025040-00002. PMID: 10790797

Recent systematic reviews

Head and neck cancer with synchronous nodules of the lung as a diagnostic and therapeutic challenge - A systematic review.
Müller M, Li J, Giger R, Elicin O
Oral Oncol 2023 Oct;145:106529. Epub 2023 Jul 26 doi: 10.1016/j.oraloncology.2023.106529. PMID: 37506514
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Odontogenic and Maxillofacial Bone Tumours.
Vered M, Wright JM
Head Neck Pathol 2022 Mar;16(1):63-75. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01404-7. PMID: 35312978Free PMC Article
Radiofrequency ablation and thyroid nodules: updated systematic review.
Muhammad H, Santhanam P, Russell JO
Endocrine 2021 Jun;72(3):619-632. Epub 2021 Jan 15 doi: 10.1007/s12020-020-02598-6. PMID: 33449296
Esophageal dilation in head and neck cancer patients: A systematic review and meta-analysis.
Moss WJ, Pang J, Orosco RK, Weissbrod PA, Brumund KT, Weisman RA, Brigger MT, Coffey CS
Laryngoscope 2018 Jan;128(1):111-117. Epub 2017 May 12 doi: 10.1002/lary.26618. PMID: 28498643
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

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