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Short N3 sleep

MedGen UID:
1051520
•Concept ID:
CN375747
•
Finding
Synonym: Short slow wave sleep
 
HPO: HP:5200309

Definition

Disruptions in the third stage of NREM sleep. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVShort N3 sleep

Professional guidelines

PubMed

Clinical Management of Sleep and Sleep Disorders With Cannabis and Cannabinoids: Implications to Practicing Psychiatrists.
Monti JM, Pandi-Perumal SR
Clin Neuropharmacol 2022 Mar-Apr 01;45(2):27-31. doi: 10.1097/WNF.0000000000000494. PMID: 35221321
Insomnia in Elderly Patients: Recommendations for Pharmacological Management.
Abad VC, Guilleminault C
Drugs Aging 2018 Sep;35(9):791-817. doi: 10.1007/s40266-018-0569-8. PMID: 30058034
Melatonin for the prevention and treatment of jet lag.
Herxheimer A, Petrie KJ
Cochrane Database Syst Rev 2002;(2):CD001520. doi: 10.1002/14651858.CD001520. PMID: 12076414

Recent clinical studies

Etiology

Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer's disease.
Lucey BP, Wisch J, Boerwinkle AH, Landsness EC, Toedebusch CD, McLeland JS, Butt OH, Hassenstab J, Morris JC, Ances BM, Holtzman DM
Brain 2021 Oct 22;144(9):2852-2862. doi: 10.1093/brain/awab272. PMID: 34668959Free PMC Article
Insomnia in Elderly Patients: Recommendations for Pharmacological Management.
Abad VC, Guilleminault C
Drugs Aging 2018 Sep;35(9):791-817. doi: 10.1007/s40266-018-0569-8. PMID: 30058034
Inadequate sleep as a contributor to type 2 diabetes in children and adolescents.
Dutil C, Chaput JP
Nutr Diabetes 2017 May 8;7(5):e266. doi: 10.1038/nutd.2017.19. PMID: 28481337Free PMC Article
Impact of sleep on the risk of cognitive decline and dementia.
Spira AP, Chen-Edinboro LP, Wu MN, Yaffe K
Curr Opin Psychiatry 2014 Nov;27(6):478-83. doi: 10.1097/YCO.0000000000000106. PMID: 25188896Free PMC Article
Serotonin conflict in sleep-feeding.
Nonogaki K
Vitam Horm 2012;89:223-39. doi: 10.1016/B978-0-12-394623-2.00012-3. PMID: 22640616

Diagnosis

Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer's disease.
Lucey BP, Wisch J, Boerwinkle AH, Landsness EC, Toedebusch CD, McLeland JS, Butt OH, Hassenstab J, Morris JC, Ances BM, Holtzman DM
Brain 2021 Oct 22;144(9):2852-2862. doi: 10.1093/brain/awab272. PMID: 34668959Free PMC Article
Parasomnias Occurring in Non-Rapid Eye Movement Sleep.
Silber MH
Continuum (Minneap Minn) 2020 Aug;26(4):946-962. doi: 10.1212/CON.0000000000000877. PMID: 32756230
Sleep disturbances in fibromyalgia: A meta-analysis of case-control studies.
Wu YL, Chang LY, Lee HC, Fang SC, Tsai PS
J Psychosom Res 2017 May;96:89-97. Epub 2017 Mar 23 doi: 10.1016/j.jpsychores.2017.03.011. PMID: 28545798
The important role of sleep in metabolism.
Copinschi G, Leproult R, Spiegel K
Front Horm Res 2014;42:59-72. Epub 2014 Apr 7 doi: 10.1159/000358858. PMID: 24732925
Angelman syndrome.
Kyllerman M
Handb Clin Neurol 2013;111:287-90. doi: 10.1016/B978-0-444-52891-9.00032-4. PMID: 23622177

Therapy

Exposure to a more unhealthy diet impacts sleep microstructure during normal sleep and recovery sleep: A randomized trial.
Brandão LEM, Popa A, Cedernaes E, Cedernaes C, Lampola L, Cedernaes J
Obesity (Silver Spring) 2023 Jul;31(7):1755-1766. Epub 2023 May 28 doi: 10.1002/oby.23787. PMID: 37245331
The impact of acoustic stimulation during sleep on memory and sleep architecture: A meta-analysis.
Stanyer EC, Baniqued PDE, Awais M, Kouara L, Davies AG, Killan EC, Mushtaq F
J Sleep Res 2022 Jun;31(3):e13385. Epub 2021 Nov 30 doi: 10.1111/jsr.13385. PMID: 34850995
Encoding, Consolidation, and Renormalization in Depression: Synaptic Homeostasis, Plasticity, and Sleep Integrate Rapid Antidepressant Effects.
Rantamäki T, Kohtala S
Pharmacol Rev 2020 Apr;72(2):439-465. doi: 10.1124/pr.119.018697. PMID: 32139613
Opioids, sleep architecture and sleep-disordered breathing.
Wang D, Teichtahl H
Sleep Med Rev 2007 Feb;11(1):35-46. Epub 2006 Dec 1 doi: 10.1016/j.smrv.2006.03.006. PMID: 17141540
Melatonin for the prevention and treatment of jet lag.
Herxheimer A, Petrie KJ
Cochrane Database Syst Rev 2002;(2):CD001520. doi: 10.1002/14651858.CD001520. PMID: 12076414

Prognosis

Sleep architecture of short sleep time in patients with obstructive sleep apnea: a retrospective single-facility study.
Nozawa S, Urushihata K, Machida R, Hanaoka M
Sleep Breath 2022 Dec;26(4):1633-1640. Epub 2021 Nov 22 doi: 10.1007/s11325-021-02533-7. PMID: 34807406
Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer's disease.
Lucey BP, Wisch J, Boerwinkle AH, Landsness EC, Toedebusch CD, McLeland JS, Butt OH, Hassenstab J, Morris JC, Ances BM, Holtzman DM
Brain 2021 Oct 22;144(9):2852-2862. doi: 10.1093/brain/awab272. PMID: 34668959Free PMC Article
Longitudinal sleep characteristics and hypertension status: results from the Wisconsin Sleep Cohort Study.
Moon C, Hagen EW, Johnson HM, Brown RL, Peppard PE
J Hypertens 2021 Apr 1;39(4):683-691. doi: 10.1097/HJH.0000000000002692. PMID: 33186322Free PMC Article
The effects of napping on cognitive functioning.
Lovato N, Lack L
Prog Brain Res 2010;185:155-66. doi: 10.1016/B978-0-444-53702-7.00009-9. PMID: 21075238
Sleep homeostasis and models of sleep regulation.
Borbély AA, Achermann P
J Biol Rhythms 1999 Dec;14(6):557-68. doi: 10.1177/074873099129000894. PMID: 10643753

Clinical prediction guides

Sleep architecture and sleep-disordered breathing in fatal insomnia.
Pérez-Carbonell L, Muñoz-Lopetegi A, Sánchez-Valle R, Gelpi E, Farré R, Gaig C, Iranzo A, Santamaria J
Sleep Med 2022 Dec;100:311-346. Epub 2022 Sep 20 doi: 10.1016/j.sleep.2022.08.027. PMID: 36182725
Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer's disease.
Lucey BP, Wisch J, Boerwinkle AH, Landsness EC, Toedebusch CD, McLeland JS, Butt OH, Hassenstab J, Morris JC, Ances BM, Holtzman DM
Brain 2021 Oct 22;144(9):2852-2862. doi: 10.1093/brain/awab272. PMID: 34668959Free PMC Article
Inadequate sleep as a contributor to type 2 diabetes in children and adolescents.
Dutil C, Chaput JP
Nutr Diabetes 2017 May 8;7(5):e266. doi: 10.1038/nutd.2017.19. PMID: 28481337Free PMC Article
Serotonin conflict in sleep-feeding.
Nonogaki K
Vitam Horm 2012;89:223-39. doi: 10.1016/B978-0-12-394623-2.00012-3. PMID: 22640616
The effects of napping on cognitive functioning.
Lovato N, Lack L
Prog Brain Res 2010;185:155-66. doi: 10.1016/B978-0-444-53702-7.00009-9. PMID: 21075238

Recent systematic reviews

Effects of sleep manipulation on markers of insulin sensitivity: A systematic review and meta-analysis of randomized controlled trials.
Sondrup N, Termannsen AD, Eriksen JN, Hjorth MF, Færch K, Klingenberg L, Quist JS
Sleep Med Rev 2022 Apr;62:101594. Epub 2022 Feb 1 doi: 10.1016/j.smrv.2022.101594. PMID: 35189549
Short-term physical health effects of sleep disruptions attributed to the acute hospital environment: a systematic review.
Elliott R, Chawla A, Wormleaton N, Harrington Z
Sleep Health 2021 Aug;7(4):508-518. Epub 2021 Apr 16 doi: 10.1016/j.sleh.2021.03.001. PMID: 33875386
Sleep disturbances in fibromyalgia: A meta-analysis of case-control studies.
Wu YL, Chang LY, Lee HC, Fang SC, Tsai PS
J Psychosom Res 2017 May;96:89-97. Epub 2017 Mar 23 doi: 10.1016/j.jpsychores.2017.03.011. PMID: 28545798
A systematic review of the sleep, sleepiness, and performance implications of limited wake shift work schedules.
Short MA, Agostini A, Lushington K, Dorrian J
Scand J Work Environ Health 2015 Sep 1;41(5):425-40. Epub 2015 Jun 23 doi: 10.5271/sjweh.3509. PMID: 26103467
Melatonin for the prevention and treatment of jet lag.
Herxheimer A, Petrie KJ
Cochrane Database Syst Rev 2002;(2):CD001520. doi: 10.1002/14651858.CD001520. PMID: 12076414

Supplemental Content

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