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Elevated circulating CCL3 concentration

MedGen UID:
1052591
•Concept ID:
CN377516
•
Finding
HPO: HP:6000687

Definition

The concentration of C-C Motif Ligand 3 (CCL3) in the blood circulation is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating CCL3 concentration

Recent clinical studies

Etiology

Circulating chemokine levels and miscarriage.
Whitcomb BW, Schisterman EF, Klebanoff MA, Baumgarten M, Rhoton-Vlasak A, Luo X, Chegini N
Am J Epidemiol 2007 Aug 1;166(3):323-31. Epub 2007 May 15 doi: 10.1093/aje/kwm084. PMID: 17504778
Longitudinal analysis of serum chemokine levels in the course of HIV-1 infection.
Polo S, Veglia F, Malnati MS, Gobbi C, Farci P, Raiteri R, Sinicco A, Lusso P
AIDS 1999 Mar 11;13(4):447-54. doi: 10.1097/00002030-199903110-00002. PMID: 10197372

Diagnosis

Selective up-regulation of the soluble pattern-recognition receptor pentraxin 3 and of vascular endothelial growth factor in giant cell arteritis: relevance for recent optic nerve ischemia.
Baldini M, Maugeri N, Ramirez GA, Giacomassi C, Castiglioni A, Prieto-González S, Corbera-Bellalta M, Di Comite G, Papa I, Dell'antonio G, Ammirati E, Cuccovillo I, Vecchio V, Mantovani A, Rovere-Querini P, Sabbadini MG, Cid MC, Manfredi AA
Arthritis Rheum 2012 Mar;64(3):854-65. doi: 10.1002/art.33411. PMID: 21989653

Therapy

Cervicovaginal Immune Activation in Zambian Women With Female Genital Schistosomiasis.
Sturt AS, Webb EL, Patterson C, Phiri CR, Mweene T, Kjetland EF, Mudenda M, Mapani J, Mutengo MM, Chipeta J, van Dam GJ, Corstjens PLAM, Ayles H, Hayes RJ, Hansingo I, Cools P, van Lieshout L, Helmby H, McComsey GA, Francis SC, Bustinduy AL
Front Immunol 2021;12:620657. Epub 2021 Mar 2 doi: 10.3389/fimmu.2021.620657. PMID: 33737927Free PMC Article
Radiotherapy for Non-Small Cell Lung Cancer Induces DNA Damage Response in Both Irradiated and Out-of-field Normal Tissues.
Siva S, Lobachevsky P, MacManus MP, Kron T, Möller A, Lobb RJ, Ventura J, Best N, Smith J, Ball D, Martin OA
Clin Cancer Res 2016 Oct 1;22(19):4817-4826. Epub 2016 Jun 3 doi: 10.1158/1078-0432.CCR-16-0138. PMID: 27259562

Prognosis

Longitudinal analysis of serum chemokine levels in the course of HIV-1 infection.
Polo S, Veglia F, Malnati MS, Gobbi C, Farci P, Raiteri R, Sinicco A, Lusso P
AIDS 1999 Mar 11;13(4):447-54. doi: 10.1097/00002030-199903110-00002. PMID: 10197372

Clinical prediction guides

Radiotherapy for Non-Small Cell Lung Cancer Induces DNA Damage Response in Both Irradiated and Out-of-field Normal Tissues.
Siva S, Lobachevsky P, MacManus MP, Kron T, Möller A, Lobb RJ, Ventura J, Best N, Smith J, Ball D, Martin OA
Clin Cancer Res 2016 Oct 1;22(19):4817-4826. Epub 2016 Jun 3 doi: 10.1158/1078-0432.CCR-16-0138. PMID: 27259562
Circulating chemokine levels and miscarriage.
Whitcomb BW, Schisterman EF, Klebanoff MA, Baumgarten M, Rhoton-Vlasak A, Luo X, Chegini N
Am J Epidemiol 2007 Aug 1;166(3):323-31. Epub 2007 May 15 doi: 10.1093/aje/kwm084. PMID: 17504778
Longitudinal analysis of serum chemokine levels in the course of HIV-1 infection.
Polo S, Veglia F, Malnati MS, Gobbi C, Farci P, Raiteri R, Sinicco A, Lusso P
AIDS 1999 Mar 11;13(4):447-54. doi: 10.1097/00002030-199903110-00002. PMID: 10197372

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