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Abnormal CSF N-acetylaspartic acid concentration

MedGen UID:
1052918
Concept ID:
CN377502
Finding
Synonym: Elevated urine 2-betanone level
 
HPO: HP:6000673

Definition

Any deviation from the normal concentration of N-acetylaspartic acid in the cerebrospinal fluid (CSF). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal CSF N-acetylaspartic acid concentration

Professional guidelines

PubMed

Voevodskaya O, Sundgren PC, Strandberg O, Zetterberg H, Minthon L, Blennow K, Wahlund LO, Westman E, Hansson O; Swedish BioFINDER study group
Neurology 2016 May 10;86(19):1754-61. Epub 2016 Apr 15 doi: 10.1212/WNL.0000000000002672. PMID: 27164711Free PMC Article

Recent clinical studies

Etiology

Voevodskaya O, Sundgren PC, Strandberg O, Zetterberg H, Minthon L, Blennow K, Wahlund LO, Westman E, Hansson O; Swedish BioFINDER study group
Neurology 2016 May 10;86(19):1754-61. Epub 2016 Apr 15 doi: 10.1212/WNL.0000000000002672. PMID: 27164711Free PMC Article
Kirov II, Tal A, Babb JS, Herbert J, Gonen O
Neurology 2013 Jan 1;80(1):39-46. Epub 2012 Nov 21 doi: 10.1212/WNL.0b013e31827b1a8c. PMID: 23175732Free PMC Article
Seese RR, O'Neill J, Hudkins M, Siddarth P, Levitt J, Tseng B, Wu KN, Caplan R
Schizophr Res 2011 Dec;133(1-3):82-90. Epub 2011 Aug 27 doi: 10.1016/j.schres.2011.07.011. PMID: 21872444Free PMC Article
Adalsteinsson E, Langer-Gould A, Homer RJ, Rao A, Sullivan EV, Lima CA, Pfefferbaum A, Atlas SW
AJNR Am J Neuroradiol 2003 Nov-Dec;24(10):1941-5. PMID: 14625214Free PMC Article
Tsai G, Goff DC, Chang RW, Flood J, Baer L, Coyle JT
Am J Psychiatry 1998 Sep;155(9):1207-13. doi: 10.1176/ajp.155.9.1207. PMID: 9734544

Diagnosis

Kirov II, Tal A, Babb JS, Herbert J, Gonen O
Neurology 2013 Jan 1;80(1):39-46. Epub 2012 Nov 21 doi: 10.1212/WNL.0b013e31827b1a8c. PMID: 23175732Free PMC Article
Port JD, Unal SS, Mrazek DA, Marcus SM
Psychiatry Res 2008 Feb 28;162(2):113-21. Epub 2007 Dec 31 doi: 10.1016/j.pscychresns.2007.08.004. PMID: 18164911
Braun KP, Gooskens RH, Vandertop WP, Tulleken CA, van der Grond J
J Magn Reson Imaging 2003 Mar;17(3):291-9. doi: 10.1002/jmri.10270. PMID: 12594718
Auer DP, Wilke M, Grabner A, Heidenreich JO, Bronisch T, Wetter TC
Schizophr Res 2001 Oct 1;52(1-2):87-99. doi: 10.1016/s0920-9964(01)00155-4. PMID: 11595395
Tsai G, Goff DC, Chang RW, Flood J, Baer L, Coyle JT
Am J Psychiatry 1998 Sep;155(9):1207-13. doi: 10.1176/ajp.155.9.1207. PMID: 9734544

Therapy

Woermann FG, McLean MA, Bartlett PA, Barker GJ, Duncan JS
Brain 2001 Feb;124(Pt 2):427-36. doi: 10.1093/brain/124.2.427. PMID: 11157569
Rubio-Gozalbo ME, Heerschap A, Trijbels JM, De Meirleir L, Thijssen HO, Smeitink JA
Magn Reson Imaging 1999 Jul;17(6):939-44. doi: 10.1016/s0730-725x(99)00002-8. PMID: 10402601
Tsai G, Goff DC, Chang RW, Flood J, Baer L, Coyle JT
Am J Psychiatry 1998 Sep;155(9):1207-13. doi: 10.1176/ajp.155.9.1207. PMID: 9734544

Prognosis

Kuroda H, Fujihara K, Mugikura S, Takahashi S, Kushimoto S, Aoki M
J Neurol Sci 2016 Jan 15;360:161-9. Epub 2015 Dec 7 doi: 10.1016/j.jns.2015.12.006. PMID: 26723994
Kirov II, Tal A, Babb JS, Herbert J, Gonen O
Neurology 2013 Jan 1;80(1):39-46. Epub 2012 Nov 21 doi: 10.1212/WNL.0b013e31827b1a8c. PMID: 23175732Free PMC Article
Tsai G, Goff DC, Chang RW, Flood J, Baer L, Coyle JT
Am J Psychiatry 1998 Sep;155(9):1207-13. doi: 10.1176/ajp.155.9.1207. PMID: 9734544

Clinical prediction guides

Kirov II, Tal A, Babb JS, Herbert J, Gonen O
Neurology 2013 Jan 1;80(1):39-46. Epub 2012 Nov 21 doi: 10.1212/WNL.0b013e31827b1a8c. PMID: 23175732Free PMC Article
Adalsteinsson E, Langer-Gould A, Homer RJ, Rao A, Sullivan EV, Lima CA, Pfefferbaum A, Atlas SW
AJNR Am J Neuroradiol 2003 Nov-Dec;24(10):1941-5. PMID: 14625214Free PMC Article
Cecil KM, DelBello MP, Morey R, Strakowski SM
Bipolar Disord 2002 Dec;4(6):357-65. doi: 10.1034/j.1399-5618.2002.02235.x. PMID: 12519095
Auer DP, Wilke M, Grabner A, Heidenreich JO, Bronisch T, Wetter TC
Schizophr Res 2001 Oct 1;52(1-2):87-99. doi: 10.1016/s0920-9964(01)00155-4. PMID: 11595395
Huang W, Alexander GE, Chang L, Shetty HU, Krasuski JS, Rapoport SI, Schapiro MB
Neurology 2001 Aug 28;57(4):626-32. doi: 10.1212/wnl.57.4.626. PMID: 11524470

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