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Abnormal cerebrospinal fluid morphology

MedGen UID:
488781
•Concept ID:
C0151583
•
Finding
Synonym: Abnormality of the cerebrospinal fluid
 
HPO: HP:0002921

Definition

An abnormality of the cerebrospinal fluid (CSF). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal cerebrospinal fluid morphology

Professional guidelines

PubMed

Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup.
Jack CR Jr, Andrews JS, Beach TG, Buracchio T, Dunn B, Graf A, Hansson O, Ho C, Jagust W, McDade E, Molinuevo JL, Okonkwo OC, Pani L, Rafii MS, Scheltens P, Siemers E, Snyder HM, Sperling R, Teunissen CE, Carrillo MC
Alzheimers Dement 2024 Aug;20(8):5143-5169. Epub 2024 Jun 27 doi: 10.1002/alz.13859. PMID: 38934362Free PMC Article
Chronic inflammatory demyelinating polyradiculoneuropathy-Diagnostic pitfalls and treatment approach.
Stino AM, Naddaf E, Dyck PJ, Dyck PJB
Muscle Nerve 2021 Feb;63(2):157-169. Epub 2020 Sep 11 doi: 10.1002/mus.27046. PMID: 32914902
Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype.
Vermunt L, Sikkes SAM, van den Hout A, Handels R, Bos I, van der Flier WM, Kern S, Ousset PJ, Maruff P, Skoog I, Verhey FRJ, Freund-Levi Y, Tsolaki M, Wallin ÅK, Olde Rikkert M, Soininen H, Spiru L, Zetterberg H, Blennow K, Scheltens P, Muniz-Terrera G, Visser PJ; Alzheimer Disease Neuroimaging Initiative; AIBL Research Group; ICTUS/DSA study groups
Alzheimers Dement 2019 Jul;15(7):888-898. Epub 2019 Jun 1 doi: 10.1016/j.jalz.2019.04.001. PMID: 31164314Free PMC Article

Recent clinical studies

Etiology

Cerebrovascular Anomalies: Perspectives From Immunology and Cerebrospinal Fluid Flow.
Rustenhoven J, Tanumihardja C, Kipnis J
Circ Res 2021 Jun 25;129(1):174-194. Epub 2021 Jun 24 doi: 10.1161/CIRCRESAHA.121.318173. PMID: 34166075
CNS-Targeted Antiretroviral Strategies: When Are They Needed and What to Choose.
Calcagno A, Barco A, Trunfio M, Bonora S
Curr HIV/AIDS Rep 2018 Feb;15(1):84-91. doi: 10.1007/s11904-018-0375-2. PMID: 29363025
Classification and Current Management of Inner Ear Malformations.
Sennaroğlu L, Bajin MD
Balkan Med J 2017 Sep 29;34(5):397-411. Epub 2017 Aug 25 doi: 10.4274/balkanmedj.2017.0367. PMID: 28840850Free PMC Article
Pathogenesis and Cerebrospinal Fluid Hydrodynamics of the Chiari I Malformation.
Buell TJ, Heiss JD, Oldfield EH
Neurosurg Clin N Am 2015 Oct;26(4):495-9. Epub 2015 Aug 4 doi: 10.1016/j.nec.2015.06.003. PMID: 26408057Free PMC Article
Congenital hydrocephalus associated with myeloschisis.
Jeelani Y, McComb JG
Childs Nerv Syst 2011 Oct;27(10):1585-8. Epub 2011 Sep 17 doi: 10.1007/s00381-011-1560-4. PMID: 21928024

Diagnosis

Chronic inflammatory demyelinating polyradiculoneuropathy-Diagnostic pitfalls and treatment approach.
Stino AM, Naddaf E, Dyck PJ, Dyck PJB
Muscle Nerve 2021 Feb;63(2):157-169. Epub 2020 Sep 11 doi: 10.1002/mus.27046. PMID: 32914902
Occipital Encephalocele: Cause, Incidence, Neuroimaging and Surgical Management.
Markovic I, Bosnjakovic P, Milenkovic Z
Curr Pediatr Rev 2020;16(3):200-205. doi: 10.2174/1573396315666191018161535. PMID: 31656152Free PMC Article
Cerebrospinal fluid rhinorrhea and otorrhea: A multimodality imaging approach.
Hiremath SB, Gautam AA, Sasindran V, Therakathu J, Benjamin G
Diagn Interv Imaging 2019 Jan;100(1):3-15. Epub 2018 Jun 15 doi: 10.1016/j.diii.2018.05.003. PMID: 29910174
Pathogenesis and Cerebrospinal Fluid Hydrodynamics of the Chiari I Malformation.
Buell TJ, Heiss JD, Oldfield EH
Neurosurg Clin N Am 2015 Oct;26(4):495-9. Epub 2015 Aug 4 doi: 10.1016/j.nec.2015.06.003. PMID: 26408057Free PMC Article
Neurocutaneous melanosis.
Burstein F, Seier H, Hudgins PA, Zapiach L
J Craniofac Surg 2005 Sep;16(5):874-6. doi: 10.1097/01.scs.0000181050.06696.4d. PMID: 16192875

Therapy

Chronic inflammatory demyelinating polyradiculoneuropathy-Diagnostic pitfalls and treatment approach.
Stino AM, Naddaf E, Dyck PJ, Dyck PJB
Muscle Nerve 2021 Feb;63(2):157-169. Epub 2020 Sep 11 doi: 10.1002/mus.27046. PMID: 32914902
Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study.
Fortea J, Vilaplana E, Carmona-Iragui M, Benejam B, Videla L, Barroeta I, Fernández S, Altuna M, Pegueroles J, Montal V, Valldeneu S, Giménez S, González-Ortiz S, Muñoz L, Estellés T, Illán-Gala I, Belbin O, Camacho V, Wilson LR, Annus T, Osorio RS, Videla S, Lehmann S, Holland AJ, Alcolea D, Clarimón J, Zaman SH, Blesa R, Lleó A
Lancet 2020 Jun 27;395(10242):1988-1997. doi: 10.1016/S0140-6736(20)30689-9. PMID: 32593336Free PMC Article
Subacute sclerosing panencephalitis.
Garg RK, Mahadevan A, Malhotra HS, Rizvi I, Kumar N, Uniyal R
Rev Med Virol 2019 Sep;29(5):e2058. Epub 2019 Jun 24 doi: 10.1002/rmv.2058. PMID: 31237061
Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype.
Vermunt L, Sikkes SAM, van den Hout A, Handels R, Bos I, van der Flier WM, Kern S, Ousset PJ, Maruff P, Skoog I, Verhey FRJ, Freund-Levi Y, Tsolaki M, Wallin ÅK, Olde Rikkert M, Soininen H, Spiru L, Zetterberg H, Blennow K, Scheltens P, Muniz-Terrera G, Visser PJ; Alzheimer Disease Neuroimaging Initiative; AIBL Research Group; ICTUS/DSA study groups
Alzheimers Dement 2019 Jul;15(7):888-898. Epub 2019 Jun 1 doi: 10.1016/j.jalz.2019.04.001. PMID: 31164314Free PMC Article
Challenges in HSV encephalitis: normocellular CSF, unremarkable CCT, and atypical MRI findings.
Bewersdorf JP, Koedel U, Patzig M, Dimitriadis K, Paerschke G, Pfister HW, Klein M
Infection 2019 Apr;47(2):267-273. Epub 2018 Dec 1 doi: 10.1007/s15010-018-1257-7. PMID: 30506479

Prognosis

Evaluation of Long-Term Follow-Up in Ecchordosis Physaliphora versus Chordoma.
Stuebe CM, Rindler RS, Laack N, Carr CM, Choby G, Inwards CY, Van Gompel JJ
World Neurosurg 2023 Jun;174:157-168. Epub 2023 Mar 9 doi: 10.1016/j.wneu.2023.03.016. PMID: 36898627
Diagnostic Approach to Cerebellar Hypoplasia.
Accogli A, Addour-Boudrahem N, Srour M
Cerebellum 2021 Aug;20(4):631-658. Epub 2021 Feb 3 doi: 10.1007/s12311-020-01224-5. PMID: 33534089
Occipital Encephalocele: Cause, Incidence, Neuroimaging and Surgical Management.
Markovic I, Bosnjakovic P, Milenkovic Z
Curr Pediatr Rev 2020;16(3):200-205. doi: 10.2174/1573396315666191018161535. PMID: 31656152Free PMC Article
Creutzfeldt-Jakob disease.
Gençer AG, Pelin Z, Küçükali Cİ, Topçuoğlu OB, Yilmaz N
Psychogeriatrics 2011 Jun;11(2):119-24. doi: 10.1111/j.1479-8301.2011.00361.x. PMID: 21707861
Neurocutaneous melanosis.
Burstein F, Seier H, Hudgins PA, Zapiach L
J Craniofac Surg 2005 Sep;16(5):874-6. doi: 10.1097/01.scs.0000181050.06696.4d. PMID: 16192875

Clinical prediction guides

Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study.
Fortea J, Vilaplana E, Carmona-Iragui M, Benejam B, Videla L, Barroeta I, Fernández S, Altuna M, Pegueroles J, Montal V, Valldeneu S, Giménez S, González-Ortiz S, Muñoz L, Estellés T, Illán-Gala I, Belbin O, Camacho V, Wilson LR, Annus T, Osorio RS, Videla S, Lehmann S, Holland AJ, Alcolea D, Clarimón J, Zaman SH, Blesa R, Lleó A
Lancet 2020 Jun 27;395(10242):1988-1997. doi: 10.1016/S0140-6736(20)30689-9. PMID: 32593336Free PMC Article
CNS-Targeted Antiretroviral Strategies: When Are They Needed and What to Choose.
Calcagno A, Barco A, Trunfio M, Bonora S
Curr HIV/AIDS Rep 2018 Feb;15(1):84-91. doi: 10.1007/s11904-018-0375-2. PMID: 29363025
Classification and Current Management of Inner Ear Malformations.
Sennaroğlu L, Bajin MD
Balkan Med J 2017 Sep 29;34(5):397-411. Epub 2017 Aug 25 doi: 10.4274/balkanmedj.2017.0367. PMID: 28840850Free PMC Article
Pathogenesis and Cerebrospinal Fluid Hydrodynamics of the Chiari I Malformation.
Buell TJ, Heiss JD, Oldfield EH
Neurosurg Clin N Am 2015 Oct;26(4):495-9. Epub 2015 Aug 4 doi: 10.1016/j.nec.2015.06.003. PMID: 26408057Free PMC Article
Inflammation in epilepsy: clinical observations.
Aronica E, Crino PB
Epilepsia 2011 May;52 Suppl 3:26-32. doi: 10.1111/j.1528-1167.2011.03033.x. PMID: 21542843

Recent systematic reviews

Evaluation of Long-Term Follow-Up in Ecchordosis Physaliphora versus Chordoma.
Stuebe CM, Rindler RS, Laack N, Carr CM, Choby G, Inwards CY, Van Gompel JJ
World Neurosurg 2023 Jun;174:157-168. Epub 2023 Mar 9 doi: 10.1016/j.wneu.2023.03.016. PMID: 36898627
Diagnostic value of α-synuclein seeding amplification assays in α-synucleinopathies: A systematic review and meta-analysis.
Yoo D, Bang JI, Ahn C, Nyaga VN, Kim YE, Kang MJ, Ahn TB
Parkinsonism Relat Disord 2022 Nov;104:99-109. Epub 2022 Oct 19 doi: 10.1016/j.parkreldis.2022.10.007. PMID: 36289019
An eye on the future for defeating hydrocephalus, ciliary dyskinesia-related hydrocephalus: review article.
Hasanain AA, Soliman MAR, Elwy R, Ezzat AAM, Abdel-Bari SH, Marx S, Jenkins A, El Refaee E, Zohdi A
Br J Neurosurg 2022 Jun;36(3):329-339. Epub 2022 May 17 doi: 10.1080/02688697.2022.2074373. PMID: 35579079
Cochlear Implantation in Pediatric Patients With Enlarged Vestibular Aqueduct: A Systematic Review.
Benchetrit L, Jabbour N, Appachi S, Liu YC, Cohen MS, Anne S
Laryngoscope 2022 Jul;132(7):1459-1472. Epub 2021 Jul 7 doi: 10.1002/lary.29742. PMID: 34233033
Primary Angiitis of the CNS: A Systematic Review and Meta-analysis.
Beuker C, Strunk D, Rawal R, Schmidt-Pogoda A, Werring N, Milles L, Ruck T, Wiendl H, Meuth S, Minnerup H, Minnerup J
Neurol Neuroimmunol Neuroinflamm 2021 Nov;8(6) Epub 2021 Oct 18 doi: 10.1212/NXI.0000000000001093. PMID: 34663675Free PMC Article

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