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Splenic granulomatosis

MedGen UID:
1053247
•Concept ID:
CN378333
•
Finding
HPO: HP:6000981

Definition

Splenic inflammation involving a granulomatous response, i.e., a non-specific inflammatory response involving granulomas, defined as a compact organized collection of mature mononuclear phagocytes including epithelioid and giant cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSplenic granulomatosis

Professional guidelines

PubMed

Treatment of refractory Wegener's granulomatosis with humanized monoclonal antibodies.
Lockwood CM, Thiru S, Stewart S, Hale G, Isaacs J, Wraight P, Elliott J, Waldmann H
QJM 1996 Dec;89(12):903-12. doi: 10.1093/qjmed/89.12.903. PMID: 9015484

Recent clinical studies

Etiology

Splenic infarction is not rare in granulomatosis with polyangiitis.
Gercik O, Karasu S, Solmaz D, Soypacaci Z, Cakalagaoglu F, Akar S
Clin Rheumatol 2020 Jun;39(6):1929-1934. Epub 2020 Feb 27 doi: 10.1007/s10067-020-04993-w. PMID: 32107662
Angiocentric systemic granulomatosis.
Chute DJ, Rawley J, Cox J, Bready RJ, Reiber K
Am J Forensic Med Pathol 2010 Jun;31(2):146-50. doi: 10.1097/PAF.0b013e3181d3db65. PMID: 20177368
Splenic involvement in rheumatic diseases.
Fishman D, Isenberg DA
Semin Arthritis Rheum 1997 Dec;27(3):141-55. doi: 10.1016/s0049-0172(97)80013-3. PMID: 9431585
Wegener's granulomatosis: histological documentation of common and uncommon manifestations in 216 patients.
Lie JT
Vasa 1997 Nov;26(4):261-70. PMID: 9409175
Lymphomatoid granulomatosis.
Liebow AA, Carrington CR, Friedman PJ
Hum Pathol 1972 Dec;3(4):457-558. doi: 10.1016/s0046-8177(72)80005-4. PMID: 4638966

Diagnosis

Sarcoidosis: A Clinical Overview from Symptoms to Diagnosis.
Sève P, Pacheco Y, Durupt F, Jamilloux Y, Gerfaud-Valentin M, Isaac S, Boussel L, Calender A, Androdias G, Valeyre D, El Jammal T
Cells 2021 Mar 31;10(4) doi: 10.3390/cells10040766. PMID: 33807303Free PMC Article
Splenic infarction is not rare in granulomatosis with polyangiitis.
Gercik O, Karasu S, Solmaz D, Soypacaci Z, Cakalagaoglu F, Akar S
Clin Rheumatol 2020 Jun;39(6):1929-1934. Epub 2020 Feb 27 doi: 10.1007/s10067-020-04993-w. PMID: 32107662
Extracutaneous involvement of pyoderma gangrenosum.
Borda LJ, Wong LL, Marzano AV, Ortega-Loayza AG
Arch Dermatol Res 2019 Aug;311(6):425-434. Epub 2019 Mar 29 doi: 10.1007/s00403-019-01912-1. PMID: 30923901
The pathology of pulmonary sarcoidosis: update.
Ma Y, Gal A, Koss MN
Semin Diagn Pathol 2007 Aug;24(3):150-61. doi: 10.1053/j.semdp.2007.06.002. PMID: 17882899
Lymphomatoid granulomatosis.
Liebow AA, Carrington CR, Friedman PJ
Hum Pathol 1972 Dec;3(4):457-558. doi: 10.1016/s0046-8177(72)80005-4. PMID: 4638966

Therapy

A Rare Case of Eosinophilic Granulomatosis with Polyangiitis Presenting as Ischemic Stroke and Splenic Infarction.
Inaba R, Fuse Y, Kurimoto F, Suzuki S, Watanabe K
J Stroke Cerebrovasc Dis 2021 Mar;30(3):105539. Epub 2020 Dec 14 doi: 10.1016/j.jstrokecerebrovasdis.2020.105539. PMID: 33333478
Uncommon presentations in ANCA vasculitis: clinical characteristics and outcomes.
Katikineni VS, Kant S, Gapud EJ, Antiochos B, Manno RL, Phillips M, Seo P, Geetha D
Clin Rheumatol 2019 Aug;38(8):2195-2199. Epub 2019 Apr 29 doi: 10.1007/s10067-019-04568-4. PMID: 31037456
Splinter haemorrhages, splenic infarcts, and pulmonary embolism in granulomatosis with polyangiitis.
Laurent C, Dion J, Régent A
Vasc Med 2019 Jun;24(3):263-264. Epub 2018 Nov 14 doi: 10.1177/1358863X18807541. PMID: 30426847
Anti-TNF-α for necrotizing sarcoid granulomatosis of the liver.
Sebode M, Weidemann S, Wehmeyer M, Lohse AW, Schramm C
Hepatology 2017 Apr;65(4):1410-1412. Epub 2017 Feb 3 doi: 10.1002/hep.28966. PMID: 27981598
Hepatic granulomatosis and sarcoidosis.
Israel HL, Goldstein RA
Ann Intern Med 1973 Nov;79(5):669-78. doi: 10.7326/0003-4819-79-5-669. PMID: 4751743

Prognosis

Non-oncologic incidental uptake on FAPI PET/CT imaging.
Hotta M, Rieger AC, Jafarvand MG, Menon N, Farolfi A, Benz MR, Calais J
Br J Radiol 2023 Feb;96(1142):20220463. Epub 2022 Jul 13 doi: 10.1259/bjr.20220463. PMID: 35776566Free PMC Article
Uncommon presentations in ANCA vasculitis: clinical characteristics and outcomes.
Katikineni VS, Kant S, Gapud EJ, Antiochos B, Manno RL, Phillips M, Seo P, Geetha D
Clin Rheumatol 2019 Aug;38(8):2195-2199. Epub 2019 Apr 29 doi: 10.1007/s10067-019-04568-4. PMID: 31037456
Extracutaneous involvement of pyoderma gangrenosum.
Borda LJ, Wong LL, Marzano AV, Ortega-Loayza AG
Arch Dermatol Res 2019 Aug;311(6):425-434. Epub 2019 Mar 29 doi: 10.1007/s00403-019-01912-1. PMID: 30923901
The pathology of pulmonary sarcoidosis: update.
Ma Y, Gal A, Koss MN
Semin Diagn Pathol 2007 Aug;24(3):150-61. doi: 10.1053/j.semdp.2007.06.002. PMID: 17882899
Lymphomatoid granulomatosis.
Liebow AA, Carrington CR, Friedman PJ
Hum Pathol 1972 Dec;3(4):457-558. doi: 10.1016/s0046-8177(72)80005-4. PMID: 4638966

Clinical prediction guides

Wegener's granulomatosis presenting during pregnancy with acute limb ischemia.
Bessias N, Moulakakis KG, Lioupis C, Bakogiannis K, Sfyroeras G, Kakaletri K, Andrikopoulos V
J Vasc Surg 2005 Oct;42(4):800-4. doi: 10.1016/j.jvs.2005.05.038. PMID: 16242573
Beryllium, an adjuvant that promotes gamma interferon production.
Lee JY, Atochina O, King B, Taylor L, Elloso M, Scott P, Rossman MD
Infect Immun 2000 Jul;68(7):4032-9. doi: 10.1128/IAI.68.7.4032-4039.2000. PMID: 10858219Free PMC Article
Idiopathic granulomatosis manifesting as fever of unknown origin.
Telenti A, Hermans PE
Mayo Clin Proc 1989 Jan;64(1):44-50. doi: 10.1016/s0025-6196(12)65302-6. PMID: 2911215
Kinetic analysis of the blood clearance and organ uptake curves of IgG-coated red cells in HLA-typed controls and patients with Wegener's granulomatosis.
van der Woude FJ, Beekhuis H, Beelen JM, The TH
Eur J Nucl Med 1986;12(3):130-6. doi: 10.1007/BF00276705. PMID: 3758103
Peripheral corneal degeneration and occlusive vasculitis in Wegener's granulomatosis.
Austin P, Green WR, Sallyer DC, Walsh FB, Kleinfelter HT
Am J Ophthalmol 1978 Mar;85(3):311-7. doi: 10.1016/s0002-9394(14)77721-9. PMID: 306750

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