U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal spleen morphology

MedGen UID:
1382891
Concept ID:
C4476761
Anatomical Abnormality
Synonym: Splenic lesion
 
HPO: HP:0025408

Definition

Any anomaly of the structure of the spleen. [from HPO]

Conditions with this feature

DEGCAGS syndrome
MedGen UID:
1794177
Concept ID:
C5561967
Disease or Syndrome
DEGCAGS syndrome is an autosomal recessive syndromic neurodevelopmental disorder characterized by global developmental delay, coarse and dysmorphic facial features, and poor growth and feeding apparent from infancy. Affected individuals have variable systemic manifestations often with significant structural defects of the cardiovascular, genitourinary, gastrointestinal, and/or skeletal systems. Additional features may include sensorineural hearing loss, hypotonia, anemia or pancytopenia, and immunodeficiency with recurrent infections. Death in childhood may occur (summary by Bertoli-Avella et al., 2021).

Professional guidelines

PubMed

Liu YP, Huang YL, Tsai PS, Lin DC, Chen CP
Taiwan J Obstet Gynecol 2021 Jan;60(1):13-19. doi: 10.1016/j.tjog.2020.11.003. PMID: 33494985
Xu L, Feng J, Gao G, Tang H
Expert Opin Pharmacother 2019 Nov;20(16):1943-1951. Epub 2019 Aug 26 doi: 10.1080/14656566.2019.1657093. PMID: 31450973
Tefferi A
Am J Hematol 2016 Dec;91(12):1262-1271. doi: 10.1002/ajh.24592. PMID: 27870387

Recent clinical studies

Etiology

Tamber GS, Chévarie-Davis M, Warner M, Séguin C, Caron C, Michel RP
Histopathology 2021 Dec;79(6):1072-1086. Epub 2021 Sep 22 doi: 10.1111/his.14535. PMID: 34333806
Long B, Koyfman A, Gottlieb M
Am J Emerg Med 2021 Jun;44:452-457. Epub 2020 Mar 26 doi: 10.1016/j.ajem.2020.03.049. PMID: 32247651
Lee GM
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):328-335. doi: 10.1182/hematology.2020000117. PMID: 33275684Free PMC Article
Sekhar M, McVinnie K, Burroughs AK
Br J Haematol 2013 Sep;162(6):730-47. Epub 2013 Jul 15 doi: 10.1111/bjh.12461. PMID: 23855810
Harrison C, Kiladjian JJ, Al-Ali HK, Gisslinger H, Waltzman R, Stalbovskaya V, McQuitty M, Hunter DS, Levy R, Knoops L, Cervantes F, Vannucchi AM, Barbui T, Barosi G
N Engl J Med 2012 Mar 1;366(9):787-98. doi: 10.1056/NEJMoa1110556. PMID: 22375970

Diagnosis

Serai SD, Elsingergy MM, Hartung EA, Otero HJ
Clin Imaging 2022 Sep;89:147-154. Epub 2022 Jul 8 doi: 10.1016/j.clinimag.2022.06.022. PMID: 35835018
Rodríguez Vargas D, Parada Blázquez MJ, Vargas Serrano B
Radiologia (Engl Ed) 2019 Jan-Feb;61(1):26-34. Epub 2018 Aug 4 doi: 10.1016/j.rx.2018.07.002. PMID: 30087001
Vancauwenberghe T, Snoeckx A, Vanbeckevoort D, Dymarkowski S, Vanhoenacker FM
Singapore Med J 2015 Mar;56(3):133-44. doi: 10.11622/smedj.2015040. PMID: 25820845Free PMC Article
Warshauer DM, Hall HL
Semin Ultrasound CT MR 2006 Oct;27(5):370-88. doi: 10.1053/j.sult.2006.06.003. PMID: 17048453
Balaji KC, Caldamone AA, Rabinowitz R, Ortenberg J, Diamond DA
J Urol 1996 Aug;156(2 Pt 2):854-6. doi: 10.1097/00005392-199608001-00086. PMID: 8683800

Therapy

Mesa RA, Kiladjian JJ, Catalano JV, Devos T, Egyed M, Hellmann A, McLornan D, Shimoda K, Winton EF, Deng W, Dubowy RL, Maltzman JD, Cervantes F, Gotlib J
J Clin Oncol 2017 Dec 1;35(34):3844-3850. Epub 2017 Sep 20 doi: 10.1200/JCO.2017.73.4418. PMID: 28930494Free PMC Article
Rubin LG, Schaffner W
N Engl J Med 2014 Jul 24;371(4):349-56. doi: 10.1056/NEJMcp1314291. PMID: 25054718
Harrison C, Kiladjian JJ, Al-Ali HK, Gisslinger H, Waltzman R, Stalbovskaya V, McQuitty M, Hunter DS, Levy R, Knoops L, Cervantes F, Vannucchi AM, Barbui T, Barosi G
N Engl J Med 2012 Mar 1;366(9):787-98. doi: 10.1056/NEJMoa1110556. PMID: 22375970
Di Sabatino A, Carsetti R, Corazza GR
Lancet 2011 Jul 2;378(9785):86-97. Epub 2011 Apr 5 doi: 10.1016/S0140-6736(10)61493-6. PMID: 21474172
Rosenberg HK, Markowitz RI, Kolberg H, Park C, Hubbard A, Bellah RD
AJR Am J Roentgenol 1991 Jul;157(1):119-21. doi: 10.2214/ajr.157.1.2048509. PMID: 2048509

Prognosis

Bonfiglio F, Bruscaggin A, Guidetti F, Terzi di Bergamo L, Faderl M, Spina V, Condoluci A, Bonomini L, Forestieri G, Koch R, Piffaretti D, Pini K, Pirosa MC, Cittone MG, Arribas A, Lucioni M, Ghilardi G, Wu W, Arcaini L, Baptista MJ, Bastidas G, Bea S, Boldorini R, Broccoli A, Buehler MM, Canzonieri V, Cascione L, Ceriani L, Cogliatti S, Corradini P, Derenzini E, Devizzi L, Dietrich S, Elia AR, Facchetti F, Gaidano G, Garcia JF, Gerber B, Ghia P, Gomes da Silva M, Gritti G, Guidetti A, Hitz F, Inghirami G, Ladetto M, Lopez-Guillermo A, Lucchini E, Maiorana A, Marasca R, Matutes E, Meignin V, Merli M, Moccia A, Mollejo M, Montalban C, Novak U, Oscier DG, Passamonti F, Piazza F, Pizzolitto S, Rambaldi A, Sabattini E, Salles G, Santambrogio E, Scarfò L, Stathis A, Stüssi G, Geyer JT, Tapia G, Tarella C, Thieblemont C, Tousseyn T, Tucci A, Vanini G, Visco C, Vitolo U, Walewska R, Zaja F, Zenz T, Zinzani PL, Khiabanian H, Calcinotto A, Bertoni F, Bhagat G, Campo E, De Leval L, Dirnhofer S, Pileri SA, Piris MA, Traverse-Glehen A, Tzankov A, Paulli M, Ponzoni M, Mazzucchelli L, Cavalli F, Zucca E, Rossi D
Blood 2022 Feb 3;139(5):732-747. doi: 10.1182/blood.2021012386. PMID: 34653238
Mesa RA, Kiladjian JJ, Catalano JV, Devos T, Egyed M, Hellmann A, McLornan D, Shimoda K, Winton EF, Deng W, Dubowy RL, Maltzman JD, Cervantes F, Gotlib J
J Clin Oncol 2017 Dec 1;35(34):3844-3850. Epub 2017 Sep 20 doi: 10.1200/JCO.2017.73.4418. PMID: 28930494Free PMC Article
Ioannidis I, Kahn AG
Arch Pathol Lab Med 2015 Feb;139(2):278-82. doi: 10.5858/arpa.2013-0656-RS. PMID: 25611113
Harrison C, Kiladjian JJ, Al-Ali HK, Gisslinger H, Waltzman R, Stalbovskaya V, McQuitty M, Hunter DS, Levy R, Knoops L, Cervantes F, Vannucchi AM, Barbui T, Barosi G
N Engl J Med 2012 Mar 1;366(9):787-98. doi: 10.1056/NEJMoa1110556. PMID: 22375970
Di Sabatino A, Carsetti R, Corazza GR
Lancet 2011 Jul 2;378(9785):86-97. Epub 2011 Apr 5 doi: 10.1016/S0140-6736(10)61493-6. PMID: 21474172

Clinical prediction guides

Veras PST, de Santana MBR, Brodskyn CI, Fraga DBM, Solcà MS, De Menezes JPB, Leite BMM, Teixeira HMP
Front Cell Infect Microbiol 2023;13:1261074. Epub 2023 Oct 4 doi: 10.3389/fcimb.2023.1261074. PMID: 37860064Free PMC Article
De Gottardi A, Sempoux C, Berzigotti A
J Hepatol 2022 Oct;77(4):1124-1135. Epub 2022 Jun 9 doi: 10.1016/j.jhep.2022.05.033. PMID: 35690264
Tamber GS, Chévarie-Davis M, Warner M, Séguin C, Caron C, Michel RP
Histopathology 2021 Dec;79(6):1072-1086. Epub 2021 Sep 22 doi: 10.1111/his.14535. PMID: 34333806
Mesa RA, Kiladjian JJ, Catalano JV, Devos T, Egyed M, Hellmann A, McLornan D, Shimoda K, Winton EF, Deng W, Dubowy RL, Maltzman JD, Cervantes F, Gotlib J
J Clin Oncol 2017 Dec 1;35(34):3844-3850. Epub 2017 Sep 20 doi: 10.1200/JCO.2017.73.4418. PMID: 28930494Free PMC Article
Maruyama H, Yokosuka O
Gut Liver 2017 Jul 15;11(4):464-473. doi: 10.5009/gnl16078. PMID: 28267700Free PMC Article

Recent systematic reviews

Slot S, van de Donk NWCJ, Otten RHJ, Boden BJH, Zijlstra J, Raijmakers PGHM, Zweegman S
Cancer Imaging 2021 Apr 20;21(1):36. doi: 10.1186/s40644-021-00405-7. PMID: 33879266Free PMC Article
Calle-Toro JS, Back SJ, Viteri B, Andronikou S, Kaplan SL
J Ultrasound Med 2020 Feb;39(2):223-230. Epub 2019 Aug 16 doi: 10.1002/jum.15114. PMID: 31418892Free PMC Article
Li BQ, Lu J, Seery S, Guo JC
Pancreatology 2019 Jan;19(1):10-16. Epub 2018 Oct 22 doi: 10.1016/j.pan.2018.10.008. PMID: 30366677
Vikse J, Sanna B, Henry BM, Taterra D, Sanna S, Pękala PA, Walocha JA, Tomaszewski KA
Int J Surg 2017 Sep;45:18-28. Epub 2017 Jul 15 doi: 10.1016/j.ijsu.2017.07.045. PMID: 28716661
Loomba RS, Geddes GC, Basel D, Benson DW, Leuthner SR, Hehir DA, Ghanayem N, Shillingford AJ
Congenit Heart Dis 2016 Dec;11(6):537-547. Epub 2016 Jul 18 doi: 10.1111/chd.12395. PMID: 27425254

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...