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Elevated circulating plasminogen activator inhibitor 1 activity

MedGen UID:
1053373
•Concept ID:
CN377068
•
Finding
HPO: HP:0430125

Definition

The activity or concentration of plasminogen activator inhibitor-1 in the blood circulation is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating plasminogen activator inhibitor 1 activity

Professional guidelines

PubMed

Targeting Fibrinolytic Inhibition for Venous Thromboembolism Treatment: Overview of an Emerging Therapeutic Approach.
Singh S, Kumar P, Padwad YS, Jaffer FA, Reed GL
Circulation 2024 Sep 10;150(11):884-898. Epub 2024 Sep 9 doi: 10.1161/CIRCULATIONAHA.124.069728. PMID: 39250537Free PMC Article
Combination treatment with N-acetyl-seryl-aspartyl-lysyl-proline and tissue plasminogen activator provides potent neuroprotection in rats after stroke.
Zhang L, Chopp M, Teng H, Ding G, Jiang Q, Yang XP, Rhaleb NE, Zhang ZG
Stroke 2014 Apr;45(4):1108-14. Epub 2014 Feb 18 doi: 10.1161/STROKEAHA.113.004399. PMID: 24549864Free PMC Article
Five frequent polymorphisms of the PAI-1 gene: lack of association between genotypes, PAI activity, and triglyceride levels in a healthy population.
Henry M, Chomiki N, Scarabin PY, Alessi MC, Peiretti F, Arveiler D, Ferrières J, Evans A, Amouyel P, Poirier O, Cambien F, Juhan-Vague I
Arterioscler Thromb Vasc Biol 1997 May;17(5):851-8. doi: 10.1161/01.atv.17.5.851. PMID: 9157947

Recent clinical studies

Etiology

Targeting Fibrinolytic Inhibition for Venous Thromboembolism Treatment: Overview of an Emerging Therapeutic Approach.
Singh S, Kumar P, Padwad YS, Jaffer FA, Reed GL
Circulation 2024 Sep 10;150(11):884-898. Epub 2024 Sep 9 doi: 10.1161/CIRCULATIONAHA.124.069728. PMID: 39250537Free PMC Article
Endothelial dysfunction, thrombophilia, and nailfold capillaroscopic features in livedoid vasculopathy.
Apti Sengun O, Ergun T, Guctekin T, Alibaz Oner F
Microvasc Res 2023 Nov;150:104591. Epub 2023 Aug 4 doi: 10.1016/j.mvr.2023.104591. PMID: 37543163
Coagulopathy in malaria.
Angchaisuksiri P
Thromb Res 2014 Jan;133(1):5-9. Epub 2013 Sep 26 doi: 10.1016/j.thromres.2013.09.030. PMID: 24099998
Plasminogen activator inhibitor-1 in vascular thrombosis.
Westrick RJ, Eitzman DT
Curr Drug Targets 2007 Sep;8(9):966-1002. doi: 10.2174/138945007781662328. PMID: 17896948
Plasminogen activator inhibitor type-1 in cardiovascular disease. Status report 2001.
Huber K, Christ G, Wojta J, Gulba D
Thromb Res 2001 Sep 30;103 Suppl 1:S7-19. doi: 10.1016/s0049-3848(01)00293-6. PMID: 11567664

Diagnosis

Endothelial dysfunction, thrombophilia, and nailfold capillaroscopic features in livedoid vasculopathy.
Apti Sengun O, Ergun T, Guctekin T, Alibaz Oner F
Microvasc Res 2023 Nov;150:104591. Epub 2023 Aug 4 doi: 10.1016/j.mvr.2023.104591. PMID: 37543163
In peripartum cardiomyopathy plasminogen activator inhibitor-1 is a potential new biomarker with controversial roles.
Ricke-Hoch M, Hoes MF, Pfeffer TJ, Schlothauer S, Nonhoff J, Haidari S, Bomer N, Scherr M, Stapel B, Stelling E, Kiyan Y, Falk C, Haghikia A, Binah O, Arany Z, Thum T, Bauersachs J, van der Meer P, Hilfiker-Kleiner D
Cardiovasc Res 2020 Sep 1;116(11):1875-1886. doi: 10.1093/cvr/cvz300. PMID: 31711127
PAI-1 is a critical regulator of FGF23 homeostasis.
Eren M, Place AT, Thomas PM, Flevaris P, Miyata T, Vaughan DE
Sci Adv 2017 Sep;3(9):e1603259. Epub 2017 Sep 13 doi: 10.1126/sciadv.1603259. PMID: 28924605Free PMC Article
Association of inflammatory and hemostatic markers with stroke and thromboembolic events in atrial fibrillation: a systematic review and meta-analysis.
Wu N, Chen X, Cai T, Wu L, Xiang Y, Zhang M, Li Y, Song Z, Zhong L
Can J Cardiol 2015 Mar;31(3):278-86. Epub 2014 Dec 9 doi: 10.1016/j.cjca.2014.12.002. PMID: 25746020
Plasminogen activator inhibitor type 1 deficiency.
Mehta R, Shapiro AD
Haemophilia 2008 Nov;14(6):1255-60. doi: 10.1111/j.1365-2516.2008.01834.x. PMID: 19141166

Therapy

Targeting Fibrinolytic Inhibition for Venous Thromboembolism Treatment: Overview of an Emerging Therapeutic Approach.
Singh S, Kumar P, Padwad YS, Jaffer FA, Reed GL
Circulation 2024 Sep 10;150(11):884-898. Epub 2024 Sep 9 doi: 10.1161/CIRCULATIONAHA.124.069728. PMID: 39250537Free PMC Article
Endothelial extracellular vesicles induce acute lung injury via follistatin-like protein 1.
Yuan HX, Chen YT, Li YQ, Wang YS, Ou ZJ, Li Y, Gao JJ, Deng MJ, Song YK, Fu L, Ci HB, Chang FJ, Cao Y, Jian YP, Kang BA, Mo ZW, Ning DS, Peng YM, Liu ZL, Liu XJ, Xu YQ, Xu J, Ou JS
Sci China Life Sci 2024 Mar;67(3):475-487. Epub 2023 May 17 doi: 10.1007/s11427-022-2328-x. PMID: 37219765Free PMC Article
Plasminogen activator inhibitor type 1 deficiency.
Mehta R, Shapiro AD
Haemophilia 2008 Nov;14(6):1255-60. doi: 10.1111/j.1365-2516.2008.01834.x. PMID: 19141166
Plasminogen activator inhibitor-1 in vascular thrombosis.
Westrick RJ, Eitzman DT
Curr Drug Targets 2007 Sep;8(9):966-1002. doi: 10.2174/138945007781662328. PMID: 17896948
Effect of plasminogen activator inhibitor-1 in diabetes mellitus and cardiovascular disease.
Lyon CJ, Hsueh WA
Am J Med 2003 Dec 8;115 Suppl 8A:62S-68S. doi: 10.1016/j.amjmed.2003.08.014. PMID: 14678868

Prognosis

Impaired fibrinolysis in patients with atrial fibrillation and elevated circulating lipopolysaccharide.
Sadowski M, Ząbczyk M, Undas A
J Thromb Thrombolysis 2024 Jun;57(5):842-851. Epub 2024 Apr 21 doi: 10.1007/s11239-024-02980-5. PMID: 38643439Free PMC Article
In peripartum cardiomyopathy plasminogen activator inhibitor-1 is a potential new biomarker with controversial roles.
Ricke-Hoch M, Hoes MF, Pfeffer TJ, Schlothauer S, Nonhoff J, Haidari S, Bomer N, Scherr M, Stapel B, Stelling E, Kiyan Y, Falk C, Haghikia A, Binah O, Arany Z, Thum T, Bauersachs J, van der Meer P, Hilfiker-Kleiner D
Cardiovasc Res 2020 Sep 1;116(11):1875-1886. doi: 10.1093/cvr/cvz300. PMID: 31711127
How the association between obesity and inflammation may lead to insulin resistance and cancer.
Amin MN, Hussain MS, Sarwar MS, Rahman Moghal MM, Das A, Hossain MZ, Chowdhury JA, Millat MS, Islam MS
Diabetes Metab Syndr 2019 Mar-Apr;13(2):1213-1224. Epub 2019 Jan 29 doi: 10.1016/j.dsx.2019.01.041. PMID: 31336467
Plasminogen activator inhibitor type-1 in cardiovascular disease. Status report 2001.
Huber K, Christ G, Wojta J, Gulba D
Thromb Res 2001 Sep 30;103 Suppl 1:S7-19. doi: 10.1016/s0049-3848(01)00293-6. PMID: 11567664
Postprandial triglycerides and blood coagulation.
Silveira A
Exp Clin Endocrinol Diabetes 2001;109(4):S527-32. doi: 10.1055/s-2001-15115. PMID: 11453040

Clinical prediction guides

Impaired fibrinolysis in patients with atrial fibrillation and elevated circulating lipopolysaccharide.
Sadowski M, Ząbczyk M, Undas A
J Thromb Thrombolysis 2024 Jun;57(5):842-851. Epub 2024 Apr 21 doi: 10.1007/s11239-024-02980-5. PMID: 38643439Free PMC Article
Identification of genomic loci regulating platelet plasminogen activator inhibitor-1 in mice.
Siebert AE, Brake MA, Verbeek SC, Johnston AJ, Morgan AP, Cleuren AC, Jurek AM, Schneider CD, Germain DM, Battistuzzi FU, Zhu G, Miller DR, Johnsen JM, Pardo-Manuel de Villena F, Rondina MT, Westrick RJ
J Thromb Haemost 2023 Oct;21(10):2917-2928. Epub 2023 Jun 25 doi: 10.1016/j.jtha.2023.06.018. PMID: 37364776Free PMC Article
PAI-1 is a critical regulator of FGF23 homeostasis.
Eren M, Place AT, Thomas PM, Flevaris P, Miyata T, Vaughan DE
Sci Adv 2017 Sep;3(9):e1603259. Epub 2017 Sep 13 doi: 10.1126/sciadv.1603259. PMID: 28924605Free PMC Article
Plasminogen activator inhibitor-1 in vascular thrombosis.
Westrick RJ, Eitzman DT
Curr Drug Targets 2007 Sep;8(9):966-1002. doi: 10.2174/138945007781662328. PMID: 17896948
Postprandial triglycerides and blood coagulation.
Silveira A
Exp Clin Endocrinol Diabetes 2001;109(4):S527-32. doi: 10.1055/s-2001-15115. PMID: 11453040

Recent systematic reviews

The Effect of Whole-Grain Intake on Biomarkers of Subclinical Inflammation: A Comprehensive Meta-analysis of Randomized Controlled Trials.
Rahmani S, Sadeghi O, Sadeghian M, Sadeghi N, Larijani B, Esmaillzadeh A
Adv Nutr 2020 Jan 1;11(1):52-65. doi: 10.1093/advances/nmz063. PMID: 31301131Free PMC Article
Association of inflammatory and hemostatic markers with stroke and thromboembolic events in atrial fibrillation: a systematic review and meta-analysis.
Wu N, Chen X, Cai T, Wu L, Xiang Y, Zhang M, Li Y, Song Z, Zhong L
Can J Cardiol 2015 Mar;31(3):278-86. Epub 2014 Dec 9 doi: 10.1016/j.cjca.2014.12.002. PMID: 25746020

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