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Abnormal circulating plasminogen activator inhibitor 1 activity

MedGen UID:
1053811
•Concept ID:
CN377069
•
Finding
HPO: HP:0430126

Definition

The activity or concentration of plasminogen activator inhibitor-1 in the blood circulation is outside of the limits of the normal range. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating plasminogen activator inhibitor 1 activity

Recent clinical studies

Etiology

Endothelial dysfunction, thrombophilia, and nailfold capillaroscopic features in livedoid vasculopathy.
Apti Sengun O, Ergun T, Guctekin T, Alibaz Oner F
Microvasc Res 2023 Nov;150:104591. Epub 2023 Aug 4 doi: 10.1016/j.mvr.2023.104591. PMID: 37543163
Coagulopathy in malaria.
Angchaisuksiri P
Thromb Res 2014 Jan;133(1):5-9. Epub 2013 Sep 26 doi: 10.1016/j.thromres.2013.09.030. PMID: 24099998
Does uremia cause vascular dysfunction?
Brunet P, Gondouin B, Duval-Sabatier A, Dou L, Cerini C, Dignat-George F, Jourde-Chiche N, Argiles A, Burtey S
Kidney Blood Press Res 2011;34(4):284-90. Epub 2011 Jun 21 doi: 10.1159/000327131. PMID: 21691132
Obesity and thromboembolic disease.
Stein PD, Goldman J
Clin Chest Med 2009 Sep;30(3):489-93, viii. doi: 10.1016/j.ccm.2009.05.006. PMID: 19700047
Metabolic syndrome, haemostasis and thrombosis.
Alessi MC, Juhan-Vague I
Thromb Haemost 2008 Jun;99(6):995-1000. doi: 10.1160/TH07-11-0682. PMID: 18521499

Diagnosis

Endothelial dysfunction, thrombophilia, and nailfold capillaroscopic features in livedoid vasculopathy.
Apti Sengun O, Ergun T, Guctekin T, Alibaz Oner F
Microvasc Res 2023 Nov;150:104591. Epub 2023 Aug 4 doi: 10.1016/j.mvr.2023.104591. PMID: 37543163
Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis.
Yende S, Kellum JA, Talisa VB, Peck Palmer OM, Chang CH, Filbin MR, Shapiro NI, Hou PC, Venkat A, LoVecchio F, Hawkins K, Crouser ED, Newman AB, Angus DC
JAMA Netw Open 2019 Aug 2;2(8):e198686. doi: 10.1001/jamanetworkopen.2019.8686. PMID: 31390038Free PMC Article
Elevated circulating levels of tissue factor in polycystic ovary syndrome.
González F, Kirwan JP, Rote NS, Minium J
Clin Appl Thromb Hemost 2013 Jan-Feb;19(1):66-72. Epub 2012 Feb 12 doi: 10.1177/1076029612436673. PMID: 22327820
Progression of plasminogen activator inhibitor-1 and fibrinogen levels in relation to incident type 2 diabetes.
Festa A, Williams K, Tracy RP, Wagenknecht LE, Haffner SM
Circulation 2006 Apr 11;113(14):1753-9. Epub 2006 Apr 3 doi: 10.1161/CIRCULATIONAHA.106.616177. PMID: 16585388
Platelet dysfunction in type 2 diabetes.
Vinik AI, Erbas T, Park TS, Nolan R, Pittenger GL
Diabetes Care 2001 Aug;24(8):1476-85. doi: 10.2337/diacare.24.8.1476. PMID: 11473089

Therapy

Residual perfusion defects in patients with pulmonary embolism are related to impaired fibrinolytic capacity.
Lami D, Cellai AP, Antonucci E, Fiorillo C, Becatti M, Grifoni E, Cenci C, Marcucci R, Mannini L, Miniati M, Abbate R, Prisco D
Thromb Res 2014 Sep;134(3):737-41. Epub 2014 Jul 17 doi: 10.1016/j.thromres.2014.07.013. PMID: 25074740
Elevated circulating levels of tissue factor in polycystic ovary syndrome.
González F, Kirwan JP, Rote NS, Minium J
Clin Appl Thromb Hemost 2013 Jan-Feb;19(1):66-72. Epub 2012 Feb 12 doi: 10.1177/1076029612436673. PMID: 22327820
Pathophysiological basis for anticoagulant and antithrombotic therapy in pulmonary hypertension.
Lopes AA
Cardiovasc Hematol Agents Med Chem 2006 Jan;4(1):53-9. doi: 10.2174/187152506775268794. PMID: 16529549
Tibolone and its metabolites enhance tissue factor and PAI-1 expression in human endometrial stromal cells: Evidence of progestogenic effects.
Schatz F, Kuczynski E, Kloosterboer HJ, Buchwalder L, Tang C, Krikun G, Lockwood CJ
Steroids 2005 Nov;70(12):840-5. doi: 10.1016/j.steroids.2005.04.010. PMID: 16011840
Lipids, risk factors and ischaemic heart disease.
Castelli WP
Atherosclerosis 1996 Jul;124 Suppl:S1-9. doi: 10.1016/0021-9150(96)05851-0. PMID: 8831910

Prognosis

Pediatric ECMO: unfavorable outcomes are associated with inflammation and endothelial activation.
Caprarola SD, Ng DK, Carroll MK, Tekes A, Felling RJ, Salorio CF, Almuqati R, Schwartz JM, Everett AD, Bembea MM
Pediatr Res 2022 Aug;92(2):549-556. Epub 2021 Nov 3 doi: 10.1038/s41390-021-01817-8. PMID: 34732815Free PMC Article
Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis.
Yende S, Kellum JA, Talisa VB, Peck Palmer OM, Chang CH, Filbin MR, Shapiro NI, Hou PC, Venkat A, LoVecchio F, Hawkins K, Crouser ED, Newman AB, Angus DC
JAMA Netw Open 2019 Aug 2;2(8):e198686. doi: 10.1001/jamanetworkopen.2019.8686. PMID: 31390038Free PMC Article
Circulating levels and hepatic expression of molecular mediators of atherosclerosis in nonalcoholic fatty liver disease.
Sookoian S, Castaño GO, Burgueño AL, Rosselli MS, Gianotti TF, Mallardi P, Martino JS, Pirola CJ
Atherosclerosis 2010 Apr;209(2):585-91. Epub 2009 Oct 13 doi: 10.1016/j.atherosclerosis.2009.10.011. PMID: 19896127
Altered endothelial function following the Fontan procedure.
Binotto MA, Maeda NY, Lopes AA
Cardiol Young 2008 Feb;18(1):70-4. Epub 2007 Dec 20 doi: 10.1017/S1047951107001680. PMID: 18093358
Progression of plasminogen activator inhibitor-1 and fibrinogen levels in relation to incident type 2 diabetes.
Festa A, Williams K, Tracy RP, Wagenknecht LE, Haffner SM
Circulation 2006 Apr 11;113(14):1753-9. Epub 2006 Apr 3 doi: 10.1161/CIRCULATIONAHA.106.616177. PMID: 16585388

Clinical prediction guides

Pediatric ECMO: unfavorable outcomes are associated with inflammation and endothelial activation.
Caprarola SD, Ng DK, Carroll MK, Tekes A, Felling RJ, Salorio CF, Almuqati R, Schwartz JM, Everett AD, Bembea MM
Pediatr Res 2022 Aug;92(2):549-556. Epub 2021 Nov 3 doi: 10.1038/s41390-021-01817-8. PMID: 34732815Free PMC Article
Fibrin Network Formation and Lysis in Septic Shock Patients.
Larsen JB, Aggerbeck MA, Larsen KM, Hvas CL, Hvas AM
Int J Mol Sci 2021 Sep 2;22(17) doi: 10.3390/ijms22179540. PMID: 34502446Free PMC Article
Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis.
Yende S, Kellum JA, Talisa VB, Peck Palmer OM, Chang CH, Filbin MR, Shapiro NI, Hou PC, Venkat A, LoVecchio F, Hawkins K, Crouser ED, Newman AB, Angus DC
JAMA Netw Open 2019 Aug 2;2(8):e198686. doi: 10.1001/jamanetworkopen.2019.8686. PMID: 31390038Free PMC Article
Role of plasminogen activator inhibitor-1 in glucocorticoid-induced diabetes and osteopenia in mice.
Tamura Y, Kawao N, Yano M, Okada K, Okumoto K, Chiba Y, Matsuo O, Kaji H
Diabetes 2015 Jun;64(6):2194-206. Epub 2014 Dec 31 doi: 10.2337/db14-1192. PMID: 25552599
Obesity and thromboembolic disease.
Stein PD, Goldman J
Clin Chest Med 2009 Sep;30(3):489-93, viii. doi: 10.1016/j.ccm.2009.05.006. PMID: 19700047

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