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Elevated circulating lipoprotein(a) concentration

MedGen UID:
1053955
Concept ID:
CN377352
Finding
HPO: HP:6000521

Definition

The concentration of lipoprotein(a) in the blood circulation is above the upper limit of normal. Lipoprotein(a), also known as apolipoprotein(A), is encoded by LPA (HGNC:6667). [from HPO]

Term Hierarchy

Recent clinical studies

Etiology

Safarova MS, Moriarty PM
Curr Atheroscler Rep 2023 Jul;25(7):391-404. Epub 2023 Jun 5 doi: 10.1007/s11883-023-01113-2. PMID: 37273067
Schwartz GG, Ballantyne CM
Atherosclerosis 2022 May;349:110-122. doi: 10.1016/j.atherosclerosis.2022.04.020. PMID: 35606071
Santangelo G, Faggiano A, Bernardi N, Carugo S, Giammanco A, Faggiano P
Nutr Metab Cardiovasc Dis 2022 Feb;32(2):309-317. Epub 2021 Oct 27 doi: 10.1016/j.numecd.2021.10.015. PMID: 34893419
O'Donoghue ML, Fazio S, Giugliano RP, Stroes ESG, Kanevsky E, Gouni-Berthold I, Im K, Lira Pineda A, Wasserman SM, Češka R, Ezhov MV, Jukema JW, Jensen HK, Tokgözoğlu SL, Mach F, Huber K, Sever PS, Keech AC, Pedersen TR, Sabatine MS
Circulation 2019 Mar 19;139(12):1483-1492. doi: 10.1161/CIRCULATIONAHA.118.037184. PMID: 30586750
Hanssen R, Gouni-Berthold I
Curr Med Chem 2017;24(10):957-968. doi: 10.2174/0929867324666170112110928. PMID: 28078998

Diagnosis

Ward NC, Watts GF, Bishop W, Colquhoun D, Hamilton-Craig C, Hare DL, Kangaharan N, Kostner KM, Kritharides L, O'Brien R, Mori TA, Nestel PJ, Nicholls SJ, Psaltis PJ, Raffoul N, White HD, Sullivan DR
Heart Lung Circ 2023 Mar;32(3):287-296. Epub 2023 Jan 25 doi: 10.1016/j.hlc.2022.11.015. PMID: 36707360
Jamialahmadi T, Reiner Ž, Alidadi M, Kroh M, Almahmeed W, Ruscica M, Sirtori C, Rizzo M, Santos RD, Sahebkar A
Biomed Res Int 2022;2022:8435133. Epub 2022 Aug 17 doi: 10.1155/2022/8435133. PMID: 36033567Free PMC Article
Hu K, Perez-Matos MC, Argemi J, Vilar-Gomez E, Shalaurova I, Bullitt E, Landeen L, Sugahara G, Deng H, Mathur K, Tran S, Cai H, He H, Yalcin Y, Vieira Barbosa J, Ventura-Cots M, Marx K, Gad AP, Niezen S, Izunza Barba S, Ang LH, Popov YV, Fricker Z, Lai M, Curry M, Afdhal N, Szabo G, Mukamal KJ, Sanyal AJ, Otvos JD, Malik R, Saito T, Connelly MA, Chalasani NP, Bataller R, Jiang ZG
Hepatology 2022 Apr;75(4):968-982. Epub 2021 Dec 7 doi: 10.1002/hep.32203. PMID: 34662439Free PMC Article
Anagnostis P, Vaitsi K, Mintziori G, Goulis DG, Mikhailidis DP
Curr Med Res Opin 2020 May;36(5):731-740. Epub 2020 Mar 9 doi: 10.1080/03007995.2020.1734783. PMID: 32096673
Kunutsor SK, Mäkikallio TH, Kauhanen J, Voutilainen A, Laukkanen JA
Scand Cardiovasc J 2019 Jun;53(3):125-132. Epub 2019 May 9 doi: 10.1080/14017431.2019.1612087. PMID: 31032650

Therapy

Yanai H, Adachi H, Hakoshima M, Katsuyama H
Int J Mol Sci 2022 Nov 4;23(21) doi: 10.3390/ijms232113499. PMID: 36362288Free PMC Article
Jamialahmadi T, Reiner Ž, Alidadi M, Kroh M, Almahmeed W, Ruscica M, Sirtori C, Rizzo M, Santos RD, Sahebkar A
Biomed Res Int 2022;2022:8435133. Epub 2022 Aug 17 doi: 10.1155/2022/8435133. PMID: 36033567Free PMC Article
O'Donoghue ML, Fazio S, Giugliano RP, Stroes ESG, Kanevsky E, Gouni-Berthold I, Im K, Lira Pineda A, Wasserman SM, Češka R, Ezhov MV, Jukema JW, Jensen HK, Tokgözoğlu SL, Mach F, Huber K, Sever PS, Keech AC, Pedersen TR, Sabatine MS
Circulation 2019 Mar 19;139(12):1483-1492. doi: 10.1161/CIRCULATIONAHA.118.037184. PMID: 30586750
Schreml J, Gouni-Berthold I
Curr Pharm Des 2017;23(10):1562-1570. doi: 10.2174/1381612823666170125160108. PMID: 28128058
Hanssen R, Gouni-Berthold I
Curr Med Chem 2017;24(10):957-968. doi: 10.2174/0929867324666170112110928. PMID: 28078998

Prognosis

Wang HP, Zhang N, Liu YJ, Xia TL, Chen GC, Yang J, Li FR
J Lipid Res 2023 Jul;64(7):100398. Epub 2023 Jun 3 doi: 10.1016/j.jlr.2023.100398. PMID: 37276941Free PMC Article
Safarova MS, Moriarty PM
Curr Atheroscler Rep 2023 Jul;25(7):391-404. Epub 2023 Jun 5 doi: 10.1007/s11883-023-01113-2. PMID: 37273067
Bartoli-Leonard F, Turner ME, Zimmer J, Chapurlat R, Pham T, Aikawa M, Pradhan AD, Szulc P, Aikawa E
J Lipid Res 2022 Aug;63(8):100242. Epub 2022 Jun 18 doi: 10.1016/j.jlr.2022.100242. PMID: 35724702Free PMC Article
Hu K, Perez-Matos MC, Argemi J, Vilar-Gomez E, Shalaurova I, Bullitt E, Landeen L, Sugahara G, Deng H, Mathur K, Tran S, Cai H, He H, Yalcin Y, Vieira Barbosa J, Ventura-Cots M, Marx K, Gad AP, Niezen S, Izunza Barba S, Ang LH, Popov YV, Fricker Z, Lai M, Curry M, Afdhal N, Szabo G, Mukamal KJ, Sanyal AJ, Otvos JD, Malik R, Saito T, Connelly MA, Chalasani NP, Bataller R, Jiang ZG
Hepatology 2022 Apr;75(4):968-982. Epub 2021 Dec 7 doi: 10.1002/hep.32203. PMID: 34662439Free PMC Article
O'Donoghue ML, Fazio S, Giugliano RP, Stroes ESG, Kanevsky E, Gouni-Berthold I, Im K, Lira Pineda A, Wasserman SM, Češka R, Ezhov MV, Jukema JW, Jensen HK, Tokgözoğlu SL, Mach F, Huber K, Sever PS, Keech AC, Pedersen TR, Sabatine MS
Circulation 2019 Mar 19;139(12):1483-1492. doi: 10.1161/CIRCULATIONAHA.118.037184. PMID: 30586750

Clinical prediction guides

Wang HP, Zhang N, Liu YJ, Xia TL, Chen GC, Yang J, Li FR
J Lipid Res 2023 Jul;64(7):100398. Epub 2023 Jun 3 doi: 10.1016/j.jlr.2023.100398. PMID: 37276941Free PMC Article
Bartoli-Leonard F, Turner ME, Zimmer J, Chapurlat R, Pham T, Aikawa M, Pradhan AD, Szulc P, Aikawa E
J Lipid Res 2022 Aug;63(8):100242. Epub 2022 Jun 18 doi: 10.1016/j.jlr.2022.100242. PMID: 35724702Free PMC Article
Boffa MB, Koschinsky ML
Curr Opin Lipidol 2022 Jun 1;33(3):185-192. doi: 10.1097/MOL.0000000000000823. PMID: 35695615
Santangelo G, Faggiano A, Bernardi N, Carugo S, Giammanco A, Faggiano P
Nutr Metab Cardiovasc Dis 2022 Feb;32(2):309-317. Epub 2021 Oct 27 doi: 10.1016/j.numecd.2021.10.015. PMID: 34893419
Hu K, Perez-Matos MC, Argemi J, Vilar-Gomez E, Shalaurova I, Bullitt E, Landeen L, Sugahara G, Deng H, Mathur K, Tran S, Cai H, He H, Yalcin Y, Vieira Barbosa J, Ventura-Cots M, Marx K, Gad AP, Niezen S, Izunza Barba S, Ang LH, Popov YV, Fricker Z, Lai M, Curry M, Afdhal N, Szabo G, Mukamal KJ, Sanyal AJ, Otvos JD, Malik R, Saito T, Connelly MA, Chalasani NP, Bataller R, Jiang ZG
Hepatology 2022 Apr;75(4):968-982. Epub 2021 Dec 7 doi: 10.1002/hep.32203. PMID: 34662439Free PMC Article

Recent systematic reviews

Dai H, Zhu Y, Chen Z, Yan R, Liu J, He Z, Zhang L, Zhang F, Yan S
Endokrynol Pol 2023;74(3):234-242. Epub 2023 Jun 19 doi: 10.5603/EP.a2023.0036. PMID: 37335067
Kunutsor SK, Mäkikallio TH, Kauhanen J, Voutilainen A, Laukkanen JA
Scand Cardiovasc J 2019 Jun;53(3):125-132. Epub 2019 May 9 doi: 10.1080/14017431.2019.1612087. PMID: 31032650

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