U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Elevated circulating CXCL10 concentration

MedGen UID:
1053989
•Concept ID:
CN377317
•
Finding
HPO: HP:6000486

Definition

The concentration of C-X-C motif chemokine 10 (CXCL10) in the blood circulation is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating CXCL10 concentration

Professional guidelines

PubMed

Effect of antiviral and immunomodulatory treatment on a cytokine profile in patients with COVID-19.
Martonik D, Parfieniuk-Kowerda A, Starosz A, Grubczak K, Moniuszko M, Flisiak R
Front Immunol 2023;14:1222170. Epub 2023 Jul 6 doi: 10.3389/fimmu.2023.1222170. PMID: 37483627Free PMC Article

Recent clinical studies

Etiology

Circulating markers of inflammation and angiogenesis and clinical outcomes across subtypes of pulmonary arterial hypertension.
Hirsch K, Nolley S, Ralph DD, Zheng Y, Altemeier WA, Rhodes CJ, Morrell NW, Wilkins MR, Leary PJ, Rayner SG
J Heart Lung Transplant 2023 Feb;42(2):173-182. Epub 2022 Nov 7 doi: 10.1016/j.healun.2022.10.026. PMID: 36470771Free PMC Article
Elevated cell-free fetal DNA contributes to placental inflammation and antiangiogenesis via AIM2 and IFI16 during pre-eclampsia.
Li N, He F, Gao H, Ge Y, Fan X, Zhang J, Qi H, Ren L
J Cell Physiol 2020 Dec;235(12):9577-9588. Epub 2020 May 7 doi: 10.1002/jcp.29766. PMID: 32383175
The identification of CCL18 as biomarker of disease activity in localized scleroderma.
Mertens JS, de Jong EMGJ, van den Hoogen LL, Wienke J, Thurlings RM, Seyger MMB, Hoppenreijs EPAH, Wijngaarde CA, van Vlijmen-Willems IMJJ, van den Bogaard E, Giovannone B, van Wijk F, van Royen-Kerkhof A, Marut W, Radstake TRD
J Autoimmun 2019 Jul;101:86-93. Epub 2019 Apr 18 doi: 10.1016/j.jaut.2019.04.008. PMID: 31006523
Serum CXCL10, CXCL11, CXCL12, and CXCL14 chemokine patterns in patients with acute liver injury.
Chalin A, Lefevre B, Devisme C, Pronier C, Carrière V, Thibault V, Amiot L, Samson M
Cytokine 2018 Nov;111:500-504. Epub 2018 Jun 4 doi: 10.1016/j.cyto.2018.05.029. PMID: 29880273
Circulating levels of both Th1 and Th2 chemokines are elevated in patients with sarcoidosis.
Nureki S, Miyazaki E, Ando M, Ueno T, Fukami T, Kumamoto T, Sugisaki K, Tsuda T
Respir Med 2008 Feb;102(2):239-47. Epub 2007 Oct 18 doi: 10.1016/j.rmed.2007.09.006. PMID: 17949965

Diagnosis

Effect of antiviral and immunomodulatory treatment on a cytokine profile in patients with COVID-19.
Martonik D, Parfieniuk-Kowerda A, Starosz A, Grubczak K, Moniuszko M, Flisiak R
Front Immunol 2023;14:1222170. Epub 2023 Jul 6 doi: 10.3389/fimmu.2023.1222170. PMID: 37483627Free PMC Article
The identification of CCL18 as biomarker of disease activity in localized scleroderma.
Mertens JS, de Jong EMGJ, van den Hoogen LL, Wienke J, Thurlings RM, Seyger MMB, Hoppenreijs EPAH, Wijngaarde CA, van Vlijmen-Willems IMJJ, van den Bogaard E, Giovannone B, van Wijk F, van Royen-Kerkhof A, Marut W, Radstake TRD
J Autoimmun 2019 Jul;101:86-93. Epub 2019 Apr 18 doi: 10.1016/j.jaut.2019.04.008. PMID: 31006523
Circulating levels of CXCL11 and CXCL12 are biomarkers of cirrhosis in patients with chronic hepatitis C infection.
Chalin A, Lefevre B, Devisme C, Barget N, Amiot L, Samson M
Cytokine 2019 May;117:72-78. Epub 2019 Feb 28 doi: 10.1016/j.cyto.2019.02.006. PMID: 30826602
Submicroscopic infections with Plasmodium falciparum during pregnancy and their association with circulating cytokine, chemokine, and cellular profiles.
Ibitokou SA, Boström S, Brutus L, Tuikue Ndam N, Vianou B, Agbowaï C, Amadoudji Zin M, Huynh BT, Massougbodji A, Deloron P, Troye-Blomberg M, Fievet N, Luty AJ
Clin Vaccine Immunol 2014 Jun;21(6):859-66. Epub 2014 Apr 9 doi: 10.1128/CVI.00009-14. PMID: 24717969Free PMC Article
Serum leptin levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in normal pregnancy and preeclampsia.
Molvarec A, Szarka A, Walentin S, Beko G, Karádi I, Prohászka Z, Rigó J Jr
Reprod Biol Endocrinol 2011 Sep 9;9:124. doi: 10.1186/1477-7827-9-124. PMID: 21906313Free PMC Article

Therapy

Effect of antiviral and immunomodulatory treatment on a cytokine profile in patients with COVID-19.
Martonik D, Parfieniuk-Kowerda A, Starosz A, Grubczak K, Moniuszko M, Flisiak R
Front Immunol 2023;14:1222170. Epub 2023 Jul 6 doi: 10.3389/fimmu.2023.1222170. PMID: 37483627Free PMC Article
Cervicovaginal Immune Activation in Zambian Women With Female Genital Schistosomiasis.
Sturt AS, Webb EL, Patterson C, Phiri CR, Mweene T, Kjetland EF, Mudenda M, Mapani J, Mutengo MM, Chipeta J, van Dam GJ, Corstjens PLAM, Ayles H, Hayes RJ, Hansingo I, Cools P, van Lieshout L, Helmby H, McComsey GA, Francis SC, Bustinduy AL
Front Immunol 2021;12:620657. Epub 2021 Mar 2 doi: 10.3389/fimmu.2021.620657. PMID: 33737927Free PMC Article
Elevated chronic inflammatory factors and myeloid-derived suppressor cells indicate poor prognosis in advanced melanoma patients.
Jiang H, Gebhardt C, Umansky L, Beckhove P, Schulze TJ, Utikal J, Umansky V
Int J Cancer 2015 May 15;136(10):2352-60. Epub 2014 Nov 12 doi: 10.1002/ijc.29297. PMID: 25353097
BAFF/APRIL system in pediatric OMS: relation to severity, neuroinflammation, and immunotherapy.
Pranzatelli MR, Tate ED, McGee NR, Travelstead AL, Colliver JA, Ness JM, Ransohoff RM
J Neuroinflammation 2013 Jan 16;10:10. doi: 10.1186/1742-2094-10-10. PMID: 23324534Free PMC Article
Dynamic changes in clinical features and cytokine/chemokine responses in SARS patients treated with interferon alfacon-1 plus corticosteroids.
Ward SE, Loutfy MR, Blatt LM, Siminovitch KA, Chen J, Hinek A, Wolff B, Pham DH, Deif H, LaMere EA, Kain KC, Farcas GA, Ferguson P, Latchford M, Levy G, Fung L, Dennis JW, Lai EK, Fish EN
Antivir Ther 2005;10(2):263-75. PMID: 15865221

Prognosis

Elevated chronic inflammatory factors and myeloid-derived suppressor cells indicate poor prognosis in advanced melanoma patients.
Jiang H, Gebhardt C, Umansky L, Beckhove P, Schulze TJ, Utikal J, Umansky V
Int J Cancer 2015 May 15;136(10):2352-60. Epub 2014 Nov 12 doi: 10.1002/ijc.29297. PMID: 25353097
Submicroscopic infections with Plasmodium falciparum during pregnancy and their association with circulating cytokine, chemokine, and cellular profiles.
Ibitokou SA, Boström S, Brutus L, Tuikue Ndam N, Vianou B, Agbowaï C, Amadoudji Zin M, Huynh BT, Massougbodji A, Deloron P, Troye-Blomberg M, Fievet N, Luty AJ
Clin Vaccine Immunol 2014 Jun;21(6):859-66. Epub 2014 Apr 9 doi: 10.1128/CVI.00009-14. PMID: 24717969Free PMC Article
CXC chemokines CXCL1, CXCL9, CXCL10 and CXCL12 are variably expressed in patients with sickle cell disease and carriers: are they predictive tools for disease complications?
Ostadebrahimi H, Jamali Z, Nazari M, Bahri M, Farahmandnia Z, Khandany BK, Taheri M, Khorramdelazad H, Hakimizadeh E, Zaker F, Rezaeian M, Hassanshahi G
Clin Lab 2014;60(1):99-104. doi: 10.7754/clin.lab.2013.121237. PMID: 24600982
Dynamic changes in clinical features and cytokine/chemokine responses in SARS patients treated with interferon alfacon-1 plus corticosteroids.
Ward SE, Loutfy MR, Blatt LM, Siminovitch KA, Chen J, Hinek A, Wolff B, Pham DH, Deif H, LaMere EA, Kain KC, Farcas GA, Ferguson P, Latchford M, Levy G, Fung L, Dennis JW, Lai EK, Fish EN
Antivir Ther 2005;10(2):263-75. PMID: 15865221

Clinical prediction guides

Circulating markers of inflammation and angiogenesis and clinical outcomes across subtypes of pulmonary arterial hypertension.
Hirsch K, Nolley S, Ralph DD, Zheng Y, Altemeier WA, Rhodes CJ, Morrell NW, Wilkins MR, Leary PJ, Rayner SG
J Heart Lung Transplant 2023 Feb;42(2):173-182. Epub 2022 Nov 7 doi: 10.1016/j.healun.2022.10.026. PMID: 36470771Free PMC Article
Galectin-9 as a biomarker for disease activity in systemic lupus erythematosus.
Matsuoka N, Fujita Y, Temmoku J, Furuya MY, Asano T, Sato S, Matsumoto H, Kobayashi H, Watanabe H, Suzuki E, Kozuru H, Yastuhashi H, Migita K
PLoS One 2020;15(1):e0227069. Epub 2020 Jan 27 doi: 10.1371/journal.pone.0227069. PMID: 31986153Free PMC Article
The identification of CCL18 as biomarker of disease activity in localized scleroderma.
Mertens JS, de Jong EMGJ, van den Hoogen LL, Wienke J, Thurlings RM, Seyger MMB, Hoppenreijs EPAH, Wijngaarde CA, van Vlijmen-Willems IMJJ, van den Bogaard E, Giovannone B, van Wijk F, van Royen-Kerkhof A, Marut W, Radstake TRD
J Autoimmun 2019 Jul;101:86-93. Epub 2019 Apr 18 doi: 10.1016/j.jaut.2019.04.008. PMID: 31006523
CXC chemokines CXCL1, CXCL9, CXCL10 and CXCL12 are variably expressed in patients with sickle cell disease and carriers: are they predictive tools for disease complications?
Ostadebrahimi H, Jamali Z, Nazari M, Bahri M, Farahmandnia Z, Khandany BK, Taheri M, Khorramdelazad H, Hakimizadeh E, Zaker F, Rezaeian M, Hassanshahi G
Clin Lab 2014;60(1):99-104. doi: 10.7754/clin.lab.2013.121237. PMID: 24600982
Serum leptin levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in normal pregnancy and preeclampsia.
Molvarec A, Szarka A, Walentin S, Beko G, Karádi I, Prohászka Z, Rigó J Jr
Reprod Biol Endocrinol 2011 Sep 9;9:124. doi: 10.1186/1477-7827-9-124. PMID: 21906313Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...