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Abnormal circulating interleukin 12 concentration

MedGen UID:
1054103
•Concept ID:
CN377044
•
Finding
HPO: HP:6000442

Definition

Any deviation from the normal range of the concentration of interleukin 12 in the blood circulation. [from HPO]

Recent clinical studies

Etiology

Preeclampsia at term: evidence of disease heterogeneity based on the profile of circulating cytokines and angiogenic factors.
Chaiworapongsa T, Romero R, Gomez-Lopez N, Suksai M, Gallo DM, Jung E, Berry SM, Awonuga A, Tarca AL, Bryant DR
Am J Obstet Gynecol 2024 Apr;230(4):450.e1-450.e18. Epub 2023 Oct 6 doi: 10.1016/j.ajog.2023.10.002. PMID: 37806612Free PMC Article
The elevated systemic cytokine levels in HIV patients are not associated with an elevated pulmonary cytokine environment.
Fernandez-Botran R, Vega AR, García Y, Tirumala CC, Srisailam P, Raghuram A, Peyrani P, Furmanek S, Tella MA, Ritzhentaler JD, Roman J, Ramírez JA
Cytokine 2020 Feb;126:154874. Epub 2019 Oct 23 doi: 10.1016/j.cyto.2019.154874. PMID: 31655458Free PMC Article
Elevation of plasma interleukin-18 concentration is associated with insulin levels in patients with systemic lupus erythematosus.
Tso TK, Huang WN, Huang HY, Chang CK
Lupus 2006;15(4):207-12. doi: 10.1191/0961203306lu2284oa. PMID: 16686259
Increased circulating interleukin-12 (IL-12) p40 in pulmonary sarcoidosis.
Shigehara K, Shijubo N, Ohmichi M, Kamiguchi K, Takahashi R, Morita-Ichimura S, Ohchi T, Tatsuno T, Hiraga Y, Abe S, Sato N
Clin Exp Immunol 2003 Apr;132(1):152-7. doi: 10.1046/j.1365-2249.2003.02105.x. PMID: 12653850Free PMC Article
Changes in circulating dendritic cells and IL-12 in relation to the angiogenic factor VEGF during IL-2 immunotherapy of metastatic renal cell cancer.
Bonfanti A, Lissoni P, Bucovec R, Rovelli F, Brivio F, Fumagalli L
Int J Biol Markers 2000 Apr-Jun;15(2):161-4. doi: 10.1177/172460080001500206. PMID: 10883890

Diagnosis

Relationship Between Serum IL-12 and p40 Subunit Concentrations and Lipid Parameters in Overweight and Obese Women.
Nikołajuk A, Karczewska-Kupczewska M, Straczkowski M
Metab Syndr Relat Disord 2015 Oct;13(8):336-42. Epub 2015 Jun 3 doi: 10.1089/met.2014.0164. PMID: 26038987

Therapy

Changes in circulating dendritic cells and IL-12 in relation to the angiogenic factor VEGF during IL-2 immunotherapy of metastatic renal cell cancer.
Bonfanti A, Lissoni P, Bucovec R, Rovelli F, Brivio F, Fumagalli L
Int J Biol Markers 2000 Apr-Jun;15(2):161-4. doi: 10.1177/172460080001500206. PMID: 10883890

Prognosis

Abnormally enhanced blood concentrations of vascular endothelial growth factor (VEGF) in metastatic cancer patients and their relation to circulating dendritic cells, IL-12 and endothelin-1.
Lissoni P, Malugani F, Bonfanti A, Bucovec R, Secondino S, Brivio F, Ferrari-Bravo A, Ferrante R, Vigoré L, Rovelli F, Mandalà M, Viviani S, Fumagalli L, Gardani GS
J Biol Regul Homeost Agents 2001 Apr-Jun;15(2):140-4. PMID: 11501971

Clinical prediction guides

Preeclampsia at term: evidence of disease heterogeneity based on the profile of circulating cytokines and angiogenic factors.
Chaiworapongsa T, Romero R, Gomez-Lopez N, Suksai M, Gallo DM, Jung E, Berry SM, Awonuga A, Tarca AL, Bryant DR
Am J Obstet Gynecol 2024 Apr;230(4):450.e1-450.e18. Epub 2023 Oct 6 doi: 10.1016/j.ajog.2023.10.002. PMID: 37806612Free PMC Article
Relationship Between Serum IL-12 and p40 Subunit Concentrations and Lipid Parameters in Overweight and Obese Women.
Nikołajuk A, Karczewska-Kupczewska M, Straczkowski M
Metab Syndr Relat Disord 2015 Oct;13(8):336-42. Epub 2015 Jun 3 doi: 10.1089/met.2014.0164. PMID: 26038987
Abnormally enhanced blood concentrations of vascular endothelial growth factor (VEGF) in metastatic cancer patients and their relation to circulating dendritic cells, IL-12 and endothelin-1.
Lissoni P, Malugani F, Bonfanti A, Bucovec R, Secondino S, Brivio F, Ferrari-Bravo A, Ferrante R, Vigoré L, Rovelli F, Mandalà M, Viviani S, Fumagalli L, Gardani GS
J Biol Regul Homeost Agents 2001 Apr-Jun;15(2):140-4. PMID: 11501971
Changes in circulating dendritic cells and IL-12 in relation to the angiogenic factor VEGF during IL-2 immunotherapy of metastatic renal cell cancer.
Bonfanti A, Lissoni P, Bucovec R, Rovelli F, Brivio F, Fumagalli L
Int J Biol Markers 2000 Apr-Jun;15(2):161-4. doi: 10.1177/172460080001500206. PMID: 10883890

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