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Increased circulating interleukin 12 concentration

MedGen UID:
1841844
•Concept ID:
C5826429
•
Finding
Synonym: IL-12 high in blood
 
HPO: HP:0034487

Definition

An increased concentration of interleukin-12 in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating interleukin 12 concentration

Recent clinical studies

Etiology

Dietary intervention with an Okinawan-based Nordic diet in type 2 diabetes renders decreased interleukin-18 concentrations and increased neurofilament light concentrations in plasma.
Nilholm C, Roth B, Höglund P, Blennow K, Englund E, Hansson O, Zetterberg H, Ohlsson B
Nutr Res 2018 Dec;60:13-25. Epub 2018 Aug 19 doi: 10.1016/j.nutres.2018.08.002. PMID: 30527256
Diminished circulating concentration of interleukin-35 in Helicobacter pylori-infected patients with peptic ulcer: Its association with FOXP3 gene polymorphism, bacterial virulence factor CagA, and gender of patients.
Bassagh A, Hayatbakhsh Abasi M, Larussa T, Ghazizadeh M, Nemati M, Mirkamandar E, Jafarzadeh A
Helicobacter 2018 Aug;23(4):e12501. Epub 2018 Jun 25 doi: 10.1111/hel.12501. PMID: 29938865
Role of leptin in reverse epidemiology in chronic kidney disease.
Scholze A, Tepel M
Semin Dial 2007 Nov-Dec;20(6):534-8. doi: 10.1111/j.1525-139X.2007.00334.x. PMID: 17991200
Interleukin 12 is associated with reduced relapse without increased incidence of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Reddy V, Winer AG, Eksioglu E, Meier-Kriesche HU, Schold JD, Wingard JR
Biol Blood Marrow Transplant 2005 Dec;11(12):1014-21. doi: 10.1016/j.bbmt.2005.08.032. PMID: 16338624
Increased circulating interleukin-12 (IL-12) p40 in pulmonary sarcoidosis.
Shigehara K, Shijubo N, Ohmichi M, Kamiguchi K, Takahashi R, Morita-Ichimura S, Ohchi T, Tatsuno T, Hiraga Y, Abe S, Sato N
Clin Exp Immunol 2003 Apr;132(1):152-7. doi: 10.1046/j.1365-2249.2003.02105.x. PMID: 12653850Free PMC Article

Diagnosis

Gliadin-reactive vitamin D-sensitive proinflammatory ILCPs are enriched in celiac patients.
Ercolano G, Moretti A, Falquet M, Wyss T, Tran NL, Senoner I, Marinoni M, Agosti M, Salvatore S, Jandus C, Trabanelli S
Cell Rep 2022 Jun 14;39(11):110956. doi: 10.1016/j.celrep.2022.110956. PMID: 35705047
Galectin-3 and aldosterone as potential tandem biomarkers in pulmonary arterial hypertension.
Calvier L, Legchenko E, Grimm L, Sallmon H, Hatch A, Plouffe BD, Schroeder C, Bauersachs J, Murthy SK, Hansmann G
Heart 2016 Mar;102(5):390-6. doi: 10.1136/heartjnl-2015-308365. PMID: 26869635
Relationship Between Serum IL-12 and p40 Subunit Concentrations and Lipid Parameters in Overweight and Obese Women.
Nikołajuk A, Karczewska-Kupczewska M, Straczkowski M
Metab Syndr Relat Disord 2015 Oct;13(8):336-42. Epub 2015 Jun 3 doi: 10.1089/met.2014.0164. PMID: 26038987
Proinflammatory cytokine profile in active kidney tuberculosis patients.
Koziol-Montewka M, Kolodziejek A, Oles J, Janicka L
Immunol Invest 2004 Aug;33(3):277-85. doi: 10.1081/imm-120037270. PMID: 15495787
Circulating cytokines and hormones with immunosuppressive but neutrophil-priming potentials rise after endurance exercise in humans.
Suzuki K, Yamada M, Kurakake S, Okamura N, Yamaya K, Liu Q, Kudoh S, Kowatari K, Nakaji S, Sugawara K
Eur J Appl Physiol 2000 Mar;81(4):281-7. doi: 10.1007/s004210050044. PMID: 10664086

Therapy

Ustekinumab Decreases Circulating Th17 Cells in Ulcerative Colitis.
Imazu N, Torisu T, Ihara Y, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Kitazono T
Intern Med 2024 Jan 15;63(2):153-158. Epub 2023 May 17 doi: 10.2169/internalmedicine.1724-23. PMID: 37197955Free PMC Article
A Single Dose of Ibuprofen Impacts IL-10 Response to 164-km Road Cycling in the Heat.
Vingren JL, Boyett JC, Lee EC, Levitt DE, Luk HY, McDermott BP, Munoz CX, Ganio MS, Armstrong LE, Hill DW
Res Q Exerc Sport 2023 Jun;94(2):344-350. Epub 2022 Mar 28 doi: 10.1080/02701367.2021.1981539. PMID: 35344476
Dietary intervention with an Okinawan-based Nordic diet in type 2 diabetes renders decreased interleukin-18 concentrations and increased neurofilament light concentrations in plasma.
Nilholm C, Roth B, Höglund P, Blennow K, Englund E, Hansson O, Zetterberg H, Ohlsson B
Nutr Res 2018 Dec;60:13-25. Epub 2018 Aug 19 doi: 10.1016/j.nutres.2018.08.002. PMID: 30527256
Interleukin 12 is associated with reduced relapse without increased incidence of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Reddy V, Winer AG, Eksioglu E, Meier-Kriesche HU, Schold JD, Wingard JR
Biol Blood Marrow Transplant 2005 Dec;11(12):1014-21. doi: 10.1016/j.bbmt.2005.08.032. PMID: 16338624
Phase II clinical trial of interleukin-12 in patients with relapsed and refractory non-Hodgkin's lymphoma and Hodgkin's disease.
Younes A, Pro B, Robertson MJ, Flinn IW, Romaguera JE, Hagemeister F, Dang NH, Fiumara P, Loyer EM, Cabanillas FF, McLaughlin PW, Rodriguez MA, Samaniego F
Clin Cancer Res 2004 Aug 15;10(16):5432-8. doi: 10.1158/1078-0432.CCR-04-0540. PMID: 15328181

Prognosis

Increased IFN-γ-producing Th17/Th1 cells and their association with lung function and current smoking status in patients with chronic obstructive pulmonary disease.
Xu W, Li R, Sun Y
BMC Pulm Med 2019 Jul 26;19(1):137. doi: 10.1186/s12890-019-0899-2. PMID: 31349846Free PMC Article
Galectin-3 and aldosterone as potential tandem biomarkers in pulmonary arterial hypertension.
Calvier L, Legchenko E, Grimm L, Sallmon H, Hatch A, Plouffe BD, Schroeder C, Bauersachs J, Murthy SK, Hansmann G
Heart 2016 Mar;102(5):390-6. doi: 10.1136/heartjnl-2015-308365. PMID: 26869635
The suppression of immune activation during enfuvirtide-based salvage therapy is associated with reduced CCR5 expression and decreased concentrations of circulating interleukin-12 and IP-10 during 48 weeks of longitudinal follow-up.
Carsenti-Dellamonica H, Saïdi H, Ticchioni M, Guillouet de Salvador F, Dufayard Cottalorda J, Garraffo R, Dellamonica P, Durant J, Gougeon ML
HIV Med 2011 Feb;12(2):65-77. doi: 10.1111/j.1468-1293.2010.00848.x. PMID: 20500532
Association between nucleated red blood cells in blood and the levels of erythropoietin, interleukin 3, interleukin 6, and interleukin 12p70.
Stachon A, Bolulu O, Holland-Letz T, Krieg M
Shock 2005 Jul;24(1):34-9. doi: 10.1097/01.shk.0000164693.11649.91. PMID: 15988318
Repeated administrations of interleukin (IL)-12 are associated with persistently elevated plasma levels of IL-10 and declining IFN-gamma, tumor necrosis factor-alpha, IL-6, and IL-8 responses.
Portielje JE, Lamers CH, Kruit WH, Sparreboom A, Bolhuis RL, Stoter G, Huber C, Gratama JW
Clin Cancer Res 2003 Jan;9(1):76-83. PMID: 12538454

Clinical prediction guides

Ustekinumab Decreases Circulating Th17 Cells in Ulcerative Colitis.
Imazu N, Torisu T, Ihara Y, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Kitazono T
Intern Med 2024 Jan 15;63(2):153-158. Epub 2023 May 17 doi: 10.2169/internalmedicine.1724-23. PMID: 37197955Free PMC Article
Increased IFN-γ-producing Th17/Th1 cells and their association with lung function and current smoking status in patients with chronic obstructive pulmonary disease.
Xu W, Li R, Sun Y
BMC Pulm Med 2019 Jul 26;19(1):137. doi: 10.1186/s12890-019-0899-2. PMID: 31349846Free PMC Article
Galectin-3 and aldosterone as potential tandem biomarkers in pulmonary arterial hypertension.
Calvier L, Legchenko E, Grimm L, Sallmon H, Hatch A, Plouffe BD, Schroeder C, Bauersachs J, Murthy SK, Hansmann G
Heart 2016 Mar;102(5):390-6. doi: 10.1136/heartjnl-2015-308365. PMID: 26869635
Relationship Between Serum IL-12 and p40 Subunit Concentrations and Lipid Parameters in Overweight and Obese Women.
Nikołajuk A, Karczewska-Kupczewska M, Straczkowski M
Metab Syndr Relat Disord 2015 Oct;13(8):336-42. Epub 2015 Jun 3 doi: 10.1089/met.2014.0164. PMID: 26038987
Exhaustive exercise and type-1/type-2 cytokine balance with special focus on interleukin-12 p40/p70.
Suzuki K, Nakaji S, Kurakake S, Totsuka M, Sato K, Kuriyama T, Fujimoto H, Shibusawa K, Machida K, Sugawara K
Exerc Immunol Rev 2003;9:48-57. PMID: 14686094

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