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Abnormal peripapillary microvascular network

MedGen UID:
1054123
•Concept ID:
CN377920
•
Finding
HPO: HP:6000771

Definition

The density of the deep peripapillary microvascular network (i.e., the number of blood vessels) is below the lower limit of normal. This finding is observable by optical coherence tomography angiography. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal peripapillary microvascular network

Recent clinical studies

Etiology

Abnormalities of retinal structure and microvasculature are associated with cerebral white matter hyperintensities.
Zhou X, Li T, Qu W, Pan D, Qiu Q, Wu L, Zhao J, Yu Z, Hao H, Luo X
Eur J Neurol 2022 Aug;29(8):2289-2298. Epub 2022 May 16 doi: 10.1111/ene.15378. PMID: 35503727
Quantification of the Peripapillary Microvasculature in Eyes with Glaucomatous Paracentral Visual Field Loss.
Nascimento E Silva R, Chiou CA, Wang M, Devlin J, Li D, Lovelace S, Wang H, Greenstein SH, Brauner SC, Shen LQ
Ophthalmol Glaucoma 2021 May-Jun;4(3):286-294. Epub 2020 Oct 16 doi: 10.1016/j.ogla.2020.10.009. PMID: 33075548Free PMC Article
Assessment of retinal vascular network in amnestic mild cognitive impairment by optical coherence tomography angiography.
Criscuolo C, Cennamo G, Montorio D, Carotenuto A, Strianese A, Salvatore E, Tranfa F, Cennamo G, Lanzillo R, Brescia Morra V
PLoS One 2020;15(6):e0233975. Epub 2020 Jun 3 doi: 10.1371/journal.pone.0233975. PMID: 32492054Free PMC Article
Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography.
Abe M, Omodaka K, Kikawa T, Nakazawa T
BMC Ophthalmol 2020 May 24;20(1):199. doi: 10.1186/s12886-020-01453-6. PMID: 32448227Free PMC Article
Peripapillary microcirculation in Leber hereditary optic neuropathy.
Kousal B, Kolarova H, Meliska M, Bydzovsky J, Diblik P, Kulhanek J, Votruba M, Honzik T, Liskova P
Acta Ophthalmol 2019 Feb;97(1):e71-e76. Epub 2018 Sep 26 doi: 10.1111/aos.13817. PMID: 30259673

Diagnosis

Radial peripapillary capillary network in optic disc anomalies with abnormal tissues on disc surface.
Mansoori T
Indian J Ophthalmol 2023 May;71(5):2324. doi: 10.4103/IJO.IJO_3137_22. PMID: 37203011Free PMC Article
Paired Optic Nerve Microvasculature and Nailfold Capillary Measurements in Primary Open-Angle Glaucoma.
Shoji MK, Cousins CC, Saini C, Nascimento E Silva R, Wang M, Brauner SC, Greenstein SH, Pasquale LR, Shen LQ
Transl Vis Sci Technol 2021 Jun 1;10(7):13. doi: 10.1167/tvst.10.7.13. PMID: 34110389Free PMC Article
Quantification of the Peripapillary Microvasculature in Eyes with Glaucomatous Paracentral Visual Field Loss.
Nascimento E Silva R, Chiou CA, Wang M, Devlin J, Li D, Lovelace S, Wang H, Greenstein SH, Brauner SC, Shen LQ
Ophthalmol Glaucoma 2021 May-Jun;4(3):286-294. Epub 2020 Oct 16 doi: 10.1016/j.ogla.2020.10.009. PMID: 33075548Free PMC Article
Peripapillary microcirculation in Leber hereditary optic neuropathy.
Kousal B, Kolarova H, Meliska M, Bydzovsky J, Diblik P, Kulhanek J, Votruba M, Honzik T, Liskova P
Acta Ophthalmol 2019 Feb;97(1):e71-e76. Epub 2018 Sep 26 doi: 10.1111/aos.13817. PMID: 30259673
Familial retinal arteriolar tortuosity: a review.
Sutter FK, Helbig H
Surv Ophthalmol 2003 May-Jun;48(3):245-55. doi: 10.1016/s0039-6257(03)00029-8. PMID: 12745002

Therapy

Prospective assessment of peripapillary microvasculature using optical coherence tomography angiography in para-optic intracranial and sinonasal tumors treated with proton therapy.
Boudoux O, Bailleul H, Marty PA, Miguel A, Quintyn JC, Thariat J
J Fr Ophtalmol 2024 Oct;47(8):104239. Epub 2024 Jul 3 doi: 10.1016/j.jfo.2024.104239. PMID: 38964279
Changes in Density of Peripapillary and Intrapapillary Capillaries on OCT Angiography in Acute Retinal Necrosis Treated by Pharmacotherapy Alone without Surgery.
Tsubota K, Usui Y, Kezuka T, Sakai J, Goto H
Ocul Immunol Inflamm 2024 Sep;32(7):1250-1256. Epub 2023 Jun 22 doi: 10.1080/09273948.2023.2221741. PMID: 37348115
Microvascular retinal changes in pre-clinical diabetic retinopathy as detected by optical coherence tomographic angiography.
Yang JY, Wang Q, Yan YN, Zhou WJ, Wang YX, Wu SL, Yuan MX, Wei WB, Jonas JB
Graefes Arch Clin Exp Ophthalmol 2020 Mar;258(3):513-520. Epub 2020 Jan 2 doi: 10.1007/s00417-019-04590-x. PMID: 31897704
Changes in Ganglion Cell-Inner Plexiform Layer Thickness and Retinal Microvasculature in Hypertension: An Optical Coherence Tomography Angiography Study.
Lim HB, Lee MW, Park JH, Kim K, Jo YJ, Kim JY
Am J Ophthalmol 2019 Mar;199:167-176. Epub 2018 Nov 29 doi: 10.1016/j.ajo.2018.11.016. PMID: 30502337

Prognosis

Changes in Density of Peripapillary and Intrapapillary Capillaries on OCT Angiography in Acute Retinal Necrosis Treated by Pharmacotherapy Alone without Surgery.
Tsubota K, Usui Y, Kezuka T, Sakai J, Goto H
Ocul Immunol Inflamm 2024 Sep;32(7):1250-1256. Epub 2023 Jun 22 doi: 10.1080/09273948.2023.2221741. PMID: 37348115
Evaluation of microvascular network with optical coherence tomography angiography (OCTA) in branch retinal vein occlusion (BRVO).
Chen L, Yuan M, Sun L, Wang Y, Chen Y
BMC Ophthalmol 2020 Apr 19;20(1):154. doi: 10.1186/s12886-020-01405-0. PMID: 32306978Free PMC Article
Relationship between nailfold capillary morphology and retinal thickness and retinal vessel density in primary open-angle and angle-closure glaucoma.
Rong X, Cai Y, Li M, Chen X, Kang L, Yang L
Acta Ophthalmol 2020 Nov;98(7):e882-e887. Epub 2020 Apr 3 doi: 10.1111/aos.14416. PMID: 32243735
Optical coherence tomography angiography characterization of acute and late stage Purtscher retinopathy.
Gil P, Raimundo M, Marques JP, Póvoa J, Silva R
Eur J Ophthalmol 2018 Jul;28(4):NP1-NP6. Epub 2018 Apr 18 doi: 10.1177/1120672118769788. PMID: 29667428
The distinct optic disk and peripapillary appearance in Donnai-Barrow syndrome.
Khan AO, Ghazi NG
Ophthalmic Genet 2018 Jun;39(3):321-324. Epub 2018 Feb 1 doi: 10.1080/13816810.2018.1430245. PMID: 29388841

Clinical prediction guides

Abnormalities of retinal structure and microvasculature are associated with cerebral white matter hyperintensities.
Zhou X, Li T, Qu W, Pan D, Qiu Q, Wu L, Zhao J, Yu Z, Hao H, Luo X
Eur J Neurol 2022 Aug;29(8):2289-2298. Epub 2022 May 16 doi: 10.1111/ene.15378. PMID: 35503727
Paired Optic Nerve Microvasculature and Nailfold Capillary Measurements in Primary Open-Angle Glaucoma.
Shoji MK, Cousins CC, Saini C, Nascimento E Silva R, Wang M, Brauner SC, Greenstein SH, Pasquale LR, Shen LQ
Transl Vis Sci Technol 2021 Jun 1;10(7):13. doi: 10.1167/tvst.10.7.13. PMID: 34110389Free PMC Article
Assessment of retinal vascular network in amnestic mild cognitive impairment by optical coherence tomography angiography.
Criscuolo C, Cennamo G, Montorio D, Carotenuto A, Strianese A, Salvatore E, Tranfa F, Cennamo G, Lanzillo R, Brescia Morra V
PLoS One 2020;15(6):e0233975. Epub 2020 Jun 3 doi: 10.1371/journal.pone.0233975. PMID: 32492054Free PMC Article
Peripapillary microcirculation in Leber hereditary optic neuropathy.
Kousal B, Kolarova H, Meliska M, Bydzovsky J, Diblik P, Kulhanek J, Votruba M, Honzik T, Liskova P
Acta Ophthalmol 2019 Feb;97(1):e71-e76. Epub 2018 Sep 26 doi: 10.1111/aos.13817. PMID: 30259673
SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF THE OPTIC DISK IN OPTIC NEUROPATHY.
Ghasemi Falavarjani K, Tian JJ, Akil H, Garcia GA, Sadda SR, Sadun AA
Retina 2016 Dec;36 Suppl 1:S168-S177. doi: 10.1097/IAE.0000000000001259. PMID: 28005675

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