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Elevated circulating alpha-ketoglutarate concentration

MedGen UID:
1054353
•Concept ID:
CN377031
•
Finding
Synonym: Alpha-ketoglutarate high in blood
 
HPO: HP:6000435

Definition

The concentration of alpha-ketoglutarate in the blood circulation is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating alpha-ketoglutarate concentration

Recent clinical studies

Etiology

A randomized crossover trial assessing the effects of acute exercise on appetite, circulating ghrelin concentrations, and butyrylcholinesterase activity in normal-weight males with variants of the obesity-linked FTO rs9939609 polymorphism.
Dorling JL, Clayton DJ, Jones J, Carter WG, Thackray AE, King JA, Pucci A, Batterham RL, Stensel DJ
Am J Clin Nutr 2019 Nov 1;110(5):1055-1066. doi: 10.1093/ajcn/nqz188. PMID: 31504106
Vitamins, metabolomics, and prostate cancer.
Mondul AM, Weinstein SJ, Albanes D
World J Urol 2017 Jun;35(6):883-893. Epub 2016 Jun 23 doi: 10.1007/s00345-016-1878-3. PMID: 27339624Free PMC Article
Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis.
Forni LG, McKinnon W, Lord GA, Treacher DF, Peron JM, Hilton PJ
Crit Care 2005 Oct 5;9(5):R591-5. Epub 2005 Sep 13 doi: 10.1186/cc3806. PMID: 16277723Free PMC Article

Diagnosis

Vitamins, metabolomics, and prostate cancer.
Mondul AM, Weinstein SJ, Albanes D
World J Urol 2017 Jun;35(6):883-893. Epub 2016 Jun 23 doi: 10.1007/s00345-016-1878-3. PMID: 27339624Free PMC Article

Therapy

Gain-of-function Tibetan PHD2(D4E;C127S) variant suppresses monocyte function: A lesson in inflammatory response to inspired hypoxia.
Bhattacharya S, Shrimali NM, Mohammad G, Koul PA, Prchal JT, Guchhait P
EBioMedicine 2021 Jun;68:103418. Epub 2021 Jun 5 doi: 10.1016/j.ebiom.2021.103418. PMID: 34102396Free PMC Article
A randomized crossover trial assessing the effects of acute exercise on appetite, circulating ghrelin concentrations, and butyrylcholinesterase activity in normal-weight males with variants of the obesity-linked FTO rs9939609 polymorphism.
Dorling JL, Clayton DJ, Jones J, Carter WG, Thackray AE, King JA, Pucci A, Batterham RL, Stensel DJ
Am J Clin Nutr 2019 Nov 1;110(5):1055-1066. doi: 10.1093/ajcn/nqz188. PMID: 31504106
Vitamins, metabolomics, and prostate cancer.
Mondul AM, Weinstein SJ, Albanes D
World J Urol 2017 Jun;35(6):883-893. Epub 2016 Jun 23 doi: 10.1007/s00345-016-1878-3. PMID: 27339624Free PMC Article

Prognosis

Vitamins, metabolomics, and prostate cancer.
Mondul AM, Weinstein SJ, Albanes D
World J Urol 2017 Jun;35(6):883-893. Epub 2016 Jun 23 doi: 10.1007/s00345-016-1878-3. PMID: 27339624Free PMC Article

Clinical prediction guides

Gain-of-function Tibetan PHD2(D4E;C127S) variant suppresses monocyte function: A lesson in inflammatory response to inspired hypoxia.
Bhattacharya S, Shrimali NM, Mohammad G, Koul PA, Prchal JT, Guchhait P
EBioMedicine 2021 Jun;68:103418. Epub 2021 Jun 5 doi: 10.1016/j.ebiom.2021.103418. PMID: 34102396Free PMC Article
A randomized crossover trial assessing the effects of acute exercise on appetite, circulating ghrelin concentrations, and butyrylcholinesterase activity in normal-weight males with variants of the obesity-linked FTO rs9939609 polymorphism.
Dorling JL, Clayton DJ, Jones J, Carter WG, Thackray AE, King JA, Pucci A, Batterham RL, Stensel DJ
Am J Clin Nutr 2019 Nov 1;110(5):1055-1066. doi: 10.1093/ajcn/nqz188. PMID: 31504106
Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis.
Forni LG, McKinnon W, Lord GA, Treacher DF, Peron JM, Hilton PJ
Crit Care 2005 Oct 5;9(5):R591-5. Epub 2005 Sep 13 doi: 10.1186/cc3806. PMID: 16277723Free PMC Article

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