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Abnormal circulating carboxylic acid concentration

MedGen UID:
1684666
•Concept ID:
C5139039
•
Finding
Synonym: Abnormality of carboxylic acid metabolism
 
HPO: HP:0004354

Definition

Any deviation from the normal concentration of a carboxylic acid in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating carboxylic acid concentration

Professional guidelines

PubMed

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment.
Yang K, Deng HB, Man AWC, Song E, Zhang J, Luo C, Cheung BMY, Yuen KY, Jensen PS, Irmukhamedov A, Elie AGIM, Vanhoutte PM, Xu A, De Mey JGR, Wang Y
ESC Heart Fail 2017 Nov;4(4):563-575. Epub 2017 Jun 27 doi: 10.1002/ehf2.12183. PMID: 29154418Free PMC Article
Ibuprofen lysine for the prevention and treatment of patent ductus arteriosus.
Pai VB, Sakadjian A, Puthoff TD
Pharmacotherapy 2008 Sep;28(9):1162-82. doi: 10.1592/phco.28.9.1162. PMID: 18752387

Recent clinical studies

Etiology

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Somatic and cerebral near infrared spectroscopy for the monitoring of perfusion during neonatal cardiopulmonary bypass.
Bojan M, Bonaveglio E, Dolcino A, Mirabile C
Interact Cardiovasc Thorac Surg 2019 Dec 1;29(6):955-959. doi: 10.1093/icvts/ivz197. PMID: 31384917
Low-flow antegrade cerebral perfusion attenuates early renal and intestinal injury during neonatal aortic arch reconstruction.
Algra SO, Schouten AN, van Oeveren W, van der Tweel I, Schoof PH, Jansen NJ, Haas F
J Thorac Cardiovasc Surg 2012 Dec;144(6):1323-8, 1328.e1-2. Epub 2012 Apr 13 doi: 10.1016/j.jtcvs.2012.03.008. PMID: 22503201
Relevance of the measurement of the concentration of lactate in the serum subsequent to the Fontan procedure in small children.
Hamamoto M, Uemura H, Imanaka H, Yagihara T
Cardiol Young 2006 Jun;16(3):275-80. doi: 10.1017/S1047951106000369. PMID: 16725067
Prophylactic ibuprofen in premature infants: a multicentre, randomised, double-blind, placebo-controlled trial.
Van Overmeire B, Allegaert K, Casaer A, Debauche C, Decaluwé W, Jespers A, Weyler J, Harrewijn I, Langhendries JP
Lancet 2004 Nov 27-Dec 3;364(9449):1945-9. doi: 10.1016/S0140-6736(04)17477-1. PMID: 15567010

Diagnosis

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Chemical mediators of the muscle ergoreflex in chronic heart failure: a putative role for prostaglandins in reflex ventilatory control.
Scott AC, Wensel R, Davos CH, Kemp M, Kaczmarek A, Hooper J, Coats AJ, Piepoli MF
Circulation 2002 Jul 9;106(2):214-20. doi: 10.1161/01.cir.0000021603.36744.5e. PMID: 12105161
Complement activation in the central nervous system following blood-brain barrier damage in man.
Lindsberg PJ, Ohman J, Lehto T, Karjalainen-Lindsberg ML, Paetau A, Wuorimaa T, Carpén O, Kaste M, Meri S
Ann Neurol 1996 Oct;40(4):587-96. doi: 10.1002/ana.410400408. PMID: 8871578
Cerebral lactate-oxygen index in acute brain injury with acute anemia: assessment of false versus true ischemia.
Cruz J, Hoffstad OJ, Jaggi JL
Crit Care Med 1994 Sep;22(9):1465-70. doi: 10.1097/00003246-199409000-00018. PMID: 8062571
DOPA metabolism in neuroblastoma.
Helson L, Johnson GA, Smith R
Med Pediatr Oncol 1980;8(4):317-22. doi: 10.1002/mpo.2950080402. PMID: 6779102

Therapy

5-HT2A receptor antagonist increases circulating adiponectin in patients with type 2 diabetes.
Nomura S, Shouzu A, Omoto S, Nishikawa M, Iwasaka T
Blood Coagul Fibrinolysis 2005 Sep;16(6):423-8. doi: 10.1097/01.mbc.0000176197.48134.08. PMID: 16093733
Prophylactic ibuprofen in premature infants: a multicentre, randomised, double-blind, placebo-controlled trial.
Van Overmeire B, Allegaert K, Casaer A, Debauche C, Decaluwé W, Jespers A, Weyler J, Harrewijn I, Langhendries JP
Lancet 2004 Nov 27-Dec 3;364(9449):1945-9. doi: 10.1016/S0140-6736(04)17477-1. PMID: 15567010
Complement activation in the central nervous system following blood-brain barrier damage in man.
Lindsberg PJ, Ohman J, Lehto T, Karjalainen-Lindsberg ML, Paetau A, Wuorimaa T, Carpén O, Kaste M, Meri S
Ann Neurol 1996 Oct;40(4):587-96. doi: 10.1002/ana.410400408. PMID: 8871578
Anabolic effects of fluoride on bone.
Pak CY, Zerwekh JE, Antich P
Trends Endocrinol Metab 1995 Sep;6(7):229-34. doi: 10.1016/1043-2760(95)00111-t. PMID: 11540313
Urate metabolism and renal calcium stone disease.
Fellström B
Scand J Urol Nephrol Suppl 1981;62:1-59. PMID: 6960474

Prognosis

Somatic and cerebral near infrared spectroscopy for the monitoring of perfusion during neonatal cardiopulmonary bypass.
Bojan M, Bonaveglio E, Dolcino A, Mirabile C
Interact Cardiovasc Thorac Surg 2019 Dec 1;29(6):955-959. doi: 10.1093/icvts/ivz197. PMID: 31384917
Relevance of the measurement of the concentration of lactate in the serum subsequent to the Fontan procedure in small children.
Hamamoto M, Uemura H, Imanaka H, Yagihara T
Cardiol Young 2006 Jun;16(3):275-80. doi: 10.1017/S1047951106000369. PMID: 16725067
Chemical mediators of the muscle ergoreflex in chronic heart failure: a putative role for prostaglandins in reflex ventilatory control.
Scott AC, Wensel R, Davos CH, Kemp M, Kaczmarek A, Hooper J, Coats AJ, Piepoli MF
Circulation 2002 Jul 9;106(2):214-20. doi: 10.1161/01.cir.0000021603.36744.5e. PMID: 12105161
Urate metabolism and renal calcium stone disease.
Fellström B
Scand J Urol Nephrol Suppl 1981;62:1-59. PMID: 6960474
DOPA metabolism in neuroblastoma.
Helson L, Johnson GA, Smith R
Med Pediatr Oncol 1980;8(4):317-22. doi: 10.1002/mpo.2950080402. PMID: 6779102

Clinical prediction guides

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2.
Galiè N, Olschewski H, Oudiz RJ, Torres F, Frost A, Ghofrani HA, Badesch DB, McGoon MD, McLaughlin VV, Roecker EB, Gerber MJ, Dufton C, Wiens BL, Rubin LJ; Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy Studies (ARIES) Group
Circulation 2008 Jun 10;117(23):3010-9. Epub 2008 May 27 doi: 10.1161/CIRCULATIONAHA.107.742510. PMID: 18506008
Chemical mediators of the muscle ergoreflex in chronic heart failure: a putative role for prostaglandins in reflex ventilatory control.
Scott AC, Wensel R, Davos CH, Kemp M, Kaczmarek A, Hooper J, Coats AJ, Piepoli MF
Circulation 2002 Jul 9;106(2):214-20. doi: 10.1161/01.cir.0000021603.36744.5e. PMID: 12105161
Cerebral lactate-oxygen index in acute brain injury with acute anemia: assessment of false versus true ischemia.
Cruz J, Hoffstad OJ, Jaggi JL
Crit Care Med 1994 Sep;22(9):1465-70. doi: 10.1097/00003246-199409000-00018. PMID: 8062571
DOPA metabolism in neuroblastoma.
Helson L, Johnson GA, Smith R
Med Pediatr Oncol 1980;8(4):317-22. doi: 10.1002/mpo.2950080402. PMID: 6779102

Recent systematic reviews

Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.
Oussalah A, Levy J, Filhine-Trésarrieu P, Namour F, Guéant JL
Am J Clin Nutr 2017 Oct;106(4):1142-1156. Epub 2017 Aug 16 doi: 10.3945/ajcn.117.156349. PMID: 28814397Free PMC Article

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