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Reduced hepatic glucose-6-phosphatase activity

MedGen UID:
1054604
•Concept ID:
CN376713
•
Finding
HPO: HP:6000200

Definition

Activity of glucose-6-phosphatase (EC 3.1.3.9) in the liver below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced hepatic glucose-6-phosphatase activity

Recent clinical studies

Etiology

Molecular mechanism underlying impaired hepatic autophagy in glycogen storage disease type Ib.
Gautam S, Zhang L, Lee C, Arnaoutova I, Chen HD, Resaz R, Eva A, Mansfield BC, Chou JY
Hum Mol Genet 2023 Jan 6;32(2):262-275. doi: 10.1093/hmg/ddac197. PMID: 35961004Free PMC Article
Endurance exercise-mediated metabolic reshuffle attenuates high-caloric diet-induced non-alcoholic fatty liver disease.
Cook JJ, Wei M, Segovia B, Cosio-Lima L, Simpson J, Taylor S, Koh Y, Kim S, Lee Y
Ann Hepatol 2022 Jul-Aug;27(4):100709. Epub 2022 Apr 28 doi: 10.1016/j.aohep.2022.100709. PMID: 35489641
Effects of Pterostilbene on Diabetes, Liver Steatosis and Serum Lipids.
Gómez-Zorita S, Milton-Laskíbar I, Aguirre L, Fernández-Quintela A, Xiao J, Portillo MP
Curr Med Chem 2021;28(2):238-252. doi: 10.2174/0929867326666191029112626. PMID: 31663469
The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through RORα and SRC-2 coactivator transcriptional activity.
Madsen A, Bjune JI, Bjørkhaug L, Mellgren G, Sagen JV
Mol Cell Endocrinol 2016 Jan 5;419:92-101. Epub 2015 Oct 9 doi: 10.1016/j.mce.2015.10.003. PMID: 26455881
Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1.
Li X, Xu M, Wang F, Kohan AB, Haas MK, Yang Q, Lou D, Obici S, Davidson WS, Tso P
J Biol Chem 2014 Jan 24;289(4):2396-404. Epub 2013 Dec 5 doi: 10.1074/jbc.M113.511766. PMID: 24311788Free PMC Article

Diagnosis

FOXO1 is downregulated in obese mice subjected to short-term strength training.
Pereira RM, da Cruz Rodrigues KC, Sant'Ana MR, da Rocha AL, Morelli AP, Veras ASC, Gaspar RS, da Costa Fernandes CJ, Teixeira GR, Simabuco FM, da Silva ASR, Cintra DE, Ropelle ER, Pauli JR, de Moura LP
J Cell Physiol 2022 Nov;237(11):4262-4274. Epub 2022 Sep 20 doi: 10.1002/jcp.30882. PMID: 36125908
Glucose-6-Phosphate Regulates Hepatic Bile Acid Synthesis in Mice.
Hoogerland JA, Lei Y, Wolters JC, de Boer JF, Bos T, Bleeker A, Mulder NL, van Dijk TH, Kuivenhoven JA, Rajas F, Mithieux G, Haeusler RA, Verkade HJ, Bloks VW, Kuipers F, Oosterveer MH
Hepatology 2019 Dec;70(6):2171-2184. Epub 2019 Jun 24 doi: 10.1002/hep.30778. PMID: 31102537Free PMC Article
Protective effect of esculin on streptozotocin-induced diabetic renal damage in mice.
Kang KS, Lee W, Jung Y, Lee JH, Lee S, Eom DW, Jeon Y, Yoo HH, Jin MJ, Song KI, Kim WJ, Ham J, Kim HJ, Kim SN
J Agric Food Chem 2014 Mar 5;62(9):2069-76. Epub 2014 Feb 26 doi: 10.1021/jf403840c. PMID: 24484395
Prevention of diabetes, hepatic injury, and colon cancer with dehydroepiandrosterone.
Aoki K, Nakajima A, Mukasa K, Osawa E, Mori Y, Sekihara H
J Steroid Biochem Mol Biol 2003 Jun;85(2-5):469-72. doi: 10.1016/s0960-0760(03)00219-x. PMID: 12943737
The antihyperglycaemic effect of metformin: therapeutic and cellular mechanisms.
Wiernsperger NF, Bailey CJ
Drugs 1999;58 Suppl 1:31-9; discussion 75-82. doi: 10.2165/00003495-199958001-00009. PMID: 10576523

Therapy

Endurance exercise-mediated metabolic reshuffle attenuates high-caloric diet-induced non-alcoholic fatty liver disease.
Cook JJ, Wei M, Segovia B, Cosio-Lima L, Simpson J, Taylor S, Koh Y, Kim S, Lee Y
Ann Hepatol 2022 Jul-Aug;27(4):100709. Epub 2022 Apr 28 doi: 10.1016/j.aohep.2022.100709. PMID: 35489641
Jieduquyuziyin Prescription alleviates hepatic gluconeogenesis via PI3K/Akt/PGC-1α pathway in glucocorticoid-induced MRL/lpr mice.
Ji LN, Wu S, Fu DQ, Fang SJ, Xie GQ, Fan YS, Bao J
J Ethnopharmacol 2022 Feb 10;284:114815. Epub 2021 Nov 8 doi: 10.1016/j.jep.2021.114815. PMID: 34763039
Pterostilbene reverses palmitic acid mediated insulin resistance in HepG2 cells by reducing oxidative stress and triglyceride accumulation.
Malik SA, Acharya JD, Mehendale NK, Kamat SS, Ghaskadbi SS
Free Radic Res 2019 Jul;53(7):815-827. Epub 2019 Jul 10 doi: 10.1080/10715762.2019.1635252. PMID: 31223033Free PMC Article
An evolutionary approach to optimizing glucose-6-phosphatase-α enzymatic activity for gene therapy of glycogen storage disease type Ia.
Zhang L, Cho JH, Arnaoutova I, Mansfield BC, Chou JY
J Inherit Metab Dis 2019 May;42(3):470-479. Epub 2019 Feb 22 doi: 10.1002/jimd.12069. PMID: 30714174Free PMC Article
Prevention of diabetes, hepatic injury, and colon cancer with dehydroepiandrosterone.
Aoki K, Nakajima A, Mukasa K, Osawa E, Mori Y, Sekihara H
J Steroid Biochem Mol Biol 2003 Jun;85(2-5):469-72. doi: 10.1016/s0960-0760(03)00219-x. PMID: 12943737

Prognosis

Molecular and Metabolic Markers of Fructose Induced Hepatic Insulin Resistance in Developing and Adult Rats are Distinct and Aegle marmelos is an Effective Modulator.
Nair J, Velpandian T, Das US, Sharma P, Nag T, Mathur SR, Mathur R
Sci Rep 2018 Oct 29;8(1):15950. doi: 10.1038/s41598-018-33503-x. PMID: 30374065Free PMC Article
Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug.
Cameron AR, Logie L, Patel K, Bacon S, Forteath C, Harthill J, Roberts A, Sutherland C, Stewart D, Viollet B, Sakamoto K, McDougall G, Foretz M, Rena G
Biochim Biophys Acta 2016 Aug;1862(8):1412-22. Epub 2016 Apr 27 doi: 10.1016/j.bbadis.2016.04.015. PMID: 27130437Free PMC Article
Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease.
Valenti L, Mendoza RM, Rametta R, Maggioni M, Kitajewski C, Shawber CJ, Pajvani UB
Diabetes 2013 Dec;62(12):4052-62. Epub 2013 Aug 29 doi: 10.2337/db13-0769. PMID: 23990360Free PMC Article
Clinical and enzymological studies in a child with type I glycogen storage disease associated with partial deficiency of hepatic glucose-6-phosphatase.
Nuki G, Parker J
Adv Exp Med Biol 1980;122A:189-201. doi: 10.1007/978-1-4615-9140-5_31. PMID: 6158847

Clinical prediction guides

Rev-erbα activation down-regulates hepatic Pck1 enzyme to lower plasma glucose in mice.
Yuan X, Dong D, Li Z, Wu B
Pharmacol Res 2019 Mar;141:310-318. Epub 2019 Jan 11 doi: 10.1016/j.phrs.2019.01.010. PMID: 30639375
Liraglutide improves hepatic insulin resistance via the canonical Wnt signaling pathway.
Qin Y, Chen M, Yang Y, Zhou XR, Shao SY, Wang DW, Yuan G
Mol Med Rep 2018 May;17(5):7372-7380. Epub 2018 Mar 14 doi: 10.3892/mmr.2018.8737. PMID: 29568881
Reduced cellular Mg²⁺ content enhances hexose 6-phosphate dehydrogenase activity and expression in HepG2 and HL-60 cells.
Voma C, Barfell A, Croniger C, Romani A
Arch Biochem Biophys 2014 Apr 15;548:11-9. Epub 2014 Mar 11 doi: 10.1016/j.abb.2014.02.016. PMID: 24631573Free PMC Article
Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease.
Valenti L, Mendoza RM, Rametta R, Maggioni M, Kitajewski C, Shawber CJ, Pajvani UB
Diabetes 2013 Dec;62(12):4052-62. Epub 2013 Aug 29 doi: 10.2337/db13-0769. PMID: 23990360Free PMC Article
Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression.
Lochhead PA, Coghlan M, Rice SQ, Sutherland C
Diabetes 2001 May;50(5):937-46. doi: 10.2337/diabetes.50.5.937. PMID: 11334436

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