U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Elevated circulating CCL4 concentration

MedGen UID:
1054844
•Concept ID:
CN377517
•
Finding
HPO: HP:6000688

Definition

The concentration of C-C Motif Ligand 4 (CCL4) in the blood circulation is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating CCL4 concentration

Recent clinical studies

Etiology

Circulating interleukin-8 and osteopontin are promising biomarkers of clinical outcomes in advanced melanoma patients treated with targeted therapy.
Levati L, Tabolacci C, Facchiano A, Facchiano F, Alvino E, Antonini Cappellini GC, Scala E, Bonmassar L, Caporali S, Lacal PM, Bresin A, De Galitiis F, Russo G, D'Atri S
J Exp Clin Cancer Res 2024 Aug 15;43(1):226. doi: 10.1186/s13046-024-03151-3. PMID: 39143551Free PMC Article
Effects of β-hydroxy-β-methylbutyrate free acid and cold water immersion on expression of CR3 and MIP-1β following resistance exercise.
Gonzalez AM, Fragala MS, Jajtner AR, Townsend JR, Wells AJ, Beyer KS, Boone CH, Pruna GJ, Mangine GT, Bohner JD, Fukuda DH, Stout JR, Hoffman JR
Am J Physiol Regul Integr Comp Physiol 2014 Apr 1;306(7):R483-9. Epub 2014 Feb 5 doi: 10.1152/ajpregu.00542.2013. PMID: 24500432
Circulating chemokine levels and miscarriage.
Whitcomb BW, Schisterman EF, Klebanoff MA, Baumgarten M, Rhoton-Vlasak A, Luo X, Chegini N
Am J Epidemiol 2007 Aug 1;166(3):323-31. Epub 2007 May 15 doi: 10.1093/aje/kwm084. PMID: 17504778
Chemoattractant factors in breast milk from allergic and nonallergic mothers.
Böttcher MF, Jenmalm MC, Björkstén B, Garofalo RP
Pediatr Res 2000 May;47(5):592-7. doi: 10.1203/00006450-200005000-00006. PMID: 10813582
Longitudinal analysis of serum chemokine levels in the course of HIV-1 infection.
Polo S, Veglia F, Malnati MS, Gobbi C, Farci P, Raiteri R, Sinicco A, Lusso P
AIDS 1999 Mar 11;13(4):447-54. doi: 10.1097/00002030-199903110-00002. PMID: 10197372

Diagnosis

Serum inflammatory factors and circulating immunosuppressive cells are predictive markers for efficacy of radiofrequency ablation in non-small-cell lung cancer.
Schneider T, Sevko A, Heussel CP, Umansky L, Beckhove P, Dienemann H, Safi S, Utikal J, Hoffmann H, Umansky V
Clin Exp Immunol 2015 Jun;180(3):467-74. Epub 2015 Apr 15 doi: 10.1111/cei.12596. PMID: 25644608Free PMC Article
Selective up-regulation of the soluble pattern-recognition receptor pentraxin 3 and of vascular endothelial growth factor in giant cell arteritis: relevance for recent optic nerve ischemia.
Baldini M, Maugeri N, Ramirez GA, Giacomassi C, Castiglioni A, Prieto-González S, Corbera-Bellalta M, Di Comite G, Papa I, Dell'antonio G, Ammirati E, Cuccovillo I, Vecchio V, Mantovani A, Rovere-Querini P, Sabbadini MG, Cid MC, Manfredi AA
Arthritis Rheum 2012 Mar;64(3):854-65. doi: 10.1002/art.33411. PMID: 21989653

Therapy

Cervicovaginal Immune Activation in Zambian Women With Female Genital Schistosomiasis.
Sturt AS, Webb EL, Patterson C, Phiri CR, Mweene T, Kjetland EF, Mudenda M, Mapani J, Mutengo MM, Chipeta J, van Dam GJ, Corstjens PLAM, Ayles H, Hayes RJ, Hansingo I, Cools P, van Lieshout L, Helmby H, McComsey GA, Francis SC, Bustinduy AL
Front Immunol 2021;12:620657. Epub 2021 Mar 2 doi: 10.3389/fimmu.2021.620657. PMID: 33737927Free PMC Article
Effects of β-hydroxy-β-methylbutyrate free acid and cold water immersion on expression of CR3 and MIP-1β following resistance exercise.
Gonzalez AM, Fragala MS, Jajtner AR, Townsend JR, Wells AJ, Beyer KS, Boone CH, Pruna GJ, Mangine GT, Bohner JD, Fukuda DH, Stout JR, Hoffman JR
Am J Physiol Regul Integr Comp Physiol 2014 Apr 1;306(7):R483-9. Epub 2014 Feb 5 doi: 10.1152/ajpregu.00542.2013. PMID: 24500432
Epoprostenol therapy decreases elevated circulating levels of monocyte chemoattractant protein-1 in patients with primary pulmonary hypertension.
Katsushi H, Kazufumi N, Hideki F, Katsumasa M, Hiroshi M, Kengo K, Hiroshi D, Nobuyoshi S, Tetsuro E, Hiromi M, Tohru O
Circ J 2004 Mar;68(3):227-31. doi: 10.1253/circj.68.227. PMID: 14993777
Chemoattractant factors in breast milk from allergic and nonallergic mothers.
Böttcher MF, Jenmalm MC, Björkstén B, Garofalo RP
Pediatr Res 2000 May;47(5):592-7. doi: 10.1203/00006450-200005000-00006. PMID: 10813582

Prognosis

Circulating interleukin-8 and osteopontin are promising biomarkers of clinical outcomes in advanced melanoma patients treated with targeted therapy.
Levati L, Tabolacci C, Facchiano A, Facchiano F, Alvino E, Antonini Cappellini GC, Scala E, Bonmassar L, Caporali S, Lacal PM, Bresin A, De Galitiis F, Russo G, D'Atri S
J Exp Clin Cancer Res 2024 Aug 15;43(1):226. doi: 10.1186/s13046-024-03151-3. PMID: 39143551Free PMC Article
Serum inflammatory factors and circulating immunosuppressive cells are predictive markers for efficacy of radiofrequency ablation in non-small-cell lung cancer.
Schneider T, Sevko A, Heussel CP, Umansky L, Beckhove P, Dienemann H, Safi S, Utikal J, Hoffmann H, Umansky V
Clin Exp Immunol 2015 Jun;180(3):467-74. Epub 2015 Apr 15 doi: 10.1111/cei.12596. PMID: 25644608Free PMC Article
Effects of β-hydroxy-β-methylbutyrate free acid and cold water immersion on expression of CR3 and MIP-1β following resistance exercise.
Gonzalez AM, Fragala MS, Jajtner AR, Townsend JR, Wells AJ, Beyer KS, Boone CH, Pruna GJ, Mangine GT, Bohner JD, Fukuda DH, Stout JR, Hoffman JR
Am J Physiol Regul Integr Comp Physiol 2014 Apr 1;306(7):R483-9. Epub 2014 Feb 5 doi: 10.1152/ajpregu.00542.2013. PMID: 24500432
Longitudinal analysis of serum chemokine levels in the course of HIV-1 infection.
Polo S, Veglia F, Malnati MS, Gobbi C, Farci P, Raiteri R, Sinicco A, Lusso P
AIDS 1999 Mar 11;13(4):447-54. doi: 10.1097/00002030-199903110-00002. PMID: 10197372

Clinical prediction guides

Circulating interleukin-8 and osteopontin are promising biomarkers of clinical outcomes in advanced melanoma patients treated with targeted therapy.
Levati L, Tabolacci C, Facchiano A, Facchiano F, Alvino E, Antonini Cappellini GC, Scala E, Bonmassar L, Caporali S, Lacal PM, Bresin A, De Galitiis F, Russo G, D'Atri S
J Exp Clin Cancer Res 2024 Aug 15;43(1):226. doi: 10.1186/s13046-024-03151-3. PMID: 39143551Free PMC Article
Serum inflammatory factors and circulating immunosuppressive cells are predictive markers for efficacy of radiofrequency ablation in non-small-cell lung cancer.
Schneider T, Sevko A, Heussel CP, Umansky L, Beckhove P, Dienemann H, Safi S, Utikal J, Hoffmann H, Umansky V
Clin Exp Immunol 2015 Jun;180(3):467-74. Epub 2015 Apr 15 doi: 10.1111/cei.12596. PMID: 25644608Free PMC Article
Effects of β-hydroxy-β-methylbutyrate free acid and cold water immersion on expression of CR3 and MIP-1β following resistance exercise.
Gonzalez AM, Fragala MS, Jajtner AR, Townsend JR, Wells AJ, Beyer KS, Boone CH, Pruna GJ, Mangine GT, Bohner JD, Fukuda DH, Stout JR, Hoffman JR
Am J Physiol Regul Integr Comp Physiol 2014 Apr 1;306(7):R483-9. Epub 2014 Feb 5 doi: 10.1152/ajpregu.00542.2013. PMID: 24500432
Circulating chemokine levels and miscarriage.
Whitcomb BW, Schisterman EF, Klebanoff MA, Baumgarten M, Rhoton-Vlasak A, Luo X, Chegini N
Am J Epidemiol 2007 Aug 1;166(3):323-31. Epub 2007 May 15 doi: 10.1093/aje/kwm084. PMID: 17504778
Longitudinal analysis of serum chemokine levels in the course of HIV-1 infection.
Polo S, Veglia F, Malnati MS, Gobbi C, Farci P, Raiteri R, Sinicco A, Lusso P
AIDS 1999 Mar 11;13(4):447-54. doi: 10.1097/00002030-199903110-00002. PMID: 10197372

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...