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Moderate dysplasia of rectum

MedGen UID:
107951
•Concept ID:
C0586372
•
Disease or Syndrome
Synonyms: Moderate Dysplasia of Rectum; Moderate Dysplasia of the Rectum; Moderate Rectal Dysplasia
SNOMED CT: Moderate dysplasia of rectum (308878006)

Definition

A morphologic finding indicating the presence of moderate dysplastic cellular changes and moderate architectural changes in the glandular epithelium of the rectal mucosa. There is no evidence of invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerate dysplasia of rectum

Professional guidelines

PubMed

Colorectal polypectomy and endoscopic mucosal resection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2024.
Ferlitsch M, Hassan C, Bisschops R, Bhandari P, Dinis-Ribeiro M, Risio M, Paspatis GA, Moss A, Libânio D, Lorenzo-Zúñiga V, Voiosu AM, Rutter MD, Pellisé M, Moons LMG, Probst A, Awadie H, Amato A, Takeuchi Y, Repici A, Rahmi G, Koecklin HU, Albéniz E, Rockenbauer LM, Waldmann E, Messmann H, Triantafyllou K, Jover R, Gralnek IM, Dekker E, Bourke MJ
Endoscopy 2024 Jul;56(7):516-545. Epub 2024 Apr 26 doi: 10.1055/a-2304-3219. PMID: 38670139
Juvenile polyposis syndrome: a study of genotype, phenotype, and long-term outcome.
Latchford AR, Neale K, Phillips RK, Clark SK
Dis Colon Rectum 2012 Oct;55(10):1038-43. doi: 10.1097/DCR.0b013e31826278b3. PMID: 22965402
Surgical approach to ulcerative colitis: when is the best timing after medical treatment?
Spinelli A, Sampietro GM, Bazzi P, Sacchi M, Montorsi M
Curr Drug Targets 2011 Sep;12(10):1462-6. doi: 10.2174/138945011796818199. PMID: 21466484

Recent clinical studies

Etiology

Colorectal polypectomy and endoscopic mucosal resection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2024.
Ferlitsch M, Hassan C, Bisschops R, Bhandari P, Dinis-Ribeiro M, Risio M, Paspatis GA, Moss A, Libânio D, Lorenzo-Zúñiga V, Voiosu AM, Rutter MD, Pellisé M, Moons LMG, Probst A, Awadie H, Amato A, Takeuchi Y, Repici A, Rahmi G, Koecklin HU, Albéniz E, Rockenbauer LM, Waldmann E, Messmann H, Triantafyllou K, Jover R, Gralnek IM, Dekker E, Bourke MJ
Endoscopy 2024 Jul;56(7):516-545. Epub 2024 Apr 26 doi: 10.1055/a-2304-3219. PMID: 38670139
Endoscopic tissue sampling - Part 2: Lower gastrointestinal tract. European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Pouw RE, Bisschops R, Gecse KB, de Hertogh G, Iacucci M, Rutter M, Barret M, Biermann K, Czakó L, Hucl T, Jansen M, Savarino E, Spaander MCW, Schmidt PT, Dinis-Ribeiro M, Vieth M, van Hooft JE
Endoscopy 2021 Dec;53(12):1261-1273. Epub 2021 Oct 29 doi: 10.1055/a-1671-6336. PMID: 34715702
Clinicopathological characterization of colonic polyps.
Qari YA
Niger J Clin Pract 2020 Aug;23(8):1048-1053. doi: 10.4103/njcp.njcp_490_19. PMID: 32788480
AGA Institute Clinical Practice Update: Endoscopic Submucosal Dissection in the United States.
Draganov PV, Wang AY, Othman MO, Fukami N
Clin Gastroenterol Hepatol 2019 Jan;17(1):16-25.e1. Epub 2018 Aug 2 doi: 10.1016/j.cgh.2018.07.041. PMID: 30077787
Intestinal neuronal dysplasia.
Schofield DE, Yunis EJ
J Pediatr Gastroenterol Nutr 1991 Feb;12(2):182-9. doi: 10.1097/00005176-199102000-00008. PMID: 2051270

Diagnosis

Juvenile polyposis syndrome might be misdiagnosed as familial adenomatous polyposis: a case report and literature review.
Gao XH, Li J, Zhao ZY, Xu XD, Du YQ, Yan HL, Liu LJ, Bai CG, Zhang W
BMC Gastroenterol 2020 Jun 1;20(1):167. doi: 10.1186/s12876-020-01238-7. PMID: 32487124Free PMC Article
Ulcerative Colitis.
Feuerstein JD, Moss AC, Farraye FA
Mayo Clin Proc 2019 Jul;94(7):1357-1373. doi: 10.1016/j.mayocp.2019.01.018. PMID: 31272578
Interobserver and intraobserver bias exists in the interpretation of anal dysplasia.
Colquhoun P, Nogueras JJ, Dipasquale B, Petras R, Wexner SD, Woodhouse S
Dis Colon Rectum 2003 Oct;46(10):1332-6; discussion 1336-8. doi: 10.1007/s10350-004-6744-5. PMID: 14530670
Pathologic features of initial adenomas as predictors for metachronous adenomas of the rectum.
Yang G, Zheng W, Sun QR, Shu XO, Li WD, Yu H, Shen GF, Shen YZ, Potter JD, Zheng S
J Natl Cancer Inst 1998 Nov 4;90(21):1661-5. doi: 10.1093/jnci/90.21.1661. PMID: 9811316
Intestinal neuronal dysplasia.
Schofield DE, Yunis EJ
J Pediatr Gastroenterol Nutr 1991 Feb;12(2):182-9. doi: 10.1097/00005176-199102000-00008. PMID: 2051270

Therapy

Medical therapy versus surgery in moderate-to-severe ulcerative colitis.
Fiorino G, Danese S, Giacobazzi G, Spinelli A
Dig Liver Dis 2021 Apr;53(4):403-408. Epub 2020 Oct 10 doi: 10.1016/j.dld.2020.09.022. PMID: 33051163
Elective surgery for ulcerative colitis, ileo-rectal anastomosis or restorative proctocolectomy An Update.
Fornaro R, Casaccia M, Caristo G, Batistotti P, Di Maira L, Atzori G, Oliva A, Stratta E, Razzore A, Caratto M, Caratto E, Giovinazzo D, Frascio M
Ann Ital Chir 2019;90:565-573. PMID: 31929176
Anal condyloma treatment and recurrence in HIV-negative men who have sex with men.
Silvera RJ, Smith CK, Swedish KA, Goldstone SE
Dis Colon Rectum 2014 Jun;57(6):752-61. doi: 10.1097/DCR.0000000000000080. PMID: 24807601
Surgical approach to ulcerative colitis: when is the best timing after medical treatment?
Spinelli A, Sampietro GM, Bazzi P, Sacchi M, Montorsi M
Curr Drug Targets 2011 Sep;12(10):1462-6. doi: 10.2174/138945011796818199. PMID: 21466484
Colorectal adenoma characteristics as predictors of recurrence.
Bonithon-Kopp C, Piard F, Fenger C, Cabeza E, O'Morain C, Kronborg O, Faivre J; European Cancer Prevention Organisation Study Group
Dis Colon Rectum 2004 Mar;47(3):323-33. doi: 10.1007/s10350-003-0054-1. PMID: 14991494

Prognosis

AGA Institute Clinical Practice Update: Endoscopic Submucosal Dissection in the United States.
Draganov PV, Wang AY, Othman MO, Fukami N
Clin Gastroenterol Hepatol 2019 Jan;17(1):16-25.e1. Epub 2018 Aug 2 doi: 10.1016/j.cgh.2018.07.041. PMID: 30077787
Surgical approach to ulcerative colitis: when is the best timing after medical treatment?
Spinelli A, Sampietro GM, Bazzi P, Sacchi M, Montorsi M
Curr Drug Targets 2011 Sep;12(10):1462-6. doi: 10.2174/138945011796818199. PMID: 21466484
Pathology of colorectal cancer.
Ponz de Leon M, Di Gregorio C
Dig Liver Dis 2001 May;33(4):372-88. doi: 10.1016/s1590-8658(01)80095-5. PMID: 11432519
Pathologic features of initial adenomas as predictors for metachronous adenomas of the rectum.
Yang G, Zheng W, Sun QR, Shu XO, Li WD, Yu H, Shen GF, Shen YZ, Potter JD, Zheng S
J Natl Cancer Inst 1998 Nov 4;90(21):1661-5. doi: 10.1093/jnci/90.21.1661. PMID: 9811316
Intestinal neuronal dysplasia.
Schofield DE, Yunis EJ
J Pediatr Gastroenterol Nutr 1991 Feb;12(2):182-9. doi: 10.1097/00005176-199102000-00008. PMID: 2051270

Clinical prediction guides

AGA Institute Clinical Practice Update: Endoscopic Submucosal Dissection in the United States.
Draganov PV, Wang AY, Othman MO, Fukami N
Clin Gastroenterol Hepatol 2019 Jan;17(1):16-25.e1. Epub 2018 Aug 2 doi: 10.1016/j.cgh.2018.07.041. PMID: 30077787
Interobserver and intraobserver bias exists in the interpretation of anal dysplasia.
Colquhoun P, Nogueras JJ, Dipasquale B, Petras R, Wexner SD, Woodhouse S
Dis Colon Rectum 2003 Oct;46(10):1332-6; discussion 1336-8. doi: 10.1007/s10350-004-6744-5. PMID: 14530670
Pathologic features of initial adenomas as predictors for metachronous adenomas of the rectum.
Yang G, Zheng W, Sun QR, Shu XO, Li WD, Yu H, Shen GF, Shen YZ, Potter JD, Zheng S
J Natl Cancer Inst 1998 Nov 4;90(21):1661-5. doi: 10.1093/jnci/90.21.1661. PMID: 9811316
Overexpression of p53 protein and histologic grades of dysplasia in colorectal adenomas.
Sameshima S, Kubota Y, Sawada T, Watanabe T, Kuroda T, Tsuno N, Higuchi Y, Shinozaki M, Sunouchi K, Masaki T, Saito Y, Muto T
Dis Colon Rectum 1996 May;39(5):562-7. doi: 10.1007/BF02058712. PMID: 8620809
Intestinal neuronal dysplasia.
Schofield DE, Yunis EJ
J Pediatr Gastroenterol Nutr 1991 Feb;12(2):182-9. doi: 10.1097/00005176-199102000-00008. PMID: 2051270

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