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Dysplasia

MedGen UID:
87191
Concept ID:
C0334044
Pathologic Function
Synonyms: Dyscrasia; Dysplastic
SNOMED CT: Dysplasia (25723000)

Definition

A usually neoplastic transformation of the cell, associated with altered architectural tissue patterns. The cellular changes include nuclear and cytoplasmic abnormalities. Molecular genetic abnormalities are also often found and, in some instances, may lead to cancer. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDysplasia

Professional guidelines

PubMed

Ohtsuka T, Fernandez-Del Castillo C, Furukawa T, Hijioka S, Jang JY, Lennon AM, Miyasaka Y, Ohno E, Salvia R, Wolfgang CL, Wood LD
Pancreatology 2024 Mar;24(2):255-270. Epub 2023 Dec 28 doi: 10.1016/j.pan.2023.12.009. PMID: 38182527
Sekeres MA, Taylor J
JAMA 2022 Sep 6;328(9):872-880. doi: 10.1001/jama.2022.14578. PMID: 36066514
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806

Recent clinical studies

Etiology

Gilfillan M, Bhandari A, Bhandari V
BMJ 2021 Oct 20;375:n1974. doi: 10.1136/bmj.n1974. PMID: 34670756
Escribano García C, Bachiller Carnicero L, Marín Urueña SI, Del Mar Montejo Vicente M, Izquierdo Caballero R, Morales Luengo F, Caserío Carbonero S
An Pediatr (Engl Ed) 2021 Oct;95(4):240-245. Epub 2021 Sep 10 doi: 10.1016/j.anpede.2020.07.024. PMID: 34511400
Khoury MH, Gornik HL
Vasc Med 2017 Jun;22(3):248-252. Epub 2017 Apr 3 doi: 10.1177/1358863X17700716. PMID: 28367730
Jensen EA, Schmidt B
Birth Defects Res A Clin Mol Teratol 2014 Mar;100(3):145-57. Epub 2014 Mar 17 doi: 10.1002/bdra.23235. PMID: 24639412Free PMC Article
Begelman SM, Olin JW
Curr Opin Rheumatol 2000 Jan;12(1):41-7. doi: 10.1097/00002281-200001000-00007. PMID: 10647953

Diagnosis

Escribano García C, Bachiller Carnicero L, Marín Urueña SI, Del Mar Montejo Vicente M, Izquierdo Caballero R, Morales Luengo F, Caserío Carbonero S
An Pediatr (Engl Ed) 2021 Oct;95(4):240-245. Epub 2021 Sep 10 doi: 10.1016/j.anpede.2020.07.024. PMID: 34511400
Piersigilli F, Bhandari V
Clin Chim Acta 2020 Jan;500:109-114. Epub 2019 Nov 2 doi: 10.1016/j.cca.2019.09.025. PMID: 31689411
Khoury MH, Gornik HL
Vasc Med 2017 Jun;22(3):248-252. Epub 2017 Apr 3 doi: 10.1177/1358863X17700716. PMID: 28367730
Riddle ND, Bui MM
Arch Pathol Lab Med 2013 Jan;137(1):134-8. doi: 10.5858/arpa.2012.0013-RS. PMID: 23276185
Dreizin D, Glen C, Jose J
Am J Orthop (Belle Mead NJ) 2012 Jul;41(7):332-5. PMID: 22893885

Therapy

Navarrete-Dechent C, Marghoob AA, Marchetti MA
J Dermatolog Treat 2021 Aug;32(5):572-574. Epub 2019 Oct 30 doi: 10.1080/09546634.2019.1682504. PMID: 31621454
Barkhuff WD, Soll RF
Neonatology 2019;115(4):411-422. Epub 2019 Apr 11 doi: 10.1159/000497328. PMID: 30974437
Sankar MN, Bhombal S, Benitz WE
Congenit Heart Dis 2019 Jan;14(1):46-51. doi: 10.1111/chd.12708. PMID: 30811796
Dumpa V, Bhandari V
Semin Perinatol 2018 Nov;42(7):444-452. Epub 2018 Oct 2 doi: 10.1053/j.semperi.2018.09.006. PMID: 30343941
Ahn SY, Chang YS, Park WS
Neonatology 2016;109(4):377-83. Epub 2016 Jun 3 doi: 10.1159/000444905. PMID: 27251746

Prognosis

Philpot PA, Bhandari V
Expert Rev Respir Med 2019 Sep;13(9):871-884. Epub 2019 Aug 4 doi: 10.1080/17476348.2019.1648215. PMID: 31340666
Misurac J
Semin Fetal Neonatal Med 2017 Apr;22(2):98-103. Epub 2016 Oct 10 doi: 10.1016/j.siny.2016.09.003. PMID: 27733241
Jain V, Sen B
J Pediatr Orthop B 2014 Sep;23(5):485-8. doi: 10.1097/BPB.0000000000000058. PMID: 24800790
Bhandari A, Bhandari V
Pediatrics 2009 Jun;123(6):1562-73. doi: 10.1542/peds.2008-1962. PMID: 19482769
Tudehope DI
J Paediatr Child Health 1993 Apr;29(2):86-9. doi: 10.1111/j.1440-1754.1993.tb00455.x. PMID: 8489805

Clinical prediction guides

Yang Y, Wei X, Lu G, Xie J, Tan Z, Du Z, Ye W, Xu H, Li X, Liu E, Zhang Q, Liu Y, Li J, Liu H
J Cardiovasc Magn Reson 2023 Nov 30;25(1):72. doi: 10.1186/s12968-023-00986-1. PMID: 38031154Free PMC Article
Khoshiwal AM, Frei NF, Pouw RE; TissueCypher SURF LGD Study Pathologists Consortium, Smolko C, Arora M, Siegel JJ, Duits LC, Critchley-Thorne RJ, Bergman JJGHM
Gastroenterology 2023 Nov;165(5):1168-1179.e6. Epub 2023 Aug 30 doi: 10.1053/j.gastro.2023.07.029. PMID: 37657759
Edmonds EW, Hughes JL, Bomar JD, Brooks JT, Upasani VV
JBJS Rev 2019 Dec;7(12):e5. doi: 10.2106/JBJS.RVW.19.00063. PMID: 31880623
Khoury MH, Gornik HL
Vasc Med 2017 Jun;22(3):248-252. Epub 2017 Apr 3 doi: 10.1177/1358863X17700716. PMID: 28367730
Lauwers GY, Riddell RH
Gut 1999 Nov;45(5):784-90. doi: 10.1136/gut.45.5.784. PMID: 10517922Free PMC Article

Recent systematic reviews

Bouet B, Schlund M, De Massary M, Nicot R
J Stomatol Oral Maxillofac Surg 2023 Dec;124(6S2):101660. Epub 2023 Oct 20 doi: 10.1016/j.jormas.2023.101660. PMID: 37866506
Vered M, Wright JM
Head Neck Pathol 2022 Mar;16(1):63-75. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01404-7. PMID: 35312978Free PMC Article
Healy H, Croonen LEE, Onland W, van Kaam AH, Gupta M
Semin Fetal Neonatal Med 2021 Feb;26(1):101201. Epub 2021 Jan 30 doi: 10.1016/j.siny.2021.101201. PMID: 33563565
Smith C, Egunsola O, Choonara I, Kotecha S, Jacqz-Aigrain E, Sammons H
BMJ Open 2015 Dec 9;5(12):e008194. doi: 10.1136/bmjopen-2015-008194. PMID: 26656010Free PMC Article
Steinhorn RH
Pediatr Crit Care Med 2010 Mar;11(2 Suppl):S79-84. doi: 10.1097/PCC.0b013e3181c76cdc. PMID: 20216169Free PMC Article

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