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Minimal Deviation Melanoma

MedGen UID:
108173
•Concept ID:
C0545071
•
Neoplastic Process

Definition

A melanocytic neoplasm displaying morphologic features that are intermediate between those of benign nevus and melanoma. It is characterized by a nodular architectural growth resembling a melanoma, and a loss of nevus cell maturation. The melanocytic cells forming the nodular growth are uniform, and they may display a high mitotic rate, but they do not show cytologic atypia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMinimal Deviation Melanoma

Professional guidelines

PubMed

Clinical and pathologic diagnosis, staging and prognostic factors of melanoma and management of primary disease.
Ruiter DJ
Curr Opin Oncol 1992 Apr;4(2):357-67. doi: 10.1097/00001622-199204000-00019. PMID: 1591309

Recent clinical studies

Etiology

Ki-67 and p53 expression in minimal deviation melanomas as compared with other nevomelanocytic lesions.
Chorny JA, Barr RJ, Kyshtoobayeva A, Jakowatz J, Reed RJ
Mod Pathol 2003 Jun;16(6):525-9. doi: 10.1097/01.MP.0000072747.08404.38. PMID: 12808056
Clinical and pathologic diagnosis, staging and prognostic factors of melanoma and management of primary disease.
Ruiter DJ
Curr Opin Oncol 1992 Apr;4(2):357-67. doi: 10.1097/00001622-199204000-00019. PMID: 1591309
The spectrum of minimal deviation melanoma: a clinicopathologic study of 21 cases.
Phillips ME, Margolis RJ, Merot Y, Sober AJ, Reed RJ, Muhlbauer JE, Mihm MC Jr
Hum Pathol 1986 Aug;17(8):796-806. doi: 10.1016/s0046-8177(86)80199-x. PMID: 3733068
Minimal deviation melanoma.
Barr LH, Goldman LI, Solomon JA, Sanusi DI, Reed RJ
Surg Gynecol Obstet 1984 Dec;159(6):546-8. PMID: 6505940
Minimal deviation melanoma: a histologic variant of cutaneous malignant melanoma in its vertical growth phase.
Muhlbauer JE, Margolis RJ, Mihm MC Jr, Reed RJ
J Invest Dermatol 1983 Jun;80 Suppl:63s-65s. PMID: 6854057

Diagnosis

Unusual variants of malignant melanoma.
Magro CM, Crowson AN, Mihm MC
Mod Pathol 2006 Feb;19 Suppl 2:S41-70. doi: 10.1038/modpathol.3800516. PMID: 16446716
Minimal deviation melanoma.
Podnos YD, Jimenez JC, Zainabadi K, Jakowatz JG, Barr RJ
Cancer Treat Rev 2002 Oct;28(5):219-21. doi: 10.1016/s0305-7372(02)00035-x. PMID: 12435369
Variants of melanoma.
Reed RJ, Martin P
Semin Cutan Med Surg 1997 Jun;16(2):137-58. doi: 10.1016/s1085-5629(97)80008-9. PMID: 9220553
Clinical and pathologic diagnosis, staging and prognostic factors of melanoma and management of primary disease.
Ruiter DJ
Curr Opin Oncol 1992 Apr;4(2):357-67. doi: 10.1097/00001622-199204000-00019. PMID: 1591309
Minimal deviation melanoma.
Reed RJ
Monogr Pathol 1988;(30):110-52. PMID: 3050461

Therapy

Clinical and pathologic diagnosis, staging and prognostic factors of melanoma and management of primary disease.
Ruiter DJ
Curr Opin Oncol 1992 Apr;4(2):357-67. doi: 10.1097/00001622-199204000-00019. PMID: 1591309

Prognosis

Minimal deviation melanoma.
Podnos YD, Jimenez JC, Zainabadi K, Jakowatz JG, Barr RJ
Cancer Treat Rev 2002 Oct;28(5):219-21. doi: 10.1016/s0305-7372(02)00035-x. PMID: 12435369
Clinical and pathologic diagnosis, staging and prognostic factors of melanoma and management of primary disease.
Ruiter DJ
Curr Opin Oncol 1992 Apr;4(2):357-67. doi: 10.1097/00001622-199204000-00019. PMID: 1591309
Minimal deviation melanoma.
Reed RJ
Monogr Pathol 1988;(30):110-52. PMID: 3050461
The spectrum of minimal deviation melanoma: a clinicopathologic study of 21 cases.
Phillips ME, Margolis RJ, Merot Y, Sober AJ, Reed RJ, Muhlbauer JE, Mihm MC Jr
Hum Pathol 1986 Aug;17(8):796-806. doi: 10.1016/s0046-8177(86)80199-x. PMID: 3733068
Minimal deviation melanoma.
Barr LH, Goldman LI, Solomon JA, Sanusi DI, Reed RJ
Surg Gynecol Obstet 1984 Dec;159(6):546-8. PMID: 6505940

Clinical prediction guides

Minimal deviation melanoma.
Podnos YD, Jimenez JC, Zainabadi K, Jakowatz JG, Barr RJ
Cancer Treat Rev 2002 Oct;28(5):219-21. doi: 10.1016/s0305-7372(02)00035-x. PMID: 12435369
Dimensionalities: borderline and intermediate melanocytic neoplasia.
Reed RJ
Hum Pathol 1999 May;30(5):521-4. doi: 10.1016/s0046-8177(99)90194-6. PMID: 10333220
Pathology of melanoma.
Rabinowitz AD, Silvers DN
Dermatol Clin 1985 Apr;3(2):285-95. PMID: 3830491
Minimal deviation melanoma: a histologic variant of cutaneous malignant melanoma in its vertical growth phase.
Muhlbauer JE, Margolis RJ, Mihm MC Jr, Reed RJ
J Invest Dermatol 1983 Jun;80 Suppl:63s-65s. PMID: 6854057

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