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Egg allergy

MedGen UID:
108241
•Concept ID:
C0559469
•
Disease or Syndrome
Synonyms: Allergies, Egg; Allergy, Egg; Egg Allergies; Egg Allergy; Egg Hypersensitivities; Egg Hypersensitivity; Hypersensitivities, Egg; Hypersensitivity, Egg
 
HPO: HP:0410328

Definition

Hypersensitivity in form of an adverse immune reaction against eggs. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEgg allergy

Professional guidelines

PubMed

Immunotherapy and biologics in the management of IgE-mediated food allergy: Systematic review and meta-analyses of efficacy and safety.
Riggioni C, Oton T, Carmona L, Du Toit G, Skypala I, Santos AF
Allergy 2024 Aug;79(8):2097-2127. Epub 2024 May 15 doi: 10.1111/all.16129. PMID: 38747333
Diagnosis and management of hypersensitivity reactions to vaccines.
Sarti L, Lezmi G, Mori F, Giovannini M, Caubet JC
Expert Rev Clin Immunol 2020 Sep;16(9):883-896. Epub 2020 Sep 29 doi: 10.1080/1744666X.2020.1814745. PMID: 32838592
Food Allergy: Common Causes, Diagnosis, and Treatment.
Patel BY, Volcheck GW
Mayo Clin Proc 2015 Oct;90(10):1411-9. doi: 10.1016/j.mayocp.2015.07.012. PMID: 26434966

Recent clinical studies

Etiology

Egg Allergy in Children and Weaning Diet.
Caffarelli C, Giannetti A, Rossi A, Ricci G
Nutrients 2022 Apr 7;14(8) doi: 10.3390/nu14081540. PMID: 35458102Free PMC Article
A Consensus Approach to the Primary Prevention of Food Allergy Through Nutrition: Guidance from the American Academy of Allergy, Asthma, and Immunology; American College of Allergy, Asthma, and Immunology; and the Canadian Society for Allergy and Clinical Immunology.
Fleischer DM, Chan ES, Venter C, Spergel JM, Abrams EM, Stukus D, Groetch M, Shaker M, Greenhawt M
J Allergy Clin Immunol Pract 2021 Jan;9(1):22-43.e4. Epub 2020 Nov 26 doi: 10.1016/j.jaip.2020.11.002. PMID: 33250376
Vaccine-associated hypersensitivity.
McNeil MM, DeStefano F
J Allergy Clin Immunol 2018 Feb;141(2):463-472. doi: 10.1016/j.jaci.2017.12.971. PMID: 29413255Free PMC Article
Complementary Feeding: A Position Paper by the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) Committee on Nutrition.
Fewtrell M, Bronsky J, Campoy C, Domellöf M, Embleton N, Fidler Mis N, Hojsak I, Hulst JM, Indrio F, Lapillonne A, Molgaard C
J Pediatr Gastroenterol Nutr 2017 Jan;64(1):119-132. doi: 10.1097/MPG.0000000000001454. PMID: 28027215
Randomized trial of peanut consumption in infants at risk for peanut allergy.
Du Toit G, Roberts G, Sayre PH, Bahnson HT, Radulovic S, Santos AF, Brough HA, Phippard D, Basting M, Feeney M, Turcanu V, Sever ML, Gomez Lorenzo M, Plaut M, Lack G; LEAP Study Team
N Engl J Med 2015 Feb 26;372(9):803-13. Epub 2015 Feb 23 doi: 10.1056/NEJMoa1414850. PMID: 25705822Free PMC Article

Diagnosis

Early food intervention and skin emollients to prevent food allergy in young children (PreventADALL): a factorial, multicentre, cluster-randomised trial.
Skjerven HO, Lie A, Vettukattil R, Rehbinder EM, LeBlanc M, Asarnoj A, Carlsen KH, Despriee ÅW, Färdig M, Gerdin SW, Granum B, Gudmundsdóttir HK, Haugen G, Hedlin G, Håland G, Jonassen CM, Landrø L, Mägi CO, Olsen IC, Rudi K, Saunders CM, Skram MK, Staff AC, Söderhäll C, Tedner SG, Aadalen S, Aaneland H, Nordlund B, Lødrup Carlsen KC
Lancet 2022 Jun 25;399(10344):2398-2411. doi: 10.1016/S0140-6736(22)00687-0. PMID: 35753340
Food allergy and hypersensitivity reactions in children and adults-A review.
Tedner SG, Asarnoj A, Thulin H, Westman M, Konradsen JR, Nilsson C
J Intern Med 2022 Mar;291(3):283-302. Epub 2021 Dec 22 doi: 10.1111/joim.13422. PMID: 34875122
Egg Allergy: Diagnosis and Immunotherapy.
Dona DW, Suphioglu C
Int J Mol Sci 2020 Jul 16;21(14) doi: 10.3390/ijms21145010. PMID: 32708567Free PMC Article
Complementary feeding and food allergy, atopic dermatitis/eczema, asthma, and allergic rhinitis: a systematic review.
Obbagy JE, English LK, Wong YP, Butte NF, Dewey KG, Fleischer DM, Fox MK, Greer FR, Krebs NF, Scanlon KS, Stoody EE
Am J Clin Nutr 2019 Mar 1;109(Suppl_7):890S-934S. doi: 10.1093/ajcn/nqy220. PMID: 30982864
Randomized trial of peanut consumption in infants at risk for peanut allergy.
Du Toit G, Roberts G, Sayre PH, Bahnson HT, Radulovic S, Santos AF, Brough HA, Phippard D, Basting M, Feeney M, Turcanu V, Sever ML, Gomez Lorenzo M, Plaut M, Lack G; LEAP Study Team
N Engl J Med 2015 Feb 26;372(9):803-13. Epub 2015 Feb 23 doi: 10.1056/NEJMoa1414850. PMID: 25705822Free PMC Article

Therapy

Egg Allergy in Children and Weaning Diet.
Caffarelli C, Giannetti A, Rossi A, Ricci G
Nutrients 2022 Apr 7;14(8) doi: 10.3390/nu14081540. PMID: 35458102Free PMC Article
A Consensus Approach to the Primary Prevention of Food Allergy Through Nutrition: Guidance from the American Academy of Allergy, Asthma, and Immunology; American College of Allergy, Asthma, and Immunology; and the Canadian Society for Allergy and Clinical Immunology.
Fleischer DM, Chan ES, Venter C, Spergel JM, Abrams EM, Stukus D, Groetch M, Shaker M, Greenhawt M
J Allergy Clin Immunol Pract 2021 Jan;9(1):22-43.e4. Epub 2020 Nov 26 doi: 10.1016/j.jaip.2020.11.002. PMID: 33250376
Vaccine-associated hypersensitivity.
McNeil MM, DeStefano F
J Allergy Clin Immunol 2018 Feb;141(2):463-472. doi: 10.1016/j.jaci.2017.12.971. PMID: 29413255Free PMC Article
Complementary Feeding: A Position Paper by the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) Committee on Nutrition.
Fewtrell M, Bronsky J, Campoy C, Domellöf M, Embleton N, Fidler Mis N, Hojsak I, Hulst JM, Indrio F, Lapillonne A, Molgaard C
J Pediatr Gastroenterol Nutr 2017 Jan;64(1):119-132. doi: 10.1097/MPG.0000000000001454. PMID: 28027215
Randomized trial of peanut consumption in infants at risk for peanut allergy.
Du Toit G, Roberts G, Sayre PH, Bahnson HT, Radulovic S, Santos AF, Brough HA, Phippard D, Basting M, Feeney M, Turcanu V, Sever ML, Gomez Lorenzo M, Plaut M, Lack G; LEAP Study Team
N Engl J Med 2015 Feb 26;372(9):803-13. Epub 2015 Feb 23 doi: 10.1056/NEJMoa1414850. PMID: 25705822Free PMC Article

Prognosis

Baked milk and egg diets revisited.
Upton JEM, Wong D, Nowak-Wegrzyn A
Ann Allergy Asthma Immunol 2024 Mar;132(3):328-336.e5. Epub 2023 Dec 26 doi: 10.1016/j.anai.2023.12.024. PMID: 38151097
Vaccine-associated hypersensitivity.
McNeil MM, DeStefano F
J Allergy Clin Immunol 2018 Feb;141(2):463-472. doi: 10.1016/j.jaci.2017.12.971. PMID: 29413255Free PMC Article
Food Allergy in South Africa.
Gray CL
Curr Allergy Asthma Rep 2017 Jun;17(6):35. doi: 10.1007/s11882-017-0703-4. PMID: 28470372
Hen's Egg Allergy.
Urisu A, Kondo Y, Tsuge I
Chem Immunol Allergy 2015;101:124-30. Epub 2015 May 21 doi: 10.1159/000375416. PMID: 26022872
Food allergy.
Sicherer SH
Mt Sinai J Med 2011 Sep-Oct;78(5):683-96. doi: 10.1002/msj.20292. PMID: 21913199

Clinical prediction guides

Early food intervention and skin emollients to prevent food allergy in young children (PreventADALL): a factorial, multicentre, cluster-randomised trial.
Skjerven HO, Lie A, Vettukattil R, Rehbinder EM, LeBlanc M, Asarnoj A, Carlsen KH, Despriee ÅW, Färdig M, Gerdin SW, Granum B, Gudmundsdóttir HK, Haugen G, Hedlin G, Håland G, Jonassen CM, Landrø L, Mägi CO, Olsen IC, Rudi K, Saunders CM, Skram MK, Staff AC, Söderhäll C, Tedner SG, Aadalen S, Aaneland H, Nordlund B, Lødrup Carlsen KC
Lancet 2022 Jun 25;399(10344):2398-2411. doi: 10.1016/S0140-6736(22)00687-0. PMID: 35753340
Vaccine-associated hypersensitivity.
McNeil MM, DeStefano F
J Allergy Clin Immunol 2018 Feb;141(2):463-472. doi: 10.1016/j.jaci.2017.12.971. PMID: 29413255Free PMC Article
Food Allergy in South Africa.
Gray CL
Curr Allergy Asthma Rep 2017 Jun;17(6):35. doi: 10.1007/s11882-017-0703-4. PMID: 28470372
Hen's Egg Allergy.
Urisu A, Kondo Y, Tsuge I
Chem Immunol Allergy 2015;101:124-30. Epub 2015 May 21 doi: 10.1159/000375416. PMID: 26022872
Food allergy.
Sicherer SH
Mt Sinai J Med 2011 Sep-Oct;78(5):683-96. doi: 10.1002/msj.20292. PMID: 21913199

Recent systematic reviews

Immunotherapy and biologics in the management of IgE-mediated food allergy: Systematic review and meta-analyses of efficacy and safety.
Riggioni C, Oton T, Carmona L, Du Toit G, Skypala I, Santos AF
Allergy 2024 Aug;79(8):2097-2127. Epub 2024 May 15 doi: 10.1111/all.16129. PMID: 38747333
Timing of Allergenic Food Introduction and Risk of Immunoglobulin E-Mediated Food Allergy: A Systematic Review and Meta-analysis.
Scarpone R, Kimkool P, Ierodiakonou D, Leonardi-Bee J, Garcia-Larsen V, Perkin MR, Boyle RJ
JAMA Pediatr 2023 May 1;177(5):489-497. doi: 10.1001/jamapediatrics.2023.0142. PMID: 36972063Free PMC Article
Allergen immunotherapy and/or biologicals for IgE-mediated food allergy: A systematic review and meta-analysis.
de Silva D, Rodríguez Del Río P, de Jong NW, Khaleva E, Singh C, Nowak-Wegrzyn A, Muraro A, Begin P, Pajno G, Fiocchi A, Sanchez A, Jones C, Nilsson C, Bindslev-Jensen C, Wong G, Sampson H, Beyer K, Marchisotto MJ, Fernandez Rivas M, Meyer R, Lau S, Nurmatov U, Roberts G; GA2LEN Food Allergy Guidelines Group
Allergy 2022 Jun;77(6):1852-1862. Epub 2022 Jan 19 doi: 10.1111/all.15211. PMID: 35001400Free PMC Article
Preventing food allergy in infancy and childhood: Systematic review of randomised controlled trials.
de Silva D, Halken S, Singh C, Muraro A, Angier E, Arasi S, Arshad H, Beyer K, Boyle R, du Toit G, Eigenmann P, Grimshaw K, Hoest A, Jones C, Khaleva E, Lack G, Szajewska H, Venter C, Verhasselt V, Roberts G; European Academy of Allergy, Clinical Immunology Food Allergy, Anaphylaxis Guidelines Group
Pediatr Allergy Immunol 2020 Oct;31(7):813-826. Epub 2020 Jun 18 doi: 10.1111/pai.13273. PMID: 32396244
Complementary feeding and food allergy, atopic dermatitis/eczema, asthma, and allergic rhinitis: a systematic review.
Obbagy JE, English LK, Wong YP, Butte NF, Dewey KG, Fleischer DM, Fox MK, Greer FR, Krebs NF, Scanlon KS, Stoody EE
Am J Clin Nutr 2019 Mar 1;109(Suppl_7):890S-934S. doi: 10.1093/ajcn/nqy220. PMID: 30982864

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