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Mild dysplasia of rectum

MedGen UID:
108448
•Concept ID:
C0586371
•
Disease or Syndrome
Synonyms: Mild Dysplasia of Rectum; Mild Dysplasia of the Rectum; Mild Rectal Dysplasia
SNOMED CT: Mild dysplasia of rectum (308876005)

Definition

A morphologic finding indicating the presence of mild dysplastic cellular changes and mild architectural changes in the glandular epithelium of the rectal mucosa. There is no evidence of invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMild dysplasia of rectum

Professional guidelines

PubMed

Juvenile polyposis syndrome: a study of genotype, phenotype, and long-term outcome.
Latchford AR, Neale K, Phillips RK, Clark SK
Dis Colon Rectum 2012 Oct;55(10):1038-43. doi: 10.1097/DCR.0b013e31826278b3. PMID: 22965402
Prevention and early diagnosis of cancer in the rectal stump of ulcerative colitis patients after colectomy and topical treatment.
Trabucchi E, Baratti C, Centemero A, Rizzitelli E, Colombo R, Siardi C, Mariscotti C, Ferla G, Montorsi W
Int J Clin Pharmacol Res 1987;7(2):157-64. PMID: 2884192

Recent clinical studies

Etiology

Clinicopathological characterization of colonic polyps.
Qari YA
Niger J Clin Pract 2020 Aug;23(8):1048-1053. doi: 10.4103/njcp.njcp_490_19. PMID: 32788480
Elective surgery for ulcerative colitis, ileo-rectal anastomosis or restorative proctocolectomy An Update.
Fornaro R, Casaccia M, Caristo G, Batistotti P, Di Maira L, Atzori G, Oliva A, Stratta E, Razzore A, Caratto M, Caratto E, Giovinazzo D, Frascio M
Ann Ital Chir 2019;90:565-573. PMID: 31929176
Prevalence and morphology of pouch and ileal adenomas in familial adenomatous polyposis.
Groves CJ, Beveridge lG, Swain DJ, Saunders BP, Talbot IC, Nicholls RJ, Phillips RK
Dis Colon Rectum 2005 Apr;48(4):816-23. doi: 10.1007/s10350-004-0835-1. PMID: 15747076
Pathologic features of initial adenomas as predictors for metachronous adenomas of the rectum.
Yang G, Zheng W, Sun QR, Shu XO, Li WD, Yu H, Shen GF, Shen YZ, Potter JD, Zheng S
J Natl Cancer Inst 1998 Nov 4;90(21):1661-5. doi: 10.1093/jnci/90.21.1661. PMID: 9811316
Intestinal neuronal dysplasia.
Schofield DE, Yunis EJ
J Pediatr Gastroenterol Nutr 1991 Feb;12(2):182-9. doi: 10.1097/00005176-199102000-00008. PMID: 2051270

Diagnosis

Juvenile polyposis syndrome might be misdiagnosed as familial adenomatous polyposis: a case report and literature review.
Gao XH, Li J, Zhao ZY, Xu XD, Du YQ, Yan HL, Liu LJ, Bai CG, Zhang W
BMC Gastroenterol 2020 Jun 1;20(1):167. doi: 10.1186/s12876-020-01238-7. PMID: 32487124Free PMC Article
Ulcerative Colitis.
Feuerstein JD, Moss AC, Farraye FA
Mayo Clin Proc 2019 Jul;94(7):1357-1373. doi: 10.1016/j.mayocp.2019.01.018. PMID: 31272578
Clinical aspects of intestinal neuronal dysplasia.
Montedonico S, Acevedo S, Fadda B
J Pediatr Surg 2002 Dec;37(12):1772-4. doi: 10.1053/jpsu.2002.36720. PMID: 12483654
Pathologic features of initial adenomas as predictors for metachronous adenomas of the rectum.
Yang G, Zheng W, Sun QR, Shu XO, Li WD, Yu H, Shen GF, Shen YZ, Potter JD, Zheng S
J Natl Cancer Inst 1998 Nov 4;90(21):1661-5. doi: 10.1093/jnci/90.21.1661. PMID: 9811316
Intestinal neuronal dysplasia.
Schofield DE, Yunis EJ
J Pediatr Gastroenterol Nutr 1991 Feb;12(2):182-9. doi: 10.1097/00005176-199102000-00008. PMID: 2051270

Therapy

Elective surgery for ulcerative colitis, ileo-rectal anastomosis or restorative proctocolectomy An Update.
Fornaro R, Casaccia M, Caristo G, Batistotti P, Di Maira L, Atzori G, Oliva A, Stratta E, Razzore A, Caratto M, Caratto E, Giovinazzo D, Frascio M
Ann Ital Chir 2019;90:565-573. PMID: 31929176
Prevalence and morphology of pouch and ileal adenomas in familial adenomatous polyposis.
Groves CJ, Beveridge lG, Swain DJ, Saunders BP, Talbot IC, Nicholls RJ, Phillips RK
Dis Colon Rectum 2005 Apr;48(4):816-23. doi: 10.1007/s10350-004-0835-1. PMID: 15747076
Increased expression of proliferative Ki-67 nuclear antigen is correlated with dysplastic colorectal epithelium in ulcerative colitis.
Sjöqvist U, Ost A, Löfberg R
Int J Colorectal Dis 1999 Apr;14(2):107-13. doi: 10.1007/s003840050194. PMID: 10367256
Long-term results of ileorectal anastomosis in ulcerative colitis in Stockholm County.
Leijonmarck CE, Löfberg R, Ost A, Hellers G
Dis Colon Rectum 1990 Mar;33(3):195-200. doi: 10.1007/BF02134178. PMID: 2311462
Prevention and early diagnosis of cancer in the rectal stump of ulcerative colitis patients after colectomy and topical treatment.
Trabucchi E, Baratti C, Centemero A, Rizzitelli E, Colombo R, Siardi C, Mariscotti C, Ferla G, Montorsi W
Int J Clin Pharmacol Res 1987;7(2):157-64. PMID: 2884192

Prognosis

A Prospective, Dual-Center Trial of Circumferential Radiofrequency Ablation of Anal High-Grade Squamous Intraepithelial Lesions Demonstrate Improved Long-term Efficacy Over Historical Controls of Targeted Ablation.
Goldstone SE, Terlizzi JP, Levine RA, Moshier E, Pereira Vera B
Dis Colon Rectum 2023 Jun 1;66(6):764-773. Epub 2023 May 4 doi: 10.1097/DCR.0000000000002365. PMID: 35522783
Prevalence and morphology of pouch and ileal adenomas in familial adenomatous polyposis.
Groves CJ, Beveridge lG, Swain DJ, Saunders BP, Talbot IC, Nicholls RJ, Phillips RK
Dis Colon Rectum 2005 Apr;48(4):816-23. doi: 10.1007/s10350-004-0835-1. PMID: 15747076
Pathologic features of initial adenomas as predictors for metachronous adenomas of the rectum.
Yang G, Zheng W, Sun QR, Shu XO, Li WD, Yu H, Shen GF, Shen YZ, Potter JD, Zheng S
J Natl Cancer Inst 1998 Nov 4;90(21):1661-5. doi: 10.1093/jnci/90.21.1661. PMID: 9811316
Intestinal neuronal dysplasia.
Schofield DE, Yunis EJ
J Pediatr Gastroenterol Nutr 1991 Feb;12(2):182-9. doi: 10.1097/00005176-199102000-00008. PMID: 2051270
Colorectal adenomas: morphologic features and the risk of developing metachronous adenomas and carcinomas in the colorectum.
Kellokumpu I, Husa A
Scand J Gastroenterol 1987 Sep;22(7):833-41. doi: 10.3109/00365528708991923. PMID: 3672041

Clinical prediction guides

Elective surgery for ulcerative colitis, ileo-rectal anastomosis or restorative proctocolectomy An Update.
Fornaro R, Casaccia M, Caristo G, Batistotti P, Di Maira L, Atzori G, Oliva A, Stratta E, Razzore A, Caratto M, Caratto E, Giovinazzo D, Frascio M
Ann Ital Chir 2019;90:565-573. PMID: 31929176
Prevalence and morphology of pouch and ileal adenomas in familial adenomatous polyposis.
Groves CJ, Beveridge lG, Swain DJ, Saunders BP, Talbot IC, Nicholls RJ, Phillips RK
Dis Colon Rectum 2005 Apr;48(4):816-23. doi: 10.1007/s10350-004-0835-1. PMID: 15747076
Pathologic features of initial adenomas as predictors for metachronous adenomas of the rectum.
Yang G, Zheng W, Sun QR, Shu XO, Li WD, Yu H, Shen GF, Shen YZ, Potter JD, Zheng S
J Natl Cancer Inst 1998 Nov 4;90(21):1661-5. doi: 10.1093/jnci/90.21.1661. PMID: 9811316
Overexpression of p53 protein and histologic grades of dysplasia in colorectal adenomas.
Sameshima S, Kubota Y, Sawada T, Watanabe T, Kuroda T, Tsuno N, Higuchi Y, Shinozaki M, Sunouchi K, Masaki T, Saito Y, Muto T
Dis Colon Rectum 1996 May;39(5):562-7. doi: 10.1007/BF02058712. PMID: 8620809
Intestinal neuronal dysplasia.
Schofield DE, Yunis EJ
J Pediatr Gastroenterol Nutr 1991 Feb;12(2):182-9. doi: 10.1097/00005176-199102000-00008. PMID: 2051270

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