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Acute pharyngitis

MedGen UID:
114
•Concept ID:
C0001344
•
Disease or Syndrome
Synonyms: Acute Pharyngitis; acute pharyngitis; pharyngitis, acute
SNOMED CT: Acute pharyngitis (363746003)
 
Monarch Initiative: MONDO:0020600

Definition

An acute and painful inflammatory process that affects the pharynx. It is usually caused by viruses and less often bacteria. Signs and symptoms include discomfort on swallowing, low-grade fever, headache, and earache. [from NCI]

Professional guidelines

PubMed

Treatment of acute pharyngitis in children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-FIMMG).
Chiappini E, Simeone G, Bergamini M, Pellegrino R, Guarino A, Staiano A, Esposito S, Gattinara GC, Vecchio AL, Stefani S, Iacono ID, Scotese I, Tezza G, Dinardo G, Riccio S, Pellizzari S, Iavarone S, Lorenzetti G, Venturini E, Donà D, Pierantoni L, Doria M, Garazzino S, Midulla F, Cricelli C, Terracciano L, Capuano A, Bruzzese E, Ghiglioni D, Fusani L, Fusco E, Biasci P, Reggiani L, Matera L, Mancino E, Barbieri E, D'Avino A, Cursi L, Sullo MG, Scotti S, Marseglia GL, Di Mauro G, Principi N, Galli L, Verga MC
Ital J Pediatr 2024 Nov 6;50(1):235. doi: 10.1186/s13052-024-01789-5. PMID: 39501298Free PMC Article
Diagnostic Methods, Clinical Guidelines, and Antibiotic Treatment for Group A Streptococcal Pharyngitis: A Narrative Review.
Mustafa Z, Ghaffari M
Front Cell Infect Microbiol 2020;10:563627. Epub 2020 Oct 15 doi: 10.3389/fcimb.2020.563627. PMID: 33178623Free PMC Article
Recommendations for management of acute pharyngitis in adults.
Cots JM, Alós JI, Bárcena M, Boleda X, Cañada JL, Gómez N, Mendoza A, Vilaseca I, Llor C
Acta Otorrinolaringol Esp 2015 May-Jun;66(3):159-70. Epub 2015 Mar 12 doi: 10.1016/j.otorri.2015.01.001. PMID: 25772389Free PMC Article

Recent clinical studies

Etiology

Acute pharyngitis in children and adults: descriptive comparison of current recommendations from national and international guidelines and future perspectives.
Pellegrino R, Timitilli E, Verga MC, Guarino A, Iacono ID, Scotese I, Tezza G, Dinardo G, Riccio S, Pellizzari S, Iavarone S, Lorenzetti G, Simeone G, Bergamini M, Donà D, Pierantoni L, Garazzino S, Esposito S, Venturini E, Gattinara GC, Lo Vecchio A, Marseglia GL, Di Mauro G, Principi N, Galli L, Chiappini E; Other members of the Italian Panel for the Management of Acute Pharyngitis in Children
Eur J Pediatr 2023 Dec;182(12):5259-5273. Epub 2023 Oct 11 doi: 10.1007/s00431-023-05211-w. PMID: 37819417Free PMC Article
Diagnostic Methods, Clinical Guidelines, and Antibiotic Treatment for Group A Streptococcal Pharyngitis: A Narrative Review.
Mustafa Z, Ghaffari M
Front Cell Infect Microbiol 2020;10:563627. Epub 2020 Oct 15 doi: 10.3389/fcimb.2020.563627. PMID: 33178623Free PMC Article
Recommendations for management of acute pharyngitis in adults.
Cots JM, Alós JI, Bárcena M, Boleda X, Cañada JL, Gómez N, Mendoza A, Vilaseca I, Llor C
Acta Otorrinolaringol Esp 2015 May-Jun;66(3):159-70. Epub 2015 Mar 12 doi: 10.1016/j.otorri.2015.01.001. PMID: 25772389Free PMC Article
Streptococcal acute pharyngitis.
Anjos LM, Marcondes MB, Lima MF, Mondelli AL, Okoshi MP
Rev Soc Bras Med Trop 2014 Jul;47(4):409-13. doi: 10.1590/0037-8682-0265-2013. PMID: 25229278
Upper respiratory tract infections.
Jain N, Lodha R, Kabra SK
Indian J Pediatr 2001 Dec;68(12):1135-8. doi: 10.1007/BF02722930. PMID: 11838568Free PMC Article

Diagnosis

Acute pharyngitis in children and adults: descriptive comparison of current recommendations from national and international guidelines and future perspectives.
Pellegrino R, Timitilli E, Verga MC, Guarino A, Iacono ID, Scotese I, Tezza G, Dinardo G, Riccio S, Pellizzari S, Iavarone S, Lorenzetti G, Simeone G, Bergamini M, Donà D, Pierantoni L, Garazzino S, Esposito S, Venturini E, Gattinara GC, Lo Vecchio A, Marseglia GL, Di Mauro G, Principi N, Galli L, Chiappini E; Other members of the Italian Panel for the Management of Acute Pharyngitis in Children
Eur J Pediatr 2023 Dec;182(12):5259-5273. Epub 2023 Oct 11 doi: 10.1007/s00431-023-05211-w. PMID: 37819417Free PMC Article
Diagnostic Methods, Clinical Guidelines, and Antibiotic Treatment for Group A Streptococcal Pharyngitis: A Narrative Review.
Mustafa Z, Ghaffari M
Front Cell Infect Microbiol 2020;10:563627. Epub 2020 Oct 15 doi: 10.3389/fcimb.2020.563627. PMID: 33178623Free PMC Article
Lemierre's syndrome: A forgotten and re-emerging infection.
Lee WS, Jean SS, Chen FL, Hsieh SM, Hsueh PR
J Microbiol Immunol Infect 2020 Aug;53(4):513-517. Epub 2020 Apr 4 doi: 10.1016/j.jmii.2020.03.027. PMID: 32303484
Streptococcal acute pharyngitis.
Anjos LM, Marcondes MB, Lima MF, Mondelli AL, Okoshi MP
Rev Soc Bras Med Trop 2014 Jul;47(4):409-13. doi: 10.1590/0037-8682-0265-2013. PMID: 25229278
Upper respiratory tract infections.
Jain N, Lodha R, Kabra SK
Indian J Pediatr 2001 Dec;68(12):1135-8. doi: 10.1007/BF02722930. PMID: 11838568Free PMC Article

Therapy

Acute pharyngitis in children and adults: descriptive comparison of current recommendations from national and international guidelines and future perspectives.
Pellegrino R, Timitilli E, Verga MC, Guarino A, Iacono ID, Scotese I, Tezza G, Dinardo G, Riccio S, Pellizzari S, Iavarone S, Lorenzetti G, Simeone G, Bergamini M, Donà D, Pierantoni L, Garazzino S, Esposito S, Venturini E, Gattinara GC, Lo Vecchio A, Marseglia GL, Di Mauro G, Principi N, Galli L, Chiappini E; Other members of the Italian Panel for the Management of Acute Pharyngitis in Children
Eur J Pediatr 2023 Dec;182(12):5259-5273. Epub 2023 Oct 11 doi: 10.1007/s00431-023-05211-w. PMID: 37819417Free PMC Article
Diagnostic Methods, Clinical Guidelines, and Antibiotic Treatment for Group A Streptococcal Pharyngitis: A Narrative Review.
Mustafa Z, Ghaffari M
Front Cell Infect Microbiol 2020;10:563627. Epub 2020 Oct 15 doi: 10.3389/fcimb.2020.563627. PMID: 33178623Free PMC Article
Lemierre's syndrome: A forgotten and re-emerging infection.
Lee WS, Jean SS, Chen FL, Hsieh SM, Hsueh PR
J Microbiol Immunol Infect 2020 Aug;53(4):513-517. Epub 2020 Apr 4 doi: 10.1016/j.jmii.2020.03.027. PMID: 32303484
Streptococcal acute pharyngitis.
Anjos LM, Marcondes MB, Lima MF, Mondelli AL, Okoshi MP
Rev Soc Bras Med Trop 2014 Jul;47(4):409-13. doi: 10.1590/0037-8682-0265-2013. PMID: 25229278
Upper respiratory tract infections.
Jain N, Lodha R, Kabra SK
Indian J Pediatr 2001 Dec;68(12):1135-8. doi: 10.1007/BF02722930. PMID: 11838568Free PMC Article

Prognosis

Acute pharyngitis in children and adults: descriptive comparison of current recommendations from national and international guidelines and future perspectives.
Pellegrino R, Timitilli E, Verga MC, Guarino A, Iacono ID, Scotese I, Tezza G, Dinardo G, Riccio S, Pellizzari S, Iavarone S, Lorenzetti G, Simeone G, Bergamini M, Donà D, Pierantoni L, Garazzino S, Esposito S, Venturini E, Gattinara GC, Lo Vecchio A, Marseglia GL, Di Mauro G, Principi N, Galli L, Chiappini E; Other members of the Italian Panel for the Management of Acute Pharyngitis in Children
Eur J Pediatr 2023 Dec;182(12):5259-5273. Epub 2023 Oct 11 doi: 10.1007/s00431-023-05211-w. PMID: 37819417Free PMC Article
Short-Term Systemic Corticosteroids: Appropriate Use in Primary Care.
Dvorin EL, Ebell MH
Am Fam Physician 2020 Jan 15;101(2):89-94. PMID: 31939645
Are systemic corticosteroids useful for the management of acute pharyngitis?
Alarcón-Andrade G, Bravo-Soto G, Rada G
Medwave 2017 Dec 26;17(9):e7111. doi: 10.5867/medwave.2017.09.7111. PMID: 29286352
Recommendations for management of acute pharyngitis in adults.
Cots JM, Alós JI, Bárcena M, Boleda X, Cañada JL, Gómez N, Mendoza A, Vilaseca I, Llor C
Acta Otorrinolaringol Esp 2015 May-Jun;66(3):159-70. Epub 2015 Mar 12 doi: 10.1016/j.otorri.2015.01.001. PMID: 25772389Free PMC Article
Streptococcal acute pharyngitis.
Anjos LM, Marcondes MB, Lima MF, Mondelli AL, Okoshi MP
Rev Soc Bras Med Trop 2014 Jul;47(4):409-13. doi: 10.1590/0037-8682-0265-2013. PMID: 25229278

Clinical prediction guides

Review: Current Laboratory and Point-of-Care Pharyngitis Diagnostic Testing and Knowledge Gaps.
Boyanton BL Jr, Caldwell JM, Ledeboer NA
J Infect Dis 2024 Oct 23;230(Supplement_3):S182-S189. doi: 10.1093/infdis/jiae415. PMID: 39441195Free PMC Article
Review: Known, Emerging, and Remerging Pharyngitis Pathogens.
Caldwell JM, Ledeboer NA, Boyanton BL Jr
J Infect Dis 2024 Oct 23;230(Supplement_3):S173-S181. doi: 10.1093/infdis/jiae391. PMID: 39441194Free PMC Article
Diagnostic Methods, Clinical Guidelines, and Antibiotic Treatment for Group A Streptococcal Pharyngitis: A Narrative Review.
Mustafa Z, Ghaffari M
Front Cell Infect Microbiol 2020;10:563627. Epub 2020 Oct 15 doi: 10.3389/fcimb.2020.563627. PMID: 33178623Free PMC Article
Recommendations for management of acute pharyngitis in adults.
Cots JM, Alós JI, Bárcena M, Boleda X, Cañada JL, Gómez N, Mendoza A, Vilaseca I, Llor C
Acta Otorrinolaringol Esp 2015 May-Jun;66(3):159-70. Epub 2015 Mar 12 doi: 10.1016/j.otorri.2015.01.001. PMID: 25772389Free PMC Article
Streptococcal acute pharyngitis.
Anjos LM, Marcondes MB, Lima MF, Mondelli AL, Okoshi MP
Rev Soc Bras Med Trop 2014 Jul;47(4):409-13. doi: 10.1590/0037-8682-0265-2013. PMID: 25229278

Recent systematic reviews

Treatment of acute pharyngitis in children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-FIMMG).
Chiappini E, Simeone G, Bergamini M, Pellegrino R, Guarino A, Staiano A, Esposito S, Gattinara GC, Vecchio AL, Stefani S, Iacono ID, Scotese I, Tezza G, Dinardo G, Riccio S, Pellizzari S, Iavarone S, Lorenzetti G, Venturini E, Donà D, Pierantoni L, Doria M, Garazzino S, Midulla F, Cricelli C, Terracciano L, Capuano A, Bruzzese E, Ghiglioni D, Fusani L, Fusco E, Biasci P, Reggiani L, Matera L, Mancino E, Barbieri E, D'Avino A, Cursi L, Sullo MG, Scotti S, Marseglia GL, Di Mauro G, Principi N, Galli L, Verga MC
Ital J Pediatr 2024 Nov 6;50(1):235. doi: 10.1186/s13052-024-01789-5. PMID: 39501298Free PMC Article
Systematic review and meta-analysis of the accuracy of McIsaac and Centor score in patients presenting to secondary care with pharyngitis.
Kanagasabai A, Evans C, Jones HE, Hay AD, Dawson S, Savović J, Elwenspoek MMC
Clin Microbiol Infect 2024 Apr;30(4):445-452. Epub 2024 Jan 3 doi: 10.1016/j.cmi.2023.12.025. PMID: 38182052
Chinese medicinal herbs for sore throat.
Huang Y, Wu T, Zeng L, Li S
Cochrane Database Syst Rev 2012 Mar 14;2012(3):CD004877. doi: 10.1002/14651858.CD004877.pub3. PMID: 22419300Free PMC Article
Soothing a sore throat: the efficacy and safety of steroids in acute pharyngitis.
Mullarkey C
Ir J Med Sci 2011 Dec;180(4):837-40. Epub 2011 May 27 doi: 10.1007/s11845-011-0719-z. PMID: 21618052
Effectiveness of corticosteroid treatment in acute pharyngitis: a systematic review of the literature.
Wing A, Villa-Roel C, Yeh B, Eskin B, Buckingham J, Rowe BH
Acad Emerg Med 2010 May;17(5):476-83. doi: 10.1111/j.1553-2712.2010.00723.x. PMID: 20536799

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