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Synostosis

MedGen UID:
11689
•Concept ID:
C0039093
•
Congenital Abnormality
Synonym: Synostoses
 
Monarch Initiative: MONDO:0001411

Definition

A disease characterized by abnormal union between adjacent bones or parts of a single bone formed by osseous material, such as ossified connecting cartilage or fibrous tissue. [from MONDO]

Professional guidelines

PubMed

The clinical manifestations, molecular mechanisms and treatment of craniosynostosis.
Stanton E, Urata M, Chen JF, Chai Y
Dis Model Mech 2022 Apr 1;15(4) Epub 2022 Apr 22 doi: 10.1242/dmm.049390. PMID: 35451466Free PMC Article
Ophthalmological management in craniosynostosis.
Touzé R, Bremond-Gignac D, Robert MP
Neurochirurgie 2019 Nov;65(5):310-317. Epub 2019 Sep 28 doi: 10.1016/j.neuchi.2019.09.016. PMID: 31574284
An update on the evaluation and treatment of syndesmotic injuries.
Rammelt S, Obruba P
Eur J Trauma Emerg Surg 2015 Dec;41(6):601-14. Epub 2014 Nov 12 doi: 10.1007/s00068-014-0466-8. PMID: 26037997

Recent clinical studies

Etiology

Ophthalmic Manifestations of Unilateral Coronal Synostosis.
Huynh EM, Elhusseiny AM, Dagi LR
Curr Eye Res 2023 Oct;48(10):879-886. Epub 2023 Jun 29 doi: 10.1080/02713683.2023.2224536. PMID: 37382098
Squamosal Suture Synostosis: An Under-Recognized Phenomenon.
W Beiriger J, Zhu X, Bruce MK, Irgebay Z, Smetona J, Losee JE, Goldstein JA
Cleft Palate Craniofac J 2023 Oct;60(10):1267-1272. Epub 2022 May 20 doi: 10.1177/10556656221100675. PMID: 35593077
Management options of non-syndromic sagittal craniosynostosis.
Lee BS, Hwang LS, Doumit GD, Wooley J, Papay FA, Luciano MG, Recinos VM
J Clin Neurosci 2017 May;39:28-34. Epub 2017 Mar 6 doi: 10.1016/j.jocn.2017.02.042. PMID: 28279556
Adult post-traumatic radioulnar synostosis.
Dohn P, Khiami F, Rolland E, Goubier JN
Orthop Traumatol Surg Res 2012 Oct;98(6):709-14. Epub 2012 Sep 19 doi: 10.1016/j.otsr.2012.04.018. PMID: 23000035
Occipital plagiocephaly.
David DJ, Menard RM
Br J Plast Surg 2000 Jul;53(5):367-77. doi: 10.1054/bjps.2000.3329. PMID: 10876272

Diagnosis

Congenital Radioulnar Synostosis.
Rutkowski PT, Samora JB
J Am Acad Orthop Surg 2021 Jul 1;29(13):563-570. doi: 10.5435/JAAOS-D-20-01133. PMID: 33826558
Unicoronal Synostosis.
Weng F, Meara JG, Dagi LR
J Pediatr 2019 Oct;213:243-243.e1. Epub 2019 Jun 27 doi: 10.1016/j.jpeds.2019.05.043. PMID: 31255389
Tarsal Coalitions--Calcaneonavicular Coalitions.
Swensen SJ, Otsuka NY
Foot Ankle Clin 2015 Dec;20(4):669-79. doi: 10.1016/j.fcl.2015.08.001. PMID: 26589085
Complex craniosynostosis.
Czerwinski M, Kolar JC, Fearon JA
Plast Reconstr Surg 2011 Oct;128(4):955-961. doi: 10.1097/PRS.0b013e3182268ca6. PMID: 21681124
Tarsal coalitions.
Zaw H, Calder JD
Foot Ankle Clin 2010 Jun;15(2):349-64. doi: 10.1016/j.fcl.2010.02.003. PMID: 20534361

Therapy

Outcomes of surgical management for tarsal coalitions: a systematic review.
Polt M, Graf DA, Brunner S, Helmy N, Tondelli T, Karczewski D, Andronic O
Arch Orthop Trauma Surg 2023 Dec;143(12):6993-7008. Epub 2023 Jul 18 doi: 10.1007/s00402-023-04982-z. PMID: 37462747
Sagittal Synostosis and Its Association With Cognitive, Behavioral, and Psychological Functioning: A Meta-analysis.
Osborn AJ, Roberts RM, Dorstyn DS, Grave BG, David DJ
JAMA Netw Open 2021 Sep 1;4(9):e2121937. doi: 10.1001/jamanetworkopen.2021.21937. PMID: 34515785Free PMC Article
Management of sagittal synostosis in the Synostosis Research Group: baseline data and early outcomes.
Baker CM, Ravindra VM, Gociman B, Siddiqi FA, Goldstein JA, Smyth MD, Lee A, Anderson RCE, Patel KB, Birgfeld C, Pollack IF, Imahiyerobo T, Kestle JRW; Synostosis Research Group
Neurosurg Focus 2021 Apr;50(4):E3. doi: 10.3171/2021.1.FOCUS201029. PMID: 33794498
Recent advances in trigonocephaly.
Mocquard C, Aillet S, Riffaud L
Neurochirurgie 2019 Nov;65(5):246-251. Epub 2019 Sep 27 doi: 10.1016/j.neuchi.2019.09.014. PMID: 31568780
Endoscopic coalition resection.
Bonasia DE, Phisitkul P, Amendola A
Foot Ankle Clin 2015 Mar;20(1):81-91. Epub 2014 Dec 15 doi: 10.1016/j.fcl.2014.10.006. PMID: 25726485

Prognosis

Squamosal Suture Synostosis: An Under-Recognized Phenomenon.
W Beiriger J, Zhu X, Bruce MK, Irgebay Z, Smetona J, Losee JE, Goldstein JA
Cleft Palate Craniofac J 2023 Oct;60(10):1267-1272. Epub 2022 May 20 doi: 10.1177/10556656221100675. PMID: 35593077
Complex craniosynostosis.
Czerwinski M, Kolar JC, Fearon JA
Plast Reconstr Surg 2011 Oct;128(4):955-961. doi: 10.1097/PRS.0b013e3182268ca6. PMID: 21681124
Sagittal synostosis.
Jane JA Jr, Lin KY, Jane JA Sr
Neurosurg Focus 2000 Sep 15;9(3):e3. doi: 10.3171/foc.2000.9.3.4. PMID: 16833254
Radioulnar synostosis.
Sachar K, Akelman E, Ehrlich MG
Hand Clin 1994 Aug;10(3):399-404. PMID: 7962146
Ulnar dysmelia.
Ogden JA, Watson HK, Bohne W
J Bone Joint Surg Am 1976 Jun;58(4):467-75. PMID: 818089

Clinical prediction guides

Molecular Mechanisms Involved in Craniosynostosis.
Yapijakis C, Pachis N, Sotiriadou T, Vaila C, Michopoulou V, Vassiliou S
In Vivo 2023 Jan-Feb;37(1):36-46. doi: 10.21873/invivo.13052. PMID: 36593018Free PMC Article
Congenital Radioulnar Synostosis.
Rutkowski PT, Samora JB
J Am Acad Orthop Surg 2021 Jul 1;29(13):563-570. doi: 10.5435/JAAOS-D-20-01133. PMID: 33826558
Recent advances in trigonocephaly.
Mocquard C, Aillet S, Riffaud L
Neurochirurgie 2019 Nov;65(5):246-251. Epub 2019 Sep 27 doi: 10.1016/j.neuchi.2019.09.014. PMID: 31568780
Sagittal synostosis.
Jane JA Jr, Lin KY, Jane JA Sr
Neurosurg Focus 2000 Sep 15;9(3):e3. doi: 10.3171/foc.2000.9.3.4. PMID: 16833254
Ulnar dysmelia.
Ogden JA, Watson HK, Bohne W
J Bone Joint Surg Am 1976 Jun;58(4):467-75. PMID: 818089

Recent systematic reviews

Clavicular bone defects managed with free vascularised fibular grafting: evidence to date.
Wakefield SM, Giannoudis VP, Giannoudis PV
Eur J Orthop Surg Traumatol 2023 Dec;33(8):3307-3318. Epub 2023 Jun 8 doi: 10.1007/s00590-023-03598-8. PMID: 37289244Free PMC Article
Tarsal coalition: Systematic review of arthroscopic management.
Addar A, Marwan Y, Algarni N, Algarni N, Berry GK, Benaroch T
Foot (Edinb) 2021 Dec;49:101864. Epub 2021 Sep 22 doi: 10.1016/j.foot.2021.101864. PMID: 34597922
Nervous system involvement in Pfeiffer syndrome.
Mavridis IN, Rodrigues D
Childs Nerv Syst 2021 Feb;37(2):367-374. Epub 2020 Oct 20 doi: 10.1007/s00381-020-04934-7. PMID: 33083874
Classification and diagnosis of acute isolated syndesmotic injuries: ESSKA-AFAS consensus and guidelines.
van Dijk CN, Longo UG, Loppini M, Florio P, Maltese L, Ciuffreda M, Denaro V
Knee Surg Sports Traumatol Arthrosc 2016 Apr;24(4):1200-16. Epub 2015 Dec 24 doi: 10.1007/s00167-015-3942-8. PMID: 26704800
Surgical correction for unilateral lambdoid synostosis: a systematic review.
Al-Jabri T, Eccles S
J Craniofac Surg 2014 Jul;25(4):1266-72. doi: 10.1097/SCS.0000000000000961. PMID: 24978452

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