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Infantile colic

MedGen UID:
120591
•Concept ID:
C0266836
•
Sign or Symptom
Synonyms: Colic, Infantile; Infantile Colic
SNOMED CT: Three month colic (35363006); Infantile colic (35363006)

Definition

Paroxysms of irritability, fussing or crying that starts and stops without obvious cause in an infant up to four months of age without failure to thrive. Episodes last three or more hours per day for at least three days per week for at least on week. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfantile colic

Professional guidelines

PubMed

Spinal manipulation and mobilisation in the treatment of infants, children, and adolescents: a systematic scoping review.
Milne N, Longeri L, Patel A, Pool J, Olson K, Basson A, Gross AR
BMC Pediatr 2022 Dec 19;22(1):721. doi: 10.1186/s12887-022-03781-6. PMID: 36536328Free PMC Article
Comparison of common interventions for the treatment of infantile colic: a systematic review of reviews and guidelines.
Ellwood J, Draper-Rodi J, Carnes D
BMJ Open 2020 Feb 25;10(2):e035405. doi: 10.1136/bmjopen-2019-035405. PMID: 32102827Free PMC Article
Infantile Colic: Recognition and Treatment.
Johnson JD, Cocker K, Chang E
Am Fam Physician 2015 Oct 1;92(7):577-82. PMID: 26447441

Recent clinical studies

Etiology

Infantile colic.
Gelfand AA
Handb Clin Neurol 2023;198:203-207. doi: 10.1016/B978-0-12-823356-6.00010-X. PMID: 38043962
Probiotics to prevent infantile colic.
Ong TG, Gordon M, Banks SS, Thomas MR, Akobeng AK
Cochrane Database Syst Rev 2019 Mar 13;3(3):CD012473. doi: 10.1002/14651858.CD012473.pub2. PMID: 30865287Free PMC Article
Manipulative Therapies: What Works.
Smith MS, Olivas J, Smith K
Am Fam Physician 2019 Feb 15;99(4):248-252. PMID: 30763049
Infantile Colic: New Insights into an Old Problem.
Mai T, Fatheree NY, Gleason W, Liu Y, Rhoads JM
Gastroenterol Clin North Am 2018 Dec;47(4):829-844. Epub 2018 Sep 28 doi: 10.1016/j.gtc.2018.07.008. PMID: 30337035Free PMC Article
Dietary modifications for infantile colic.
Gordon M, Biagioli E, Sorrenti M, Lingua C, Moja L, Banks SS, Ceratto S, Savino F
Cochrane Database Syst Rev 2018 Oct 10;10(10):CD011029. doi: 10.1002/14651858.CD011029.pub2. PMID: 30306546Free PMC Article

Diagnosis

Infantile colic.
Gelfand AA
Handb Clin Neurol 2023;198:203-207. doi: 10.1016/B978-0-12-823356-6.00010-X. PMID: 38043962
Probiotics to prevent infantile colic.
Ong TG, Gordon M, Banks SS, Thomas MR, Akobeng AK
Cochrane Database Syst Rev 2019 Mar 13;3(3):CD012473. doi: 10.1002/14651858.CD012473.pub2. PMID: 30865287Free PMC Article
Infantile Colic: New Insights into an Old Problem.
Mai T, Fatheree NY, Gleason W, Liu Y, Rhoads JM
Gastroenterol Clin North Am 2018 Dec;47(4):829-844. Epub 2018 Sep 28 doi: 10.1016/j.gtc.2018.07.008. PMID: 30337035Free PMC Article
Infantile Colic: An Update.
Sarasu JM, Narang M, Shah D
Indian Pediatr 2018 Nov 15;55(11):979-987. Epub 2018 Jun 13 PMID: 29941700
Infantile Colic: Recognition and Treatment.
Johnson JD, Cocker K, Chang E
Am Fam Physician 2015 Oct 1;92(7):577-82. PMID: 26447441

Therapy

Manual therapy for the pediatric population: a systematic review.
Parnell Prevost C, Gleberzon B, Carleo B, Anderson K, Cark M, Pohlman KA
BMC Complement Altern Med 2019 Mar 13;19(1):60. doi: 10.1186/s12906-019-2447-2. PMID: 30866915Free PMC Article
Probiotics to prevent infantile colic.
Ong TG, Gordon M, Banks SS, Thomas MR, Akobeng AK
Cochrane Database Syst Rev 2019 Mar 13;3(3):CD012473. doi: 10.1002/14651858.CD012473.pub2. PMID: 30865287Free PMC Article
Manipulative Therapies: What Works.
Smith MS, Olivas J, Smith K
Am Fam Physician 2019 Feb 15;99(4):248-252. PMID: 30763049
Infantile Colic: An Update.
Sarasu JM, Narang M, Shah D
Indian Pediatr 2018 Nov 15;55(11):979-987. Epub 2018 Jun 13 PMID: 29941700
Infantile Colic: Recognition and Treatment.
Johnson JD, Cocker K, Chang E
Am Fam Physician 2015 Oct 1;92(7):577-82. PMID: 26447441

Prognosis

Contribution of ghrelin to functional gastrointestinal disorders' pathogenesis.
Koutouratsas T, Kalli T, Karamanolis G, Gazouli M
World J Gastroenterol 2019 Feb 7;25(5):539-551. doi: 10.3748/wjg.v25.i5.539. PMID: 30774270Free PMC Article
Signs and symptoms associated with digestive tract development.
Morais MB
J Pediatr (Rio J) 2016 May-Jun;92(3 Suppl 1):S46-56. Epub 2016 Mar 25 doi: 10.1016/j.jped.2016.02.008. PMID: 27020622
Looking for new treatments of Infantile Colic.
Savino F, Ceratto S, De Marco A, Cordero di Montezemolo L
Ital J Pediatr 2014 Jun 5;40:53. doi: 10.1186/1824-7288-40-53. PMID: 24898541Free PMC Article
New treatments for infant colic.
Savino F, Tarasco V
Curr Opin Pediatr 2010 Dec;22(6):791-7. doi: 10.1097/MOP.0b013e32833fac24. PMID: 20859207
Focus on infantile colic.
Savino F
Acta Paediatr 2007 Sep;96(9):1259-64. doi: 10.1111/j.1651-2227.2007.00428.x. PMID: 17718777

Clinical prediction guides

Infantile Colic and Long-Term Outcomes in Childhood: A Narrative Synthesis of the Evidence.
Indrio F, Dargenio VN, Francavilla R, Szajewska H, Vandenplas Y
Nutrients 2023 Jan 25;15(3) doi: 10.3390/nu15030615. PMID: 36771322Free PMC Article
Antibiotic exposure and adverse long-term health outcomes in children: A systematic review and meta-analysis.
Duong QA, Pittet LF, Curtis N, Zimmermann P
J Infect 2022 Sep;85(3):213-300. Epub 2022 Jan 10 doi: 10.1016/j.jinf.2022.01.005. PMID: 35021114
The global summit on the efficacy and effectiveness of spinal manipulative therapy for the prevention and treatment of non-musculoskeletal disorders: a systematic review of the literature.
Côté P, Hartvigsen J, Axén I, Leboeuf-Yde C, Corso M, Shearer H, Wong J, Marchand AA, Cassidy JD, French S, Kawchuk GN, Mior S, Poulsen E, Srbely J, Ammendolia C, Blanchette MA, Busse JW, Bussières A, Cancelliere C, Christensen HW, De Carvalho D, De Luca K, Du Rose A, Eklund A, Engel R, Goncalves G, Hebert J, Hincapié CA, Hondras M, Kimpton A, Lauridsen HH, Innes S, Meyer AL, Newell D, O'Neill S, Pagé I, Passmore S, Perle SM, Quon J, Rezai M, Stupar M, Swain M, Vitiello A, Weber K, Young KJ, Yu H
Chiropr Man Therap 2021 Feb 17;29(1):8. doi: 10.1186/s12998-021-00362-9. PMID: 33596925Free PMC Article
Nutritional supplements and other complementary medicines for infantile colic: a systematic review.
Perry R, Hunt K, Ernst E
Pediatrics 2011 Apr;127(4):720-33. Epub 2011 Mar 28 doi: 10.1542/peds.2010-2098. PMID: 21444591
Infantile colic.
Lucassen P
BMJ Clin Evid 2007 Jul 1;2007 PMID: 19454097

Recent systematic reviews

Probiotics for infantile colic: Is there evidence beyond doubt? A meta-analysis and systematic review.
Vaz SR, Tofoli MH, Avelino MAG, da Costa PSS
Acta Paediatr 2024 Feb;113(2):170-182. Epub 2023 Nov 14 doi: 10.1111/apa.17036. PMID: 37962097
Effects of maternal probiotic supplementation on breast milk microbiome and infant gut microbiome and health: a systematic review and meta-analysis of randomized controlled trials.
Alemu BK, Azeze GG, Wu L, Lau SL, Wang CC, Wang Y
Am J Obstet Gynecol MFM 2023 Nov;5(11):101148. Epub 2023 Sep 1 doi: 10.1016/j.ajogmf.2023.101148. PMID: 37660760
Manual therapy for the pediatric population: a systematic review.
Parnell Prevost C, Gleberzon B, Carleo B, Anderson K, Cark M, Pohlman KA
BMC Complement Altern Med 2019 Mar 13;19(1):60. doi: 10.1186/s12906-019-2447-2. PMID: 30866915Free PMC Article
Probiotics to prevent infantile colic.
Ong TG, Gordon M, Banks SS, Thomas MR, Akobeng AK
Cochrane Database Syst Rev 2019 Mar 13;3(3):CD012473. doi: 10.1002/14651858.CD012473.pub2. PMID: 30865287Free PMC Article
Dietary modifications for infantile colic.
Gordon M, Biagioli E, Sorrenti M, Lingua C, Moja L, Banks SS, Ceratto S, Savino F
Cochrane Database Syst Rev 2018 Oct 10;10(10):CD011029. doi: 10.1002/14651858.CD011029.pub2. PMID: 30306546Free PMC Article

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