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Chemosis

MedGen UID:
124393
•Concept ID:
C0271298
•
Pathologic Function
Synonym: Chemosis of conjunctiva
SNOMED CT: Chemosis of conjunctiva (8148005); Chemosis (8148005)
 
HPO: HP:0012375

Definition

Edema (swelling) of the bulbar conjunctiva. [from HPO]

Conditions with this feature

Heme oxygenase 1 deficiency
MedGen UID:
333882
•Concept ID:
C1841651
•
Disease or Syndrome
Heme oxygenase-1 deficiency (HMOX1D) is a rare autosomal recessive disorder with a complex clinical presentation including direct antibody negative hemolytic anemia, low bilirubin, and hyperinflammation (summary by Chau et al., 2020). Other features may include asplenia and nephritis (Radhakrishnan et al., 2011).
See: Condition Record
Heme oxygenase 1 deficiency

Professional guidelines

PubMed

The Management of Chemosis after Blepharoplasty.
Ní Dhubhghaill S, Faris C
Facial Plast Surg 2023 Feb;39(1):53-56. Epub 2022 Oct 25 doi: 10.1055/a-1967-6050. PMID: 36283416
Management of periorbital cellulitis at the Pediatric Emergency Department: A ten years study.
Lahmini W, Oumou M, Bourrous M
J Fr Ophtalmol 2022 Feb;45(2):166-172. Epub 2021 Dec 29 doi: 10.1016/j.jfo.2021.09.012. PMID: 34973820
Occult globe rupture: diagnostic and treatment challenge.
Chronopoulos A, Ong JM, Thumann G, Schutz JS
Surv Ophthalmol 2018 Sep-Oct;63(5):694-699. Epub 2018 Apr 9 doi: 10.1016/j.survophthal.2018.04.001. PMID: 29649485

Recent clinical studies

Etiology

The Management of Chemosis after Blepharoplasty.
Ní Dhubhghaill S, Faris C
Facial Plast Surg 2023 Feb;39(1):53-56. Epub 2022 Oct 25 doi: 10.1055/a-1967-6050. PMID: 36283416
Allergic Conjunctivitis: An Update.
Mueller A
Handb Exp Pharmacol 2022;268:95-99. doi: 10.1007/164_2021_491. PMID: 34136960
Odontogenic orbital inflammation.
Costan VV, Bogdănici CM, Gheorghe L, Obadă O, Budacu C, Grigoraș C, Andronic DG, Niagu IA
Rom J Ophthalmol 2020 Apr-Jun;64(2):116-121. PMID: 32685776Free PMC Article
Orbital cellulitis.
Tsirouki T, Dastiridou AI, Ibánez Flores N, Cerpa JC, Moschos MM, Brazitikos P, Androudi S
Surv Ophthalmol 2018 Jul-Aug;63(4):534-553. Epub 2017 Dec 15 doi: 10.1016/j.survophthal.2017.12.001. PMID: 29248536
Complications of blepharoplasty.
Morax S, Touitou V
Orbit 2006 Dec;25(4):303-18. doi: 10.1080/01676830600985841. PMID: 17182405

Diagnosis

Bacterial orbital cellulitis - A review.
Yadalla D, Jayagayathri R, Padmanaban K, Ramasamy R, Rammohan R, Nisar SP, Rangarajan V, Menon V
Indian J Ophthalmol 2023 Jul;71(7):2687-2693. doi: 10.4103/IJO.IJO_3283_22. PMID: 37417106Free PMC Article
Allergic Conjunctivitis: An Update.
Mueller A
Handb Exp Pharmacol 2022;268:95-99. doi: 10.1007/164_2021_491. PMID: 34136960
Fedratinib-induced orbital inflammation.
Lee JY, Gallo RA, Vu DM, Anagnostopoulos AG, Rong AJ
Orbit 2022 Jun;41(3):346-349. Epub 2020 Nov 26 doi: 10.1080/01676830.2020.1852263. PMID: 33243070
Odontogenic orbital inflammation.
Costan VV, Bogdănici CM, Gheorghe L, Obadă O, Budacu C, Grigoraș C, Andronic DG, Niagu IA
Rom J Ophthalmol 2020 Apr-Jun;64(2):116-121. PMID: 32685776Free PMC Article
Orbital cellulitis.
Tsirouki T, Dastiridou AI, Ibánez Flores N, Cerpa JC, Moschos MM, Brazitikos P, Androudi S
Surv Ophthalmol 2018 Jul-Aug;63(4):534-553. Epub 2017 Dec 15 doi: 10.1016/j.survophthal.2017.12.001. PMID: 29248536

Therapy

Bacterial orbital cellulitis - A review.
Yadalla D, Jayagayathri R, Padmanaban K, Ramasamy R, Rammohan R, Nisar SP, Rangarajan V, Menon V
Indian J Ophthalmol 2023 Jul;71(7):2687-2693. doi: 10.4103/IJO.IJO_3283_22. PMID: 37417106Free PMC Article
The Management of Chemosis after Blepharoplasty.
Ní Dhubhghaill S, Faris C
Facial Plast Surg 2023 Feb;39(1):53-56. Epub 2022 Oct 25 doi: 10.1055/a-1967-6050. PMID: 36283416
Fedratinib-induced orbital inflammation.
Lee JY, Gallo RA, Vu DM, Anagnostopoulos AG, Rong AJ
Orbit 2022 Jun;41(3):346-349. Epub 2020 Nov 26 doi: 10.1080/01676830.2020.1852263. PMID: 33243070
Orbital cellulitis.
Tsirouki T, Dastiridou AI, Ibánez Flores N, Cerpa JC, Moschos MM, Brazitikos P, Androudi S
Surv Ophthalmol 2018 Jul-Aug;63(4):534-553. Epub 2017 Dec 15 doi: 10.1016/j.survophthal.2017.12.001. PMID: 29248536
Thyroid eye disease.
Scott IU, Siatkowski MR
Semin Ophthalmol 1999 Jun;14(2):52-61. doi: 10.3109/08820539909056064. PMID: 10758212

Prognosis

Antibiotic prophylaxis for corneal abrasion.
Algarni AM, Guyatt GH, Turner A, Alamri S
Cochrane Database Syst Rev 2022 May 27;5(5):CD014617. doi: 10.1002/14651858.CD014617.pub2. PMID: 35622535Free PMC Article
Odontogenic orbital inflammation.
Costan VV, Bogdănici CM, Gheorghe L, Obadă O, Budacu C, Grigoraș C, Andronic DG, Niagu IA
Rom J Ophthalmol 2020 Apr-Jun;64(2):116-121. PMID: 32685776Free PMC Article
Ocular manifestations of pulmonary hypertension.
Lewczuk N, Zdebik A, Bogusławska J, Turno-Kręcicka A, Misiuk-Hojło M
Surv Ophthalmol 2019 Sep-Oct;64(5):694-699. Epub 2019 Mar 6 doi: 10.1016/j.survophthal.2019.02.009. PMID: 30849428
Occult globe rupture: diagnostic and treatment challenge.
Chronopoulos A, Ong JM, Thumann G, Schutz JS
Surv Ophthalmol 2018 Sep-Oct;63(5):694-699. Epub 2018 Apr 9 doi: 10.1016/j.survophthal.2018.04.001. PMID: 29649485
Orbital cellulitis.
Tsirouki T, Dastiridou AI, Ibánez Flores N, Cerpa JC, Moschos MM, Brazitikos P, Androudi S
Surv Ophthalmol 2018 Jul-Aug;63(4):534-553. Epub 2017 Dec 15 doi: 10.1016/j.survophthal.2017.12.001. PMID: 29248536

Clinical prediction guides

Association of Patient Age and the Thyroid Eye Disease-Clinical Activity Score.
North VS, Zhou HW, Tran AQ, Godfrey KJ, Kazim M
Ophthalmic Plast Reconstr Surg 2023 Dec 1;39(6S):S46-S50. Epub 2023 Dec 4 doi: 10.1097/IOP.0000000000002501. PMID: 38054985
Aflibercept-Related Sterile Intraocular Inflammation Outcomes.
Greenberg JP, Belin P, Butler J, Feiler D, Mueller C, Tye A, Friedlander SM, Emerson GG, Ferrone PJ; Aflibercept Sterile Inflammation Research Group
Ophthalmol Retina 2019 Sep;3(9):753-759. Epub 2019 Apr 11 doi: 10.1016/j.oret.2019.04.006. PMID: 31153850
Ocular manifestations of pulmonary hypertension.
Lewczuk N, Zdebik A, Bogusławska J, Turno-Kręcicka A, Misiuk-Hojło M
Surv Ophthalmol 2019 Sep-Oct;64(5):694-699. Epub 2019 Mar 6 doi: 10.1016/j.survophthal.2019.02.009. PMID: 30849428
Pathophysiology of Graves' ophthalmopathy.
Stiebel-Kalish H, Robenshtok E, Gaton DD
Pediatr Endocrinol Rev 2010 Mar;7 Suppl 2:178-81. PMID: 20467359
Complications of blepharoplasty.
Morax S, Touitou V
Orbit 2006 Dec;25(4):303-18. doi: 10.1080/01676830600985841. PMID: 17182405

Recent systematic reviews

Antibiotic prophylaxis for corneal abrasion.
Algarni AM, Guyatt GH, Turner A, Alamri S
Cochrane Database Syst Rev 2022 May 27;5(5):CD014617. doi: 10.1002/14651858.CD014617.pub2. PMID: 35622535Free PMC Article
Diclofenac Versus Dexamethasone Following Strabismus Surgery: A Systematic Review and Meta-Analysis.
Alsaif A, Karam M, Al-Naseem A, Almuhanna A, Aldubaikhi A, Aljebreen M, Alfreihi S
J Ocul Pharmacol Ther 2021 Jul-Aug;37(6):343-353. Epub 2021 Apr 30 doi: 10.1089/jop.2020.0133. PMID: 33944620
An Update on COVID-19 Related Ophthalmic Manifestations.
Jevnikar K, Jaki Mekjavic P, Vidovic Valentincic N, Petrovski G, Globocnik Petrovic M
Ocul Immunol Inflamm 2021 May 19;29(4):684-689. Epub 2021 Apr 7 doi: 10.1080/09273948.2021.1896008. PMID: 33826465
Efficacy, safety and complications of autologous fat grafting to the eyelids and periorbital area: A systematic review and meta-analysis.
Yang F, Ji Z, Peng L, Fu T, Liu K, Dou W, Li J, Li Y, Long Y, Zhang W
PLoS One 2021;16(4):e0248505. Epub 2021 Apr 1 doi: 10.1371/journal.pone.0248505. PMID: 33793573Free PMC Article
Peribulbar versus retrobulbar anaesthesia for cataract surgery.
Alhassan MB, Kyari F, Ejere HO
Cochrane Database Syst Rev 2015 Jul 2;2015(7):CD004083. doi: 10.1002/14651858.CD004083.pub3. PMID: 26133124Free PMC Article

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