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Chemosis

MedGen UID:
124393
Concept ID:
C0271298
Pathologic Function
Synonym: Chemosis of conjunctiva
SNOMED CT: Chemosis of conjunctiva (8148005); Chemosis (8148005)
 
HPO: HP:0012375

Definition

Edema (swelling) of the bulbar conjunctiva. [from HPO]

Conditions with this feature

Heme oxygenase 1 deficiency
MedGen UID:
333882
Concept ID:
C1841651
Disease or Syndrome
Heme oxygenase-1 deficiency (HMOX1D) is a rare autosomal recessive disorder with a complex clinical presentation including direct antibody negative hemolytic anemia, low bilirubin, and hyperinflammation (summary by Chau et al., 2020). Other features may include asplenia and nephritis (Radhakrishnan et al., 2011).

Professional guidelines

PubMed

Ní Dhubhghaill S, Faris C
Facial Plast Surg 2023 Feb;39(1):53-56. Epub 2022 Oct 25 doi: 10.1055/a-1967-6050. PMID: 36283416
Lahmini W, Oumou M, Bourrous M
J Fr Ophtalmol 2022 Feb;45(2):166-172. Epub 2021 Dec 29 doi: 10.1016/j.jfo.2021.09.012. PMID: 34973820
Chronopoulos A, Ong JM, Thumann G, Schutz JS
Surv Ophthalmol 2018 Sep-Oct;63(5):694-699. Epub 2018 Apr 9 doi: 10.1016/j.survophthal.2018.04.001. PMID: 29649485

Recent clinical studies

Etiology

Ní Dhubhghaill S, Faris C
Facial Plast Surg 2023 Feb;39(1):53-56. Epub 2022 Oct 25 doi: 10.1055/a-1967-6050. PMID: 36283416
Mueller A
Handb Exp Pharmacol 2022;268:95-99. doi: 10.1007/164_2021_491. PMID: 34136960
Costan VV, Bogdănici CM, Gheorghe L, Obadă O, Budacu C, Grigoraș C, Andronic DG, Niagu IA
Rom J Ophthalmol 2020 Apr-Jun;64(2):116-121. PMID: 32685776Free PMC Article
Tsirouki T, Dastiridou AI, Ibánez Flores N, Cerpa JC, Moschos MM, Brazitikos P, Androudi S
Surv Ophthalmol 2018 Jul-Aug;63(4):534-553. Epub 2017 Dec 15 doi: 10.1016/j.survophthal.2017.12.001. PMID: 29248536
Morax S, Touitou V
Orbit 2006 Dec;25(4):303-18. doi: 10.1080/01676830600985841. PMID: 17182405

Diagnosis

Yadalla D, Jayagayathri R, Padmanaban K, Ramasamy R, Rammohan R, Nisar SP, Rangarajan V, Menon V
Indian J Ophthalmol 2023 Jul;71(7):2687-2693. doi: 10.4103/IJO.IJO_3283_22. PMID: 37417106Free PMC Article
Mueller A
Handb Exp Pharmacol 2022;268:95-99. doi: 10.1007/164_2021_491. PMID: 34136960
Lee JY, Gallo RA, Vu DM, Anagnostopoulos AG, Rong AJ
Orbit 2022 Jun;41(3):346-349. Epub 2020 Nov 26 doi: 10.1080/01676830.2020.1852263. PMID: 33243070
Costan VV, Bogdănici CM, Gheorghe L, Obadă O, Budacu C, Grigoraș C, Andronic DG, Niagu IA
Rom J Ophthalmol 2020 Apr-Jun;64(2):116-121. PMID: 32685776Free PMC Article
Tsirouki T, Dastiridou AI, Ibánez Flores N, Cerpa JC, Moschos MM, Brazitikos P, Androudi S
Surv Ophthalmol 2018 Jul-Aug;63(4):534-553. Epub 2017 Dec 15 doi: 10.1016/j.survophthal.2017.12.001. PMID: 29248536

Therapy

Yadalla D, Jayagayathri R, Padmanaban K, Ramasamy R, Rammohan R, Nisar SP, Rangarajan V, Menon V
Indian J Ophthalmol 2023 Jul;71(7):2687-2693. doi: 10.4103/IJO.IJO_3283_22. PMID: 37417106Free PMC Article
Ní Dhubhghaill S, Faris C
Facial Plast Surg 2023 Feb;39(1):53-56. Epub 2022 Oct 25 doi: 10.1055/a-1967-6050. PMID: 36283416
Lee JY, Gallo RA, Vu DM, Anagnostopoulos AG, Rong AJ
Orbit 2022 Jun;41(3):346-349. Epub 2020 Nov 26 doi: 10.1080/01676830.2020.1852263. PMID: 33243070
Tsirouki T, Dastiridou AI, Ibánez Flores N, Cerpa JC, Moschos MM, Brazitikos P, Androudi S
Surv Ophthalmol 2018 Jul-Aug;63(4):534-553. Epub 2017 Dec 15 doi: 10.1016/j.survophthal.2017.12.001. PMID: 29248536
Scott IU, Siatkowski MR
Semin Ophthalmol 1999 Jun;14(2):52-61. doi: 10.3109/08820539909056064. PMID: 10758212

Prognosis

Algarni AM, Guyatt GH, Turner A, Alamri S
Cochrane Database Syst Rev 2022 May 27;5(5):CD014617. doi: 10.1002/14651858.CD014617.pub2. PMID: 35622535Free PMC Article
Costan VV, Bogdănici CM, Gheorghe L, Obadă O, Budacu C, Grigoraș C, Andronic DG, Niagu IA
Rom J Ophthalmol 2020 Apr-Jun;64(2):116-121. PMID: 32685776Free PMC Article
Lewczuk N, Zdebik A, Bogusławska J, Turno-Kręcicka A, Misiuk-Hojło M
Surv Ophthalmol 2019 Sep-Oct;64(5):694-699. Epub 2019 Mar 6 doi: 10.1016/j.survophthal.2019.02.009. PMID: 30849428
Chronopoulos A, Ong JM, Thumann G, Schutz JS
Surv Ophthalmol 2018 Sep-Oct;63(5):694-699. Epub 2018 Apr 9 doi: 10.1016/j.survophthal.2018.04.001. PMID: 29649485
Tsirouki T, Dastiridou AI, Ibánez Flores N, Cerpa JC, Moschos MM, Brazitikos P, Androudi S
Surv Ophthalmol 2018 Jul-Aug;63(4):534-553. Epub 2017 Dec 15 doi: 10.1016/j.survophthal.2017.12.001. PMID: 29248536

Clinical prediction guides

North VS, Zhou HW, Tran AQ, Godfrey KJ, Kazim M
Ophthalmic Plast Reconstr Surg 2023 Dec 1;39(6S):S46-S50. Epub 2023 Dec 4 doi: 10.1097/IOP.0000000000002501. PMID: 38054985
Lewczuk N, Zdebik A, Bogusławska J, Turno-Kręcicka A, Misiuk-Hojło M
Surv Ophthalmol 2019 Sep-Oct;64(5):694-699. Epub 2019 Mar 6 doi: 10.1016/j.survophthal.2019.02.009. PMID: 30849428
Alhassan MB, Kyari F, Ejere HO
Cochrane Database Syst Rev 2015 Jul 2;2015(7):CD004083. doi: 10.1002/14651858.CD004083.pub3. PMID: 26133124Free PMC Article
Stiebel-Kalish H, Robenshtok E, Gaton DD
Pediatr Endocrinol Rev 2010 Mar;7 Suppl 2:178-81. PMID: 20467359
Morax S, Touitou V
Orbit 2006 Dec;25(4):303-18. doi: 10.1080/01676830600985841. PMID: 17182405

Recent systematic reviews

Algarni AM, Guyatt GH, Turner A, Alamri S
Cochrane Database Syst Rev 2022 May 27;5(5):CD014617. doi: 10.1002/14651858.CD014617.pub2. PMID: 35622535Free PMC Article
Alsaif A, Karam M, Al-Naseem A, Almuhanna A, Aldubaikhi A, Aljebreen M, Alfreihi S
J Ocul Pharmacol Ther 2021 Jul-Aug;37(6):343-353. Epub 2021 Apr 30 doi: 10.1089/jop.2020.0133. PMID: 33944620
Jevnikar K, Jaki Mekjavic P, Vidovic Valentincic N, Petrovski G, Globocnik Petrovic M
Ocul Immunol Inflamm 2021 May 19;29(4):684-689. Epub 2021 Apr 7 doi: 10.1080/09273948.2021.1896008. PMID: 33826465
Yang F, Ji Z, Peng L, Fu T, Liu K, Dou W, Li J, Li Y, Long Y, Zhang W
PLoS One 2021;16(4):e0248505. Epub 2021 Apr 1 doi: 10.1371/journal.pone.0248505. PMID: 33793573Free PMC Article
Alhassan MB, Kyari F, Ejere HO
Cochrane Database Syst Rev 2015 Jul 2;2015(7):CD004083. doi: 10.1002/14651858.CD004083.pub3. PMID: 26133124Free PMC Article

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