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Hurthle cell metaplasia of thyroid gland

MedGen UID:
124411
•Concept ID:
C0271819
•
Disease or Syndrome
Synonym: Hurthle Cell Metaplasia of Thyroid Gland
SNOMED CT: Hurthle cell metaplasia of thyroid gland (19608008)

Definition

A morphologic finding indicating transformation of follicular cells to large cells with abundant eosinophilic and granular cytoplasm (Hurthle cells) in the thyroid gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHurthle cell metaplasia of thyroid gland

Recent clinical studies

Etiology

Thyroid cancer associated with Hashimoto thyroiditis: similarities and differences in an endemic area.
Hussein O, Abdelwahab K, Hamdy O, Awny S, Megahed NA, Hafez MT, Elalfi AF, Abdelaziz M, Gaballah K, Abdelkhalek M
J Egypt Natl Canc Inst 2020 Jan 17;32(1):7. doi: 10.1186/s43046-020-0017-9. PMID: 32372240
Malignancy risk for solitary and multiple nodules in Hürthle cell-predominant thyroid fine-needle aspirations: A multi-institutional study.
Wong KS, Jo VY, Lowe AC, Faquin WC, Renshaw AA, Shah AA, Roh MH, Stelow EB, Krane JF
Cancer Cytopathol 2020 Jan;128(1):68-75. Epub 2019 Nov 21 doi: 10.1002/cncy.22213. PMID: 31751003Free PMC Article
Hürthle cell metaplasia on fine-needle aspiration biopsy is not by itself an indication for thyroid surgery.
Hudak K, Mazeh H, Sippel RS, Chen H
Am J Surg 2012 Mar;203(3):287-90; discussion 290-1. Epub 2012 Jan 20 doi: 10.1016/j.amjsurg.2011.09.019. PMID: 22264740
Fine-needle aspiration biopsy of Hurthle cell lesions of the thyroid gland: A cytomorphologic study of 139 cases with statistical analysis.
Elliott DD, Pitman MB, Bloom L, Faquin WC
Cancer 2006 Apr 25;108(2):102-9. doi: 10.1002/cncr.21716. PMID: 16453320

Diagnosis

Top Ten Oncocytic Head and Neck Lesions to Contemplate.
Bullock MJ, Jiang XS
Head Neck Pathol 2023 Mar;17(1):53-65. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01520-y. PMID: 36928735Free PMC Article
Thyroid cancer associated with Hashimoto thyroiditis: similarities and differences in an endemic area.
Hussein O, Abdelwahab K, Hamdy O, Awny S, Megahed NA, Hafez MT, Elalfi AF, Abdelaziz M, Gaballah K, Abdelkhalek M
J Egypt Natl Canc Inst 2020 Jan 17;32(1):7. doi: 10.1186/s43046-020-0017-9. PMID: 32372240
Malignancy risk for solitary and multiple nodules in Hürthle cell-predominant thyroid fine-needle aspirations: A multi-institutional study.
Wong KS, Jo VY, Lowe AC, Faquin WC, Renshaw AA, Shah AA, Roh MH, Stelow EB, Krane JF
Cancer Cytopathol 2020 Jan;128(1):68-75. Epub 2019 Nov 21 doi: 10.1002/cncy.22213. PMID: 31751003Free PMC Article
Differentiated thyroid cancers: a comprehensive review of novel targeted therapies.
Kojic KL, Kojic SL, Wiseman SM
Expert Rev Anticancer Ther 2012 Mar;12(3):345-57. doi: 10.1586/era.12.8. PMID: 22369326
The thyroid Hürthle (oncocytic) cell and its associated pathologic conditions: a surgical pathology and cytopathology review.
Montone KT, Baloch ZW, LiVolsi VA
Arch Pathol Lab Med 2008 Aug;132(8):1241-50. doi: 10.5858/2008-132-1241-TTHOCA. PMID: 18684023

Therapy

Differentiated thyroid cancers: a comprehensive review of novel targeted therapies.
Kojic KL, Kojic SL, Wiseman SM
Expert Rev Anticancer Ther 2012 Mar;12(3):345-57. doi: 10.1586/era.12.8. PMID: 22369326

Prognosis

Thyroid cancer associated with Hashimoto thyroiditis: similarities and differences in an endemic area.
Hussein O, Abdelwahab K, Hamdy O, Awny S, Megahed NA, Hafez MT, Elalfi AF, Abdelaziz M, Gaballah K, Abdelkhalek M
J Egypt Natl Canc Inst 2020 Jan 17;32(1):7. doi: 10.1186/s43046-020-0017-9. PMID: 32372240
Cytomorphologic Spectrum of Hurthle Cell Lesions of Thyroid: A Study of 54 Cases.
Anila KR, Nayak N, George PS, Jayasree K
Gulf J Oncolog 2018 Jan;1(26):6-10. PMID: 29607815
Differentiated thyroid cancers: a comprehensive review of novel targeted therapies.
Kojic KL, Kojic SL, Wiseman SM
Expert Rev Anticancer Ther 2012 Mar;12(3):345-57. doi: 10.1586/era.12.8. PMID: 22369326
Fine-needle aspiration biopsy of Hurthle cell lesions of the thyroid gland: A cytomorphologic study of 139 cases with statistical analysis.
Elliott DD, Pitman MB, Bloom L, Faquin WC
Cancer 2006 Apr 25;108(2):102-9. doi: 10.1002/cncr.21716. PMID: 16453320

Clinical prediction guides

Thyroid cancer associated with Hashimoto thyroiditis: similarities and differences in an endemic area.
Hussein O, Abdelwahab K, Hamdy O, Awny S, Megahed NA, Hafez MT, Elalfi AF, Abdelaziz M, Gaballah K, Abdelkhalek M
J Egypt Natl Canc Inst 2020 Jan 17;32(1):7. doi: 10.1186/s43046-020-0017-9. PMID: 32372240
Cytomorphologic Spectrum of Hurthle Cell Lesions of Thyroid: A Study of 54 Cases.
Anila KR, Nayak N, George PS, Jayasree K
Gulf J Oncolog 2018 Jan;1(26):6-10. PMID: 29607815
The thyroid Hürthle (oncocytic) cell and its associated pathologic conditions: a surgical pathology and cytopathology review.
Montone KT, Baloch ZW, LiVolsi VA
Arch Pathol Lab Med 2008 Aug;132(8):1241-50. doi: 10.5858/2008-132-1241-TTHOCA. PMID: 18684023
Fine-needle aspiration biopsy of Hurthle cell lesions of the thyroid gland: A cytomorphologic study of 139 cases with statistical analysis.
Elliott DD, Pitman MB, Bloom L, Faquin WC
Cancer 2006 Apr 25;108(2):102-9. doi: 10.1002/cncr.21716. PMID: 16453320
Mitochondria-rich normal, metaplastic, and neoplastic cells show overexpression of the epitope H recognized by the monoclonal antibody H.
Arvanitis DL, Arvanitis LD, Panourias IG, Kitsoulis P, Kanavaros P
Pathol Res Pract 2005;201(4):319-24. doi: 10.1016/j.prp.2005.01.007. PMID: 15991839

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