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Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive

MedGen UID:
124511
•Concept ID:
C0278787
•
Neoplastic Process
Synonyms: Recurrent Chronic Myelogenous Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR::ABL1 Positive; Relapsed CGL; Relapsed Chronic Myelogenous Leukemia; Relapsed CML

Definition

The reemergence of chronic myelogenous leukemia after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive

Professional guidelines

PubMed

European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia.
Cross NCP, Ernst T, Branford S, Cayuela JM, Deininger M, Fabarius A, Kim DDH, Machova Polakova K, Radich JP, Hehlmann R, Hochhaus A, Apperley JF, Soverini S
Leukemia 2023 Nov;37(11):2150-2167. Epub 2023 Oct 4 doi: 10.1038/s41375-023-02048-y. PMID: 37794101Free PMC Article
Blast phase myeloproliferative neoplasm: contemporary review and 2024 treatment algorithm.
Tefferi A, Alkhateeb H, Gangat N
Blood Cancer J 2023 Jul 18;13(1):108. doi: 10.1038/s41408-023-00878-8. PMID: 37460550Free PMC Article
Rationale and motivating factors for treatment-free remission in chronic myeloid leukemia.
Caldemeyer L, Akard LP
Leuk Lymphoma 2016 Dec;57(12):2739-2751. Epub 2016 Aug 10 doi: 10.1080/10428194.2016.1198959. PMID: 27562641

Recent clinical studies

Etiology

Blast phase myeloproliferative neoplasm: contemporary review and 2024 treatment algorithm.
Tefferi A, Alkhateeb H, Gangat N
Blood Cancer J 2023 Jul 18;13(1):108. doi: 10.1038/s41408-023-00878-8. PMID: 37460550Free PMC Article
CD36 Drives Metastasis and Relapse in Acute Myeloid Leukemia.
Farge T, Nakhle J, Lagarde D, Cognet G, Polley N, Castellano R, Nicolau ML, Bosc C, Sabatier M, Sahal A, Saland E, Jeanson Y, Guiraud N, Boet E, Bergoglio C, Gotanègre M, Mouchel PL, Stuani L, Larrue C, Sallese M, De Mas V, Moro C, Dray C, Collette Y, Raymond-Letron I, Ader I, Récher C, Sarry JE, Cabon F, Vergez F, Carrière A
Cancer Res 2023 Sep 1;83(17):2824-2838. doi: 10.1158/0008-5472.CAN-22-3682. PMID: 37327406Free PMC Article
Autoimmune Hemolytic Anemia in Chronic Myeloid Leukemia.
Hamamyh T, Yassin MA
Pharmacology 2020;105(11-12):630-638. Epub 2020 Jun 2 doi: 10.1159/000507295. PMID: 32485715Free PMC Article
Efficacy of Ruxolitinib in Patients With Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia.
Dao KT, Gotlib J, Deininger MMN, Oh ST, Cortes JE, Collins RH Jr, Winton EF, Parker DR, Lee H, Reister A, Schultz, Savage S, Stevens, Brockett C, Subbiah N, Press RD, Raess PW, Cascio M, Dunlap J, Chen Y, Degnin C, Maxson JE, Tognon CE, Macey T, Druker BJ, Tyner JW
J Clin Oncol 2020 Apr 1;38(10):1006-1018. Epub 2019 Dec 27 doi: 10.1200/JCO.19.00895. PMID: 31880950Free PMC Article
Chronic myelogenous leukaemia.
Lee SJ
Br J Haematol 2000 Dec;111(4):993-1009. doi: 10.1046/j.1365-2141.2000.02216.x. PMID: 11167734

Diagnosis

European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia.
Cross NCP, Ernst T, Branford S, Cayuela JM, Deininger M, Fabarius A, Kim DDH, Machova Polakova K, Radich JP, Hehlmann R, Hochhaus A, Apperley JF, Soverini S
Leukemia 2023 Nov;37(11):2150-2167. Epub 2023 Oct 4 doi: 10.1038/s41375-023-02048-y. PMID: 37794101Free PMC Article
Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring.
Jabbour E, Kantarjian H
Am J Hematol 2022 Sep;97(9):1236-1256. Epub 2022 Jul 6 doi: 10.1002/ajh.26642. PMID: 35751859
The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML.
Vetrie D, Helgason GV, Copland M
Nat Rev Cancer 2020 Mar;20(3):158-173. Epub 2020 Jan 6 doi: 10.1038/s41568-019-0230-9. PMID: 31907378
Efficacy of Ruxolitinib in Patients With Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia.
Dao KT, Gotlib J, Deininger MMN, Oh ST, Cortes JE, Collins RH Jr, Winton EF, Parker DR, Lee H, Reister A, Schultz, Savage S, Stevens, Brockett C, Subbiah N, Press RD, Raess PW, Cascio M, Dunlap J, Chen Y, Degnin C, Maxson JE, Tognon CE, Macey T, Druker BJ, Tyner JW
J Clin Oncol 2020 Apr 1;38(10):1006-1018. Epub 2019 Dec 27 doi: 10.1200/JCO.19.00895. PMID: 31880950Free PMC Article
T-cell acute lymphoblastic leukemia.
Raetz EA, Teachey DT
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):580-588. doi: 10.1182/asheducation-2016.1.580. PMID: 27913532Free PMC Article

Therapy

Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring.
Jabbour E, Kantarjian H
Am J Hematol 2022 Sep;97(9):1236-1256. Epub 2022 Jul 6 doi: 10.1002/ajh.26642. PMID: 35751859
Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: a focused review.
Patnaik MM, Lasho T
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):460-464. doi: 10.1182/hematology.2020000163. PMID: 33275673Free PMC Article
Declaration of Bcr-Abl1 independence.
Zhao H, Deininger MW
Leukemia 2020 Nov;34(11):2827-2836. Epub 2020 Sep 10 doi: 10.1038/s41375-020-01037-9. PMID: 32908250
The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.
Wylie AA, Schoepfer J, Jahnke W, Cowan-Jacob SW, Loo A, Furet P, Marzinzik AL, Pelle X, Donovan J, Zhu W, Buonamici S, Hassan AQ, Lombardo F, Iyer V, Palmer M, Berellini G, Dodd S, Thohan S, Bitter H, Branford S, Ross DM, Hughes TP, Petruzzelli L, Vanasse KG, Warmuth M, Hofmann F, Keen NJ, Sellers WR
Nature 2017 Mar 30;543(7647):733-737. Epub 2017 Mar 22 doi: 10.1038/nature21702. PMID: 28329763
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.
Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, Lydon NB, Kantarjian H, Capdeville R, Ohno-Jones S, Sawyers CL
N Engl J Med 2001 Apr 5;344(14):1031-7. doi: 10.1056/NEJM200104053441401. PMID: 11287972

Prognosis

European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia.
Cross NCP, Ernst T, Branford S, Cayuela JM, Deininger M, Fabarius A, Kim DDH, Machova Polakova K, Radich JP, Hehlmann R, Hochhaus A, Apperley JF, Soverini S
Leukemia 2023 Nov;37(11):2150-2167. Epub 2023 Oct 4 doi: 10.1038/s41375-023-02048-y. PMID: 37794101Free PMC Article
CD36 Drives Metastasis and Relapse in Acute Myeloid Leukemia.
Farge T, Nakhle J, Lagarde D, Cognet G, Polley N, Castellano R, Nicolau ML, Bosc C, Sabatier M, Sahal A, Saland E, Jeanson Y, Guiraud N, Boet E, Bergoglio C, Gotanègre M, Mouchel PL, Stuani L, Larrue C, Sallese M, De Mas V, Moro C, Dray C, Collette Y, Raymond-Letron I, Ader I, Récher C, Sarry JE, Cabon F, Vergez F, Carrière A
Cancer Res 2023 Sep 1;83(17):2824-2838. doi: 10.1158/0008-5472.CAN-22-3682. PMID: 37327406Free PMC Article
Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: a focused review.
Patnaik MM, Lasho T
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):460-464. doi: 10.1182/hematology.2020000163. PMID: 33275673Free PMC Article
Efficacy of Ruxolitinib in Patients With Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia.
Dao KT, Gotlib J, Deininger MMN, Oh ST, Cortes JE, Collins RH Jr, Winton EF, Parker DR, Lee H, Reister A, Schultz, Savage S, Stevens, Brockett C, Subbiah N, Press RD, Raess PW, Cascio M, Dunlap J, Chen Y, Degnin C, Maxson JE, Tognon CE, Macey T, Druker BJ, Tyner JW
J Clin Oncol 2020 Apr 1;38(10):1006-1018. Epub 2019 Dec 27 doi: 10.1200/JCO.19.00895. PMID: 31880950Free PMC Article
Recurrent Cytogenetic Abnormalities in Myeloproliferative Neoplasms and Chronic Myeloid Leukemia.
Swansbury J
Methods Mol Biol 2017;1541:247-256. doi: 10.1007/978-1-4939-6703-2_20. PMID: 27910028

Clinical prediction guides

The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML.
Vetrie D, Helgason GV, Copland M
Nat Rev Cancer 2020 Mar;20(3):158-173. Epub 2020 Jan 6 doi: 10.1038/s41568-019-0230-9. PMID: 31907378
Efficacy of Ruxolitinib in Patients With Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia.
Dao KT, Gotlib J, Deininger MMN, Oh ST, Cortes JE, Collins RH Jr, Winton EF, Parker DR, Lee H, Reister A, Schultz, Savage S, Stevens, Brockett C, Subbiah N, Press RD, Raess PW, Cascio M, Dunlap J, Chen Y, Degnin C, Maxson JE, Tognon CE, Macey T, Druker BJ, Tyner JW
J Clin Oncol 2020 Apr 1;38(10):1006-1018. Epub 2019 Dec 27 doi: 10.1200/JCO.19.00895. PMID: 31880950Free PMC Article
The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.
Wylie AA, Schoepfer J, Jahnke W, Cowan-Jacob SW, Loo A, Furet P, Marzinzik AL, Pelle X, Donovan J, Zhu W, Buonamici S, Hassan AQ, Lombardo F, Iyer V, Palmer M, Berellini G, Dodd S, Thohan S, Bitter H, Branford S, Ross DM, Hughes TP, Petruzzelli L, Vanasse KG, Warmuth M, Hofmann F, Keen NJ, Sellers WR
Nature 2017 Mar 30;543(7647):733-737. Epub 2017 Mar 22 doi: 10.1038/nature21702. PMID: 28329763
T-cell acute lymphoblastic leukemia.
Raetz EA, Teachey DT
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):580-588. doi: 10.1182/asheducation-2016.1.580. PMID: 27913532Free PMC Article
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.
Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, Lydon NB, Kantarjian H, Capdeville R, Ohno-Jones S, Sawyers CL
N Engl J Med 2001 Apr 5;344(14):1031-7. doi: 10.1056/NEJM200104053441401. PMID: 11287972

Recent systematic reviews

A Systematic Review on Second Treatment-Free Remission (TFR) Attempt in Chronic Myeloid Leukemia (CML): Can it be Applied in Clinical Practice?
Çiftçiler R, Akın MG, Erat Z, Eşkazan AE
Clin Lymphoma Myeloma Leuk 2023 Jan;23(1):8-14. Epub 2022 Oct 5 doi: 10.1016/j.clml.2022.09.004. PMID: 36344420
Avascular necrosis in patients with chronic myeloid leukemia: A systematic review.
Yassin M, Al-Mashdali AF, Al-Dubai HN
Acta Biomed 2022 Mar 14;93(1):e2022017. doi: 10.23750/abm.v93i1.12270. PMID: 35315390Free PMC Article
Efficacy of Allogeneic Hematopoietic Cell Transplantation in Patients With Chronic Phase CML Resistant or Intolerant to Tyrosine Kinase Inhibitors.
Yassine F, Reljic T, Moustafa MA, Iqbal M, Murthy HS, Kumar A, Kharfan-Dabaja MA
Hematol Oncol Stem Cell Ther 2022 Mar 1;15(1):36-43. doi: 10.1016/j.hemonc.2021.02.003. PMID: 33789163
Second-Generation Tyrosine Kinase Inhibitor Discontinuation in Chronic Myeloid Leukemia Patients with Stable Deep Molecular Response: A Systematic Review and a Meta-Analysis.
Di Q, Deng H, Zhao Y, Li BY, Qin L
Comput Math Methods Med 2021;2021:3110622. Epub 2021 Dec 16 doi: 10.1155/2021/3110622. PMID: 34956393Free PMC Article
Imatinib discontinuation in chronic myeloid leukaemia patients with undetectable BCR-ABL transcript level: A systematic review and a meta-analysis.
Campiotti L, Suter MB, Guasti L, Piazza R, Gambacorti-Passerini C, Grandi AM, Squizzato A
Eur J Cancer 2017 May;77:48-56. Epub 2017 Mar 30 doi: 10.1016/j.ejca.2017.02.028. PMID: 28365527

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