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Bone marrow cancer

MedGen UID:
438070
•Concept ID:
C2703042
•
Neoplastic Process
Synonyms: bone marrow cancer; cancer of bone marrow; Malignant Bone Marrow Neoplasm; malignant bone marrow neoplasm; Malignant Bone Marrow Tumor; malignant bone marrow tumor; malignant neoplasm of bone marrow
 
Monarch Initiative: MONDO:0021138

Definition

Malignant neoplasms that either originate from the bone marrow (e.g. myeloid leukemias) or involve the bone marrow as secondary-metastatic tumors (e.g. metastatic carcinomas to the bone marrow). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone marrow cancer

Professional guidelines

PubMed

Biomimetic nanoparticles for siRNA delivery in the treatment of leukaemia.
Guo J, Cahill MR, McKenna SL, O'Driscoll CM
Biotechnol Adv 2014 Dec;32(8):1396-409. Epub 2014 Sep 16 doi: 10.1016/j.biotechadv.2014.08.007. PMID: 25218571
Colony-stimulating factors for prevention and treatment of infectious complications in patients with acute myelogenous leukemia.
Gurion R, Belnik-Plitman Y, Gafter-Gvili A, Paul M, Vidal L, Ben-Bassat I, Shpilberg O, Raanani P
Cochrane Database Syst Rev 2012 Jun 13;2012(6):CD008238. doi: 10.1002/14651858.CD008238.pub3. PMID: 22696376Free PMC Article
Colony-stimulating factors for prevention and treatment of infectious complications in patients with acute myelogenous leukemia.
Gurion R, Belnik-Plitman Y, Gafter-Gvili A, Paul M, Vidal L, Ben-Bassat I, Shpilberg O, Raanani P
Cochrane Database Syst Rev 2011 Sep 7;(9):CD008238. doi: 10.1002/14651858.CD008238.pub2. PMID: 21901718

Recent clinical studies

Etiology

Cellular senescence in cancers: relationship between bone marrow cancer and cellular senescence.
Sarikhani M, Firouzamandi M
Mol Biol Rep 2022 May;49(5):4003-4012. Epub 2022 Apr 21 doi: 10.1007/s11033-021-07101-6. PMID: 35449316
Leveraging RSF and PET images for prognosis of multiple myeloma at diagnosis.
Morvan L, Carlier T, Jamet B, Bailly C, Bodet-Milin C, Moreau P, Kraeber-Bodéré F, Mateus D
Int J Comput Assist Radiol Surg 2020 Jan;15(1):129-139. Epub 2019 Jun 29 doi: 10.1007/s11548-019-02015-y. PMID: 31256359
A Subpopulation of Stromal Cells Controls Cancer Cell Homing to the Bone Marrow.
Rossnagl S, Ghura H, Groth C, Altrock E, Jakob F, Schott S, Wimberger P, Link T, Kuhlmann JD, Stenzl A, Hennenlotter J, Todenhöfer T, Rojewski M, Bieback K, Nakchbandi IA
Cancer Res 2018 Jan 1;78(1):129-142. Epub 2017 Oct 24 doi: 10.1158/0008-5472.CAN-16-3507. PMID: 29066511
Prophylaxis and treatment of respiratory syncytial virus in adult immunocompromised patients.
Hynicka LM, Ensor CR
Ann Pharmacother 2012 Apr;46(4):558-66. Epub 2012 Mar 6 doi: 10.1345/aph.1Q553. PMID: 22395247
Hematological and toxicological evaluation of formaldehyde as a potential cause of human leukemia.
Goldstein BD
Hum Exp Toxicol 2011 Jul;30(7):725-35. Epub 2010 Aug 20 doi: 10.1177/0960327110381682. PMID: 20729258

Diagnosis

Predicting outcomes and monitoring disease in patients with multiple myeloma.
Kim S, Berenson JR
Clin Adv Hematol Oncol 2023 Sep;21(9):484-493. PMID: 37647495
Association of RANK and RANKL gene polymorphism with survival and calcium levels in multiple myeloma.
Łacina P, Butrym A, Humiński M, Dratwa M, Frontkiewicz D, Mazur G, Bogunia-Kubik K
Mol Carcinog 2021 Feb;60(2):106-112. Epub 2020 Dec 7 doi: 10.1002/mc.23272. PMID: 33283899
High-risk smoldering myeloma versus early detection of multiple myeloma: Current models, goals of therapy, and clinical implications.
Kunacheewa C, Manasanch EE
Best Pract Res Clin Haematol 2020 Mar;33(1):101152. Epub 2020 Jan 25 doi: 10.1016/j.beha.2020.101152. PMID: 32139017Free PMC Article
Leveraging RSF and PET images for prognosis of multiple myeloma at diagnosis.
Morvan L, Carlier T, Jamet B, Bailly C, Bodet-Milin C, Moreau P, Kraeber-Bodéré F, Mateus D
Int J Comput Assist Radiol Surg 2020 Jan;15(1):129-139. Epub 2019 Jun 29 doi: 10.1007/s11548-019-02015-y. PMID: 31256359
Readmissions After Surgical Resection of Metastatic Tumors of the Spine at a Single Institution.
Abu-Bonsrah N, Goodwin CR, De la Garza-Ramos R, Sankey EW, Liu A, Kosztowski T, Elder BD, Bettegowda C, Bydon A, Witham TF, Wolinsky JP, Gokaslan ZL, Sciubba DM
World Neurosurg 2017 May;101:695-701.e1. Epub 2017 Feb 22 doi: 10.1016/j.wneu.2017.02.065. PMID: 28254537

Therapy

Metabolic Disorders in Multiple Myeloma.
Gavriatopoulou M, Paschou SA, Ntanasis-Stathopoulos I, Dimopoulos MA
Int J Mol Sci 2021 Oct 22;22(21) doi: 10.3390/ijms222111430. PMID: 34768861Free PMC Article
Proteasome inhibition in multiple myeloma: lessons for other cancers.
Saavedra-García P, Martini F, Auner HW
Am J Physiol Cell Physiol 2020 Mar 1;318(3):C451-C462. Epub 2019 Dec 25 doi: 10.1152/ajpcell.00286.2019. PMID: 31875696
Biomimetic nanoparticles for siRNA delivery in the treatment of leukaemia.
Guo J, Cahill MR, McKenna SL, O'Driscoll CM
Biotechnol Adv 2014 Dec;32(8):1396-409. Epub 2014 Sep 16 doi: 10.1016/j.biotechadv.2014.08.007. PMID: 25218571
Hematological and toxicological evaluation of formaldehyde as a potential cause of human leukemia.
Goldstein BD
Hum Exp Toxicol 2011 Jul;30(7):725-35. Epub 2010 Aug 20 doi: 10.1177/0960327110381682. PMID: 20729258
Thalidomide in multiple myeloma.
García-Sanz R
Expert Opin Pharmacother 2006 Feb;7(2):195-213. doi: 10.1517/14656566.7.2.195. PMID: 16433584

Prognosis

Predicting outcomes and monitoring disease in patients with multiple myeloma.
Kim S, Berenson JR
Clin Adv Hematol Oncol 2023 Sep;21(9):484-493. PMID: 37647495
ADRB3 induces mobilization and inhibits differentiation of both breast cancer cells and myeloid-derived suppressor cells.
Zhou Z, Zhan J, Luo Q, Hou X, Wang S, Xiao D, Xie Z, Liang H, Lin S, Zheng M
Cell Death Dis 2022 Feb 10;13(2):141. doi: 10.1038/s41419-022-04603-4. PMID: 35145073Free PMC Article
Metabolic Disorders in Multiple Myeloma.
Gavriatopoulou M, Paschou SA, Ntanasis-Stathopoulos I, Dimopoulos MA
Int J Mol Sci 2021 Oct 22;22(21) doi: 10.3390/ijms222111430. PMID: 34768861Free PMC Article
Leveraging RSF and PET images for prognosis of multiple myeloma at diagnosis.
Morvan L, Carlier T, Jamet B, Bailly C, Bodet-Milin C, Moreau P, Kraeber-Bodéré F, Mateus D
Int J Comput Assist Radiol Surg 2020 Jan;15(1):129-139. Epub 2019 Jun 29 doi: 10.1007/s11548-019-02015-y. PMID: 31256359
Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics.
McAleer CW, Long CJ, Elbrecht D, Sasserath T, Bridges LR, Rumsey JW, Martin C, Schnepper M, Wang Y, Schuler F, Roth AB, Funk C, Shuler ML, Hickman JJ
Sci Transl Med 2019 Jun 19;11(497) doi: 10.1126/scitranslmed.aav1386. PMID: 31217335

Clinical prediction guides

Predicting outcomes and monitoring disease in patients with multiple myeloma.
Kim S, Berenson JR
Clin Adv Hematol Oncol 2023 Sep;21(9):484-493. PMID: 37647495
High-risk smoldering myeloma versus early detection of multiple myeloma: Current models, goals of therapy, and clinical implications.
Kunacheewa C, Manasanch EE
Best Pract Res Clin Haematol 2020 Mar;33(1):101152. Epub 2020 Jan 25 doi: 10.1016/j.beha.2020.101152. PMID: 32139017Free PMC Article
Leveraging RSF and PET images for prognosis of multiple myeloma at diagnosis.
Morvan L, Carlier T, Jamet B, Bailly C, Bodet-Milin C, Moreau P, Kraeber-Bodéré F, Mateus D
Int J Comput Assist Radiol Surg 2020 Jan;15(1):129-139. Epub 2019 Jun 29 doi: 10.1007/s11548-019-02015-y. PMID: 31256359
Exploration of quinolone and quinoline derivatives as potential anticancer agents.
Iqbal J, Ejaz SA, Khan I, Ausekle E, Miliutina M, Langer P
Daru 2019 Dec;27(2):613-626. Epub 2019 Aug 13 doi: 10.1007/s40199-019-00290-3. PMID: 31410781Free PMC Article
Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics.
McAleer CW, Long CJ, Elbrecht D, Sasserath T, Bridges LR, Rumsey JW, Martin C, Schnepper M, Wang Y, Schuler F, Roth AB, Funk C, Shuler ML, Hickman JJ
Sci Transl Med 2019 Jun 19;11(497) doi: 10.1126/scitranslmed.aav1386. PMID: 31217335

Recent systematic reviews

A systematic review of recent trends in research on therapeutically significant L-asparaginase and acute lymphoblastic leukemia.
Suresh SA, Ethiraj S, Rajnish KN
Mol Biol Rep 2022 Dec;49(12):11281-11287. Epub 2022 Jul 10 doi: 10.1007/s11033-022-07688-4. PMID: 35816224
Colony-stimulating factors for prevention and treatment of infectious complications in patients with acute myelogenous leukemia.
Gurion R, Belnik-Plitman Y, Gafter-Gvili A, Paul M, Vidal L, Ben-Bassat I, Shpilberg O, Raanani P
Cochrane Database Syst Rev 2012 Jun 13;2012(6):CD008238. doi: 10.1002/14651858.CD008238.pub3. PMID: 22696376Free PMC Article
Colony-stimulating factors for prevention and treatment of infectious complications in patients with acute myelogenous leukemia.
Gurion R, Belnik-Plitman Y, Gafter-Gvili A, Paul M, Vidal L, Ben-Bassat I, Shpilberg O, Raanani P
Cochrane Database Syst Rev 2011 Sep 7;(9):CD008238. doi: 10.1002/14651858.CD008238.pub2. PMID: 21901718

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