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Bone marrow disorder

MedGen UID:: 2311
•Concept ID:: C0005956
•: Disease or Syndrome

Synonyms:	Bone Marrow Disease; Bone Marrow Diseases; Disease, Bone Marrow; Diseases, Bone Marrow; Marrow Disease, Bone; Marrow Diseases, Bone
SNOMED CT:	Bone marrow disorder (127035006)

Definition

Any disease of the bone marrow. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBone marrow disorder

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Hematopoietic and Lymphoid System Disorder
        Hematologic disorder
        Bone marrow disorder
        Bone marrow failure syndrome
        Aplastic anemia
        Aplastic anemia due to drugs
        Aplastic anemia due to infection
        Aplastic anemia due to radiation
        Hypoplastic anemia - familial
        Idiopathic aplastic anemia
        Non-Severe Aplastic Anemia
        Recurrent Aplastic Anemia
        Severe Aplastic Anemia
        Very Severe Aplastic Anemia
        Inherited bone marrow failure syndrome
        Diamond-Blackfan anemia
        Dyskeratosis congenita
        Fanconi anemia
        Shwachman syndrome
        Bone marrow neoplasm
        Acquired polycythemia vera
        Polycythemia Vera, Polycythemic Phase
        Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase
        Bone marrow cancer
        Erythroid neoplasm
        Megakaryocytic Neoplasm
        Metastatic Malignant Neoplasm in the Bone Marrow
        Myelodysplastic syndrome
        Myelodysplastic/myeloproliferative neoplasm
        Myeloid leukemia
        Myeloproliferative neoplasm
        Therapy related acute myeloid leukemia and myelodysplastic syndrome
        Bone Marrow Suppression
        Gelatinous Bone Marrow Transformation
        Myelofibrosis
        Myelofibrosis due to another disorder
        Myelofibrosis Transformation in Essential Thrombocythemia
        Primary myelofibrosis
        Cellular phase chronic idiopathic myelofibrosis
        Overt Primary Myelofibrosis
        Recurrent Primary Myelofibrosis
        Refractory Primary Myelofibrosis
        Recurrent Myelofibrosis
        Refractory Myelofibrosis
        Myeloproliferative disorder
        Acute myeloid leukemia, M6 type
        Adult Acute Erythroid Leukemia
        Childhood Acute Erythroid Leukemia
        Erythroleukemia
        Erythroleukemia, familial, susceptibility to
        Pure Erythroid Leukemia
        Recurrent Acute Erythroid Leukemia
        Chronic myelogenous leukemia, BCR-ABL1 positive
        Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
        Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
        Leukemia, myeloid, accelerated-phase
        Chronic neutrophilic leukemia
        Leukemoid reaction
        Leukemoid reaction of the newborn
        Myelophthisic anemia
        Thrombocytosis
        Essential thrombocythemia
        Familial thrombocytosis
        Transient myeloproliferative syndrome
        Pancytopenia
        Aplastic bone marrow
        Pancytopenia caused by medication

Professional guidelines

PubMed

Multiple myeloma: 2022 update on diagnosis, risk stratification, and management.

Rajkumar SV
Am J Hematol 2022 Aug;97(8):1086-1107. Epub 2022 May 23 doi: 10.1002/ajh.26590. PMID: 35560063 Free PMC Article

Multiple myeloma: 2020 update on diagnosis, risk-stratification and management.

Rajkumar SV
Am J Hematol 2020 May;95(5):548-567. doi: 10.1002/ajh.25791. PMID: 32212178

Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management.

Rajkumar SV
Am J Hematol 2016 Jul;91(7):719-34. doi: 10.1002/ajh.24402. PMID: 27291302 Free PMC Article

See all (7)

Recent clinical studies

Etiology

Updated recommendations on the use of ruxolitinib for the treatment of myelofibrosis.

Devos T, Selleslag D, Granacher N, Havelange V, Benghiat FS
Hematology 2022 Dec;27(1):23-31. doi: 10.1080/16078454.2021.2009645. PMID: 34957926

GATA2 deficiency-associated bone marrow disorder differs from idiopathic aplastic anemia.

Ganapathi KA, Townsley DM, Hsu AP, Arthur DC, Zerbe CS, Cuellar-Rodriguez J, Hickstein DD, Rosenzweig SD, Braylan RC, Young NS, Holland SM, Calvo KR
Blood 2015 Jan 1;125(1):56-70. Epub 2014 Oct 30 doi: 10.1182/blood-2014-06-580340. PMID: 25359990 Free PMC Article

The applications of buckminsterfullerene C60 and derivatives in orthopaedic research.

Liu Q, Cui Q, Li XJ, Jin L
Connect Tissue Res 2014 Apr;55(2):71-9. Epub 2014 Jan 24 doi: 10.3109/03008207.2013.877894. PMID: 24409811 Free PMC Article

Unexplained macrocytosis.

Younes M, Dagher GA, Dulanto JV, Njeim M, Kuriakose P
South Med J 2013 Feb;106(2):121-5. doi: 10.1097/SMJ.0b013e3182824cdf. PMID: 23380746

Evaluation of anemia in children.

Janus J, Moerschel SK
Am Fam Physician 2010 Jun 15;81(12):1462-71. PMID: 20540485

See all (24)

Diagnosis

Updated recommendations on the use of ruxolitinib for the treatment of myelofibrosis.

Devos T, Selleslag D, Granacher N, Havelange V, Benghiat FS
Hematology 2022 Dec;27(1):23-31. doi: 10.1080/16078454.2021.2009645. PMID: 34957926

Cold agglutinin disease.

Berentsen S
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):226-231. doi: 10.1182/asheducation-2016.1.226. PMID: 27913484 Free PMC Article

The clinical and laboratory evaluation of the patient with erythrocytosis.

Lee G, Arcasoy MO
Eur J Intern Med 2015 Jun;26(5):297-302. Epub 2015 Mar 31 doi: 10.1016/j.ejim.2015.03.007. PMID: 25837692

Unexplained macrocytosis.

Younes M, Dagher GA, Dulanto JV, Njeim M, Kuriakose P
South Med J 2013 Feb;106(2):121-5. doi: 10.1097/SMJ.0b013e3182824cdf. PMID: 23380746

Evaluation of anemia in children.

Janus J, Moerschel SK
Am Fam Physician 2010 Jun 15;81(12):1462-71. PMID: 20540485

See all (30)

Therapy

Updated recommendations on the use of ruxolitinib for the treatment of myelofibrosis.

Devos T, Selleslag D, Granacher N, Havelange V, Benghiat FS
Hematology 2022 Dec;27(1):23-31. doi: 10.1080/16078454.2021.2009645. PMID: 34957926

DNA-hypomethylating agents as epigenetic therapy before and after allogeneic hematopoietic stem cell transplantation in myelodysplastic syndromes and juvenile myelomonocytic leukemia.

Flotho C, Sommer S, Lübbert M
Semin Cancer Biol 2018 Aug;51:68-79. Epub 2017 Nov 9 doi: 10.1016/j.semcancer.2017.10.011. PMID: 29129488

Cold agglutinin disease.

Berentsen S
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):226-231. doi: 10.1182/asheducation-2016.1.226. PMID: 27913484 Free PMC Article

Evaluation of anemia in children.

Janus J, Moerschel SK
Am Fam Physician 2010 Jun 15;81(12):1462-71. PMID: 20540485

DNA methyltransferases as targets for cancer therapy.

Ghoshal K, Bai S
Drugs Today (Barc) 2007 Jun;43(6):395-422. doi: 10.1358/dot.2007.43.6.1062666. PMID: 17612710

See all (26)

Prognosis

MiR-181a-2-3p as a potential diagnostic and prognostic marker for myelodysplastic syndrome.

Liang X, Shi Z, Huang X, Wan C, Zhu S, Wu M, Li Z, Tang Z, Li J, Zhao W, Luo J, Liu Z
Hematology 2022 Dec;27(1):1246-1252. doi: 10.1080/16078454.2022.2149971. PMID: 36444993

Updated recommendations on the use of ruxolitinib for the treatment of myelofibrosis.

Devos T, Selleslag D, Granacher N, Havelange V, Benghiat FS
Hematology 2022 Dec;27(1):23-31. doi: 10.1080/16078454.2021.2009645. PMID: 34957926

Janus kinase-1 and Janus kinase-2 inhibitors for treating myelofibrosis.

Martí-Carvajal AJ, Anand V, Solà I
Cochrane Database Syst Rev 2015 Apr 10;2015(4):CD010298. doi: 10.1002/14651858.CD010298.pub2. PMID: 25860512 Free PMC Article

Unexplained macrocytosis.

Younes M, Dagher GA, Dulanto JV, Njeim M, Kuriakose P
South Med J 2013 Feb;106(2):121-5. doi: 10.1097/SMJ.0b013e3182824cdf. PMID: 23380746

Bone and joint lesions associated with pustulosis palmaris et plantaris. A clinical and histological study.

Kawai K, Doita M, Tateishi H, Hirohata K
J Bone Joint Surg Br 1988 Jan;70(1):117-22. doi: 10.1302/0301-620X.70B1.3276698. PMID: 3276698

See all (12)

Clinical prediction guides

Efficacy of ALK5 inhibition in myelofibrosis.

Yue L, Bartenstein M, Zhao W, Ho WT, Han Y, Murdun C, Mailloux AW, Zhang L, Wang X, Budhathoki A, Pradhan K, Rapaport F, Wang H, Shao Z, Ren X, Steidl U, Levine RL, Zhao ZJ, Verma A, Epling-Burnette PK
JCI Insight 2017 Apr 6;2(7):e90932. doi: 10.1172/jci.insight.90932. PMID: 28405618 Free PMC Article

A retrospective study of paroxysmal nocturnal hemoglobinuria in pediatric and adolescent patients.

Mercuri A, Farruggia P, Timeus F, Lombardi L, Onofrillo D, Putti MC, Pillon M, Cantarini ME, Corti P, Tridello G, De Bortoli M, Pegoraro A, Cesaro S
Blood Cells Mol Dis 2017 May;64:45-50. Epub 2017 Mar 18 doi: 10.1016/j.bcmd.2017.03.006. PMID: 28380398

Janus kinase-1 and Janus kinase-2 inhibitors for treating myelofibrosis.

Martí-Carvajal AJ, Anand V, Solà I
Cochrane Database Syst Rev 2015 Apr 10;2015(4):CD010298. doi: 10.1002/14651858.CD010298.pub2. PMID: 25860512 Free PMC Article

Pediatric aplastic anemia and refractory cytopenia: A retrospective analysis assessing outcomes and histomorphologic predictors.

Forester CM, Sartain SE, Guo D, Harris MH, Weinberg OK, Fleming MD, London WB, Williams DA, Hofmann I
Am J Hematol 2015 Apr;90(4):320-6. Epub 2015 Mar 2 doi: 10.1002/ajh.23937. PMID: 25580823 Free PMC Article

Peripheral neuropathies in Waldenström's macroglobulinaemia.

Levine T, Pestronk A, Florence J, Al-Lozi MT, Lopate G, Miller T, Ramneantu I, Waheed W, Stambuk M, Stone MJ, Choksi R
J Neurol Neurosurg Psychiatry 2006 Feb;77(2):224-8. doi: 10.1136/jnnp.2005.071175. PMID: 16421127 Free PMC Article

See all (10)

Recent systematic reviews

Comparison of a therapeutic-only versus prophylactic platelet transfusion policy for people with congenital or acquired bone marrow failure disorders.

Malouf R, Ashraf A, Hadjinicolaou AV, Doree C, Hopewell S, Estcourt LJ
Cochrane Database Syst Rev 2018 May 14;5(5):CD012342. doi: 10.1002/14651858.CD012342.pub2. PMID: 29758592 Free PMC Article

Janus kinase-1 and Janus kinase-2 inhibitors for treating myelofibrosis.

Martí-Carvajal AJ, Anand V, Solà I
Cochrane Database Syst Rev 2015 Apr 10;2015(4):CD010298. doi: 10.1002/14651858.CD010298.pub2. PMID: 25860512 Free PMC Article

See all (2)

MedGen

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Bone marrow disorder

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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