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Childhood Acute Myelomonocytic Leukemia

MedGen UID:
124639
•Concept ID:
C0279644
•
Neoplastic Process
Synonyms: Childhood Acute M4 Leukemia; Childhood Acute Myelomonocytic Leukemia (M4); Childhood AMML; M4 Childhood Acute Myelomonocytic Leukemia; M4 Pediatric Acute Myelomonocytic Leukemia; Pediatric Acute M4 Leukemia; Pediatric Acute Myelomonocytic Leukemia; Pediatric AMML

Definition

An acute myelomonocytic leukemia occurring in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Acute Myelomonocytic Leukemia

Professional guidelines

PubMed

Recent advances in the pathogenesis and treatment of juvenile myelomonocytic leukaemia.
Loh ML
Br J Haematol 2011 Mar;152(6):677-87. doi: 10.1111/j.1365-2141.2010.08525.x. PMID: 21623760
Childhood myelodysplastic syndrome: focus on the approach to diagnosis and treatment of juvenile myelomonocytic leukemia.
Loh ML
Hematology Am Soc Hematol Educ Program 2010;2010:357-62. doi: 10.1182/asheducation-2010.1.357. PMID: 21239819
Recent advances in management of acute myeloid leukemia (AML).
Shah M, Agarwal B
Indian J Pediatr 2008 Aug;75(8):831-7. Epub 2008 Sep 4 doi: 10.1007/s12098-008-0155-x. PMID: 18769895

Recent clinical studies

Etiology

Phase II study of VP-16-213 in childhood malignant disease: a Children's Cancer Study Group Report.
Chard RL Jr, Krivit W, Bleyer WA, Hammond D
Cancer Treat Rep 1979 Nov-Dec;63(11-12):1755-9. PMID: 294306

Diagnosis

Childhood acute myelomonocytic leukemia (AML-M4) presenting as catastrophic antiphospholipid antibody syndrome.
Orsino A, Schneider R, DeVeber G, Grant R, Massicotte P, Canning P, Carcao M
J Pediatr Hematol Oncol 2004 May;26(5):327-30. doi: 10.1097/00043426-200405000-00015. PMID: 15111789

Therapy

Phase II study of VP-16-213 in childhood malignant disease: a Children's Cancer Study Group Report.
Chard RL Jr, Krivit W, Bleyer WA, Hammond D
Cancer Treat Rep 1979 Nov-Dec;63(11-12):1755-9. PMID: 294306

Prognosis

Childhood acute myelomonocytic leukemia (AML-M4) presenting as catastrophic antiphospholipid antibody syndrome.
Orsino A, Schneider R, DeVeber G, Grant R, Massicotte P, Canning P, Carcao M
J Pediatr Hematol Oncol 2004 May;26(5):327-30. doi: 10.1097/00043426-200405000-00015. PMID: 15111789
Phase II study of VP-16-213 in childhood malignant disease: a Children's Cancer Study Group Report.
Chard RL Jr, Krivit W, Bleyer WA, Hammond D
Cancer Treat Rep 1979 Nov-Dec;63(11-12):1755-9. PMID: 294306

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