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Acute myelomonocytic leukemia M4

MedGen UID:
9732
Concept ID:
C0023479
Neoplastic Process
Synonym: Acute myelomonocytic leukemia
SNOMED CT: M4 - Acute myelomonocytic leukemia (110005000); AMML - Acute myelomonocytic leukemia (110005000); Acute myelomonocytic leukemia, FAB M4 (110005000); Acute myelomonocytic leukemia (clinical) (110005000); Acute myelomonocytic leukemia (30962008); FAB M4 (30962008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
HPO: HP:0004820
Monarch Initiative: MONDO:0018871
Orphanet: ORPHA517

Definition

An acute leukemia characterized by the proliferation of both neutrophil and monocyte precursors. [from HPO]

Conditions with this feature

Ataxia-pancytopenia syndrome
MedGen UID:
230896
Concept ID:
C1327919
Disease or Syndrome
SAMD9L ataxia-pancytopenia (ATXPC) syndrome is characterized by cerebellar ataxia, variable hematologic cytopenias, and predisposition to marrow failure, myelodysplasia, and myeloid leukemia, sometimes associated with monosomy 7. The onset of hematologic abnormalities has been reported as early as age three months. The cytopenias in all cell lineages range from mild to very severe. Onset of neurologic impairment is variable. Nystagmus, dysmetria, increased deep tendon reflexes, and clonus are common. Gait impairment and other neurologic abnormalities are slowly progressive.

Professional guidelines

PubMed

Anami Y, Deng M, Gui X, Yamaguchi A, Yamazaki CM, Zhang N, Zhang CC, An Z, Tsuchikama K
Mol Cancer Ther 2020 Nov;19(11):2330-2339. Epub 2020 Sep 2 doi: 10.1158/1535-7163.MCT-20-0407. PMID: 32879051Free PMC Article
Nishimoto M, Nakamae H, Watanabe K, Koh H, Nakane T, Ohsawa M, Arakawa T, Hino M
Transplant Proc 2013 Sep;45(7):2854-7. doi: 10.1016/j.transproceed.2013.03.049. PMID: 24034064

Recent clinical studies

Etiology

Anami Y, Deng M, Gui X, Yamaguchi A, Yamazaki CM, Zhang N, Zhang CC, An Z, Tsuchikama K
Mol Cancer Ther 2020 Nov;19(11):2330-2339. Epub 2020 Sep 2 doi: 10.1158/1535-7163.MCT-20-0407. PMID: 32879051Free PMC Article
Bitter MA, Le Beau MM, Larson RA, Rosner MC, Golomb HM, Rowley JD, Vardiman JW
Am J Clin Pathol 1984 Jun;81(6):733-41. doi: 10.1093/ajcp/81.6.733. PMID: 6203400
Rowley JD
Natl Cancer Inst Monogr 1982;60:17-23. PMID: 6956808
Rowley JD
Cancer Res 1981 Sep;41(9 Pt 1):3407-10. PMID: 6942914

Diagnosis

Nishimoto M, Nakamae H, Watanabe K, Koh H, Nakane T, Ohsawa M, Arakawa T, Hino M
Transplant Proc 2013 Sep;45(7):2854-7. doi: 10.1016/j.transproceed.2013.03.049. PMID: 24034064
Anan T, Imamura T, Yokoyama S, Fujiwara S
J Dermatol 2004 Sep;31(9):741-7. doi: 10.1111/j.1346-8138.2004.tb00588.x. PMID: 15628321
Santos-Machado TM, Zerbini MC, Cristofani LM, Azevedo PM, Almeida MT, Maluf PT Jr, Odone-Filho V
Pediatr Hematol Oncol 2001 Mar;18(2):129-35. doi: 10.1080/088800101300002964. PMID: 11255731
Harth H, Pees H, Zankl H
Cancer Genet Cytogenet 1986 Oct;23(2):127-33. PMID: 3463402
Le Beau MM, Larson RA, Bitter MA, Vardiman JW, Golomb HM, Rowley JD
N Engl J Med 1983 Sep 15;309(11):630-6. doi: 10.1056/NEJM198309153091103. PMID: 6577285

Therapy

Zamani F, Karimi H, Mansoorian M, Basi A, Hosseini SA, Zahed Z, Seyedghasemipour N, Sahraie R
J Med Case Rep 2023 Sep 5;17(1):398. doi: 10.1186/s13256-023-04126-2. PMID: 37667403Free PMC Article
Nishimoto M, Nakamae H, Watanabe K, Koh H, Nakane T, Ohsawa M, Arakawa T, Hino M
Transplant Proc 2013 Sep;45(7):2854-7. doi: 10.1016/j.transproceed.2013.03.049. PMID: 24034064
Santos-Machado TM, Zerbini MC, Cristofani LM, Azevedo PM, Almeida MT, Maluf PT Jr, Odone-Filho V
Pediatr Hematol Oncol 2001 Mar;18(2):129-35. doi: 10.1080/088800101300002964. PMID: 11255731
Sato S, Sakashita A, Ishiyama T, Nakamaki T, Hino K, Tomoyasu S, Tsuruoka N, Honma Y, Hozumi M
Anticancer Res 1992 Mar-Apr;12(2):371-6. PMID: 1580553

Prognosis

Zamani F, Karimi H, Mansoorian M, Basi A, Hosseini SA, Zahed Z, Seyedghasemipour N, Sahraie R
J Med Case Rep 2023 Sep 5;17(1):398. doi: 10.1186/s13256-023-04126-2. PMID: 37667403Free PMC Article
Santos-Machado TM, Zerbini MC, Cristofani LM, Azevedo PM, Almeida MT, Maluf PT Jr, Odone-Filho V
Pediatr Hematol Oncol 2001 Mar;18(2):129-35. doi: 10.1080/088800101300002964. PMID: 11255731
Sato S, Sakashita A, Ishiyama T, Nakamaki T, Hino K, Tomoyasu S, Tsuruoka N, Honma Y, Hozumi M
Anticancer Res 1992 Mar-Apr;12(2):371-6. PMID: 1580553
Holmes RI, Keating MJ, Cork A, Trujillo JM, McCredie KB, Freireich EJ
Cancer Genet Cytogenet 1985 Jul;17(3):269-78. doi: 10.1016/0165-4608(85)90018-4. PMID: 3859363
Le Beau MM, Larson RA, Bitter MA, Vardiman JW, Golomb HM, Rowley JD
N Engl J Med 1983 Sep 15;309(11):630-6. doi: 10.1056/NEJM198309153091103. PMID: 6577285

Clinical prediction guides

Zamani F, Karimi H, Mansoorian M, Basi A, Hosseini SA, Zahed Z, Seyedghasemipour N, Sahraie R
J Med Case Rep 2023 Sep 5;17(1):398. doi: 10.1186/s13256-023-04126-2. PMID: 37667403Free PMC Article
Sato S, Sakashita A, Ishiyama T, Nakamaki T, Hino K, Tomoyasu S, Tsuruoka N, Honma Y, Hozumi M
Anticancer Res 1992 Mar-Apr;12(2):371-6. PMID: 1580553
Saito N
Am J Hematol 1990 Dec;35(4):238-46. doi: 10.1002/ajh.2830350404. PMID: 2239918
Kanoh T, Hashimoto S, Usui T, Uchino H
Tohoku J Exp Med 1986 Jan;148(1):99-102. doi: 10.1620/tjem.148.99. PMID: 3010501
Rowley JD
Natl Cancer Inst Monogr 1982;60:17-23. PMID: 6956808

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