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Regional Renal Pelvis and Ureter Urothelial Carcinoma

MedGen UID:
124713
•Concept ID:
C0280281
•
Neoplastic Process
Synonyms: Regional Transitional Cell Cancer of Renal Pelvis and Ureter; Regional Transitional Cell Cancer of the Renal Pelvis and Ureter; Regional Transitional Cell Carcinoma of Renal Pelvis and Ureter; Regional Upper Urinary Tract Urothelial Carcinoma; Regional Urothelial Carcinoma of the Renal Pelvis and Ureter

Definition

Urothelial carcinoma of the renal pelvis or ureter that has spread to adjacent tissues and/or regional lymph nodes but not to distant anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRegional Renal Pelvis and Ureter Urothelial Carcinoma

Professional guidelines

PubMed

Update of the ICUD-SIU consultation on upper tract urothelial carcinoma 2016: treatment of localized high-risk disease.
Gakis G, Schubert T, Alemozaffar M, Bellmunt J, Bochner BH, Boorjian SA, Daneshmand S, Huang WC, Kondo T, Konety BR, Laguna MP, Matin SF, Siefker-Radtke AO, Shariat SF, Stenzl A
World J Urol 2017 Mar;35(3):327-335. Epub 2016 Apr 4 doi: 10.1007/s00345-016-1819-1. PMID: 27043218
The role of systemic chemotherapy in management of upper tract urothelial cancer.
Gayed BA, Thoreson GR, Margulis V
Curr Urol Rep 2013 Apr;14(2):94-101. doi: 10.1007/s11934-013-0307-z. PMID: 23344684
European guidelines for the diagnosis and management of upper urinary tract urothelial cell carcinomas: 2011 update.
Rouprêt M, Zigeuner R, Palou J, Boehle A, Kaasinen E, Sylvester R, Babjuk M, Oosterlinck W
Eur Urol 2011 Apr;59(4):584-94. Epub 2011 Jan 14 doi: 10.1016/j.eururo.2010.12.042. PMID: 21269756

Recent clinical studies

Etiology

Enfortumab vedotin following platinum-based chemotherapy and immune checkpoint inhibitors for advanced urothelial carcinoma: response, survival and safety analysis from a multicentre real-world Japanese cohort.
Miyake M, Nishimura N, Oda Y, Miyamoto T, Ohmori C, Takamatsu N, Itami Y, Tachibana A, Matsumoto Y, Kiba K, Tomioka A, Yamamoto H, Okajima E, Masaomi K, Sakamoto K, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Jpn J Clin Oncol 2024 Mar 9;54(3):329-338. doi: 10.1093/jjco/hyad170. PMID: 38061911
Trends of incidence and prognosis of upper tract urothelial carcinoma.
Wu J, Chen S, Wu X, Mao W, Wang Y, Xu B, Zheng D, Chen M
Bosn J Basic Med Sci 2021 Oct 1;21(5):607-619. doi: 10.17305/bjbms.2020.5345. PMID: 33357210Free PMC Article
Preoperative Underweight Patients with Upper Tract Urothelial Carcinoma Survive Less after Radical Nephroureterectomy.
Kang HW, Jung HD, Ha YS, Kim TH, Kwon TG, Byun SS, Yun SJ, Kim WJ, Choi YD
J Korean Med Sci 2015 Oct;30(10):1483-9. Epub 2015 Sep 12 doi: 10.3346/jkms.2015.30.10.1483. PMID: 26425047Free PMC Article
The significance of lymphadenectomy in transitional cell carcinoma of the upper urinary tract.
Miyake H, Hara I, Gohji K, Arakawa S, Kamidono S
Br J Urol 1998 Oct;82(4):494-8. doi: 10.1046/j.1464-410x.1998.00800.x. PMID: 9806176
Urinary system.
Lynch CF, Cohen MB
Cancer 1995 Jan 1;75(1 Suppl):316-29. doi: 10.1002/1097-0142(19950101)75:1+<316::aid-cncr2820751314>3.0.co;2-t. PMID: 8001003

Diagnosis

Enfortumab vedotin following platinum-based chemotherapy and immune checkpoint inhibitors for advanced urothelial carcinoma: response, survival and safety analysis from a multicentre real-world Japanese cohort.
Miyake M, Nishimura N, Oda Y, Miyamoto T, Ohmori C, Takamatsu N, Itami Y, Tachibana A, Matsumoto Y, Kiba K, Tomioka A, Yamamoto H, Okajima E, Masaomi K, Sakamoto K, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Jpn J Clin Oncol 2024 Mar 9;54(3):329-338. doi: 10.1093/jjco/hyad170. PMID: 38061911
Dual-Energy CT applications in urinary tract cancers: an update.
Bicci E, Mastrorosato M, Danti G, Lattavo L, Bertelli E, Cozzi D, Pradella S, Agostini S, Miele V
Tumori 2023 Apr;109(2):148-156. Epub 2022 Apr 20 doi: 10.1177/03008916221088883. PMID: 35442120
Diffusion-weighted magnetic resonance imaging of urinary epithelial cancer with upper urinary tract obstruction: preliminary results.
Takeuchi M, Matsuzaki K, Kubo H, Nishitani H
Acta Radiol 2008 Dec;49(10):1195-9. doi: 10.1080/02841850802411857. PMID: 19031182
Management of patients with upper urinary tract transitional cell carcinoma.
Raman JD, Scherr DS
Nat Clin Pract Urol 2007 Aug;4(8):432-43. doi: 10.1038/ncpuro0875. PMID: 17673914
Urinary system.
Lynch CF, Cohen MB
Cancer 1995 Jan 1;75(1 Suppl):316-29. doi: 10.1002/1097-0142(19950101)75:1+<316::aid-cncr2820751314>3.0.co;2-t. PMID: 8001003

Therapy

Enfortumab vedotin following platinum-based chemotherapy and immune checkpoint inhibitors for advanced urothelial carcinoma: response, survival and safety analysis from a multicentre real-world Japanese cohort.
Miyake M, Nishimura N, Oda Y, Miyamoto T, Ohmori C, Takamatsu N, Itami Y, Tachibana A, Matsumoto Y, Kiba K, Tomioka A, Yamamoto H, Okajima E, Masaomi K, Sakamoto K, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Jpn J Clin Oncol 2024 Mar 9;54(3):329-338. doi: 10.1093/jjco/hyad170. PMID: 38061911
Recent advances in upper tract urothelial carcinomas: From bench to clinics.
Shao IH, Chang YH, Pang ST
Int J Urol 2019 Feb;26(2):148-159. Epub 2018 Oct 29 doi: 10.1111/iju.13826. PMID: 30372791
Update of the ICUD-SIU consultation on upper tract urothelial carcinoma 2016: treatment of localized high-risk disease.
Gakis G, Schubert T, Alemozaffar M, Bellmunt J, Bochner BH, Boorjian SA, Daneshmand S, Huang WC, Kondo T, Konety BR, Laguna MP, Matin SF, Siefker-Radtke AO, Shariat SF, Stenzl A
World J Urol 2017 Mar;35(3):327-335. Epub 2016 Apr 4 doi: 10.1007/s00345-016-1819-1. PMID: 27043218
The role of systemic chemotherapy in management of upper tract urothelial cancer.
Gayed BA, Thoreson GR, Margulis V
Curr Urol Rep 2013 Apr;14(2):94-101. doi: 10.1007/s11934-013-0307-z. PMID: 23344684
Cigarette smoking and cancers of the renal pelvis and ureter.
McLaughlin JK, Silverman DT, Hsing AW, Ross RK, Schoenberg JB, Yu MC, Stemhagen A, Lynch CF, Blot WJ, Fraumeni JF Jr
Cancer Res 1992 Jan 15;52(2):254-7. PMID: 1728398

Prognosis

Trends of incidence and prognosis of upper tract urothelial carcinoma.
Wu J, Chen S, Wu X, Mao W, Wang Y, Xu B, Zheng D, Chen M
Bosn J Basic Med Sci 2021 Oct 1;21(5):607-619. doi: 10.17305/bjbms.2020.5345. PMID: 33357210Free PMC Article
Preoperative Underweight Patients with Upper Tract Urothelial Carcinoma Survive Less after Radical Nephroureterectomy.
Kang HW, Jung HD, Ha YS, Kim TH, Kwon TG, Byun SS, Yun SJ, Kim WJ, Choi YD
J Korean Med Sci 2015 Oct;30(10):1483-9. Epub 2015 Sep 12 doi: 10.3346/jkms.2015.30.10.1483. PMID: 26425047Free PMC Article
Management of patients with upper urinary tract transitional cell carcinoma.
Raman JD, Scherr DS
Nat Clin Pract Urol 2007 Aug;4(8):432-43. doi: 10.1038/ncpuro0875. PMID: 17673914
The significance of lymphadenectomy in transitional cell carcinoma of the upper urinary tract.
Miyake H, Hara I, Gohji K, Arakawa S, Kamidono S
Br J Urol 1998 Oct;82(4):494-8. doi: 10.1046/j.1464-410x.1998.00800.x. PMID: 9806176
Urinary system.
Lynch CF, Cohen MB
Cancer 1995 Jan 1;75(1 Suppl):316-29. doi: 10.1002/1097-0142(19950101)75:1+<316::aid-cncr2820751314>3.0.co;2-t. PMID: 8001003

Clinical prediction guides

Enfortumab vedotin following platinum-based chemotherapy and immune checkpoint inhibitors for advanced urothelial carcinoma: response, survival and safety analysis from a multicentre real-world Japanese cohort.
Miyake M, Nishimura N, Oda Y, Miyamoto T, Ohmori C, Takamatsu N, Itami Y, Tachibana A, Matsumoto Y, Kiba K, Tomioka A, Yamamoto H, Okajima E, Masaomi K, Sakamoto K, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Jpn J Clin Oncol 2024 Mar 9;54(3):329-338. doi: 10.1093/jjco/hyad170. PMID: 38061911
Trends of incidence and prognosis of upper tract urothelial carcinoma.
Wu J, Chen S, Wu X, Mao W, Wang Y, Xu B, Zheng D, Chen M
Bosn J Basic Med Sci 2021 Oct 1;21(5):607-619. doi: 10.17305/bjbms.2020.5345. PMID: 33357210Free PMC Article
Preoperative Underweight Patients with Upper Tract Urothelial Carcinoma Survive Less after Radical Nephroureterectomy.
Kang HW, Jung HD, Ha YS, Kim TH, Kwon TG, Byun SS, Yun SJ, Kim WJ, Choi YD
J Korean Med Sci 2015 Oct;30(10):1483-9. Epub 2015 Sep 12 doi: 10.3346/jkms.2015.30.10.1483. PMID: 26425047Free PMC Article
Diffusion-weighted magnetic resonance imaging of urinary epithelial cancer with upper urinary tract obstruction: preliminary results.
Takeuchi M, Matsuzaki K, Kubo H, Nishitani H
Acta Radiol 2008 Dec;49(10):1195-9. doi: 10.1080/02841850802411857. PMID: 19031182
Management of patients with upper urinary tract transitional cell carcinoma.
Raman JD, Scherr DS
Nat Clin Pract Urol 2007 Aug;4(8):432-43. doi: 10.1038/ncpuro0875. PMID: 17673914

Recent systematic reviews

Potential Benefit of Lymph Node Dissection During Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review by the European Association of Urology Guidelines Panel on Non-muscle-invasive Bladder Cancer.
Dominguez-Escrig JL, Peyronnet B, Seisen T, Bruins HM, Yuan CY, Babjuk M, Böhle A, Burger M, Compérat EM, Gontero P, Lam T, MacLennan S, Mostafid H, Palou J, van Rhijn BWG, Sylvester RJ, Zigeuner R, Shariat SF, Rouprêt M
Eur Urol Focus 2019 Mar;5(2):224-241. Epub 2017 Nov 20 doi: 10.1016/j.euf.2017.09.015. PMID: 29158169

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