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Upper tract urothelial carcinoma

MedGen UID:
67388
Concept ID:
C0220648
Neoplastic Process
Synonyms: Renal Pelvis and Ureter Transitional Cell Cancer; Renal Pelvis and Ureter Transitional Cell Carcinoma; Renal Pelvis and Ureter Urothelial Carcinoma; TCC of Renal Pelvis and Ureter; Transitional Cell Cancer of Renal Pelvis and Ureter; Transitional Cell Cancer of the Renal Pelvis and Ureter; Transitional Cell Carcinoma of Renal Pelvis and Ureter; transitional cell carcinoma of the pelvis and ureter; transitional cell carcinoma of the upper urinary tract; Transitional cell carcinoma of upper urinary tract; upper tract urothelial carcinoma; Upper Urinary Tract Urothelial Carcinoma; Urothelial Carcinoma of the Renal Pelvis and Ureter; Urothelial Carcinoma of the Upper Urinary Tract; Urothelial carcinoma of upper urinary tract; UTUC
SNOMED CT: Transitional cell carcinoma of upper urinary tract (1208451008); Urothelial carcinoma of upper urinary tract (1208451008)
 
Monarch Initiative: MONDO:0020659

Definition

A urothelial carcinoma that arises from the renal pelvis and ureter. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUpper tract urothelial carcinoma

Professional guidelines

PubMed

Shvero A, Hubosky SG
Curr Oncol Rep 2022 May;24(5):611-619. Epub 2022 Feb 25 doi: 10.1007/s11912-021-01179-8. PMID: 35212921
Flaig TW, Spiess PE, Agarwal N, Bangs R, Boorjian SA, Buyyounouski MK, Chang S, Downs TM, Efstathiou JA, Friedlander T, Greenberg RE, Guru KA, Guzzo T, Herr HW, Hoffman-Censits J, Hoimes C, Inman BA, Jimbo M, Kader AK, Lele SM, Michalski J, Montgomery JS, Nandagopal L, Pagliaro LC, Pal SK, Patterson A, Plimack ER, Pohar KS, Preston MA, Sexton WJ, Siefker-Radtke AO, Tward J, Wright JL, Gurski LA, Johnson-Chilla A
J Natl Compr Canc Netw 2020 Mar;18(3):329-354. doi: 10.6004/jnccn.2020.0011. PMID: 32135513
Campbell MT, Shah AY, Matin SF, Siefker-Radtke AO
Urol Oncol 2017 Jul;35(7):492-498. Epub 2017 Jun 1 doi: 10.1016/j.urolonc.2017.05.009. PMID: 28579283

Recent clinical studies

Etiology

Coleman JA, Clark PE, Bixler BR, Buckley DI, Chang SS, Chou R, Hoffman-Censits J, Kulkarni GS, Matin SF, Pierorazio PM, Potretzke AM, Psutka SP, Raman JD, Smith AB, Smith L
J Urol 2023 Jun;209(6):1071-1081. Epub 2023 Apr 25 doi: 10.1097/JU.0000000000003480. PMID: 37096584
Zalay O, Yan M, Sigurdson S, Malone S, Vera-Badillo FE, Mahmud A
Curr Oncol 2022 Dec 20;30(1):19-36. doi: 10.3390/curroncol30010002. PMID: 36661651Free PMC Article
Shvero A, Hubosky SG
Curr Oncol Rep 2022 May;24(5):611-619. Epub 2022 Feb 25 doi: 10.1007/s11912-021-01179-8. PMID: 35212921
Joseph JP, O'Malley P, Su LM
J Endourol 2021 Sep;35(S2):S122-S131. doi: 10.1089/end.2020.1074. PMID: 34499556
Leow JJ, Chong YL, Chang SL, Valderrama BP, Powles T, Bellmunt J
Eur Urol 2021 May;79(5):635-654. Epub 2020 Aug 12 doi: 10.1016/j.eururo.2020.07.003. PMID: 32798146

Diagnosis

Coleman JA, Clark PE, Bixler BR, Buckley DI, Chang SS, Chou R, Hoffman-Censits J, Kulkarni GS, Matin SF, Pierorazio PM, Potretzke AM, Psutka SP, Raman JD, Smith AB, Smith L
J Urol 2023 Jun;209(6):1071-1081. Epub 2023 Apr 25 doi: 10.1097/JU.0000000000003480. PMID: 37096584
Teoh JY, Kamat AM, Black PC, Grivas P, Shariat SF, Babjuk M
Nat Rev Urol 2022 May;19(5):280-294. Epub 2022 Mar 31 doi: 10.1038/s41585-022-00578-1. PMID: 35361927
Li Z, Xu H, Gong Y, Chen W, Zhan Y, Yu L, Sun Y, Li A, He S, Guan B, Wu Y, Xiong G, Fang D, He Y, Tang Q, Yao L, Hu Z, Mei H, He Z, Cai Z, Guo Y, Li X, Zhou L, Huang W
Adv Sci (Weinh) 2022 Feb;9(4):e2103999. Epub 2021 Dec 16 doi: 10.1002/advs.202103999. PMID: 34914855Free PMC Article
Inamoto T, Matsuyama H, Ibuki N, Komura K, Takahara K, Fujimoto K, Shiina H, Sakano S, Nagao K, Miyake M, Tatsumi Y, Yasumoto H, Azuma H; Nishinihon Uro-Oncology Collaborative Group
J Urol 2018 Apr;199(4):933-939. Epub 2017 Oct 14 doi: 10.1016/j.juro.2017.10.019. PMID: 29037861
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375

Therapy

Liang Y, Tan Y, Guan B, Guo B, Xia M, Li J, Shi Y, Yu Z, Zhang Q, Liu D, Yang X, Hao J, Gong Y, Shakeel M, Zhou L, Ci W, Li X
Theranostics 2022;12(18):7745-7759. Epub 2022 Nov 14 doi: 10.7150/thno.77281. PMID: 36451860Free PMC Article
Li Z, Xu H, Gong Y, Chen W, Zhan Y, Yu L, Sun Y, Li A, He S, Guan B, Wu Y, Xiong G, Fang D, He Y, Tang Q, Yao L, Hu Z, Mei H, He Z, Cai Z, Guo Y, Li X, Zhou L, Huang W
Adv Sci (Weinh) 2022 Feb;9(4):e2103999. Epub 2021 Dec 16 doi: 10.1002/advs.202103999. PMID: 34914855Free PMC Article
Leow JJ, Chong YL, Chang SL, Valderrama BP, Powles T, Bellmunt J
Eur Urol 2021 May;79(5):635-654. Epub 2020 Aug 12 doi: 10.1016/j.eururo.2020.07.003. PMID: 32798146
Kleinmann N, Matin SF, Pierorazio PM, Gore JL, Shabsigh A, Hu B, Chamie K, Godoy G, Hubosky S, Rivera M, O'Donnell M, Quek M, Raman JD, Knoedler JJ, Scherr D, Stern J, Weight C, Weizer A, Woods M, Kaimakliotis H, Smith AB, Linehan J, Coleman J, Humphreys MR, Pak R, Lifshitz D, Verni M, Adibi M, Amin MB, Seltzer E, Klein I, Konorty M, Strauss-Ayali D, Hakim G, Schoenberg M, Lerner SP
Lancet Oncol 2020 Jun;21(6):776-785. Epub 2020 Apr 29 doi: 10.1016/S1470-2045(20)30147-9. PMID: 32631491
Birtle A, Johnson M, Chester J, Jones R, Dolling D, Bryan RT, Harris C, Winterbottom A, Blacker A, Catto JWF, Chakraborti P, Donovan JL, Elliott PA, French A, Jagdev S, Jenkins B, Keeley FX Jr, Kockelbergh R, Powles T, Wagstaff J, Wilson C, Todd R, Lewis R, Hall E
Lancet 2020 Apr 18;395(10232):1268-1277. Epub 2020 Mar 5 doi: 10.1016/S0140-6736(20)30415-3. PMID: 32145825Free PMC Article

Prognosis

Tomiyama E, Fujita K, Nakano K, Kuwahara K, Minami T, Kato T, Hatano K, Kawashima A, Uemura M, Takao T, Fushimi H, Katayama K, Imoto S, Yoshimura K, Imamura R, Uemura H, Nonomura N
Curr Oncol 2022 May 30;29(6):3911-3921. doi: 10.3390/curroncol29060312. PMID: 35735421Free PMC Article
Leow JJ, Chong YL, Chang SL, Valderrama BP, Powles T, Bellmunt J
Eur Urol 2021 May;79(5):635-654. Epub 2020 Aug 12 doi: 10.1016/j.eururo.2020.07.003. PMID: 32798146
Inamoto T, Matsuyama H, Ibuki N, Komura K, Takahara K, Fujimoto K, Shiina H, Sakano S, Nagao K, Miyake M, Tatsumi Y, Yasumoto H, Azuma H; Nishinihon Uro-Oncology Collaborative Group
J Urol 2018 Apr;199(4):933-939. Epub 2017 Oct 14 doi: 10.1016/j.juro.2017.10.019. PMID: 29037861
Miyazaki J, Nishiyama H
Int J Urol 2017 Oct;24(10):730-734. Epub 2017 May 21 doi: 10.1111/iju.13376. PMID: 28543959
Kammerer-Jacquet SF, Mathieu R, Peyronnet B, Rioux-Leclercq N, Bensalah K
Curr Opin Urol 2017 Jan;27(1):35-40. doi: 10.1097/MOU.0000000000000341. PMID: 27584028

Clinical prediction guides

Wu S, Li R, Jiang Y, Yu J, Zheng J, Li Z, Li M, Xin K, Wang Y, Xu Z, Li S, Chen X
Biomed Pharmacother 2023 Sep;165:115027. Epub 2023 Jun 22 doi: 10.1016/j.biopha.2023.115027. PMID: 37354812
Wu J, Jin S, Gu C, Wei Y, Zhu Y, Necchi A, Shariat SF, Pan J, Gan H, Dai B, Zhang H, Shi G, Zhu Y, Shen Y, Zhu Y, Ye D
Cell Rep Med 2023 Jan 17;4(1):100883. Epub 2023 Jan 10 doi: 10.1016/j.xcrm.2022.100883. PMID: 36630951Free PMC Article
Liang Y, Tan Y, Guan B, Guo B, Xia M, Li J, Shi Y, Yu Z, Zhang Q, Liu D, Yang X, Hao J, Gong Y, Shakeel M, Zhou L, Ci W, Li X
Theranostics 2022;12(18):7745-7759. Epub 2022 Nov 14 doi: 10.7150/thno.77281. PMID: 36451860Free PMC Article
Tomiyama E, Fujita K, Nakano K, Kuwahara K, Minami T, Kato T, Hatano K, Kawashima A, Uemura M, Takao T, Fushimi H, Katayama K, Imoto S, Yoshimura K, Imamura R, Uemura H, Nonomura N
Curr Oncol 2022 May 30;29(6):3911-3921. doi: 10.3390/curroncol29060312. PMID: 35735421Free PMC Article
Verges DP, Lallas CD, Hubosky SG, Bagley DH Jr
Curr Urol Rep 2017 Apr;18(4):31. doi: 10.1007/s11934-017-0675-x. PMID: 28251485

Recent systematic reviews

Zalay O, Yan M, Sigurdson S, Malone S, Vera-Badillo FE, Mahmud A
Curr Oncol 2022 Dec 20;30(1):19-36. doi: 10.3390/curroncol30010002. PMID: 36661651Free PMC Article
Leow JJ, Chong YL, Chang SL, Valderrama BP, Powles T, Bellmunt J
Eur Urol 2021 May;79(5):635-654. Epub 2020 Aug 12 doi: 10.1016/j.eururo.2020.07.003. PMID: 32798146
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375
Mbeutcha A, Rouprêt M, Kamat AM, Karakiewicz PI, Lawrentschuk N, Novara G, Raman JD, Seitz C, Xylinas E, Shariat SF
World J Urol 2017 Mar;35(3):337-353. Epub 2016 Apr 21 doi: 10.1007/s00345-016-1826-2. PMID: 27101100
Cutress ML, Stewart GD, Zakikhani P, Phipps S, Thomas BG, Tolley DA
BJU Int 2012 Sep;110(5):614-28. Epub 2012 Apr 3 doi: 10.1111/j.1464-410X.2012.11068.x. PMID: 22471401

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