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Upper tract urothelial carcinoma

MedGen UID:
67388
Concept ID:
C0220648
Neoplastic Process
Synonyms: Renal Pelvis and Ureter Transitional Cell Cancer; Renal Pelvis and Ureter Transitional Cell Carcinoma; Renal Pelvis and Ureter Urothelial Carcinoma; TCC of Renal Pelvis and Ureter; Transitional Cell Cancer of Renal Pelvis and Ureter; Transitional Cell Cancer of the Renal Pelvis and Ureter; Transitional Cell Carcinoma of Renal Pelvis and Ureter; transitional cell carcinoma of the pelvis and ureter; transitional cell carcinoma of the upper urinary tract; Transitional cell carcinoma of upper urinary tract; upper tract urothelial carcinoma; Upper Urinary Tract Urothelial Carcinoma; Urothelial Carcinoma of the Renal Pelvis and Ureter; Urothelial Carcinoma of the Upper Urinary Tract; Urothelial carcinoma of upper urinary tract; UTUC
SNOMED CT: Transitional cell carcinoma of upper urinary tract (1208451008); Urothelial carcinoma of upper urinary tract (1208451008)
 
Monarch Initiative: MONDO:0020659

Definition

A urothelial carcinoma that arises from the renal pelvis and ureter. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUpper tract urothelial carcinoma

Professional guidelines

PubMed

Claps F, Pavan N, Ongaro L, Tierno D, Grassi G, Trombetta C, Tulone G, Simonato A, Bartoletti R, Mertens LS, van Rhijn BWG, Mir MC, Scaggiante B
Int J Mol Sci 2023 Aug 9;24(16) doi: 10.3390/ijms241612596. PMID: 37628785Free PMC Article
Shvero A, Hubosky SG
Curr Oncol Rep 2022 May;24(5):611-619. Epub 2022 Feb 25 doi: 10.1007/s11912-021-01179-8. PMID: 35212921
Flaig TW, Spiess PE, Agarwal N, Bangs R, Boorjian SA, Buyyounouski MK, Chang S, Downs TM, Efstathiou JA, Friedlander T, Greenberg RE, Guru KA, Guzzo T, Herr HW, Hoffman-Censits J, Hoimes C, Inman BA, Jimbo M, Kader AK, Lele SM, Michalski J, Montgomery JS, Nandagopal L, Pagliaro LC, Pal SK, Patterson A, Plimack ER, Pohar KS, Preston MA, Sexton WJ, Siefker-Radtke AO, Tward J, Wright JL, Gurski LA, Johnson-Chilla A
J Natl Compr Canc Netw 2020 Mar;18(3):329-354. doi: 10.6004/jnccn.2020.0011. PMID: 32135513

Recent clinical studies

Etiology

Coleman JA, Clark PE, Bixler BR, Buckley DI, Chang SS, Chou R, Hoffman-Censits J, Kulkarni GS, Matin SF, Pierorazio PM, Potretzke AM, Psutka SP, Raman JD, Smith AB, Smith L
J Urol 2023 Jun;209(6):1071-1081. Epub 2023 Apr 25 doi: 10.1097/JU.0000000000003480. PMID: 37096584
Shvero A, Hubosky SG
Curr Oncol Rep 2022 May;24(5):611-619. Epub 2022 Feb 25 doi: 10.1007/s11912-021-01179-8. PMID: 35212921
Joseph JP, O'Malley P, Su LM
J Endourol 2021 Sep;35(S2):S122-S131. doi: 10.1089/end.2020.1074. PMID: 34499556
Leow JJ, Chong YL, Chang SL, Valderrama BP, Powles T, Bellmunt J
Eur Urol 2021 May;79(5):635-654. Epub 2020 Aug 12 doi: 10.1016/j.eururo.2020.07.003. PMID: 32798146
Knoedler JJ, Raman JD
Expert Rev Clin Pharmacol 2018 May;11(5):487-493. Epub 2018 Apr 20 doi: 10.1080/17512433.2018.1461560. PMID: 29634361

Diagnosis

Claps F, Pavan N, Ongaro L, Tierno D, Grassi G, Trombetta C, Tulone G, Simonato A, Bartoletti R, Mertens LS, van Rhijn BWG, Mir MC, Scaggiante B
Int J Mol Sci 2023 Aug 9;24(16) doi: 10.3390/ijms241612596. PMID: 37628785Free PMC Article
Teoh JY, Kamat AM, Black PC, Grivas P, Shariat SF, Babjuk M
Nat Rev Urol 2022 May;19(5):280-294. Epub 2022 Mar 31 doi: 10.1038/s41585-022-00578-1. PMID: 35361927
Li Z, Xu H, Gong Y, Chen W, Zhan Y, Yu L, Sun Y, Li A, He S, Guan B, Wu Y, Xiong G, Fang D, He Y, Tang Q, Yao L, Hu Z, Mei H, He Z, Cai Z, Guo Y, Li X, Zhou L, Huang W
Adv Sci (Weinh) 2022 Feb;9(4):e2103999. Epub 2021 Dec 16 doi: 10.1002/advs.202103999. PMID: 34914855Free PMC Article
Inamoto T, Matsuyama H, Ibuki N, Komura K, Takahara K, Fujimoto K, Shiina H, Sakano S, Nagao K, Miyake M, Tatsumi Y, Yasumoto H, Azuma H; Nishinihon Uro-Oncology Collaborative Group
J Urol 2018 Apr;199(4):933-939. Epub 2017 Oct 14 doi: 10.1016/j.juro.2017.10.019. PMID: 29037861
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375

Therapy

Claps F, Pavan N, Ongaro L, Tierno D, Grassi G, Trombetta C, Tulone G, Simonato A, Bartoletti R, Mertens LS, van Rhijn BWG, Mir MC, Scaggiante B
Int J Mol Sci 2023 Aug 9;24(16) doi: 10.3390/ijms241612596. PMID: 37628785Free PMC Article
Liang Y, Tan Y, Guan B, Guo B, Xia M, Li J, Shi Y, Yu Z, Zhang Q, Liu D, Yang X, Hao J, Gong Y, Shakeel M, Zhou L, Ci W, Li X
Theranostics 2022;12(18):7745-7759. Epub 2022 Nov 14 doi: 10.7150/thno.77281. PMID: 36451860Free PMC Article
Li Z, Xu H, Gong Y, Chen W, Zhan Y, Yu L, Sun Y, Li A, He S, Guan B, Wu Y, Xiong G, Fang D, He Y, Tang Q, Yao L, Hu Z, Mei H, He Z, Cai Z, Guo Y, Li X, Zhou L, Huang W
Adv Sci (Weinh) 2022 Feb;9(4):e2103999. Epub 2021 Dec 16 doi: 10.1002/advs.202103999. PMID: 34914855Free PMC Article
Kleinmann N, Matin SF, Pierorazio PM, Gore JL, Shabsigh A, Hu B, Chamie K, Godoy G, Hubosky S, Rivera M, O'Donnell M, Quek M, Raman JD, Knoedler JJ, Scherr D, Stern J, Weight C, Weizer A, Woods M, Kaimakliotis H, Smith AB, Linehan J, Coleman J, Humphreys MR, Pak R, Lifshitz D, Verni M, Adibi M, Amin MB, Seltzer E, Klein I, Konorty M, Strauss-Ayali D, Hakim G, Schoenberg M, Lerner SP
Lancet Oncol 2020 Jun;21(6):776-785. Epub 2020 Apr 29 doi: 10.1016/S1470-2045(20)30147-9. PMID: 32631491
Birtle A, Johnson M, Chester J, Jones R, Dolling D, Bryan RT, Harris C, Winterbottom A, Blacker A, Catto JWF, Chakraborti P, Donovan JL, Elliott PA, French A, Jagdev S, Jenkins B, Keeley FX Jr, Kockelbergh R, Powles T, Wagstaff J, Wilson C, Todd R, Lewis R, Hall E
Lancet 2020 Apr 18;395(10232):1268-1277. Epub 2020 Mar 5 doi: 10.1016/S0140-6736(20)30415-3. PMID: 32145825Free PMC Article

Prognosis

Qu Y, Yao Z, Xu N, Shi G, Su J, Ye S, Chang K, Li K, Wang Y, Tan S, Pei X, Chen Y, Qin Z, Feng J, Lv J, Zhu J, Ma F, Tang S, Xu W, Tian X, Anwaier A, Tian S, Xu W, Wu X, Zhu S, Zhu Y, Cao D, Sun M, Gan H, Zhao J, Zhang H, Ye D, Ding C
Cell Rep Med 2023 Sep 19;4(9):101166. Epub 2023 Aug 25 doi: 10.1016/j.xcrm.2023.101166. PMID: 37633276Free PMC Article
Tomiyama E, Fujita K, Nakano K, Kuwahara K, Minami T, Kato T, Hatano K, Kawashima A, Uemura M, Takao T, Fushimi H, Katayama K, Imoto S, Yoshimura K, Imamura R, Uemura H, Nonomura N
Curr Oncol 2022 May 30;29(6):3911-3921. doi: 10.3390/curroncol29060312. PMID: 35735421Free PMC Article
Leow JJ, Chong YL, Chang SL, Valderrama BP, Powles T, Bellmunt J
Eur Urol 2021 May;79(5):635-654. Epub 2020 Aug 12 doi: 10.1016/j.eururo.2020.07.003. PMID: 32798146
Inamoto T, Matsuyama H, Ibuki N, Komura K, Takahara K, Fujimoto K, Shiina H, Sakano S, Nagao K, Miyake M, Tatsumi Y, Yasumoto H, Azuma H; Nishinihon Uro-Oncology Collaborative Group
J Urol 2018 Apr;199(4):933-939. Epub 2017 Oct 14 doi: 10.1016/j.juro.2017.10.019. PMID: 29037861
Kammerer-Jacquet SF, Mathieu R, Peyronnet B, Rioux-Leclercq N, Bensalah K
Curr Opin Urol 2017 Jan;27(1):35-40. doi: 10.1097/MOU.0000000000000341. PMID: 27584028

Clinical prediction guides

Dłubak A, Karwacki J, Logoń K, Tomecka P, Brawańska K, Krajewski W, Szydełko T, Małkiewicz B
Curr Oncol Rep 2023 Nov;25(11):1327-1344. Epub 2023 Oct 6 doi: 10.1007/s11912-023-01460-y. PMID: 37801187Free PMC Article
Qu Y, Yao Z, Xu N, Shi G, Su J, Ye S, Chang K, Li K, Wang Y, Tan S, Pei X, Chen Y, Qin Z, Feng J, Lv J, Zhu J, Ma F, Tang S, Xu W, Tian X, Anwaier A, Tian S, Xu W, Wu X, Zhu S, Zhu Y, Cao D, Sun M, Gan H, Zhao J, Zhang H, Ye D, Ding C
Cell Rep Med 2023 Sep 19;4(9):101166. Epub 2023 Aug 25 doi: 10.1016/j.xcrm.2023.101166. PMID: 37633276Free PMC Article
Liang Y, Tan Y, Guan B, Guo B, Xia M, Li J, Shi Y, Yu Z, Zhang Q, Liu D, Yang X, Hao J, Gong Y, Shakeel M, Zhou L, Ci W, Li X
Theranostics 2022;12(18):7745-7759. Epub 2022 Nov 14 doi: 10.7150/thno.77281. PMID: 36451860Free PMC Article
Tomiyama E, Fujita K, Nakano K, Kuwahara K, Minami T, Kato T, Hatano K, Kawashima A, Uemura M, Takao T, Fushimi H, Katayama K, Imoto S, Yoshimura K, Imamura R, Uemura H, Nonomura N
Curr Oncol 2022 May 30;29(6):3911-3921. doi: 10.3390/curroncol29060312. PMID: 35735421Free PMC Article
Verges DP, Lallas CD, Hubosky SG, Bagley DH Jr
Curr Urol Rep 2017 Apr;18(4):31. doi: 10.1007/s11934-017-0675-x. PMID: 28251485

Recent systematic reviews

Zalay O, Yan M, Sigurdson S, Malone S, Vera-Badillo FE, Mahmud A
Curr Oncol 2022 Dec 20;30(1):19-36. doi: 10.3390/curroncol30010002. PMID: 36661651Free PMC Article
Leow JJ, Chong YL, Chang SL, Valderrama BP, Powles T, Bellmunt J
Eur Urol 2021 May;79(5):635-654. Epub 2020 Aug 12 doi: 10.1016/j.eururo.2020.07.003. PMID: 32798146
Territo A, Foerster B, Shariat SF, Rouprêt M, Gaya JM, Palou J, Breda A
Minerva Urol Nefrol 2018 Jun;70(3):242-251. Epub 2018 Feb 1 doi: 10.23736/S0393-2249.18.03058-8. PMID: 29392926
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375
Mbeutcha A, Rouprêt M, Kamat AM, Karakiewicz PI, Lawrentschuk N, Novara G, Raman JD, Seitz C, Xylinas E, Shariat SF
World J Urol 2017 Mar;35(3):337-353. Epub 2016 Apr 21 doi: 10.1007/s00345-016-1826-2. PMID: 27101100

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