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Abnormal brain choline level by MRS

MedGen UID:
1369027
•Concept ID:
C4476566
•
Finding
Synonym: Abnormal brain choline level by magnetic resonance spectroscopy
 
HPO: HP:0025047

Definition

A deviation from normal in the level of choline-containing compounds in the brain identified by magnetic resonance spectroscopy (MRS). [from HPO]

Professional guidelines

PubMed

Proton magnetic resonance spectroscopy changes after lithium treatment. Systematic review.
Szulc A, Wiedlocha M, Waszkiewicz N, Galińska-Skok B, Marcinowicz P, Gierus J, Mosiolek A
Psychiatry Res Neuroimaging 2018 Mar 30;273:1-8. Epub 2018 Jan 17 doi: 10.1016/j.pscychresns.2018.01.001. PMID: 29414126
Proton magnetic resonance spectroscopy changes after antipsychotic treatment.
Szulc A, Galinska-Skok B, Waszkiewicz N, Bibulowicz D, Konarzewska B, Tarasow E
Curr Med Chem 2013;20(3):414-27. PMID: 23157634
Guidelines for using proton MR spectroscopy in multicenter clinical MS studies.
De Stefano N, Filippi M, Miller D, Pouwels PJ, Rovira A, Gass A, Enzinger C, Matthews PM, Arnold DL
Neurology 2007 Nov 13;69(20):1942-52. doi: 10.1212/01.wnl.0000291557.62706.d3. PMID: 17998486

Recent clinical studies

Etiology

Role of brain metabolites during acute phase of mild traumatic brain injury in prognosis of post-concussion syndrome: A 1H-MRS study.
Dogahe MH, Ramezani S, Reihanian Z, Raminfard S, Feizkhah A, Alijani B, Herfeh SS
Psychiatry Res Neuroimaging 2023 Oct;335:111709. Epub 2023 Aug 28 doi: 10.1016/j.pscychresns.2023.111709. PMID: 37688998
J-difference GABA-edited MRS reveals altered cerebello-thalamo-cortical metabolism in patients with hepatic encephalopathy.
Zöllner HJ, Thiel TA, Füllenbach ND, Jördens MS, Ahn S, Wilms LM, Ljimani A, Häussinger D, Butz M, Wittsack HJ, Schnitzler A, Oeltzschner G
Metab Brain Dis 2023 Apr;38(4):1221-1238. Epub 2023 Feb 2 doi: 10.1007/s11011-023-01174-x. PMID: 36729261Free PMC Article
Whole-Brain Metabolic Abnormalities Are Associated With Mobility in Older Adults With Multiple Sclerosis.
Mueller C, Baird JF, Motl RW
Neurorehabil Neural Repair 2022 Apr;36(4-5):286-297. Epub 2022 Feb 14 doi: 10.1177/15459683221076461. PMID: 35164595Free PMC Article
Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) Imaging in Obsessive-Compulsive Disorder.
Biria M, Cantonas LM, Banca P
Curr Top Behav Neurosci 2021;49:231-268. doi: 10.1007/7854_2020_201. PMID: 33751502
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932

Diagnosis

Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status.
Yang YS, Smucny J, Zhang H, Maddock RJ
Neuroimage Clin 2023;39:103461. Epub 2023 Jun 27 doi: 10.1016/j.nicl.2023.103461. PMID: 37406595Free PMC Article
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Magnetic resonance spectroscopy to assess neuroinflammation and neuropathic pain.
Chang L, Munsaka SM, Kraft-Terry S, Ernst T
J Neuroimmune Pharmacol 2013 Jun;8(3):576-93. Epub 2013 May 12 doi: 10.1007/s11481-013-9460-x. PMID: 23666436Free PMC Article
Proton magnetic resonance spectroscopy changes after antipsychotic treatment.
Szulc A, Galinska-Skok B, Waszkiewicz N, Bibulowicz D, Konarzewska B, Tarasow E
Curr Med Chem 2013;20(3):414-27. PMID: 23157634
Guidelines for using proton MR spectroscopy in multicenter clinical MS studies.
De Stefano N, Filippi M, Miller D, Pouwels PJ, Rovira A, Gass A, Enzinger C, Matthews PM, Arnold DL
Neurology 2007 Nov 13;69(20):1942-52. doi: 10.1212/01.wnl.0000291557.62706.d3. PMID: 17998486

Therapy

Spectroscopic abnormalities in the pregenual anterior cingulate cortex in obsessive-compulsive disorder using proton magnetic resonance spectroscopy: a controlled study.
Kosová E, Pajuelo D, Fajnerová I, Greguš D, Brunovský M, Stopková P, Škoch A, Fürstová P, Španiel F, Horáček J
BMC Psychiatry 2023 Oct 10;23(1):734. doi: 10.1186/s12888-023-05228-3. PMID: 37817131Free PMC Article
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
1H-magnetic resonance spectroscopy study of glutamate-related abnormality in bipolar disorder.
Kubo H, Nakataki M, Sumitani S, Iga JI, Numata S, Kameoka N, Watanabe SY, Umehara H, Kinoshita M, Inoshita M, Tamaru M, Ohta M, Nakayama-Yamauchi C, Funakoshi Y, Harada M, Ohmori T
J Affect Disord 2017 Jan 15;208:139-144. Epub 2016 Oct 8 doi: 10.1016/j.jad.2016.08.046. PMID: 27770643
Abnormal Anterior Cingulate N-Acetylaspartate and Executive Functioning in Treatment-Resistant Depression After rTMS Therapy.
Zheng H, Jia F, Guo G, Quan D, Li G, Wu H, Zhang B, Fan C, He X, Huang H
Int J Neuropsychopharmacol 2015 May 29;18(11):pyv059. doi: 10.1093/ijnp/pyv059. PMID: 26025780Free PMC Article
Proton magnetic resonance spectroscopy changes after antipsychotic treatment.
Szulc A, Galinska-Skok B, Waszkiewicz N, Bibulowicz D, Konarzewska B, Tarasow E
Curr Med Chem 2013;20(3):414-27. PMID: 23157634

Prognosis

Role of brain metabolites during acute phase of mild traumatic brain injury in prognosis of post-concussion syndrome: A 1H-MRS study.
Dogahe MH, Ramezani S, Reihanian Z, Raminfard S, Feizkhah A, Alijani B, Herfeh SS
Psychiatry Res Neuroimaging 2023 Oct;335:111709. Epub 2023 Aug 28 doi: 10.1016/j.pscychresns.2023.111709. PMID: 37688998
BDNF rs6265 Met carriers with alcohol use disorder show greater age-related decline of N-acetylaspartate in left dorsolateral prefrontal cortex.
Durazzo TC, McNerney MW, Hansen AM, Gu M, Sacchet MD, Padula CB
Drug Alcohol Depend 2023 Jul 1;248:109901. Epub 2023 Apr 28 doi: 10.1016/j.drugalcdep.2023.109901. PMID: 37146499
In Vivo 2-Hydroxyglutarate Monitoring With Edited MR Spectroscopy for the Follow-up of IDH-Mutant Diffuse Gliomas: The IDASPE Prospective Study.
Di Stefano AL, Nichelli L, Berzero G, Valabregue R, Touat M, Capelle L, Pontoizeau C, Bielle F, Lerond J, Giry M, Villa C, Baussart B, Dehais C, Galanaud D, Baldini C, Savatovsky J, Dhermain F, Deelchand DK, Ottolenghi C, Lehéricy S, Marjańska M, Branzoli F, Sanson M
Neurology 2023 Jan 3;100(1):e94-e106. Epub 2022 Sep 30 doi: 10.1212/WNL.0000000000201137. PMID: 36180241Free PMC Article
Whole-Brain Metabolic Abnormalities Are Associated With Mobility in Older Adults With Multiple Sclerosis.
Mueller C, Baird JF, Motl RW
Neurorehabil Neural Repair 2022 Apr;36(4-5):286-297. Epub 2022 Feb 14 doi: 10.1177/15459683221076461. PMID: 35164595Free PMC Article
Cerebral folate deficiency in adults: A heterogeneous potentially treatable condition.
Masingue M, Benoist JF, Roze E, Moussa F, Sedel F, Lubetzki C, Nadjar Y
J Neurol Sci 2019 Jan 15;396:112-118. Epub 2018 Nov 10 doi: 10.1016/j.jns.2018.11.014. PMID: 30448717

Clinical prediction guides

Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status.
Yang YS, Smucny J, Zhang H, Maddock RJ
Neuroimage Clin 2023;39:103461. Epub 2023 Jun 27 doi: 10.1016/j.nicl.2023.103461. PMID: 37406595Free PMC Article
J-difference GABA-edited MRS reveals altered cerebello-thalamo-cortical metabolism in patients with hepatic encephalopathy.
Zöllner HJ, Thiel TA, Füllenbach ND, Jördens MS, Ahn S, Wilms LM, Ljimani A, Häussinger D, Butz M, Wittsack HJ, Schnitzler A, Oeltzschner G
Metab Brain Dis 2023 Apr;38(4):1221-1238. Epub 2023 Feb 2 doi: 10.1007/s11011-023-01174-x. PMID: 36729261Free PMC Article
Whole-Brain Metabolic Abnormalities Are Associated With Mobility in Older Adults With Multiple Sclerosis.
Mueller C, Baird JF, Motl RW
Neurorehabil Neural Repair 2022 Apr;36(4-5):286-297. Epub 2022 Feb 14 doi: 10.1177/15459683221076461. PMID: 35164595Free PMC Article
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Proton magnetic resonance spectroscopy changes after antipsychotic treatment.
Szulc A, Galinska-Skok B, Waszkiewicz N, Bibulowicz D, Konarzewska B, Tarasow E
Curr Med Chem 2013;20(3):414-27. PMID: 23157634

Recent systematic reviews

Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Proton magnetic resonance spectroscopy changes after lithium treatment. Systematic review.
Szulc A, Wiedlocha M, Waszkiewicz N, Galińska-Skok B, Marcinowicz P, Gierus J, Mosiolek A
Psychiatry Res Neuroimaging 2018 Mar 30;273:1-8. Epub 2018 Jan 17 doi: 10.1016/j.pscychresns.2018.01.001. PMID: 29414126
Neurochemical alterations of the brain in bipolar disorder and their implications for pathophysiology: a systematic review of the in vivo proton magnetic resonance spectroscopy findings.
Yildiz-Yesiloglu A, Ankerst DP
Prog Neuropsychopharmacol Biol Psychiatry 2006 Aug 30;30(6):969-95. Epub 2006 May 4 doi: 10.1016/j.pnpbp.2006.03.012. PMID: 16677749

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