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Reduced brain choline level by MRS

MedGen UID:
1371032
•Concept ID:
C4476567
•
Finding
Synonym: Reduced brain choline level by magnetic resonance spectroscopy
 
HPO: HP:0025048

Definition

An decrease in the level of choline-containing compounds in the brain identified by magnetic resonance spectroscopy (MRS). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced brain choline level by MRS

Professional guidelines

PubMed

Proton magnetic resonance spectroscopy changes after lithium treatment. Systematic review.
Szulc A, Wiedlocha M, Waszkiewicz N, Galińska-Skok B, Marcinowicz P, Gierus J, Mosiolek A
Psychiatry Res Neuroimaging 2018 Mar 30;273:1-8. Epub 2018 Jan 17 doi: 10.1016/j.pscychresns.2018.01.001. PMID: 29414126
Neurochemical correlates of rapid treatment response to electroconvulsive therapy in patients with major depression.
Njau S, Joshi SH, Espinoza R, Leaver AM, Vasavada M, Marquina A, Woods RP, Narr KL
J Psychiatry Neurosci 2017 Jan;42(1):6-16. doi: 10.1503/jpn.150177. PMID: 27327561Free PMC Article
Monitoring interferon β treatment response with magnetic resonance spectroscopy in relapsing remitting multiple sclerosis.
Yetkin MF, Mirza M, Dönmez H
Medicine (Baltimore) 2016 Sep;95(36):e4782. doi: 10.1097/MD.0000000000004782. PMID: 27603381Free PMC Article

Recent clinical studies

Etiology

Longitudinal Metabolite Changes in Progressive Multiple Sclerosis: A Study of 3 Potential Neuroprotective Treatments.
John NA, Solanky BS, De Angelis F, Parker RA, Weir CJ, Stutters J, Carrasco FP, Schneider T, Doshi A, Calvi A, Williams T, Plantone D, Monteverdi A, MacManus D, Marshall I, Barkhof F, Gandini Wheeler-Kingshott CAM, Chataway J; MS‐SMART Investigators
J Magn Reson Imaging 2024 Jun;59(6):2192-2201. Epub 2023 Oct 3 doi: 10.1002/jmri.29017. PMID: 37787109
Exploratory Multisite MR Spectroscopic Imaging Shows White Matter Neuroaxonal Loss Associated with Complications of Type 1 Diabetes in Children.
Cai LY, Tanase C, Anderson AW, Patel NJ, Lee CA, Jones RS, LeStourgeon LM, Mahon A, Taki I, Juvera J, Pruthi S, Gwal K, Ozturk A, Kang H, Rewers A, Rewers MJ, Alonso GT, Glaser N, Ghetti S, Jaser SS, Landman BA, Jordan LC
AJNR Am J Neuroradiol 2023 Jul;44(7):820-827. Epub 2023 Jun 1 doi: 10.3174/ajnr.A7895. PMID: 37263786Free PMC Article
Determination of Brain Metabolite T(1) Without Interference From Macromolecule Relaxation.
An L, Araneta MF, Victorino M, Shen J
J Magn Reson Imaging 2020 Nov;52(5):1352-1359. Epub 2020 Jul 3 doi: 10.1002/jmri.27259. PMID: 32618104Free PMC Article
The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial.
Ford TC, Downey LA, Simpson T, McPhee G, Oliver C, Stough C
Nutrients 2018 Dec 1;10(12) doi: 10.3390/nu10121860. PMID: 30513795Free PMC Article
Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children.
Van Dalen YW, Blokhuis C, Cohen S, Ter Stege JA, Teunissen CE, Kuhle J, Kootstra NA, Scherpbier HJ, Kuijpers TW, Reiss P, Majoie CBLM, Caan MWA, Pajkrt D
Medicine (Baltimore) 2016 Mar;95(12):e3093. doi: 10.1097/MD.0000000000003093. PMID: 27015179Free PMC Article

Diagnosis

Magnetic Resonance Spectroscopy (MRS) in Alzheimer's Disease.
Sheikh-Bahaei N, Chen M, Pappas I
Methods Mol Biol 2024;2785:115-142. doi: 10.1007/978-1-0716-3774-6_9. PMID: 38427192
Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status.
Yang YS, Smucny J, Zhang H, Maddock RJ
Neuroimage Clin 2023;39:103461. Epub 2023 Jun 27 doi: 10.1016/j.nicl.2023.103461. PMID: 37406595Free PMC Article
Usefulness of magnetic resonance spectroscopy in mesial temporal sclerosis: a systematic review.
Fernández-Vega N, Ramos-Rodriguez JR, Alfaro F, Barbancho MÁ, García-Casares N
Neuroradiology 2021 Sep;63(9):1395-1405. Epub 2021 Apr 13 doi: 10.1007/s00234-021-02704-z. PMID: 33851253
Cerebrospinal Fluid Amyloid Beta, Tau Levels, Apolipoprotein, and (1)H-MRS Brain Metabolites in Alzheimer's Disease: A Systematic Review.
Piersson AD, Mohamad M, Rajab F, Suppiah S
Acad Radiol 2021 Oct;28(10):1447-1463. Epub 2020 Jul 7 doi: 10.1016/j.acra.2020.06.006. PMID: 32651050
Magnetic Resonance Spectroscopy in Alzheimer's Disease: Systematic Review and Meta-Analysis.
Wang H, Tan L, Wang HF, Liu Y, Yin RH, Wang WY, Chang XL, Jiang T, Yu JT
J Alzheimers Dis 2015;46(4):1049-70. doi: 10.3233/JAD-143225. PMID: 26402632

Therapy

Longitudinal Metabolite Changes in Progressive Multiple Sclerosis: A Study of 3 Potential Neuroprotective Treatments.
John NA, Solanky BS, De Angelis F, Parker RA, Weir CJ, Stutters J, Carrasco FP, Schneider T, Doshi A, Calvi A, Williams T, Plantone D, Monteverdi A, MacManus D, Marshall I, Barkhof F, Gandini Wheeler-Kingshott CAM, Chataway J; MS‐SMART Investigators
J Magn Reson Imaging 2024 Jun;59(6):2192-2201. Epub 2023 Oct 3 doi: 10.1002/jmri.29017. PMID: 37787109
MRS suggests multi-regional inflammation and white matter axonal damage at 11 years following perinatal HIV infection.
Graham AS, Holmes MJ, Little F, Dobbels E, Cotton MF, Laughton B, van der Kouwe A, Meintjes EM, Robertson FC
Neuroimage Clin 2020;28:102505. Epub 2020 Nov 19 doi: 10.1016/j.nicl.2020.102505. PMID: 33395994Free PMC Article
The effect of spinal manipulation on brain neurometabolites in chronic nonspecific low back pain patients: a randomized clinical trial.
Didehdar D, Kamali F, Yoosefinejad AK, Lotfi M
Ir J Med Sci 2020 May;189(2):543-550. Epub 2019 Nov 26 doi: 10.1007/s11845-019-02140-2. PMID: 31773541
The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial.
Ford TC, Downey LA, Simpson T, McPhee G, Oliver C, Stough C
Nutrients 2018 Dec 1;10(12) doi: 10.3390/nu10121860. PMID: 30513795Free PMC Article
Cortical neurochemistry in euthymic patients with bipolar I disorder.
Scherk H, Backens M, Schneider-Axmann T, Usher J, Kemmer C, Reith W, Falkai P, Gruber O
World J Biol Psychiatry 2009;10(4):285-94. doi: 10.3109/15622970701472086. PMID: 19921970

Prognosis

Magnetic Resonance Spectroscopy (MRS) in Alzheimer's Disease.
Sheikh-Bahaei N, Chen M, Pappas I
Methods Mol Biol 2024;2785:115-142. doi: 10.1007/978-1-0716-3774-6_9. PMID: 38427192
Variation of T(2) relaxation times in pediatric brain tumors and their effect on metabolite quantification.
Carlin D, Babourina-Brooks B, Davies NP, Wilson M, Peet AC
J Magn Reson Imaging 2019 Jan;49(1):195-203. Epub 2018 Apr 26 doi: 10.1002/jmri.26054. PMID: 29697883Free PMC Article
Association between Subcortical Morphology and Cerebral White Matter Energy Metabolism in Neonates with Congenital Heart Disease.
Gertsvolf N, Votava-Smith JK, Ceschin R, Del Castillo S, Lee V, Lai HA, Bluml S, Paquette L, Panigrahy A
Sci Rep 2018 Sep 19;8(1):14057. doi: 10.1038/s41598-018-32288-3. PMID: 30232359Free PMC Article
Neurochemical correlates of rapid treatment response to electroconvulsive therapy in patients with major depression.
Njau S, Joshi SH, Espinoza R, Leaver AM, Vasavada M, Marquina A, Woods RP, Narr KL
J Psychiatry Neurosci 2017 Jan;42(1):6-16. doi: 10.1503/jpn.150177. PMID: 27327561Free PMC Article
The role of brain MRI in mitochondrial neurogastrointestinal encephalomyopathy.
Scarpelli M, Ricciardi GK, Beltramello A, Zocca I, Calabria F, Russignan A, Zappini F, Cotelli MS, Padovani A, Tomelleri G, Filosto M, Tonin P
Neuroradiol J 2013 Oct;26(5):520-30. Epub 2013 Nov 7 doi: 10.1177/197140091302600505. PMID: 24199812Free PMC Article

Clinical prediction guides

Longitudinal Metabolite Changes in Progressive Multiple Sclerosis: A Study of 3 Potential Neuroprotective Treatments.
John NA, Solanky BS, De Angelis F, Parker RA, Weir CJ, Stutters J, Carrasco FP, Schneider T, Doshi A, Calvi A, Williams T, Plantone D, Monteverdi A, MacManus D, Marshall I, Barkhof F, Gandini Wheeler-Kingshott CAM, Chataway J; MS‐SMART Investigators
J Magn Reson Imaging 2024 Jun;59(6):2192-2201. Epub 2023 Oct 3 doi: 10.1002/jmri.29017. PMID: 37787109
Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status.
Yang YS, Smucny J, Zhang H, Maddock RJ
Neuroimage Clin 2023;39:103461. Epub 2023 Jun 27 doi: 10.1016/j.nicl.2023.103461. PMID: 37406595Free PMC Article
Hippocampal MRS and subfield volumetry at 7T detects dysfunction not specific to seizure focus.
Voets NL, Hodgetts CJ, Sen A, Adcock JE, Emir U
Sci Rep 2017 Nov 23;7(1):16138. doi: 10.1038/s41598-017-16046-5. PMID: 29170537Free PMC Article
Magnetic Resonance Spectroscopy for Traumatic Brain Injury.
Croall I, Smith FE, Blamire AM
Top Magn Reson Imaging 2015 Oct;24(5):267-74. doi: 10.1097/RMR.0000000000000063. PMID: 26502308
Magnetic Resonance Spectroscopy in Alzheimer's Disease: Systematic Review and Meta-Analysis.
Wang H, Tan L, Wang HF, Liu Y, Yin RH, Wang WY, Chang XL, Jiang T, Yu JT
J Alzheimers Dis 2015;46(4):1049-70. doi: 10.3233/JAD-143225. PMID: 26402632

Recent systematic reviews

Usefulness of magnetic resonance spectroscopy in mesial temporal sclerosis: a systematic review.
Fernández-Vega N, Ramos-Rodriguez JR, Alfaro F, Barbancho MÁ, García-Casares N
Neuroradiology 2021 Sep;63(9):1395-1405. Epub 2021 Apr 13 doi: 10.1007/s00234-021-02704-z. PMID: 33851253
Cerebrospinal Fluid Amyloid Beta, Tau Levels, Apolipoprotein, and (1)H-MRS Brain Metabolites in Alzheimer's Disease: A Systematic Review.
Piersson AD, Mohamad M, Rajab F, Suppiah S
Acad Radiol 2021 Oct;28(10):1447-1463. Epub 2020 Jul 7 doi: 10.1016/j.acra.2020.06.006. PMID: 32651050
Proton magnetic resonance spectroscopy changes after lithium treatment. Systematic review.
Szulc A, Wiedlocha M, Waszkiewicz N, Galińska-Skok B, Marcinowicz P, Gierus J, Mosiolek A
Psychiatry Res Neuroimaging 2018 Mar 30;273:1-8. Epub 2018 Jan 17 doi: 10.1016/j.pscychresns.2018.01.001. PMID: 29414126
Magnetic Resonance Spectroscopy in Alzheimer's Disease: Systematic Review and Meta-Analysis.
Wang H, Tan L, Wang HF, Liu Y, Yin RH, Wang WY, Chang XL, Jiang T, Yu JT
J Alzheimers Dis 2015;46(4):1049-70. doi: 10.3233/JAD-143225. PMID: 26402632

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