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Abnormal brain creatine level by MRS

MedGen UID:
1370529
•Concept ID:
C4476568
•
Finding
Synonym: Abnormal brain creatine level by magnetic resonance spectroscopy
 
HPO: HP:0025049

Professional guidelines

PubMed

Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease.
Voevodskaya O, Sundgren PC, Strandberg O, Zetterberg H, Minthon L, Blennow K, Wahlund LO, Westman E, Hansson O; Swedish BioFINDER study group
Neurology 2016 May 10;86(19):1754-61. Epub 2016 Apr 15 doi: 10.1212/WNL.0000000000002672. PMID: 27164711Free PMC Article
Brain metabolism in Rett syndrome: age, clinical, and genotype correlations.
Horská A, Farage L, Bibat G, Nagae LM, Kaufmann WE, Barker PB, Naidu S
Ann Neurol 2009 Jan;65(1):90-7. doi: 10.1002/ana.21562. PMID: 19194883Free PMC Article
Cerebral creatine deficiency syndromes: clinical aspects, treatment and pathophysiology.
Stockler S, Schutz PW, Salomons GS
Subcell Biochem 2007;46:149-66. doi: 10.1007/978-1-4020-6486-9_8. PMID: 18652076

Recent clinical studies

Etiology

Magnetic Resonance Spectroscopy Studies of Brain Energy Metabolism in Schizophrenia: Progression from Prodrome to Chronic Psychosis.
Stein A, Zhu C, Du F, Öngür D
Curr Psychiatry Rep 2023 Nov;25(11):659-669. Epub 2023 Oct 9 doi: 10.1007/s11920-023-01457-1. PMID: 37812338
J-difference GABA-edited MRS reveals altered cerebello-thalamo-cortical metabolism in patients with hepatic encephalopathy.
Zöllner HJ, Thiel TA, Füllenbach ND, Jördens MS, Ahn S, Wilms LM, Ljimani A, Häussinger D, Butz M, Wittsack HJ, Schnitzler A, Oeltzschner G
Metab Brain Dis 2023 Apr;38(4):1221-1238. Epub 2023 Feb 2 doi: 10.1007/s11011-023-01174-x. PMID: 36729261Free PMC Article
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Brain-heart axis--Review Article.
Manea MM, Comsa M, Minca A, Dragos D, Popa C
J Med Life 2015 Jul-Sep;8(3):266-71. PMID: 26351525Free PMC Article
Cerebral creatine deficiency syndromes: clinical aspects, treatment and pathophysiology.
Stockler S, Schutz PW, Salomons GS
Subcell Biochem 2007;46:149-66. doi: 10.1007/978-1-4020-6486-9_8. PMID: 18652076

Diagnosis

Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status.
Yang YS, Smucny J, Zhang H, Maddock RJ
Neuroimage Clin 2023;39:103461. Epub 2023 Jun 27 doi: 10.1016/j.nicl.2023.103461. PMID: 37406595Free PMC Article
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Brain-heart axis--Review Article.
Manea MM, Comsa M, Minca A, Dragos D, Popa C
J Med Life 2015 Jul-Sep;8(3):266-71. PMID: 26351525Free PMC Article
Magnetic resonance spectroscopy to assess neuroinflammation and neuropathic pain.
Chang L, Munsaka SM, Kraft-Terry S, Ernst T
J Neuroimmune Pharmacol 2013 Jun;8(3):576-93. Epub 2013 May 12 doi: 10.1007/s11481-013-9460-x. PMID: 23666436Free PMC Article
Cerebral creatine deficiency syndromes: clinical aspects, treatment and pathophysiology.
Stockler S, Schutz PW, Salomons GS
Subcell Biochem 2007;46:149-66. doi: 10.1007/978-1-4020-6486-9_8. PMID: 18652076

Therapy

Magnetic Resonance Spectroscopy Studies of Brain Energy Metabolism in Schizophrenia: Progression from Prodrome to Chronic Psychosis.
Stein A, Zhu C, Du F, Öngür D
Curr Psychiatry Rep 2023 Nov;25(11):659-669. Epub 2023 Oct 9 doi: 10.1007/s11920-023-01457-1. PMID: 37812338
Intranasal Insulin Attenuates the Long-Term Adverse Effects of Neonatal Hyperglycemia on the Hippocampus in Rats.
McClure Yauch L, Ennis-Czerniak K, Frey Ii WH, Tkac I, Rao RB
Dev Neurosci 2022;44(6):590-602. Epub 2022 Aug 30 doi: 10.1159/000526627. PMID: 36041414Free PMC Article
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders.
Chang L, Cloak CC, Ernst T
J Clin Psychiatry 2003;64 Suppl 3:7-14. PMID: 12662128
Neurochemical investigation of the schizophrenic brain by in vivo phosphorus magnetic resonance spectroscopy.
Fukuzako H
World J Biol Psychiatry 2001 Apr;2(2):70-82. doi: 10.3109/15622970109027496. PMID: 12587188

Prognosis

Magnetic Resonance Spectroscopy Studies of Brain Energy Metabolism in Schizophrenia: Progression from Prodrome to Chronic Psychosis.
Stein A, Zhu C, Du F, Öngür D
Curr Psychiatry Rep 2023 Nov;25(11):659-669. Epub 2023 Oct 9 doi: 10.1007/s11920-023-01457-1. PMID: 37812338
BDNF rs6265 Met carriers with alcohol use disorder show greater age-related decline of N-acetylaspartate in left dorsolateral prefrontal cortex.
Durazzo TC, McNerney MW, Hansen AM, Gu M, Sacchet MD, Padula CB
Drug Alcohol Depend 2023 Jul 1;248:109901. Epub 2023 Apr 28 doi: 10.1016/j.drugalcdep.2023.109901. PMID: 37146499
Whole-Brain Metabolic Abnormalities Are Associated With Mobility in Older Adults With Multiple Sclerosis.
Mueller C, Baird JF, Motl RW
Neurorehabil Neural Repair 2022 Apr;36(4-5):286-297. Epub 2022 Feb 14 doi: 10.1177/15459683221076461. PMID: 35164595Free PMC Article
Cerebral folate deficiency in adults: A heterogeneous potentially treatable condition.
Masingue M, Benoist JF, Roze E, Moussa F, Sedel F, Lubetzki C, Nadjar Y
J Neurol Sci 2019 Jan 15;396:112-118. Epub 2018 Nov 10 doi: 10.1016/j.jns.2018.11.014. PMID: 30448717
Brain-heart axis--Review Article.
Manea MM, Comsa M, Minca A, Dragos D, Popa C
J Med Life 2015 Jul-Sep;8(3):266-71. PMID: 26351525Free PMC Article

Clinical prediction guides

Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status.
Yang YS, Smucny J, Zhang H, Maddock RJ
Neuroimage Clin 2023;39:103461. Epub 2023 Jun 27 doi: 10.1016/j.nicl.2023.103461. PMID: 37406595Free PMC Article
J-difference GABA-edited MRS reveals altered cerebello-thalamo-cortical metabolism in patients with hepatic encephalopathy.
Zöllner HJ, Thiel TA, Füllenbach ND, Jördens MS, Ahn S, Wilms LM, Ljimani A, Häussinger D, Butz M, Wittsack HJ, Schnitzler A, Oeltzschner G
Metab Brain Dis 2023 Apr;38(4):1221-1238. Epub 2023 Feb 2 doi: 10.1007/s11011-023-01174-x. PMID: 36729261Free PMC Article
The Auditory Afferent Pathway as a Clinical Marker of Alzheimer's Disease.
Shad KF, Soubra W, Cordato DJ
J Alzheimers Dis 2022;85(1):47-53. doi: 10.3233/JAD-215206. PMID: 34776450
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Brain-heart axis--Review Article.
Manea MM, Comsa M, Minca A, Dragos D, Popa C
J Med Life 2015 Jul-Sep;8(3):266-71. PMID: 26351525Free PMC Article

Recent systematic reviews

Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Neuroimaging correlates of narcolepsy with cataplexy: A systematic review.
Wada M, Mimura M, Noda Y, Takasu S, Plitman E, Honda M, Natsubori A, Ogyu K, Tarumi R, Graff-Guerrero A, Nakajima S
Neurosci Res 2019 May;142:16-29. Epub 2018 Mar 23 doi: 10.1016/j.neures.2018.03.005. PMID: 29580887
Neurochemical alterations of the brain in bipolar disorder and their implications for pathophysiology: a systematic review of the in vivo proton magnetic resonance spectroscopy findings.
Yildiz-Yesiloglu A, Ankerst DP
Prog Neuropsychopharmacol Biol Psychiatry 2006 Aug 30;30(6):969-95. Epub 2006 May 4 doi: 10.1016/j.pnpbp.2006.03.012. PMID: 16677749

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