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Elevated brain creatine level by MRS

MedGen UID:
1370595
•Concept ID:
C4476569
•
Finding
Synonym: Elevated brain creatine level by magnetic resonance spectroscopy
 
HPO: HP:0025050

Definition

An increase in the level of creatine in the brain identified by magnetic resonance spectroscopy (MRS). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated brain creatine level by MRS

Professional guidelines

PubMed

Association Between Anterior Cingulate Cortex Neurochemical Profile and Clinical Remission After Electroconvulsive Treatment in Major Depressive Disorder: A Longitudinal 1H Magnetic Resonance Spectroscopy Study.
Ermis C, Aydin B, Kucukguclu S, Yurt A, Renshaw PF, Yildiz A
J ECT 2021 Dec 1;37(4):263-269. doi: 10.1097/YCT.0000000000000766. PMID: 33840802
Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease.
Voevodskaya O, Sundgren PC, Strandberg O, Zetterberg H, Minthon L, Blennow K, Wahlund LO, Westman E, Hansson O; Swedish BioFINDER study group
Neurology 2016 May 10;86(19):1754-61. Epub 2016 Apr 15 doi: 10.1212/WNL.0000000000002672. PMID: 27164711Free PMC Article
Treatment-Resistant Schizophrenia Patients Show Elevated Anterior Cingulate Cortex Glutamate Compared to Treatment-Responsive.
Mouchlianitis E, Bloomfield MA, Law V, Beck K, Selvaraj S, Rasquinha N, Waldman A, Turkheimer FE, Egerton A, Stone J, Howes OD
Schizophr Bull 2016 May;42(3):744-52. Epub 2015 Dec 17 doi: 10.1093/schbul/sbv151. PMID: 26683625Free PMC Article

Recent clinical studies

Etiology

Increased prefrontal GABA concentrations in adults with autism spectrum disorders.
Maier S, Düppers AL, Runge K, Dacko M, Lange T, Fangmeier T, Riedel A, Ebert D, Endres D, Domschke K, Perlov E, Nickel K, Tebartz van Elst L
Autism Res 2022 Jul;15(7):1222-1236. Epub 2022 May 19 doi: 10.1002/aur.2740. PMID: 35587691
Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
Hone-Blanchet A, Bohsali A, Krishnamurthy LC, Shahid S, Lin Q, Zhao L, Loring D, Goldstein F, John SE, Fleischer CC, Levey A, Lah J, Qiu D, Crosson B
Neurobiol Aging 2022 Jan;109:22-30. Epub 2021 Sep 20 doi: 10.1016/j.neurobiolaging.2021.09.016. PMID: 34638000Free PMC Article
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Covert hepatic encephalopathy: elevated total glutathione and absence of brain water content changes.
Oeltzschner G, Butz M, Wickrath F, Wittsack HJ, Schnitzler A
Metab Brain Dis 2016 Jun;31(3):517-27. Epub 2015 Nov 12 doi: 10.1007/s11011-015-9760-3. PMID: 26563124
Brain-heart axis--Review Article.
Manea MM, Comsa M, Minca A, Dragos D, Popa C
J Med Life 2015 Jul-Sep;8(3):266-71. PMID: 26351525Free PMC Article

Diagnosis

Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status.
Yang YS, Smucny J, Zhang H, Maddock RJ
Neuroimage Clin 2023;39:103461. Epub 2023 Jun 27 doi: 10.1016/j.nicl.2023.103461. PMID: 37406595Free PMC Article
Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
Hone-Blanchet A, Bohsali A, Krishnamurthy LC, Shahid S, Lin Q, Zhao L, Loring D, Goldstein F, John SE, Fleischer CC, Levey A, Lah J, Qiu D, Crosson B
Neurobiol Aging 2022 Jan;109:22-30. Epub 2021 Sep 20 doi: 10.1016/j.neurobiolaging.2021.09.016. PMID: 34638000Free PMC Article
Brain-heart axis--Review Article.
Manea MM, Comsa M, Minca A, Dragos D, Popa C
J Med Life 2015 Jul-Sep;8(3):266-71. PMID: 26351525Free PMC Article
Magnetic resonance spectroscopy to assess neuroinflammation and neuropathic pain.
Chang L, Munsaka SM, Kraft-Terry S, Ernst T
J Neuroimmune Pharmacol 2013 Jun;8(3):576-93. Epub 2013 May 12 doi: 10.1007/s11481-013-9460-x. PMID: 23666436Free PMC Article
Potential of MR spectroscopy for assessment of glioma grading.
Bulik M, Jancalek R, Vanicek J, Skoch A, Mechl M
Clin Neurol Neurosurg 2013 Feb;115(2):146-53. Epub 2012 Dec 10 doi: 10.1016/j.clineuro.2012.11.002. PMID: 23237636

Therapy

Elevation of brain gamma-aminobutyric acid levels is associated with vigabatrin-associated brain abnormalities on magnetic resonance imaging.
Ikeda A, Tomiyasu M, Yamamoto A, Tsuyusaki Y, Kawai Y, Tanabe M, Tsuji M, Iai M, Aida N, Goto T
Epilepsy Res 2022 Mar;181:106881. Epub 2022 Feb 7 doi: 10.1016/j.eplepsyres.2022.106881. PMID: 35183975
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Guanidinoacetic acid loading for improved location-specific brain creatine.
Ostojic SM
Clin Nutr 2021 Jan;40(1):324-326. Epub 2020 May 11 doi: 10.1016/j.clnu.2020.05.003. PMID: 32439266
Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders.
Chang L, Cloak CC, Ernst T
J Clin Psychiatry 2003;64 Suppl 3:7-14. PMID: 12662128
Neurochemical investigation of the schizophrenic brain by in vivo phosphorus magnetic resonance spectroscopy.
Fukuzako H
World J Biol Psychiatry 2001 Apr;2(2):70-82. doi: 10.3109/15622970109027496. PMID: 12587188

Prognosis

Quantitative measurement of peritumoral concentrations of glutamate, N-acetyl aspartate, and lactate on magnetic resonance spectroscopy predicts glioblastoma-related refractory epilepsy.
Nakamura Y, Inoue A, Nishikawa M, Ohnishi T, Yano H, Kanemura Y, Ohtsuka Y, Ozaki S, Kusakabe K, Suehiro S, Yamashita D, Shigekawa S, Watanabe H, Kitazawa R, Tanaka J, Kunieda T
Acta Neurochir (Wien) 2022 Dec;164(12):3253-3266. Epub 2022 Sep 15 doi: 10.1007/s00701-022-05363-y. PMID: 36107232
Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
Hone-Blanchet A, Bohsali A, Krishnamurthy LC, Shahid S, Lin Q, Zhao L, Loring D, Goldstein F, John SE, Fleischer CC, Levey A, Lah J, Qiu D, Crosson B
Neurobiol Aging 2022 Jan;109:22-30. Epub 2021 Sep 20 doi: 10.1016/j.neurobiolaging.2021.09.016. PMID: 34638000Free PMC Article
Association Between Anterior Cingulate Cortex Neurochemical Profile and Clinical Remission After Electroconvulsive Treatment in Major Depressive Disorder: A Longitudinal 1H Magnetic Resonance Spectroscopy Study.
Ermis C, Aydin B, Kucukguclu S, Yurt A, Renshaw PF, Yildiz A
J ECT 2021 Dec 1;37(4):263-269. doi: 10.1097/YCT.0000000000000766. PMID: 33840802
Brain-heart axis--Review Article.
Manea MM, Comsa M, Minca A, Dragos D, Popa C
J Med Life 2015 Jul-Sep;8(3):266-71. PMID: 26351525Free PMC Article
Regional patterns of brain metabolites in AIDS dementia complex.
Yiannoutsos CT, Ernst T, Chang L, Lee PL, Richards T, Marra CM, Meyerhoff DJ, Jarvik JG, Kolson D, Schifitto G, Ellis RJ, Swindells S, Simpson DM, Miller EN, Gonzalez RG, Navia BA
Neuroimage 2004 Nov;23(3):928-35. doi: 10.1016/j.neuroimage.2004.07.033. PMID: 15528093

Clinical prediction guides

Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status.
Yang YS, Smucny J, Zhang H, Maddock RJ
Neuroimage Clin 2023;39:103461. Epub 2023 Jun 27 doi: 10.1016/j.nicl.2023.103461. PMID: 37406595Free PMC Article
Elevated GABA level in the precuneus and its association with pain intensity in patients with postherpetic neuralgia: An initial proton magnetic resonance spectroscopy study.
Wu X, Yuan J, Yang Y, Han S, Dai H, Wang L, Li Y
Eur J Radiol 2022 Dec;157:110568. Epub 2022 Oct 18 doi: 10.1016/j.ejrad.2022.110568. PMID: 36279626
Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
Hone-Blanchet A, Bohsali A, Krishnamurthy LC, Shahid S, Lin Q, Zhao L, Loring D, Goldstein F, John SE, Fleischer CC, Levey A, Lah J, Qiu D, Crosson B
Neurobiol Aging 2022 Jan;109:22-30. Epub 2021 Sep 20 doi: 10.1016/j.neurobiolaging.2021.09.016. PMID: 34638000Free PMC Article
Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Brain-heart axis--Review Article.
Manea MM, Comsa M, Minca A, Dragos D, Popa C
J Med Life 2015 Jul-Sep;8(3):266-71. PMID: 26351525Free PMC Article

Recent systematic reviews

Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of (1)H-MRS studies.
Scotti-Muzzi E, Umla-Runge K, Soeiro-de-Souza MG
Eur Neuropsychopharmacol 2021 Jun;47:62-73. Epub 2021 Feb 11 doi: 10.1016/j.euroneuro.2021.01.096. PMID: 33581932
Magnetic Resonance Spectroscopy in Alzheimer's Disease: Systematic Review and Meta-Analysis.
Wang H, Tan L, Wang HF, Liu Y, Yin RH, Wang WY, Chang XL, Jiang T, Yu JT
J Alzheimers Dis 2015;46(4):1049-70. doi: 10.3233/JAD-143225. PMID: 26402632
Brain glutamate levels measured by magnetic resonance spectroscopy in patients with bipolar disorder: a meta-analysis.
Gigante AD, Bond DJ, Lafer B, Lam RW, Young LT, Yatham LN
Bipolar Disord 2012 Aug;14(5):478-87. doi: 10.1111/j.1399-5618.2012.01033.x. PMID: 22834460

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