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Leakage of dye on fundus fluorescein angiography

MedGen UID:
1370943
•Concept ID:
C4476700
•
Finding
Synonym: Fluorescein leakage
 
HPO: HP:0025320

Definition

Leakage of fluorescein dye observed upon retinal fluorescein angiography. Areas of leakage can be appreciated as showing gradual enlargement with blurring of margins. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeakage of dye on fundus fluorescein angiography

Professional guidelines

PubMed

Imaging Characteristics and Clinical Utility of Half-Dose versus Full-Dose Ultrawidefield Fundus Fluorescein Angiography.
Szigiato A, Sharma S, Singh S, Baynes K, Lowder C, Kaiser PK, Ehlers JP, Srivastava SK
Ophthalmol Retina 2024 Oct;8(10):981-986. Epub 2024 May 6 doi: 10.1016/j.oret.2024.04.024. PMID: 38719190
Clinical features and differential diagnosis of acute idiopathic blind spot enlargement syndrome.
Liu X, Chen B, Zhang M, Huang H
Eye Sci 2014 Sep;29(3):143-50. PMID: 26011969
Principles of treatment of choroidal neovascularization with photodynamic therapy in age-related macular degeneration.
Donati G, Kapetanios AD, Pournaras CJ
Semin Ophthalmol 1999 Mar;14(1):2-10. doi: 10.3109/08820539909056057. PMID: 10790570

Recent clinical studies

Etiology

Indocyanine Green Angiographic Assessment of Conjunctival Melanocytic Disorders.
Palme C, Wanner A, Romano V, Franchi A, Haas G, Kaye SB, Steger B
Cornea 2021 Dec 1;40(12):1519-1524. doi: 10.1097/ICO.0000000000002681. PMID: 33591034
Retinal Vasculitis and Intraocular Inflammation after Intravitreal Injection of Brolucizumab.
Baumal CR, Spaide RF, Vajzovic L, Freund KB, Walter SD, John V, Rich R, Chaudhry N, Lakhanpal RR, Oellers PR, Leveque TK, Rutledge BK, Chittum M, Bacci T, Enriquez AB, Sund NJ, Subong ENP, Albini TA
Ophthalmology 2020 Oct;127(10):1345-1359. Epub 2020 Apr 25 doi: 10.1016/j.ophtha.2020.04.017. PMID: 32344075
Findings of OCT-angiography compared to fluorescein and indocyanine green angiography in central serous chorioretinopathy.
Min JY, Lv Y, Yu S, Gong YY
Lasers Surg Med 2018 Dec;50(10):987-993. Epub 2018 Jun 12 doi: 10.1002/lsm.22952. PMID: 29896889
Fully automatic segmentation of fluorescein leakage in subjects with diabetic macular edema.
Rabbani H, Allingham MJ, Mettu PS, Cousins SW, Farsiu S
Invest Ophthalmol Vis Sci 2015 Jan 29;56(3):1482-92. doi: 10.1167/iovs.14-15457. PMID: 25634978Free PMC Article
A case of Vogt-Koyanagi-Harada disease in a patient with Graves disease.
Seo JH, Yu HG, Chung H
Korean J Ophthalmol 2009 Jun;23(2):112-3. Epub 2009 Jun 9 doi: 10.3341/kjo.2009.23.2.112. PMID: 19568361Free PMC Article

Diagnosis

A case of Vogt-Koyanagi-Harada disease in a patient with Graves disease.
Seo JH, Yu HG, Chung H
Korean J Ophthalmol 2009 Jun;23(2):112-3. Epub 2009 Jun 9 doi: 10.3341/kjo.2009.23.2.112. PMID: 19568361Free PMC Article
Fluorescein and indocyanine green angiographic findings in progressive hemifacial atrophy.
Kawazoe M, Hirata A, Okinami S
J Pediatr Ophthalmol Strabismus 2009 Jan-Feb;46(1):56-8. doi: 10.3928/01913913-20090101-11. PMID: 19213282
Dengue-associated maculopathy.
Bacsal KE, Chee SP, Cheng CL, Flores JV
Arch Ophthalmol 2007 Apr;125(4):501-10. doi: 10.1001/archopht.125.4.501. PMID: 17420370
Idiopathic multiple serous detachments of the retinal pigment epithelium followed by bilateral central serous chorioretinopathy: a case report.
Bandello F, Incorvaia C, Parmeggiani F, Sebastiani A
Ophthalmologica 2000 Sep-Oct;214(5):362-7. doi: 10.1159/000027522. PMID: 10965253
Peripapillary fluorescein leakage in 11778 Leber's optic neuropathy.
Yen MY, Wei YH, Liu JH
J Neuroophthalmol 1996 Sep;16(3):178-81. PMID: 8865009

Therapy

Imaging Characteristics and Clinical Utility of Half-Dose versus Full-Dose Ultrawidefield Fundus Fluorescein Angiography.
Szigiato A, Sharma S, Singh S, Baynes K, Lowder C, Kaiser PK, Ehlers JP, Srivastava SK
Ophthalmol Retina 2024 Oct;8(10):981-986. Epub 2024 May 6 doi: 10.1016/j.oret.2024.04.024. PMID: 38719190
Clinical and imaging features of sympathetic ophthalmia and efficacy of the current therapy.
Zhao X, Zhao Q, Meng L, Zhang W, Chen Y
Acta Ophthalmol 2022 Nov;100(7):e1403-e1411. Epub 2022 Jan 27 doi: 10.1111/aos.15095. PMID: 35088530
Retinal Vasculitis and Intraocular Inflammation after Intravitreal Injection of Brolucizumab.
Baumal CR, Spaide RF, Vajzovic L, Freund KB, Walter SD, John V, Rich R, Chaudhry N, Lakhanpal RR, Oellers PR, Leveque TK, Rutledge BK, Chittum M, Bacci T, Enriquez AB, Sund NJ, Subong ENP, Albini TA
Ophthalmology 2020 Oct;127(10):1345-1359. Epub 2020 Apr 25 doi: 10.1016/j.ophtha.2020.04.017. PMID: 32344075
OCT Angiography Compared to Fluorescein and Indocyanine Green Angiography in Chronic Central Serous Chorioretinopathy.
Teussink MM, Breukink MB, van Grinsven MJ, Hoyng CB, Klevering BJ, Boon CJ, de Jong EK, Theelen T
Invest Ophthalmol Vis Sci 2015 Aug;56(9):5229-37. doi: 10.1167/iovs.15-17140. PMID: 26244299
Dengue-associated maculopathy.
Bacsal KE, Chee SP, Cheng CL, Flores JV
Arch Ophthalmol 2007 Apr;125(4):501-10. doi: 10.1001/archopht.125.4.501. PMID: 17420370

Prognosis

Imaging Characteristics and Clinical Utility of Half-Dose versus Full-Dose Ultrawidefield Fundus Fluorescein Angiography.
Szigiato A, Sharma S, Singh S, Baynes K, Lowder C, Kaiser PK, Ehlers JP, Srivastava SK
Ophthalmol Retina 2024 Oct;8(10):981-986. Epub 2024 May 6 doi: 10.1016/j.oret.2024.04.024. PMID: 38719190
Clinical and imaging features of sympathetic ophthalmia and efficacy of the current therapy.
Zhao X, Zhao Q, Meng L, Zhang W, Chen Y
Acta Ophthalmol 2022 Nov;100(7):e1403-e1411. Epub 2022 Jan 27 doi: 10.1111/aos.15095. PMID: 35088530
Indocyanine Green Angiographic Assessment of Conjunctival Melanocytic Disorders.
Palme C, Wanner A, Romano V, Franchi A, Haas G, Kaye SB, Steger B
Cornea 2021 Dec 1;40(12):1519-1524. doi: 10.1097/ICO.0000000000002681. PMID: 33591034
Retinal Vasculitis and Intraocular Inflammation after Intravitreal Injection of Brolucizumab.
Baumal CR, Spaide RF, Vajzovic L, Freund KB, Walter SD, John V, Rich R, Chaudhry N, Lakhanpal RR, Oellers PR, Leveque TK, Rutledge BK, Chittum M, Bacci T, Enriquez AB, Sund NJ, Subong ENP, Albini TA
Ophthalmology 2020 Oct;127(10):1345-1359. Epub 2020 Apr 25 doi: 10.1016/j.ophtha.2020.04.017. PMID: 32344075
A case of Vogt-Koyanagi-Harada disease in a patient with Graves disease.
Seo JH, Yu HG, Chung H
Korean J Ophthalmol 2009 Jun;23(2):112-3. Epub 2009 Jun 9 doi: 10.3341/kjo.2009.23.2.112. PMID: 19568361Free PMC Article

Clinical prediction guides

Imaging Characteristics and Clinical Utility of Half-Dose versus Full-Dose Ultrawidefield Fundus Fluorescein Angiography.
Szigiato A, Sharma S, Singh S, Baynes K, Lowder C, Kaiser PK, Ehlers JP, Srivastava SK
Ophthalmol Retina 2024 Oct;8(10):981-986. Epub 2024 May 6 doi: 10.1016/j.oret.2024.04.024. PMID: 38719190
Indocyanine Green Angiographic Assessment of Conjunctival Melanocytic Disorders.
Palme C, Wanner A, Romano V, Franchi A, Haas G, Kaye SB, Steger B
Cornea 2021 Dec 1;40(12):1519-1524. doi: 10.1097/ICO.0000000000002681. PMID: 33591034
Findings of OCT-angiography compared to fluorescein and indocyanine green angiography in central serous chorioretinopathy.
Min JY, Lv Y, Yu S, Gong YY
Lasers Surg Med 2018 Dec;50(10):987-993. Epub 2018 Jun 12 doi: 10.1002/lsm.22952. PMID: 29896889
Angiographic leakage of polypoidal choroidal vasculopathy on indocyanine angiography.
Zuo CG, Wen F, Huang SZ, Luo GW, Yan H, Wu WJ, Wu DZ
Chin Med J (Engl) 2010 Jun;123(12):1548-52. PMID: 20819510
Dengue-associated maculopathy.
Bacsal KE, Chee SP, Cheng CL, Flores JV
Arch Ophthalmol 2007 Apr;125(4):501-10. doi: 10.1001/archopht.125.4.501. PMID: 17420370

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