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Abnormal fundus fluorescein angiography

MedGen UID:
892879
•Concept ID:
C4073074
•
Finding
HPO: HP:0030604

Definition

An abnormality observed by retinal fluorescein angiography, which involves the intravenous injection of fluorescein dye followed by fluorescent imaging of the fundus immediately after injection and for up to ten minutes thereafter. It can be used to study various retinal abnormalities including especially anomalies of the choroidal and retinal circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal fundus fluorescein angiography

Conditions with this feature

Occult macular dystrophy
MedGen UID:
462183
•Concept ID:
C3150833
•
Disease or Syndrome
Occult macular dystrophy (OCMD) is characterized by progressive decline of visual acuity in both eyes, associated with a normal fundus and normal fluorescein angiography. Patients have normal full-field electroretinograms (ERGs) but severely reduced focal macular ERGs, as recorded by conventional techniques using small stimuli under background illumination. OCMD patients are believed to have localized retinal dysfunction distal to the ganglion cells in the central retina (summary by Piao et al., 2000).
See: Condition Record
Occult macular dystrophy

Professional guidelines

PubMed

Feasibility and clinical utility of handheld fundus cameras for retinal imaging.
Das S, Kuht HJ, De Silva I, Deol SS, Osman L, Burns J, Sarvananthan N, Sarodia U, Kapoor B, Islam T, Sampath R, Poyser A, Konidaris V, Anzidei R, Proudlock FA, Thomas MG
Eye (Lond) 2023 Feb;37(2):274-279. Epub 2022 Jan 12 doi: 10.1038/s41433-021-01926-y. PMID: 35022568Free PMC Article
Coats disease: An overview of classification, management and outcomes.
Sen M, Shields CL, Honavar SG, Shields JA
Indian J Ophthalmol 2019 Jun;67(6):763-771. doi: 10.4103/ijo.IJO_841_19. PMID: 31124484Free PMC Article
Polypoidal choroidal vasculopathy: Pearls in diagnosis and management.
Anantharaman G, Sheth J, Bhende M, Narayanan R, Natarajan S, Rajendran A, Manayath G, Sen P, Biswas R, Banker A, Gupta C
Indian J Ophthalmol 2018 Jul;66(7):896-908. doi: 10.4103/ijo.IJO_1136_17. PMID: 29941728Free PMC Article

Recent clinical studies

Etiology

Wide-field Fundus Imaging and Fluorescein Angiography Findings in Various Pseudoretinoblastoma Conditions.
Gündüz AK, Mirzayev I, Tetik D
J Pediatr Ophthalmol Strabismus 2023 Jan-Feb;60(1):60-74. Epub 2022 Apr 21 doi: 10.3928/01913913-20220228-01. PMID: 35446191
Mitochondrial Retinopathy.
Birtel J, von Landenberg C, Gliem M, Gliem C, Reimann J, Kunz WS, Herrmann P, Betz C, Caswell R, Nesbitt V, Kornblum C, Charbel Issa P
Ophthalmol Retina 2022 Jan;6(1):65-79. Epub 2021 Jul 10 doi: 10.1016/j.oret.2021.02.017. PMID: 34257060
Spectrum of pachychoroid diseases.
Akkaya S
Int Ophthalmol 2018 Oct;38(5):2239-2246. Epub 2017 Aug 1 doi: 10.1007/s10792-017-0666-4. PMID: 28766279
Clinical classification of age-related macular degeneration.
Ferris FL 3rd, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Csaky K, Sadda SR; Beckman Initiative for Macular Research Classification Committee
Ophthalmology 2013 Apr;120(4):844-51. Epub 2013 Jan 16 doi: 10.1016/j.ophtha.2012.10.036. PMID: 23332590
Eclipse retinopathy.
Dhir SP, Gupta A, Jain IS
Br J Ophthalmol 1981 Jan;65(1):42-5. doi: 10.1136/bjo.65.1.42. PMID: 7448156Free PMC Article

Diagnosis

RIDGE-SHAPED PERIPAPILLA.
Wakabayashi T, Yonekawa Y, Ohno-Matsui K, Cohen SY, Rowland C, Pulido JS
Retin Cases Brief Rep 2024 Jan 1;18(1):11-14. doi: 10.1097/ICB.0000000000001308. PMID: 36007179
Coats disease: An overview of classification, management and outcomes.
Sen M, Shields CL, Honavar SG, Shields JA
Indian J Ophthalmol 2019 Jun;67(6):763-771. doi: 10.4103/ijo.IJO_841_19. PMID: 31124484Free PMC Article
Pachychoroid disease.
Cheung CMG, Lee WK, Koizumi H, Dansingani K, Lai TYY, Freund KB
Eye (Lond) 2019 Jan;33(1):14-33. Epub 2018 Jul 11 doi: 10.1038/s41433-018-0158-4. PMID: 29995841Free PMC Article
Choroidal biomarkers.
Pichi F, Aggarwal K, Neri P, Salvetti P, Lembo A, Nucci P, Gemmy Cheung CM, Gupta V
Indian J Ophthalmol 2018 Dec;66(12):1716-1726. doi: 10.4103/ijo.IJO_893_18. PMID: 30451172Free PMC Article
Clinical classification of age-related macular degeneration.
Ferris FL 3rd, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Csaky K, Sadda SR; Beckman Initiative for Macular Research Classification Committee
Ophthalmology 2013 Apr;120(4):844-51. Epub 2013 Jan 16 doi: 10.1016/j.ophtha.2012.10.036. PMID: 23332590

Therapy

NONEXUDATIVE INTRARETINAL FLUID IN INTERMEDIATE AGE-RELATED MACULAR DEGENERATION.
Servillo A, Kesim C, Sacconi R, Battista M, Capuano V, Fragiotta S, Querques L, Parravano M, Souied EH, Bandello F, Querques G
Retina 2024 Jun 1;44(6):997-1005. doi: 10.1097/IAE.0000000000004054. PMID: 38261803
Current management strategy of polypoidal choroidal vasculopathy.
Ho CPS, Lai TYY
Indian J Ophthalmol 2018 Dec;66(12):1727-1735. doi: 10.4103/ijo.IJO_975_18. PMID: 30451173Free PMC Article
Polypoidal choroidal vasculopathy: a review.
Imamura Y, Engelbert M, Iida T, Freund KB, Yannuzzi LA
Surv Ophthalmol 2010 Nov-Dec;55(6):501-15. Epub 2010 Sep 20 doi: 10.1016/j.survophthal.2010.03.004. PMID: 20850857
Hydroxychloroquine retinopathy.
Weiner A, Sandberg MA, Gaudio AR, Kini MM, Berson EL
Am J Ophthalmol 1991 Nov 15;112(5):528-34. doi: 10.1016/s0002-9394(14)76853-9. PMID: 1951589
Niacin maculopathy.
Millay RH, Klein ML, Illingworth DR
Ophthalmology 1988 Jul;95(7):930-6. doi: 10.1016/s0161-6420(88)33073-3. PMID: 3174043

Prognosis

Emerging Issues for Ultra-Wide Field Angiography.
Rabiolo A, De Vitis LA, Sacconi R, Carnevali A, Querques L, Bandello F, Querques G
Dev Ophthalmol 2017;60:50-55. Epub 2017 Apr 20 doi: 10.1159/000459689. PMID: 28427064
Clinical classification of age-related macular degeneration.
Ferris FL 3rd, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Csaky K, Sadda SR; Beckman Initiative for Macular Research Classification Committee
Ophthalmology 2013 Apr;120(4):844-51. Epub 2013 Jan 16 doi: 10.1016/j.ophtha.2012.10.036. PMID: 23332590
Torpedo maculopathy.
Golchet PR, Jampol LM, Mathura JR Jr, Daily MJ
Br J Ophthalmol 2010 Mar;94(3):302-6. Epub 2009 Oct 12 doi: 10.1136/bjo.2009.162669. PMID: 19822914
Birdshot chorioretinopathy.
Monnet D, Brézin AP
Curr Opin Ophthalmol 2006 Dec;17(6):545-50. doi: 10.1097/ICU.0b013e3280109479. PMID: 17065923
Retinitis pigmentosa.
Merin S, Auerbach E
Surv Ophthalmol 1976 Mar-Apr;20(5):303-46. doi: 10.1016/s0039-6257(96)90001-6. PMID: 817406

Clinical prediction guides

Pachychoroid neovasculopathy.
Pang CE, Freund KB
Retina 2015 Jan;35(1):1-9. doi: 10.1097/IAE.0000000000000331. PMID: 25158945
Clinical classification of age-related macular degeneration.
Ferris FL 3rd, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Csaky K, Sadda SR; Beckman Initiative for Macular Research Classification Committee
Ophthalmology 2013 Apr;120(4):844-51. Epub 2013 Jan 16 doi: 10.1016/j.ophtha.2012.10.036. PMID: 23332590
Torpedo maculopathy.
Golchet PR, Jampol LM, Mathura JR Jr, Daily MJ
Br J Ophthalmol 2010 Mar;94(3):302-6. Epub 2009 Oct 12 doi: 10.1136/bjo.2009.162669. PMID: 19822914
Birdshot chorioretinopathy.
Monnet D, Brézin AP
Curr Opin Ophthalmol 2006 Dec;17(6):545-50. doi: 10.1097/ICU.0b013e3280109479. PMID: 17065923
Paramacular coloboma.
Pian D, Ferrucci S, Anderson SF, Wu C
Optom Vis Sci 2003 Aug;80(8):556-63. doi: 10.1097/00006324-200308000-00008. PMID: 12917574

Recent systematic reviews

Consensus Guidelines for Ocular Surveillance of von Hippel-Lindau Disease.
Daniels AB, Chang EY, Chew EY, Gombos DS, Gorin MB, Shields CL, Wiley HE
Ophthalmology 2024 May;131(5):622-633. Epub 2023 Dec 12 doi: 10.1016/j.ophtha.2023.12.014. PMID: 38092079
Retinal biomarkers of Cerebral Small Vessel Disease: A systematic review.
Biffi E, Turple Z, Chung J, Biffi A
PLoS One 2022;17(4):e0266974. Epub 2022 Apr 14 doi: 10.1371/journal.pone.0266974. PMID: 35421194Free PMC Article
A Systematic Review of the Clinical Manifestations and Diagnostic Methods for Macular Coloboma.
Hou X, Guo Y, Liu J, Li S, Fan W, Lin M, Rokohl AC, Heindl LM
Curr Eye Res 2021 Jul;46(7):913-918. Epub 2021 Jan 22 doi: 10.1080/02713683.2020.1853779. PMID: 33478254
Clinical application of ultra-widefield fundus autofluorescence.
Xu A, Chen C
Int Ophthalmol 2021 Feb;41(2):727-741. Epub 2020 Oct 11 doi: 10.1007/s10792-020-01609-9. PMID: 33040254
Spectrum of pachychoroid diseases.
Akkaya S
Int Ophthalmol 2018 Oct;38(5):2239-2246. Epub 2017 Aug 1 doi: 10.1007/s10792-017-0666-4. PMID: 28766279

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