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Moderate squamous cell atypia

MedGen UID:
137703
•Concept ID:
C0333871
•
Cell or Molecular Dysfunction
Synonym: Moderate Squamous Cell Atypia
SNOMED CT: Moderate squamous cell atypia (1138003)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerate squamous cell atypia

Professional guidelines

PubMed

Uterine Tumors Resembling Ovarian Sex Cord Tumors: A Clinicopathologic Study of 75 Cases Emphasizing Features Predicting Adverse Outcome and Differential Diagnosis.
Boyraz B, Watkins JC, Young RH, Oliva E
Am J Surg Pathol 2023 Feb 1;47(2):234-247. Epub 2022 Oct 27 doi: 10.1097/PAS.0000000000001981. PMID: 36306239
Evaluation of diagnostic criteria of actinic keratosis through reflectance confocal microscopy.
Nascimento Cavalleiro Macedo Mota A, Piñeiro-Maceira JM, Baptista Barcaui C
Skin Res Technol 2020 Nov;26(6):883-890. Epub 2020 Jun 25 doi: 10.1111/srt.12890. PMID: 32585761
Inflammatory pseudotumor and sarcoma of urinary bladder: differential diagnosis and outcome in thirty-eight spindle cell neoplasms.
Iczkowski KA, Shanks JH, Gadaleanu V, Cheng L, Jones EC, Neumann R, Nascimento AG, Bostwick DG
Mod Pathol 2001 Oct;14(10):1043-51. doi: 10.1038/modpathol.3880434. PMID: 11598176

Recent clinical studies

Etiology

Atypical Endometriosis: Comprehensive Characterization of Clinicopathologic, Immunohistochemical, and Molecular Features.
Wepy C, Nucci MR, Parra-Herran C
Int J Gynecol Pathol 2024 Jan 1;43(1):70-77. Epub 2023 Mar 13 doi: 10.1097/PGP.0000000000000952. PMID: 37043650
Abnormal p53 Immunohistochemical Patterns Shed Light on the Aggressiveness of Oral Epithelial Dysplasia.
Novack R, Zhang L, Hoang LN, Kadhim M, Ng TL, Poh CF, Kevin Ko YC
Mod Pathol 2023 Jul;36(7):100153. Epub 2023 Mar 9 doi: 10.1016/j.modpat.2023.100153. PMID: 36906072
The significance of Melan-A-positive pagetoid melanocytosis in dysplastic nevi.
Huwait H, Hijazi N, Martinka M, Crawford RI
Am J Dermatopathol 2014 Apr;36(4):340-3. doi: 10.1097/DAD.0b013e3182a7aa7c. PMID: 24736669
Cytology of nipple discharge in florid gynecomastia.
Kapila K, Verma K
Acta Cytol 2003 Jan-Feb;47(1):36-40. doi: 10.1159/000326472. PMID: 12585028
Predisposition to urinary tract epithelial metaplasia in Schistosoma haematobium infection.
Hodder SL, Mahmoud AA, Sorenson K, Weinert DM, Stein RL, Ouma JH, Koech D, King CH
Am J Trop Med Hyg 2000 Sep-Oct;63(3-4):133-8. doi: 10.4269/ajtmh.2000.63.133. PMID: 11388504

Diagnosis

Atypical Endometriosis: Comprehensive Characterization of Clinicopathologic, Immunohistochemical, and Molecular Features.
Wepy C, Nucci MR, Parra-Herran C
Int J Gynecol Pathol 2024 Jan 1;43(1):70-77. Epub 2023 Mar 13 doi: 10.1097/PGP.0000000000000952. PMID: 37043650
The First Report of Cytology of DEK::AFF2 Fusion-Associated Papillary Squamous Cell Carcinoma on Fine-Needle Aspiration.
Li JJX, Ng JKM, Chan ABW
Head Neck Pathol 2023 Dec;17(4):1058-1063. Epub 2023 Nov 8 doi: 10.1007/s12105-023-01594-2. PMID: 37938508Free PMC Article
Abnormal p53 Immunohistochemical Patterns Shed Light on the Aggressiveness of Oral Epithelial Dysplasia.
Novack R, Zhang L, Hoang LN, Kadhim M, Ng TL, Poh CF, Kevin Ko YC
Mod Pathol 2023 Jul;36(7):100153. Epub 2023 Mar 9 doi: 10.1016/j.modpat.2023.100153. PMID: 36906072
High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations.
Murali R, Davidson B, Fadare O, Carlson JA, Crum CP, Gilks CB, Irving JA, Malpica A, Matias-Guiu X, McCluggage WG, Mittal K, Oliva E, Parkash V, Rutgers JKL, Staats PN, Stewart CJR, Tornos C, Soslow RA
Int J Gynecol Pathol 2019 Jan;38 Suppl 1(Iss 1 Suppl 1):S40-S63. doi: 10.1097/PGP.0000000000000491. PMID: 30550483Free PMC Article
Superficial acral fibromyxoma: an overview.
Ashby-Richardson H, Rogers GS, Stadecker MJ
Arch Pathol Lab Med 2011 Aug;135(8):1064-6. doi: 10.5858/2009-0684-RSR1. PMID: 21810002

Therapy

Long-term Lung Cancer Risk Associated with Sputum Atypia: A 27-Year Follow-up Study of an Occupational Lung Screening Cohort in Yunnan, China.
Fan Y, Su Z, Wei M, Liang H, Jiang Y, Li X, Meng Z, Wang Y, Pan H, Song J, Qiao Y, Zhou Q
Cancer Epidemiol Biomarkers Prev 2021 Nov;30(11):2122-2129. Epub 2021 Aug 26 doi: 10.1158/1055-9965.EPI-21-0339. PMID: 34446474
Association between sputum atypia and lung cancer risk in an occupational cohort in Yunnan, China.
Fan YG, Hu P, Jiang Y, Chang RS, Yao SX, Wang W, He J, Prorok P, Qiao YL
Chest 2009 Mar;135(3):778-785. doi: 10.1378/chest.08-1469. PMID: 19265088
Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis.
Franklin WA, Gazdar AF, Haney J, Wistuba II, La Rosa FG, Kennedy T, Ritchey DM, Miller YE
J Clin Invest 1997 Oct 15;100(8):2133-7. doi: 10.1172/JCI119748. PMID: 9329980Free PMC Article
Well-differentiated thymic carcinoma. An organotypical low-grade carcinoma with relationship to cortical thymoma.
Kirchner T, Schalke B, Buchwald J, Ritter M, Marx A, Müller-Hermelink HK
Am J Surg Pathol 1992 Dec;16(12):1153-69. PMID: 1463094
A hypothesis incorporating the histologic characteristics of dysplastic nevi into the normal biological development of melanocytic nevi.
Piepkorn M
Arch Dermatol 1990 Apr;126(4):514-8. PMID: 2321996

Prognosis

Abnormal p53 Immunohistochemical Patterns Shed Light on the Aggressiveness of Oral Epithelial Dysplasia.
Novack R, Zhang L, Hoang LN, Kadhim M, Ng TL, Poh CF, Kevin Ko YC
Mod Pathol 2023 Jul;36(7):100153. Epub 2023 Mar 9 doi: 10.1016/j.modpat.2023.100153. PMID: 36906072
Pleomorphic Onychomatricoma: A Mimicker of Malignancy.
Perrin C, Ambrosetti D
Acta Derm Venereol 2022 Jan 5;102:adv00628. doi: 10.2340/actadv.v101.546. PMID: 34694416Free PMC Article
Uterine Adenosarcoma.
Pinto A, Howitt B
Arch Pathol Lab Med 2016 Mar;140(3):286-90. doi: 10.5858/arpa.2014-0523-RS. PMID: 26927725
Cytology of nipple discharge in florid gynecomastia.
Kapila K, Verma K
Acta Cytol 2003 Jan-Feb;47(1):36-40. doi: 10.1159/000326472. PMID: 12585028
Different types of mucosal adaptation in the ileal reservoir after restorative proctocolectomy. A two-year follow-up study.
Veress B, Reinholt FP, Lindquist K, Liljeqvist L
APMIS 1990 Sep;98(9):786-96. doi: 10.1111/j.1699-0463.1990.tb04999.x. PMID: 2223035

Clinical prediction guides

Abnormal p53 Immunohistochemical Patterns Shed Light on the Aggressiveness of Oral Epithelial Dysplasia.
Novack R, Zhang L, Hoang LN, Kadhim M, Ng TL, Poh CF, Kevin Ko YC
Mod Pathol 2023 Jul;36(7):100153. Epub 2023 Mar 9 doi: 10.1016/j.modpat.2023.100153. PMID: 36906072
Fine needle aspiration cytology in primary breast angiosarcoma: a case report.
Markidou S, Karydas I, Papadopoulos S, Christodoulidou I, Skarpidi E, Maounis N
Acta Cytol 2010 Sep-Oct;54(5 Suppl):764-70. PMID: 21053536
Salivary gland myoepithelioma with focal capsular invasion.
Gun BD, Ozdamar SO, Bahadir B, Uzun L
Ear Nose Throat J 2009 Jul;88(7):1005-9. PMID: 19623529
Ectopic cervical anaplastic ependymoma.
Wang Z, Huang G, Yan P, Liang R, Wang J, Yan Q, Zhang J, Cheng H, Hu P, Ma MJ
Pathol Int 2005 Dec;55(12):781-4. doi: 10.1111/j.1440-1827.2005.01906.x. PMID: 16287493
Cytomorphological spectrum in scar endometriosis: a study of eight cases.
Pathan SK, Kapila K, Haji BE, Mallik MK, Al-Ansary TA, George SS, Das DK, Francis IM
Cytopathology 2005 Apr;16(2):94-9. doi: 10.1111/j.1365-2303.2004.00218.x. PMID: 15787652

Supplemental Content

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