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Cytologic atypia

MedGen UID:
90720
•Concept ID:
C0333865
•
Cell or Molecular Dysfunction
Synonyms: Atypical cell present; Atypical Cell Present; Cytologic Atypia
SNOMED CT: Cytologic atypia (50673007); Atypical cell present (50673007)

Definition

The presence of irregularly shaped or sized cells as compared to the cells that are normally present. [from NCI]

Professional guidelines

PubMed

Evaluation of different treatment modalities for diffuse uterine leiomyomatosis: A case series report and review of the literature.
Jin X, Cao Y, Mi K, Jiang Y, Fan Q, Shi H
Int J Gynaecol Obstet 2023 Oct;163(1):51-57. Epub 2023 Apr 4 doi: 10.1002/ijgo.14769. PMID: 37014595
Gastroesophageal Glomus Tumors: Clinicopathologic and Molecular Genetic Analysis of 26 Cases With a Proposal for Malignancy Criteria.
Papke DJ Jr, Sholl LM, Doyle LA, Fletcher CDM, Hornick JL
Am J Surg Pathol 2022 Oct 1;46(10):1436-1446. Epub 2022 Jun 15 doi: 10.1097/PAS.0000000000001925. PMID: 35703141
Histopathological markers of treatment response and recurrence risk in ovarian cancers and borderline tumors.
Avril S
Pathologe 2017 Nov;38(Suppl 2):180-191. doi: 10.1007/s00292-017-0375-9. PMID: 29119232Free PMC Article

Recent clinical studies

Etiology

Uterine Smooth Muscle Tumors: An Overview.
Pinto A
Adv Anat Pathol 2024 Nov 1;31(6):397-410. Epub 2024 Apr 19 doi: 10.1097/PAP.0000000000000446. PMID: 38647238
Update on Peripheral Nerve Sheath Tumors.
Martinez AP, Fritchie KJ
Surg Pathol Clin 2019 Mar;12(1):1-19. Epub 2018 Dec 17 doi: 10.1016/j.path.2018.10.001. PMID: 30709438
When Does Atypical Ductal Hyperplasia Require Surgical Excision?
Racz JM, Degnim AC
Surg Oncol Clin N Am 2018 Jan;27(1):23-32. doi: 10.1016/j.soc.2017.07.011. PMID: 29132563
Melanomas.
Longo C, Pellacani G
Dermatol Clin 2016 Oct;34(4):411-419. doi: 10.1016/j.det.2016.05.004. PMID: 27692447
A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process.
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ; Peritoneal Surface Oncology Group International
Am J Surg Pathol 2016 Jan;40(1):14-26. doi: 10.1097/PAS.0000000000000535. PMID: 26492181

Diagnosis

Uterine Smooth Muscle Tumors: An Overview.
Pinto A
Adv Anat Pathol 2024 Nov 1;31(6):397-410. Epub 2024 Apr 19 doi: 10.1097/PAP.0000000000000446. PMID: 38647238
Update on Peripheral Nerve Sheath Tumors.
Martinez AP, Fritchie KJ
Surg Pathol Clin 2019 Mar;12(1):1-19. Epub 2018 Dec 17 doi: 10.1016/j.path.2018.10.001. PMID: 30709438
Pseudosarcomatous Vaginal Polyp.
Heller A, Ukazu A, Wang Q
Int J Surg Pathol 2017 Feb;25(1):54-55. Epub 2016 Sep 24 doi: 10.1177/1066896916666676. PMID: 27571791
Melanomas.
Longo C, Pellacani G
Dermatol Clin 2016 Oct;34(4):411-419. doi: 10.1016/j.det.2016.05.004. PMID: 27692447
Pseudosarcomas of soft tissue.
Rosenberg AE
Arch Pathol Lab Med 2008 Apr;132(4):579-86. doi: 10.5858/2008-132-579-POST. PMID: 18384209

Therapy

Chemotherapy-Associated Endometrial Atypia: A Potential Diagnostic Pitfall.
Wales C, Fadare O
Int J Surg Pathol 2018 May;26(3):229-231. Epub 2018 Feb 27 doi: 10.1177/1066896917741552. PMID: 29482404
The Role of Cytology in the 21st Century: The Integration of Cells and Molecules.
Bergeron C, von Knebel Doeberitz M
Acta Cytol 2016;60(6):540-542. Epub 2016 Oct 28 doi: 10.1159/000449402. PMID: 27788516
Primary psammocarcinoma of the peritoneum.
Bilgin T, Ozuysal S, Cankiliç H
Int J Gynecol Cancer 2006 Jan-Feb;16 Suppl 1:129-31. doi: 10.1111/j.1525-1438.2006.00320.x. PMID: 16515580
Treatment of photodamage with topical tretinoin: an overview.
Gilchrest BA
J Am Acad Dermatol 1997 Mar;36(3 Pt 2):S27-36. doi: 10.1016/s0190-9622(97)70058-6. PMID: 9091506
Well-differentiated villoglandular adenocarcinoma of the uterine cervix: a clinicopathological study of 24 cases.
Jones MW, Silverberg SG, Kurman RJ
Int J Gynecol Pathol 1993 Jan;12(1):1-7. doi: 10.1097/00004347-199301000-00001. PMID: 8418074

Prognosis

Update on Peripheral Nerve Sheath Tumors.
Martinez AP, Fritchie KJ
Surg Pathol Clin 2019 Mar;12(1):1-19. Epub 2018 Dec 17 doi: 10.1016/j.path.2018.10.001. PMID: 30709438
Histopathological markers of treatment response and recurrence risk in ovarian cancers and borderline tumors.
Avril S
Pathologe 2017 Nov;38(Suppl 2):180-191. doi: 10.1007/s00292-017-0375-9. PMID: 29119232Free PMC Article
A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process.
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ; Peritoneal Surface Oncology Group International
Am J Surg Pathol 2016 Jan;40(1):14-26. doi: 10.1097/PAS.0000000000000535. PMID: 26492181
Adenomyoepithelioma of the breast: a brief diagnostic review.
Yoon JY, Chitale D
Arch Pathol Lab Med 2013 May;137(5):725-9. doi: 10.5858/arpa.2011-0404-RS. PMID: 23627458
Salivary mucoepidermoid carcinoma: revisited.
Luna MA
Adv Anat Pathol 2006 Nov;13(6):293-307. doi: 10.1097/01.pap.0000213058.74509.d3. PMID: 17075295

Clinical prediction guides

Precursor Lesions of Cervical Clear Cell Carcinoma: Evidence For Origin From Tubo-Endometrial Metaplasia.
Talia KL, Arora R, McCluggage WG
Int J Gynecol Pathol 2022 Mar 1;41(2):105-112. doi: 10.1097/PGP.0000000000000785. PMID: 33770055
Persistent Keratoses in Vitiligo.
Cupertino F, Niemeyer-Corbellini JP, Cuzzi T, Ramos-E-Silva M
Skinmed 2019;17(6):380-385. Epub 2019 Nov 1 PMID: 31904327
Histopathological markers of treatment response and recurrence risk in ovarian cancers and borderline tumors.
Avril S
Pathologe 2017 Nov;38(Suppl 2):180-191. doi: 10.1007/s00292-017-0375-9. PMID: 29119232Free PMC Article
A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process.
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ; Peritoneal Surface Oncology Group International
Am J Surg Pathol 2016 Jan;40(1):14-26. doi: 10.1097/PAS.0000000000000535. PMID: 26492181
Adenomyoepithelioma of the breast: a brief diagnostic review.
Yoon JY, Chitale D
Arch Pathol Lab Med 2013 May;137(5):725-9. doi: 10.5858/arpa.2011-0404-RS. PMID: 23627458

Recent systematic reviews

Prognostic significance of atypical mitotic figures in smooth muscle tumors of uncertain malignant potential (STUMP) of the uterus and uterine adnexa.
Travaglino A, Raffone A, Santoro A, Gencarelli A, Angelico G, Spadola S, Marzullo L, Zullo F, Insabato L, Zannoni GF
APMIS 2021 Apr;129(4):165-169. Epub 2021 Jan 28 doi: 10.1111/apm.13114. PMID: 33445214
Significant risk of occult cancer in complex non-atypical endometrial hyperplasia.
Travaglino A, Raffone A, Saccone G, D'Alessandro P, Arduino B, de Placido G, Mascolo M, Insabato L, Zullo F
Arch Gynecol Obstet 2019 Nov;300(5):1147-1154. Epub 2019 Sep 17 doi: 10.1007/s00404-019-05299-2. PMID: 31531779
Endometrial hyperplasia and progression to cancer: which classification system stratifies the risk better? A systematic review and meta-analysis.
Raffone A, Travaglino A, Saccone G, Insabato L, Mollo A, De Placido G, Zullo F
Arch Gynecol Obstet 2019 May;299(5):1233-1242. Epub 2019 Feb 27 doi: 10.1007/s00404-019-05103-1. PMID: 30810881
Complexity of glandular architecture should be reconsidered in the classification and management of endometrial hyperplasia.
Travaglino A, Raffone A, Saccone G, Mollo A, De Placido G, Mascolo M, Insabato L, Zullo F
APMIS 2019 Jun;127(6):427-434. Epub 2019 Mar 19 doi: 10.1111/apm.12945. PMID: 30802329

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