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Severe dysplasia

MedGen UID:
137715
•Concept ID:
C0334048
•
Cell or Molecular Dysfunction
Synonym: Severe Dysplasia
SNOMED CT: Severe dysplasia (55237006)

Definition

A morphologic finding indicating the presence of severe cellular atypia associated with severe architectural changes in a tissue sample. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSevere dysplasia

Professional guidelines

PubMed

How effective is toluidine blue for screening and diagnosis of oral cancer and premalignant lesions?
Mills S
Evid Based Dent 2022 Mar;23(1):34-35. Epub 2022 Mar 25 doi: 10.1038/s41432-022-0239-x. PMID: 35338328
Management of Laryngeal Dysplasia and Early Invasive Cancer.
Hrelec C
Curr Treat Options Oncol 2021 Aug 23;22(10):90. doi: 10.1007/s11864-021-00881-w. PMID: 34424405
Oral Potentially Malignant Disorders (OPMD): What is the clinical utility of dysplasia grade?
Pritzker KPH, Darling MR, Hwang JT, Mock D
Expert Rev Mol Diagn 2021 Mar;21(3):289-298. Epub 2021 Mar 16 doi: 10.1080/14737159.2021.1898949. PMID: 33682567

Recent clinical studies

Etiology

Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype.
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979
Laryngeal dysplasia and narrow band imaging: Secondary analysis of published data supports the role in patient follow-up.
Paleri V, Sawant R, Mehanna H, Ainsworth H, Stocken D
Clin Otolaryngol 2018 Dec;43(6):1439-1442. Epub 2018 Aug 7 doi: 10.1111/coa.13182. PMID: 29972728
Laser miniconization procedure.
Békássy Z
Int J Gynaecol Obstet 1996 Dec;55(3):237-46. doi: 10.1016/s0020-7292(96)02767-1. PMID: 9003949
Barrett's oesophagus.
Bartlesman JF, Hameeteman W, Tÿtgat GN
Eur J Cancer Prev 1992 Jun;1(4):323-5. doi: 10.1097/00008469-199206000-00008. PMID: 1467782
Barrett's esophagus and adenocarcinoma.
Ribet M, Mensier E, Pruvot FR
Eur J Cardiothorac Surg 1987;1(1):29-32. doi: 10.1016/s1010-7940(87)80010-6. PMID: 3273209

Diagnosis

Management of laryngeal dysplasia: a review.
Sadri M, McMahon J, Parker A
Eur Arch Otorhinolaryngol 2006 Sep;263(9):843-52. Epub 2006 Jul 6 doi: 10.1007/s00405-006-0078-y. PMID: 16823559
Barrett's oesophagus.
Bartlesman JF, Hameeteman W, Tÿtgat GN
Eur J Cancer Prev 1992 Jun;1(4):323-5. doi: 10.1097/00008469-199206000-00008. PMID: 1467782
In-situ hybridization for the diagnosis and typing of human papillomavirus.
Amortegui AJ, Meyer MP
Clin Biochem 1990 Aug;23(4):301-6. doi: 10.1016/0009-9120(90)80057-p. PMID: 2171813
Barrett's esophagus and adenocarcinoma.
Ribet M, Mensier E, Pruvot FR
Eur J Cardiothorac Surg 1987;1(1):29-32. doi: 10.1016/s1010-7940(87)80010-6. PMID: 3273209
Definition of precursors in gynecologic cancer.
Scully RE
Cancer 1981 Jul 15;48(2 Suppl):531-7. doi: 10.1002/1097-0142(19810715)48:1+<531::aid-cncr2820481316>3.0.co;2-c. PMID: 7023663

Therapy

How should extra-large Lugol-unstained lesions of the esophagus be treated? Results from a population-based cohort study.
Liu M, Qi Z, Zhou R, Guo C, Liu A, Yang H, Li F, Duan L, Shen L, Wu Q, Liu Z, Pan Y, Liu F, Liu Y, Cai H, He Z, Ke Y
Cancer Med 2023 Oct;12(19):20129-20139. Epub 2023 Sep 21 doi: 10.1002/cam4.6592. PMID: 37732496Free PMC Article
Laryngeal dysplasia and narrow band imaging: Secondary analysis of published data supports the role in patient follow-up.
Paleri V, Sawant R, Mehanna H, Ainsworth H, Stocken D
Clin Otolaryngol 2018 Dec;43(6):1439-1442. Epub 2018 Aug 7 doi: 10.1111/coa.13182. PMID: 29972728
Is frozen section reliable in transoral CO(2) laser-assisted cordectomies?
Remacle M, Matar N, Delos M, Nollevaux MC, Jamart J, Lawson G
Eur Arch Otorhinolaryngol 2010 Mar;267(3):397-400. Epub 2009 Sep 27 doi: 10.1007/s00405-009-1101-x. PMID: 19784844
Laser miniconization procedure.
Békássy Z
Int J Gynaecol Obstet 1996 Dec;55(3):237-46. doi: 10.1016/s0020-7292(96)02767-1. PMID: 9003949
Increased risk of early colorectal neoplasms after hepatic transplant in patients with inflammatory bowel disease.
Bleday R, Lee E, Jessurun J, Heine J, Wong WD
Dis Colon Rectum 1993 Oct;36(10):908-12. doi: 10.1007/BF02050624. PMID: 8404380

Prognosis

Laryngeal dysplasia and narrow band imaging: Secondary analysis of published data supports the role in patient follow-up.
Paleri V, Sawant R, Mehanna H, Ainsworth H, Stocken D
Clin Otolaryngol 2018 Dec;43(6):1439-1442. Epub 2018 Aug 7 doi: 10.1111/coa.13182. PMID: 29972728
Management of laryngeal dysplasia: a review.
Sadri M, McMahon J, Parker A
Eur Arch Otorhinolaryngol 2006 Sep;263(9):843-52. Epub 2006 Jul 6 doi: 10.1007/s00405-006-0078-y. PMID: 16823559
Carditis, intestinal metaplasia and adenocarcinoma of oesophagogastric junction.
Conio M, Filiberti R, Blanchi S, Giacosa A
Eur J Cancer Prev 2001 Dec;10(6):483-7. doi: 10.1097/00008469-200112000-00002. PMID: 11916346
Laser miniconization procedure.
Békássy Z
Int J Gynaecol Obstet 1996 Dec;55(3):237-46. doi: 10.1016/s0020-7292(96)02767-1. PMID: 9003949
Barrett's oesophagus.
Bartlesman JF, Hameeteman W, Tÿtgat GN
Eur J Cancer Prev 1992 Jun;1(4):323-5. doi: 10.1097/00008469-199206000-00008. PMID: 1467782

Clinical prediction guides

Multiple Lugol-unstained lesions predict higher cumulative risk of malignance in the esophagus.
Qi Z, Liu M, Zhou R, Guo C, Liu A, Yang H, Li F, Duan L, Shen L, Wu Q, Wu N, Liu Z, Pan Y, Liu F, Liu Y, Cai H, He Z, Ke Y
J Gastroenterol Hepatol 2023 Mar;38(3):416-423. Epub 2022 Dec 7 doi: 10.1111/jgh.16075. PMID: 36418206
Routine colonoscopy may be needed for uncomplicated acute right colonic diverticulitis.
Lee KY, Lee J, Park YY, Oh ST
BMC Gastroenterol 2021 Feb 27;21(1):91. doi: 10.1186/s12876-021-01672-1. PMID: 33639847Free PMC Article
Meta-analysis of the predictive value of DNA aneuploidy in malignant transformation of oral potentially malignant disorders.
Alaizari NA, Sperandio M, Odell EW, Peruzzo D, Al-Maweri SA
J Oral Pathol Med 2018 Feb;47(2):97-103. Epub 2017 Jul 5 doi: 10.1111/jop.12603. PMID: 28612463
Evidence of cell fusion in carcinogen-induced mice gastric carcinoma.
Yan Y, Hsu Y, He X, Lu N, Wei W, Zhang Z, Zhu L
Tumour Biol 2015 Jul;36(7):5089-94. Epub 2015 Feb 6 doi: 10.1007/s13277-015-3160-5. PMID: 25656611
Surgical margins in squamous cell carcinomas.
Batsakis JG
Ann Otol Rhinol Laryngol 1988 Mar-Apr;97(2 Pt 1):213-4. doi: 10.1177/000348948809700223. PMID: 3355051

Recent systematic reviews

Profiles and Findings of Population-Based Esophageal Cancer Screening With Endoscopy in China: Systematic Review and Meta-analysis.
Li H, Teng Y, Yan X, Cao M, Yang F, He S, Zhang S, Li Q, Xia C, Li K, Chen W
JMIR Public Health Surveill 2023 Jun 1;9:e45360. doi: 10.2196/45360. PMID: 37261899Free PMC Article
Binary and WHO dysplasia grading systems for the prediction of malignant transformation of oral leukoplakia and erythroplakia: a systematic review and meta-analysis.
de Freitas Silva BS, Batista DCR, de Souza Roriz CF, Silva LR, Normando AGC, Dos Santos Silva AR, Silva MAG, Yamamoto-Silva FP
Clin Oral Investig 2021 Jul;25(7):4329-4340. Epub 2021 May 29 doi: 10.1007/s00784-021-04008-1. PMID: 34050426
Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype.
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979
Risk factors for metachronous colorectal cancer or polyp: A systematic review and meta-analysis.
Jayasekara H, Reece JC, Buchanan DD, Ahnen DJ, Parry S, Jenkins MA, Win AK
J Gastroenterol Hepatol 2017 Feb;32(2):301-326. doi: 10.1111/jgh.13476. PMID: 27356122
Grade of dysplasia and malignant transformation in adults with premalignant laryngeal lesions.
van Hulst AM, Kroon W, van der Linden ES, Nagtzaam L, Ottenhof SR, Wegner I, Gunning AC, Grolman W, Braunius W
Head Neck 2016 Apr;38 Suppl 1:E2284-90. Epub 2015 Aug 13 doi: 10.1002/hed.24185. PMID: 26268427

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