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Malignant Sertoli cell tumor

MedGen UID:
137755
•Concept ID:
C0334406
•
Neoplastic Process
Synonyms: Androblastoma, malignant; Arrhenoblastoma, malignant; Malignant androblastoma; malignant Androblastoma; Malignant arrhenoblastoma; Malignant Sertoli Cell Tumor; malignant Sertoli cell tumor; Sertoli cell tumor, malignant
SNOMED CT: Malignant androblastoma (12323008); Malignant arrhenoblastoma (12323008); Androblastoma, malignant (12323008); Arrhenoblastoma, malignant (12323008)
 
Monarch Initiative: MONDO:0000378

Definition

A Sertoli cell tumor that arises from the testis or the ovary. It is characterized by nuclear pleomorphism, increased mitotic activity and necrotic changes. Metastases may be present at diagnosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Sertoli cell tumor

Professional guidelines

PubMed

DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
From diagnosis to treatment of androgen-secreting ovarian tumors: a practical approach.
Rojewska P, Meczekalski B, Bala G, Luisi S, Podfigurna A
Gynecol Endocrinol 2022 Jul;38(7):537-542. Epub 2022 Jun 1 doi: 10.1080/09513590.2022.2083104. PMID: 35647677
Peutz-Jeghers Syndrome: Pathobiology, Pathologic Manifestations, and Suggestions for Recommending Genetic Testing in Pathology Reports.
Meserve EE, Nucci MR
Surg Pathol Clin 2016 Jun;9(2):243-68. doi: 10.1016/j.path.2016.01.006. PMID: 27241107

Recent clinical studies

Diagnosis

Malignant Sertoli cell tumor of the testis masquerading as seminoma with bone metastasis.
Agrawal CR, Babu Koyyala VP, Talwar V, Tayal J, Poonia DR
Indian J Pathol Microbiol 2018 Oct-Dec;61(4):596-599. doi: 10.4103/IJPM.IJPM_492_17. PMID: 30303161
Malignant Sertoli cell tumor of the ovary metastatic to the lung mimicking neuroendocrine carcinoma: report of a case.
Phadke DM, Weisenberg E, Engel G, Rhone DP
Ann Diagn Pathol 1999 Aug;3(4):213-9. doi: 10.1016/s1092-9134(99)80053-7. PMID: 10459047
Fine needle aspiration cytology in malignant Sertoli cell tumor of the testis. A case report.
Nijhawan R, Dey P, Savitri K, Gupta SK
Acta Cytol 1992 Jul-Aug;36(4):563-5. PMID: 1636354

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